| Project/Area Number |
20810041
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | Nagasaki International University |
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Principal Investigator |
NAKAHARA Hiromichi Nagasaki International University, 薬学部・薬学科, 助教 (00513235)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIBATA Osamu 長崎国際大学, 薬学部・薬学科, 教授 (10117129)
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,276,000 (Direct Cost: ¥2,520,000、Indirect Cost: ¥756,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,716,000 (Direct Cost: ¥1,320,000、Indirect Cost: ¥396,000)
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| Keywords | 表面・界面物性 / 複合材料 / 肺サーファクタント / ナノ医薬 / 超薄膜 / 表面張力 / 表面電位 / 蛍光顕微鏡 / ブリュースター角顕微鏡 / 呼吸窮迫症候群 / 未熟児 / DPPC |
|---|
| Research Abstract |
As a result of in vitro and in vivo examinations, our pulmonary surfactant preparations show the similar effect to Surfacten. In addition, an electrostatic interaction between PG (phosphatidylglycerol) and peptide (Hel 13-5) prevents irreversible transformation for the peptide from α-helix to β-sheet structures.
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