Development and mechanistic study of novel anti-Alzheimer's disease drugs based on physiologically active fatty acid
| Project/Area Number |
20890266
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | Hyogo University of Health Sciences |
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Principal Investigator |
SHIMIZU Tadashi Hyogo University of Health Sciences, 薬学部, 助教 (40509022)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Keywords | 認知症治療剤 / 生理活性脂肪酸 / 光学分割 / 光学活性誘導体 / シクロプロパン / DCP-LA |
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| Research Abstract |
We have already reported linoleic acid analogues without unstable cis-double bonds, called DCP-LA, which induced LTP-like long-lasting facilitation of hippocampal neurotransmission in both in vitro and in vivo systems. However, DCP-LA was four stereo-isomer mixtures, the determination of the most active isomer have been remained. In this reserch, we have developed synthetic route for the preparation of all of the four isomers of enantiomerically pure DCP-LA employing lipase-mediated resolution method, and found the most active stereoisomers.
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Report
(3 results)
Research Products
(4 results)
