Metabolomics in human colon cancer
| Project/Area Number |
20890124
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kobe University |
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Principal Investigator |
OKUNO Tatsuya Kobe University, 医学部附属病院, 特定助教 (50464269)
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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|---|
| Keywords | 大腸癌 / メタボローム / バイオマーカー / 大腸がん / 質量分析計 / ペプチド |
|---|
| Research Abstract |
In the cells with pathological conditions, various metabolites are produced through the secretion of disease-related proteins and the protein degradation by proteases. However, the comprehensive study of these disease-specific low-molecule metabolites has not shown the adequate results yet due to various problems. Therefore, the experiments to comprehensively analyze the low-molecule metabolites derived from gastroenterological carcinomas followed by identification of the novel cancer-spesific biomarkers was designed, and then it was investigated whether the identified biomarkers can be actually used in clinical practice.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] R eplacement of cisplatin with nedaplatin in a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma.2009
Author(s)
Kuwahara A, Yamamori M, Nishiguchi K, Okuno T, Chayahara N, Miki I, Tamura T, Inokuma T, Takemoto Y, Nakamura T, Kataoka K, Sakaeda T.
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Journal Title
Int J Med Sci. 6(6)
Pages: 305-11
NAID
Related Report
Peer Reviewed
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[Journal Article] P hase I and pharmacokinetic study of tegafur-uracil/leucovorin combined with 5-fluorouracil/leucovorin and irinotecan in patients with advanced colorectal cancer.2009
Author(s)
Chayahara N, Tamura T, Yamamori M, Kadowaki Y, Okuno T, Miki I, Tsuda M, Nishisaki H, Maeda T, Inoue Y, Okumura K, Azuma T, Kasuga M, Sakaeda T, Hirai M.
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Journal Title
Am J Clin Oncol. 32(1)
Pages: 56-60
Related Report
Peer Reviewed
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[Journal Article] V EGF G-1154A is predictive of severe acute toxicities during chemoradiotherapy for esophageal squamous cell carcinoma in Japanese patients.2008
Author(s)
Sakaeda T, Yamamori M, Kuwahara A, Hiroe S, Nakamura T, Okumura K, Okuno T, Miki I, Chayahara N, Okamura N, Tamura T.
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Journal Title
Ther Drug Monit. 30(4)
Pages: 497-503
Related Report
Peer Reviewed
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[Journal Article] R ole of metallothionein in Helicobacter pylori-positive gastric mucosa with or without early gastric cancer and the effect on its expression after eradication therapy.2008
Author(s)
Mitani T, Shirasaka D, Aoyama N, Miki I, Morita Y, Ikehara N, Matsumoto Y, Okuno T, Toyoda M, Miyachi H, Yoshida S, Chayahara N, Hori J, Tamura T, Azuma T, Kasuga M.
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Journal Title
J Gastroenterol Hepatol 23(8Pt2)
Pages: 334-9
Related Report
Peer Reviewed
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