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Study of the microRNA pathway controlling developmental timing : Utilization of the amyloid precursor protein-like gene

Research Project

Project/Area Number 20870005
Research Category

Grant-in-Aid for Young Scientists (Start-up)

Allocation TypeSingle-year Grants
Research Field Developmental biology
Research InstitutionUniversity of Tsukuba

Principal Investigator

NIWA Ryusuke  University of Tsukuba, 大学院・生命環境科学研究科, 助教 (60507945)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
Keywords発生・分化 / 発現制御 / 線虫 / 発生タイミング / マイクロRNA / 転写因子 / 核内受容体
Research Abstract

The development of multicellular organisms is tightly regulated under a precise time schedule. To unravel the molecular mechanisms underlying developmental timing in multicellular organisms, I used the nematode Caenorhabditis elegans as the model organism. I identified and characterized genes involved in the let-7 microRNA pathway, which is essential for the larva-to-adult transition. I found that the nuclear receptor gene nhr-25 plays a crucial role in the developmental fate switch from larval to adult stages in C.elegans.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (18 results)

All 2010 2009 Other

All Journal Article (1 results) Presentation (14 results) Remarks (3 results)

  • [Journal Article] The nuclear receptor gene nhr-25 plays multiple roles in the C. elegans heterochronic gene network to control the larva-to-adult transition2010

    • Author(s)
      Kazumasa Hada, Masako Asahina, Hiroshi Hasegawa, Yasunori Kanaho, Frank J. Slack, Ryusuke Niwa
    • Journal Title

      Developmental Biology (掲載決定済み)

    • Related Report
      2009 Final Research Report
  • [Presentation] 脱皮動物の発生タイミングの分子機構 : 昆虫エクジソン生合成経路および線虫ヘテロクロニック遺伝子の研究を通じて2009

    • Author(s)
      丹羽隆介
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-12-12
    • Related Report
      2009 Final Research Report
  • [Presentation] 脱皮動物の発生タイミングの分子機構:昆虫エクジソン生合成経路および線虫ヘテロクロニック遺伝子の研究を通じて2009

    • Author(s)
      丹羽隆介
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] A screen for novel heterochronic genes that regulate the let-7 microRNA-dependent developmental timing pathway in the nematode Caenorhabditis elegans2009

    • Author(s)
      Kazumasa Hada, Sora Enya, Ryusuke Niwa
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-12-11
    • Related Report
      2009 Final Research Report
  • [Presentation] A screen for novel heterochronic genes that regulate the let-7 microRNA-dependent developmental timing pathway in the nematode Caenorhabditis elegans2009

    • Author(s)
      Kazumasa Hada, Sora Enya, Ryusuke Niwa
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Hunting for new heterochronic genes that play essential roles in the let-7 microRNA-dependent pathway in Caenorhabditis elegans2009

    • Author(s)
      Kazumasa Hada, Sora Enya, Ryusuke Niwa
    • Organizer
      International Symposium on Cellular Signaling ~principles and functions~
    • Place of Presentation
      筑波大学
    • Year and Date
      2009-11-19
    • Related Report
      2009 Final Research Report
  • [Presentation] The nuclear hormone receptor nhr-25 is a heterochronic gene that has dual roles in both promoting and inhibiting C.elegans adult programs2009

    • Author(s)
      Ryusuke Niwa, Kazumasa Hada, Hiroshi Hasegawa, Masako Asahina, Yasunori Kanaho, Frank J.Slack
    • Organizer
      The 17th International C.elegans Meeting
    • Place of Presentation
      カリフォルニア州立大学ロサンゼルス校(米国)
    • Year and Date
      2009-06-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] The nuclear hormone receptor nhr-25 is a heterochronic gene that has dual roles in both promoting and inhibiting C. elegans adult programs2009

    • Author(s)
      Ryusuke Niwa, Kazumasa Hada, Hiroshi Hasegawa, Masako Asahina, Yasunori Kanaho, Frank J. Slack
    • Organizer
      17th International C. elegans Meeting
    • Place of Presentation
      カリフォルニア大学ロサンゼルス校、アメリカ合衆国
    • Year and Date
      2009-06-24
    • Related Report
      2009 Final Research Report
  • [Presentation] Identification and characterization of novel heterochronic genes involved in the let-7 microRNA-dependent developmental timing pathway in Caenorhabditis elegans2009

    • Author(s)
      Kazumasa Hada, Hiroshi Hasegawa, Yasunori Kanaho, Frank J. Slack, Ryusuke Niwa
    • Organizer
      17th International C. elegans Meeting
    • Place of Presentation
      カリフォルニア大学ロサンゼルス校、アメリカ合衆国
    • Year and Date
      2009-06-24
    • Related Report
      2009 Final Research Report
  • [Presentation] Identification and characterization of novel heterochronic genes involved in the let-7 microRNA-dependent developmental timing pathway in Caenorhabditis elegans2009

    • Author(s)
      Kazumasa Hada, Hiroshi Hasegawa, Yasunori Kanaho, Ryusuke Niwa
    • Organizer
      日本発生生物学会第42回大会
    • Place of Presentation
      新潟コンベンションセンター朱鷺メッセ
    • Year and Date
      2009-05-28
    • Related Report
      2009 Final Research Report
  • [Presentation] 線虫 C. elegans の let-7 microRNA 発生タイミング経路に関わる新規遺伝子の同定と機能解析2009

    • Author(s)
      波田一誠, 長谷川潤, 金保安則, Frank J. Slack, 丹羽隆介
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      マリンメッセ福岡
    • Year and Date
      2009-03-27
    • Related Report
      2009 Final Research Report
  • [Presentation] Identification and characterization of novel heterochronic genes involved in the let-7 microRNA-dependent developmental timing pathway in Caenorhabditis elegans2009

    • Author(s)
      Kazumasa Hada, Hiroshi Hasegawa, Yasunori Kanaho, Ryusuke Niwa
    • Organizer
      The 42nd Annual meeting for the Japanese Society of Developmental Biologists
    • Place of Presentation
      朱鷺メッセ(新潟市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification and characterization of novel heterochronic genes involved in the let-7 microRNA-dependent developmental timing pathway in Caenorhabditis elegans2009

    • Author(s)
      Kazumasa Hada, Hiroshi Hasegawa, Yasunori Kanaho, Frank J.Slack, Ryusuke Niwa
    • Organizer
      The 17th International C.elegans Meeting
    • Place of Presentation
      カリフォルニア州立大学ロサンゼルス校(米国)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Hunting for new heterochronic genes that play essential roles in the let-7 microRNA-dependent pathway in Caenorhabditis elegans2009

    • Author(s)
      Kazumasa Hada, Sora Enya, Ryusuke Niwa
    • Organizer
      International Symposium on Cellular Signaling~principles and functions~
    • Place of Presentation
      筑波大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] 線虫C. elegansのlet-7 microRNA発生タイミング経路に関わる新規遺伝子の同定と機能解析2009

    • Author(s)
      波田一誠、長谷川潤、金保安則、Frank J. Slack、丹羽隆介
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      マリンメッセ福岡
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.biol.tsukuba.ac.jp/~rniwa/

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.biol.tsukuba.ac.jp/~rniwa

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.biol.tsukuba.acjp/~rniwa

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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