The development of the newly adhesive system using the nano-spaces between dentin collagen fibrils

• Project/Area Number: 20791382
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Conservative dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: HOSAKA Keiichi Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 助教 (80451946)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 接着性レジン / 象牙質 / コラーゲンナノスペース

Research Abstract

The infiltration of hydrophobic resin monomers into the nano-spaces between dentin collagen fibrils using ethanol-wet bonding technique can increase the durability of resin-dentin bonds overtime. In the view of water sorption and mechanical property of polymerized adhesives, the bonding layer created by hydrophobic monomers is desirable.

Research Products

• [Journal Article] Relationship between mechanical properties of one-step self-etch adhesives and water sorption (2010)
  • Author(s): Hosaka K, Nakajima M, Takahashi M, Itoh S, Ikeda M, Tagami J, Pashley DH.
  • Journal Title: Dental Materials 26 Pages: 360-367
  • Peer Reviewed
• [Journal Article] Dentin bond durability and water sorption/solubility of one-step self-etch adhesives. (2010)
  • Author(s): Itoh S, Nakajima M, Hosaka K, Okuma M, Takahashi M, Shinoda Y, Seki N, Ikeda M, Kishikawa R, Foxton RM, Tagami J.
  • Journal Title: Dental Materials Journal 29 Pages: 623-630
  • NAID: 10026670069
  • Peer Reviewed
• [Journal Article] Relationship between mechanical properties of one-step self-etch adhesives and water sorption. (2010)
  • Author(s): Hosaka K, Nakajima M, Takahashi M, Itoh S, Ikeda M, Tagami J, Pashley DH.
  • Journal Title: Dental Materials Volume: 26 Pages: 360-367
  • Peer Reviewed
• [Journal Article] Translucency, opalescence and light transmission characteristics of light-cured resin composites. (2010)
  • Author(s): Arimoto A, Nakajima M, Hosaka K, Nishimura K, Ikeda M, Foxton RM, Tagami J.
  • Journal Title: Dental Materials Volume: 26 Pages: 1090-1097
  • Peer Reviewed
• [Journal Article] Effect of composite post placement on bonding to root canal dentin using 1-step self-etch dual-cure adhesive with chemical activation mode. (2010)
  • Author(s): Okuma M, Nakajima M, Hosaka K, Itoh S, Ikeda M, Foxton RM, Tagami J.
  • Journal Title: Dental Materials Journal Volume: 29 Pages: 642-648
  • NAID: 10026962473
  • Peer Reviewed
• [Journal Article] Dentin bond durability and water sorption/solubility of one-step self-etch adhesives. (2010)
  • Author(s): Itoh S, Nakajima M, Hosaka K, Okuma M, Takahashi M, Shinoda Y, Seki N, Ikeda M, Kishikawa R, Foxton RM, Tagami J.
  • Journal Title: Dental Materials Journal Volume: 29 Pages: 623-630
  • NAID: 10026670069
  • Peer Reviewed
• [Journal Article] The effect of the dentin preparation with an ultrasonic abrasion on the microtensile bond strength of self-etch adhesive systems (2010)
  • Author(s): Takanashi H, Hosaka K, Kishikawa R, Otsuki M, Tagami J
  • Journal Title: Int Chin J Dent 10 Pages: 7-15
  • Peer Reviewed
• [Journal Article] Durability of resin-dentin bonds to water-vs. ethanol-saturated dentin. (2009)
  • Author(s): Hosaka K, Nishitani Y, Tagami J, Yoshiyama M, Brackett WW, Agee KA, Tay FR, Pashley DH
  • Journal Title: Journal of Dental Research 88 Pages: 146-151
  • Peer Reviewed
• [Journal Article] Membrane permeab ility properties of dental adhesive films. (2009)
  • Author(s): Carrilho MR, Tay FR, Donnelly AM, Agee KA, Carvalho RM, Hosaka K, Reis A, Log uercio AD, Pashley DH.
  • Journal Title: J Biomed Mater Res B Appl Biomater 88 Pages: 312-320
  • Peer Reviewed
• [Journal Article] Membrane permeability properties of dental adhesive films (2009)
  • Author(s): Carrilho MR, Tay FR, Donnelly AM, Agee KA, Carvalho RM, Hosaka K, Reis A, Loguercio AD, Pashley DH.
  • Journal Title: J Biomed Mater Res B Appl Biomater 88 Pages: 312-20
  • Peer Reviewed
• [Journal Article] Improving the effect of NaOCl pretreatment on bonding to caries-affected dentin using self-etch adhesives (2009)
  • Author(s): Taniguchi G, Nakajima M, Hosaka K, Iwamoto N, Ikeda M, Foxton RM, Tagami J.
  • Journal Title: Journal of Dentistry 37 Pages: 769-775
  • Peer Reviewed
• [Journal Article] 光照射の有無がデュアルキュア型レジンセメントの象牙質接着強さに与える影響 (2009)
  • Author(s): 岸川隆蔵、田代浩史、趙永哲、保坂啓一、稲井紀通、田上順次
  • Journal Title: 接着歯学 27 Pages: 101-105
  • NAID: 10026308372
  • Peer Reviewed
• [Journal Article] Durability of resin-dentin bonds to water- vs. ethanol-saturated dentin (2009)
  • Author(s): Hosaka K, Nishitani Y, Tagami J, Yoshiyama M, Brackett WW, Agee KA, Tay FR, Pashley DH
  • Journal Title: Journal of Dental Research 88 Pages: 146-151
  • Peer Reviewed
• [Journal Article] う蝕象牙質に対する2ステップ・セルフェッチ接着システムの接着性能の改良 (2008)
  • Author(s): 中島正俊、谷口玄、Sitthikorn Kunawarote、保坂啓一、高橋真広、岩本奈々子、岸川隆蔵、田上順次
  • Journal Title: 日本歯科保存学雑誌 51 Pages: 396-401
  • Peer Reviewed
• [Presentation] The microtensile bond strength of the newly developed one step adhesive. (2011)
  • Author(s): K. HOSAKA, M. NAKAJIMA, M.TAKAHASHI, Y. SHINODA, W. SAKANO, R.KISHIKAWA, J. TAGAMI.
  • Organizer: IADR/AADR/CADR 89th General Session and Exhibition
  • Place of Presentation: サンディエゴ
  • Year and Date: 2011-03-18
• [Presentation] The microtensile bond strength of the newly developed one step adhesive (2011)
  • Author(s): K.HOSAKA, M.NAKAJIMA, M.TAKAHASHI, Y.SHINODA, W.SAKANO, R.KISHIKAWA, J.TAGAMI
  • Organizer: IADR/AADR/CADR 89th General Session and Exhibition
  • Place of Presentation: 米国サンディエゴ
  • Year and Date: 2011-03-18
• [Presentation] 新規開発接着性レジンMTB200の象牙質接着性能 (2010)
  • Author(s): 保坂啓一、中島正俊、篠田祐子、Prasansuttiporn Taweesak 、Sitthikorn Kunawarote、坂野若詠、高橋真広、岸川隆蔵、田上順次
  • Organizer: 第133回日本歯科保存学会
  • Place of Presentation: 岐阜市
  • Year and Date: 2010-10-30
• [Presentation] 新規開発接着性レジンMTB200の象牙質接着性能 (2010)
  • Author(s): 保坂啓一、中島正俊、篠田祐子、Prasansuttiporn Taweesak、Sitthikorn Kunawarote、坂野若詠、高橋真広、岸川隆蔵、田上順次
  • Organizer: 第133回日本歯科保存学会
  • Place of Presentation: 岐阜
  • Year and Date: 2010-10-30
• [Presentation] The effect of water-sorption on the mechanical-property of self-etch adhesives. (2010)
  • Author(s): K. HOSAKA, M. NAKAJIMA, M.TAKAHASHI, W. SAKANO, R. KISHIKAWA, D. PASHLEY, J. TAGAMI.
  • Organizer: IADR/AADR/CADR 88th General Session and Exhibition
  • Place of Presentation: スペインバルセロナ
• [Presentation] Water sorption and ultimate tensile strength of one-step adh esives. (2010)
  • Author(s): M. TAKAHASHI, M. NAKAJIMA, K. HOSAKA, S. ITOH, J. TAGAMI.
  • Organizer: IADR/AADR/CADR 88th General Ses sion and Exhibition.
  • Place of Presentation: スペインバルセロナ
• [Presentation] The effect of water-sorption on the mechanical-property of self-etch adhesives (2010)
  • Author(s): K.HOSAKA, M.NAKAJIMA, M.TAKAHASHI, W.SAKANO, R.KISHIKAWA, D.PASHLEY, J.TAGAMI
  • Organizer: IADR/AADR/CADR 88th General Session and Exhibition
  • Place of Presentation: スペインバルセロナ
• [Presentation] Effect of HEMA on dentin bonding durability of self-etch adhesives (2010)
  • Author(s): M.NAKAJIMA, Y.SHINODA, M.TAKAHASHI, K.HOSAKA, J.TAGAMI
  • Organizer: IADR/AADR/CADR 88th General Session and Exhibition
  • Place of Presentation: スペインバルセロナ
• [Presentation] Water sorption and ultimate tensile strength of one-step adhesives (2010)
  • Author(s): M.TAKAHASHI, M.NAKAJIMA, K.HOSAKA, S.ITOH, J.TAGAMI
  • Organizer: IADR/AADR/CADR 88th General Session and Exhibition
  • Place of Presentation: スペインバルセロナ
• [Presentation] Influence of Light-irradiation Intensity on Bonding to One-step vs Two-step (2010)
  • Author(s): N.SEKI, R.KISHIKAWA, K.HOSAKA, M.NAKAJIMA, J.TAGAMI
  • Organizer: IADR/AADR/CADR 88th General Session and Exhibition
  • Place of Presentation: スペインバルセロナ
• [Presentation] Bactericidal effect of TiO2 incorporated H2O2 photocatalysing by 405-nm diode-laser (2010)
  • Author(s): R.KISHIKAWA, K.MATIN, T.OYANAGI, M.GYO, N.SEKI, K.HOSAKA, T.HATAYAMA, M.OTSUKI, J.KATO
  • Organizer: IADR/AADR/CADR 88th General Session and Exhibition
  • Place of Presentation: スペインバルセロナ
• [Presentation] 長期水中浸漬後の1-step接着システムの象牙質接着性能に及ぼすスミヤー層の影響 (2010)
  • Author(s): 篠田佑子、中島正俊、保坂啓一、大槻昌幸、田上順次
  • Organizer: 第28回日本接着歯学会学術大会
  • Place of Presentation: 島根
• [Presentation] Dentin Bonding Durability of Recent Self-etching Adhesives. (2009)
  • Author(s): S. ITOH, M. NAKAJIMA, K. HOSAKA, M. OKUMA, Y. SHINODA, M. TAKAHASHI, N. SEKI, R. KISHIKAWA, M. IKEDA, J. TAGAMI.
  • Organizer: IADR/AADR/CADR 87th General Session and Exhibition
  • Place of Presentation: マイアミ
• [Presentation] 長期水中浸漬がワンステップボンディング材硬化体の吸水性・溶解性およびその機械的物性におよぼす影響について (2009)
  • Author(s): 高橋真広、保坂啓一、伊藤志麻、中島正俊、田上順次
  • Organizer: 第128回日本歯科保存学会
  • Place of Presentation: 宮城県
• [Presentation] セルフエッチングシステムにおける吸水と機械的強度との関係 (2009)
  • Author(s): 保坂啓一、中島正俊、高橋真広、駒田亘、大竹志保、三浦宏之、池田正臣、坂野若詠、岸川隆蔵、田上順次
  • Organizer: 第54回日本歯科理工学会
  • Place of Presentation: 鹿児島県
• [Presentation] Dentin Bonding Durability of Recent Self-etching Adhesives (2009)
  • Author(s): S.ITOH, M.NAKAJIMA, K.HOSAKA, M.OKUMA, Y.SHINODA, M.TAKAHASHI, N.SEKI, R.KISHIKAWA, M.IKEDA, J.TAGAMI
  • Organizer: IADR/AADR/CADR 87th General Session and Exhibition
  • Place of Presentation: Miami
• [Presentation] Effect of indirect-post placement on bonding to root canal dentin (2009)
  • Author(s): M.OKUMA, M.NAKAJIMA, K.HOSAKA, S.ITOH, R.KISHIKAWA, M.IKEDA, J.TAGAMI
  • Organizer: IADR/AADR/CADR 87th General Session and Exhibition
  • Place of Presentation: Miami
• [Presentation] 長期水中浸漬がワンステップボンディング材硬化体の吸水性・溶解性およびその機械的物性におよぼす影響について (2009)
  • Author(s): 高橋真広、保坂啓一、伊藤志麻、中島正俊、田上順次
  • Organizer: 第128回日本歯科保存学会
  • Place of Presentation: 仙台
• [Presentation] セルフエッチングシステムにおける吸水と機械的強度との関係 (2009)
  • Author(s): 保坂啓一、中島正俊、高橋真広、駒田亘、大竹志保、三浦宏之、池田正臣、坂野若詠、岸川隆蔵、田上順次
  • Organizer: 第54回日本歯科理工学会
  • Place of Presentation: 鹿児島
• [Presentation] Mechanical properties of one-step adhesive-polymers in dry vs.wet. (2008)
  • Author(s): K.HOSAKA, M.NAKAJIMA, M. TAKAHASHI, S.ITO, M. IKEDA, G.TANIGUCHI, Y.NISHITANI, M.YOSHIYAMA, D.H.PASHLEY, F.R.TAY, J.TAGAMI.
  • Organizer: IADR 86th General Session & Exhibition
  • Place of Presentation: トロント
  • Year and Date: 2008-07-04
• [Presentation] Mechanical properties of one-step adhesive-polymers in dry vs. wet (2008)
  • Author(s): K. HOSAKA, M. NAKAJIMA, M. TAKAHASHI, S. ITO, M. IKEDA, G. TANIGUCHI, Y. NISHITANI, M. YOSHIYAMA, D. H. PASHLEY, F. R. TAY, and J. TAGAMI
  • Organizer: IADR 86th General Session & Exhibition
  • Place of Presentation: トロント
  • Year and Date: 2008-07-04
• [Presentation] Effect of Antioxidant/Na0CI. Treatment on Bonding to Caries-Affected Dentin (2008)
  • Author(s): M. NAKAJIMA, G. TANIGUCHI, S. KUNAWAROTE, K. HOSAKA, N. IWAMOTO, M. TAKAHASHI
  • Organizer: IADR 86th General Session & Exhibition
  • Place of Presentation: トロント
  • Year and Date: 2008-07-04
• [Presentation] Correlations Between Changes in Matrix Height and μTBS (2008)
  • Author(s): D. PASHLEY, K. AGEE, K. HOSAKA, Y. NISHITANI, R. M. CARVALHO. and F. R. TAY
  • Organizer: IADR 86th General Session & Exhibition
  • Place of Presentation: トロント
  • Year and Date: 2008-07-03
• [Presentation] Effects of incorporating chlorhexidine into all-in-one adhesives (2008)
  • Author(s): Y. NISHITANI, M. YOSHIYAMA, T. HOSHIKA, K. TAKAHASHI, K. HOSAKA, J. TAGAMI, F. R. TAY, and D. PASHLEY
  • Organizer: IADR 86th General Session & Exhibition
  • Place of Presentation: トロント
  • Year and Date: 2008-07-03
• [Presentation] Improvement of Bond Strength to Caries-Affected Dentin (2008)
  • Author(s): G. TANIGUCHI, S. KUNAWARO TE, K. HOSAKA, N. IWAMOTO, M. IKEDA, M. NAKAJIMA, and J. TAGAMI
  • Organizer: IADR 86th General Session & Exhibition
  • Place of Presentation: トロント
  • Year and Date: 2008-07-03
• [Presentation] 新規MMA系レジンセメントPRC-01の歯質接着性能 (2008)
  • Author(s): 高橋真広, 池田正臣, 岩本奈々子, 保坂啓一, 青木香那子, 中島正俊, 田上順次
  • Organizer: 日本歯科保存学会2008年度春季学会第128回
  • Place of Presentation: 新潟市
  • Year and Date: 2008-06-06
• [Presentation] Durability of Resins Bonded to Water Vs. Ethanol-Saturated Acid-Etched Dentin. (2008)
  • Author(s): D.PASHLEY, Y.NISHITANI, M.YOSHIYAMA, K.HOSAKA, K.AGEE, W.W.BRACKETT, F.R.TAY.
  • Organizer: AADR 37th Annual Meeting and Exhibition
  • Place of Presentation: ダラス
  • Year and Date: 2008-04-03
• [Presentation] Durability of Resins Bonded to Water Vs. Ethanol-Saturated Acid-Etched Dentin (2008)
  • Author(s): D. H. PASHLEY, Y. NISHITANI, M. YOSHIYAMA, K HOSAKA, K. AGEE, W. W. BRACKETT, and F. R. TAY
  • Organizer: AADR 37th Annual Meeting and Exhibition
  • Place of Presentation: ダラス
  • Year and Date: 2008-04-03
• [Book] 接着治療失敗回避のためのポイント (2010)
  • Author(s): 安田登、二階堂徹、秋本尚武、遠山佳之、遠山孝之、保坂啓一、高垣智博、林正規、坪田有史、井野智
  • Total Pages: 45
  • Publisher: クインテッセンス出版(210)
• [Book] 接着治療失敗回避のためのポイント45 (2010)
  • Author(s): 安田登、二階堂徹、秋本尚武、遠山佳之、遠山孝之、保坂啓一、高垣智博、林正規、坪田有史、井野智
  • Total Pages: 210
  • Publisher: クインテッセンス出版
• [Remarks] ホームページ等
  • URL: http://aqua.tmd.ac.jp/ResDB/DispRsch/dsp_resdata.php?id=1440&la=ja