Down-regulation of salivary glands AQP5 by LPS via NF-κB signaling
| Project/Area Number |
20791353
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
YAO Chenjuan The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 (20432750)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 口腔生理学 / LPS / 唾液腺 / 水チャネル / down-regulation / NF-κBシグナリング |
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| Research Abstract |
Our results indicated that LPS induced potential down-regulation of expression of AQP5 is mediated via a complex (es) of these 2 classes of transcription factors, NF- K13 and p-c-jun/c-Fos. The two NF-κB binding sites in the AQP5 promoter played very important roles in the LPS-induced down-regulation. By co-immunoprecipitation analysis, the physical association of these transcription factors was shown in RAW264.7 cell line after LPS treatment. The mechanism of the down-regulation of AQP5 by LPS will be identified using c-Fos stable overexpression cell lines in the future.
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Report
(3 results)
Research Products
(43 results)
