Analysis of Kap proteins, novel kinetochore-binding factors

• Project/Area Number: 20870004
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Molecular biology
• Research Institution: University of Tsukuba
• Principal Investigator: SUGIYAMA Tomoyasu University of Tsukuba, 大学院・生命環境科学研究科, 助教 (80503490)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
• Keywords: 染色体分配 / キネトコア / CENP-A / キネトコァ

Research Abstract

In this study, I have identified two novel proteins of fission yeast, Kap1 and Kap2, both of which associate with kinetochore. kap1 mutation leads to defects in chromosome segregation and DNA damage responses. These results provide a new insight into kinetochore function.