• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Postnatal Developmental Expression in Gjb2 Transgenic Mice of the Organ of Corti

Research Project

Project/Area Number 20890219
Research Category

Grant-in-Aid for Young Scientists (Start-up)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionJuntendo University

Principal Investigator

INOSHITA Ayako  Juntendo University, 医学部, 助教 (00514762)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
KeywordsGJB2遺伝子変異 / コネキシン26 / 先天性難聴 / コルチ器 / アポトーシス / GER(内側隆起) / GJB2遺伝子 / 内耳 / コルチトンネル / モデルマウス
Research Abstract

A strikingly high proportion of congenital bilateral nonsyndromic sensorineural deafness cases among Japanese have been linked to mutations in the GJB2 coding for the connexin26. We aimed to evaluate the postnatal development of the organ of Corti in GJB2 mutations model mice. The mice showed incomplete development of the cochlear pillar cells and delayed apoptosis in GER. The present findings contribute strongly to one of basic remedies for the congenital deafness caused by Gjb2 mutation.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (11 results)

All 2010 2009 2008 Other

All Journal Article (4 results) (of which Peer Reviewed: 1 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Dominant negative connexin26 mutation R75W causing severe hearing loss influences normal programmed cell death in postnatal organ of Corti2010

    • Author(s)
      Ayako Inoshita, Kazusaku Kamiya, Takashi Iizuka, Masayuki Furukawa, Katsuhisa Ikeda
    • Journal Title

      American Journal of Pathology (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cochlear outer hair cells in a dominant-negative connexin26 mutant mouse preserve non-linear capacitance in spite of impaired distortion product otoacoustic emission2009

    • Author(s)
      A. MINEKAWA, T. ABE, A. INOSHITA, T. IIZUKA, S. KAKEHATA, Y. NARUI, T. KOIKE, K. KAMIYA, H. OKAMURA, H. SHINKAWA, K. IKEDA
    • Journal Title

      Neuroscience 164

      Pages: 1312-1319

    • Related Report
      2009 Final Research Report
  • [Journal Article] Postnatal development of the organ of Corti in dominant-negative GJB2 transgenic mice2008

    • Author(s)
      A. INOSHITA, T. IIZUKA, H. OKAMURA, A. MINEKAWA, K. KOJIMA, M. FURUKAWA, T. KUSUNOKI, K. IKEDA
    • Journal Title

      Neuroscience 156

      Pages: 1039-1047

    • Related Report
      2009 Final Research Report
  • [Journal Article] Postnatal development of the organ of Corti in dominant-negative Gjb2 transgenic mice.2008

    • Author(s)
      Ayako Inoshita, et al.
    • Journal Title

      Neuroscience 156

      Pages: 1039-1047

    • Related Report
      2008 Annual Research Report
  • [Presentation] Postnatal development of the organ of Corti in dominant-negative GJB2 transgenic mice2009

    • Author(s)
      Ayako Inoshita
    • Organizer
      32rd ARO Mid Winter Meeting
    • Place of Presentation
      アメリカ, フェニックス
    • Related Report
      2009 Final Research Report
  • [Presentation] Postnatal apoptosis of GER in dominant-negative Gjb2 transgenic mice2009

    • Author(s)
      Ayako Inoshita
    • Organizer
      7th Molecular Biology of Hearing and Deafness
    • Place of Presentation
      アメリカ, ボストン
    • Related Report
      2009 Final Research Report
  • [Presentation] Postnatal apoptosis of GER in dominant-negative Gjb2 transgenic mice2009

    • Author(s)
      Ayako Inoshita
    • Organizer
      7^<th> Molecular Biology of Hearing and Deafness
    • Place of Presentation
      アメリカ、ボストン
    • Related Report
      2009 Annual Research Report
  • [Presentation] Gjb2遺伝子優性阻害変異マウスの発育段階におけるコルチ器の構造と微細構造2008

    • Author(s)
      井下綾子
    • Organizer
      第109回日本耳鼻咽喉科学会総会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] Gjb2遺伝子優性阻害変異マウスの発育段階におけるコルチ器の構造と微細構造2008

    • Author(s)
      井下綾子
    • Organizer
      第18回日本耳科学会総会
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Presentation] 難聴遺伝子Gjb2優性阻害変異マウスの発育過程における解析と評価2008

    • Author(s)
      井下 綾子
    • Organizer
      日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      大阪府大阪市
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://cme.ucsd.edu/mbad/index.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi