| Project/Area Number |
20880042
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | National Institute of Agrobiological Sciences |
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Principal Investigator |
WAKABAYASHI Yoshihiro National Institute of Agrobiological Sciences, 脳神経機能研究ユニット, 任期付研究員 (00510695)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Keywords | キスペプチン / 弓状核 / GnRH / 鋤微系 / 扁桃体内側核 / GnRHパルスジェネレーター / Neurokinin B / Dynorphin A / 鋤鼻系 / メタスチン |
|---|
| Research Abstract |
In goats, the pheromone produced by the male induces out of seasonal ovulation in anestrous females, the "male effect". This pheromonal information is transmitted to the hypothalamus via main and/or vomeronasal systems, although it remains unclear about this pathway. In this study, we used goats and we investigated about this pathway in the brain using morphological techniques. The medial amygdaloid nucleus (MeA) that is one of the major nuclei for transmission of pheromone signals, connect to kisspeptin neurons in the arcuate nucleus (ARC). This result suggests that signal of "male effect" pheromone is transmitted to kisspeptin neurons in the ARC, then evokes GnRH release.
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