| Project/Area Number |
20890124
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kobe University |
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Principal Investigator |
OKUNO Tatsuya Kobe University, 医学部附属病院, 特定助教 (50464269)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Keywords | 大腸癌 / メタボローム / バイオマーカー / 大腸がん / 質量分析計 / ペプチド |
|---|
| Research Abstract |
In the cells with pathological conditions, various metabolites are produced through the secretion of disease-related proteins and the protein degradation by proteases. However, the comprehensive study of these disease-specific low-molecule metabolites has not shown the adequate results yet due to various problems. Therefore, the experiments to comprehensively analyze the low-molecule metabolites derived from gastroenterological carcinomas followed by identification of the novel cancer-spesific biomarkers was designed, and then it was investigated whether the identified biomarkers can be actually used in clinical practice.
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