The global analysis of N-α-acetylome that is aiming development of antitumor therapy by the target factor in oral cancer.
| Project/Area Number |
20791511
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Tottori University |
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Principal Investigator |
TAKUBO Kazuko Tottori University, 医学部附属病院, 助教 (90379628)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | アセチローム / αアセチル化 / 細胞死 / 細胞周期 / 5-FU / NATH / プロテオーム解析 |
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| Research Abstract |
N-acetyltransferase human (NATH) participates in a posttranslational modification of the proteins and has been reported to play a role in apoptosis. In this study, the involvement of NATH in the cytotoxic action of 5-fluorouracil (5-FU) in human squamous cell carcinoma HEp-2 cells was examined. We found that 5-FU decreased NATH expression in a dose-dependent and time-dependent manner. No change was observed after treatment with other chemotherapeutics. The results of this study suggest that NATH plays an important role in the cytotoxic activity of 5-FU.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article]
Author(s)
Kazuko Takubo, Hiroyuki Tsuchiya, Akihiro Kurimasa, Thomas Arnesen, Kazuo Ryoke, Goshi Shiota
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Journal Title
Related Report
Peer Reviewed
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