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The institution of reference nutrient intake on phosphate, aimed reduction for cardiovascular disease risk

Research Project

Project/Area Number 20800038
Research Category

Grant-in-Aid for Young Scientists (Start-up)

Allocation TypeSingle-year Grants
Research Field Applied health science
Research InstitutionThe University of Tokushima

Principal Investigator

SHUTO Emi  The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 (10512121)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
Keywords動脈硬化 / リン / 酸化ストレス / 心血管疾患
Research Abstract

Excessive dietary phosphorus may increase cardiovascular risk in healthy individuals as well as in patients with chronic kidney disease. To determine whether postprandial hyperphosphatemia may promote endothelial dysfunction, we investigated the acute effect of phosphorus loading on endothelial function in 11 healthy men. The high dietary phosphorus load increased serum phosphorus and significantly decreased flow-mediated dilation. Flow-mediated dilation correlated inversely with serum phosphorus. These findings suggest that endothelial dysfunction mediated by acute postprandial hyperphosphatemia may contribute to the relationship between serum phosphorus level and the risk for cardiovascular morbidity and mortality.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (27 results)

All 2010 2009 2008

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (21 results)

  • [Journal Article] Dietary phosphorus acutely impairs endothelial function.2009

    • Author(s)
      Emi Shuto, Yutaka Taketani, Rieko Tanaka, agakatsu Harada, Masashi lsshiki, Minako Sato, Kunitaka Nashiki, Kikuko Amo, Hironori Yamamoto, Yukihito Higashi, Yutaka Nakaya, Eiji Takeda
    • Journal Title

      Journal of the American Society of Nephrology Vol.20

      Pages: 1504-1512

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dietary Phosphorus Acutely Impairs Endothelial Function2009

    • Author(s)
      Shuto E, et al
    • Journal Title

      Journal of the American Society of Nephrology 20

      Pages: 1504-1512

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高リン血症と心血管疾患2008

    • Author(s)
      首藤恵泉
    • Journal Title

      四国医学雑誌 64(3,4)

      Pages: 114-116

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Postprandial Hyperphosphatemia is a Novel Risk Factor for Cardiovascular Disease by Involving Endothelial Dysfunction2008

    • Author(s)
      Shuto E, et al
    • Journal Title

      Journal of Bone Mineral Reseadch 23

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] リンの栄養学2008

    • Author(s)
      竹谷 豊 等
    • Journal Title

      The Bone 22(6)

      Pages: 737-741

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高リン血症と心血管疾患2008

    • Author(s)
      首藤 恵泉 等
    • Journal Title

      四国医学雑誌 64(3, 4)

      Pages: 114-116

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 食事性のリン過剰摂取は血管内皮機能を障害する2010

    • Author(s)
      首藤恵泉
    • Organizer
      第13回日本病態栄養学会年次学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report
  • [Presentation] 食事性のリン過剰摂取は血管内皮機能を障害する2010

    • Author(s)
      首藤恵泉, 等
    • Organizer
      第13回日本病態栄養学会年次学術集会
    • Place of Presentation
      京都市
    • Related Report
      2009 Annual Research Report
  • [Presentation] Excessive dietary phosphorus acutely impairs endothelial function in healthy men.2009

    • Author(s)
      Emi Shuto
    • Organizer
      The American Society of Nephrology 42nd ANNUAL MEETING & Scientific Exposition
    • Place of Presentation
      San Diego, California, America
    • Related Report
      2009 Final Research Report
  • [Presentation] ヒトにおける食事性高リン負荷による血管内皮機能障害2009

    • Author(s)
      首藤恵泉
    • Organizer
      第63回日本栄養・食糧学会大会
    • Place of Presentation
      長崎
    • Related Report
      2009 Final Research Report
  • [Presentation] ヒトにおける食事性高リン負荷による血管内皮機能障害2009

    • Author(s)
      首藤恵泉
    • Organizer
      第12回日本病態栄養学会年次学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Acute effect of elevation of serum phosphorus on endothelial function with reference to oxidative stress and NO production2009

    • Author(s)
      Taketani Y, et al
    • Organizer
      36th international congress of physiological science
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dual Role of Type III Sodium-Dependent Phosphate Transporter in the Pathogenesis of Arteriosclerosis Caused by Hyperphosphatemia2009

    • Author(s)
      Taketani Y, et al
    • Organizer
      American Society of Bone and Mineral Research 31th ANNUAL MEETING
    • Place of Presentation
      Denver, Colorado, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Excessive dietary phosphorus acutely impairs endothelial function in healthy men2009

    • Author(s)
      Shuto E, et al
    • Organizer
      The American Society of Nephrology 42nd ANNUAL MEETING & Scientific Exposition
    • Place of Presentation
      San Diego, California, America
    • Related Report
      2009 Annual Research Report
  • [Presentation] Fluctuation of Serum Phosphorus Levels Impairs Endothelial Function in Rats2009

    • Author(s)
      Watari E, et al
    • Organizer
      The American Society of Nephrology 42nd ANNUAL MEETING & Scientific Exposition
    • Place of Presentation
      San Diego, California, America
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒトにおける食事性高リン負荷による血管内皮機能障害2009

    • Author(s)
      首藤恵泉, 等
    • Organizer
      第63回日本栄養・食糧学会大会
    • Place of Presentation
      長崎市
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高リン食は血管内皮依存性の血管弛緩反応を低下させる2009

    • Author(s)
      渡里恵梨子, 等
    • Organizer
      第63回日本栄養・食糧学会大会
    • Place of Presentation
      長崎市
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高リン負荷による血管内皮細胞におけるMCP-1の発現誘導2009

    • Author(s)
      北村知世, 等
    • Organizer
      第63回日本栄養・食糧学会大会
    • Place of Presentation
      長崎市
    • Related Report
      2009 Annual Research Report
  • [Presentation] 成人女性におけるリン制限食による尿中ミネラル排泄への影響2009

    • Author(s)
      西田由香, 等
    • Organizer
      第63回日本栄養・食糧学会大会
    • Place of Presentation
      長崎市
    • Related Report
      2009 Annual Research Report
  • [Presentation] 栄養素代謝恒常性の破綻と疾患発症におけるトランスポーターの役割2009

    • Author(s)
      竹谷豊, 等
    • Organizer
      第4回トランスポーター研究会
    • Place of Presentation
      京都市
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高リン血症による血管内皮機能障害とその発生機序についての検討2008

    • Author(s)
      首藤 恵泉
    • Organizer
      第237回徳島医学会学術集会
    • Place of Presentation
      徳島
    • Year and Date
      2008-08-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] 高リン負荷による血管内皮機能障害2008

    • Author(s)
      首藤恵泉
    • Organizer
      第26回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] PostprandialIfyperphosphatemia is a Novel Risk Factor for Cardiovascular Disease by Involving Endothelial Dysfunction.2008

    • Author(s)
      Shuto E.
    • Organizer
      American Society of Bone and Mineral Research 30th ANNUAL MEETING
    • Place of Presentation
      Montreal, Quebec, Canada
    • Related Report
      2009 Final Research Report
  • [Presentation] 食後高リン血症は血管内皮機能障害を惹起し心血管疾患のリスクとなる2008

    • Author(s)
      首藤恵泉
    • Organizer
      第55回栄養改善学会
    • Place of Presentation
      鎌倉
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Postprandial Hyperphosphatemia is a Novel Risk Factor for Cardiovascular Disease by Involving Endothelial Dysfunction2008

    • Author(s)
      Shuto E
    • Organizer
      American Society of Bone and Mineral Research 30th ANNUAL MEETING
    • Place of Presentation
      Montreal, Quebec, Canada
    • Related Report
      2008 Annual Research Report
  • [Presentation] リン酸トランスポーターを介した血管内皮機能障害のメカニズム2008

    • Author(s)
      首藤 恵泉
    • Organizer
      トランスポーター研究会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] 高リン負荷による血管内皮機能障害2008

    • Author(s)
      首藤恵泉
    • Organizer
      第26回 日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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