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Molecular mechanisms to avert motor neurons vulnerability in ALS

Research Project

Project/Area Number 20H00485
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 46:Neuroscience and related fields
Research InstitutionKeio University

Principal Investigator

Okano Hideyuki  慶應義塾大学, 医学部(信濃町), 教授 (60160694)

Co-Investigator(Kenkyū-buntansha) 矢野 真人  新潟大学, 医歯学系, 准教授 (20445414)
Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥44,850,000 (Direct Cost: ¥34,500,000、Indirect Cost: ¥10,350,000)
Fiscal Year 2023: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2022: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2021: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2020: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
KeywordsALS / 運動ニューロン / ベイジアンネットワーク解析 / iPS細胞 / RNA結合蛋白質
Outline of Research at the Start

本研究計画では、HITS-CLIP/RNAseq/Interactomeというマルチオミクス解析にスーパーコンピュターによるiBRN法を駆使し、ALS神経変性モデルを徹底的に調べる。以上の探索から、トランスクリプトーム情報に対するネットワークハブ候補分子、ALS関連RNA結合蛋白質群の標的RNA群、相互作用蛋白質群の中で構造を持たない天然変性蛋白質群との3者の関連性に着目することで、ALS運動ニューロンの脆弱性回避と破綻の分子実態の普遍的原理解明を目指す。

Outline of Final Research Achievements

We established a novel platform technology, iBRN, “Non- biased” Bayesian gene regulatory network analysis based on induced pluripotent stem cell (iPSC)-derived cell model, to elucidate the molecular etiology using transcriptome of iPSC-derived MNs harboring FUS mutation. iBRN revealed “hub molecules”, which strongly influenced transcriptome network, such as miR-125b-5p-TIMELESS axis and PRKDC for the molecular etiology. And we also obtained 23 small molecule compounds that regulates the abnormal localization of FUS induced by DNA damage/PRKDC inhibition. Furthermore, we succeeded in establishing a cellular model of sporadic ALS in addition to the familial ALS, and revealed that the expression of a group of genes involved in cholesterol biosynthesis in motor neurons is a risk and therapeutic target for ALS.

Academic Significance and Societal Importance of the Research Achievements

RNA結合蛋白質をコードするALSの原因遺伝子FUSやTARDBPに変異を持つiPS細胞株、さらに孤発性ALS患者由来のiPS細胞を樹立し、多くのALS細胞モデルを構築し、細胞ベースの病態解析を行い治療標的となる分子群と分子経路、診断マーカー等を複数見出す事ができた。これらのALS細胞モデルは、今後さらに神経科学領域の基礎研究および治療法の確立に大きく貢献が期待されるものである。また、その分子システムの解明のための方法論として、新たにトランスクリプトーム情報の影響度で疾患の原因を再分類するベイジアンネットワーク解析(iBRNと命名)という有用な方法論を確立できたものと考える。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Comments on the Screening Results   Annual Research Report
  • Research Products

    (144 results)

All 2024 2023 2022 2021 2020 Other

All Journal Article (16 results) (of which Peer Reviewed: 13 results,  Open Access: 12 results) Presentation (123 results) (of which Int'l Joint Research: 37 results,  Invited: 111 results) Book (3 results) Remarks (2 results)

  • [Journal Article] Sbp2l contributes to oligodendrocyte maturation through translational control in Tcf7l2 signaling2023

    • Author(s)
      Yugami Masato、Hayakawa-Yano Yoshika、Ogasawara Takahisa、Yokoyama Kazumasa、Furukawa Takako、Hara Hiroe、Hashikami Kentaro、Tsuji Isamu、Takebayashi Hirohide、Araki Shinsuke、Okano Hideyuki、Yano Masato
    • Journal Title

      iScience

      Volume: 26 Issue: 12 Pages: 108451-108451

    • DOI

      10.1016/j.isci.2023.108451

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Attenuated cerebellar phenotypes in Inpp4a truncation mutants with preserved phosphatase activity.2023

    • Author(s)
      Tran DM, Yoshioka N, Bizen N, Mori-Ochiai Y, Yano M, Yanai S, Hasegawa J, Miyashita S, Hoshino M, Sasaki J, Sasaki T, Takebayashi H
    • Journal Title

      Dis Model Mech

      Volume: 16 Issue: 7 Pages: 192-206

    • DOI

      10.1242/dmm.050169

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery2023

    • Author(s)
      Morimoto Satoru、Takahashi Shinichi、Ito Daisuke et al.
    • Journal Title

      Cell Stem Cell

      Volume: 30 Issue: 6 Pages: 766-780.e9

    • DOI

      10.1016/j.stem.2023.04.017

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits2023

    • Author(s)
      Li Dan、Johmura Yoshikazu、Morimoto Satoru et al.
    • Journal Title

      Nature Aging

      Volume: 3 Issue: 8 Pages: 1001-1019

    • DOI

      10.1038/s43587-023-00464-4

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protein profiling of extracellular vesicles from iPSC-derived astrocytes of patients with ALS/PDC in Kii peninsula2023

    • Author(s)
      Kobayashi Hiroya、Ueda Koji、Morimoto Satoru、Ishikawa Mitsuru、Leventoux Nicolas、Sasaki Ryogen、Hirokawa Yoshifumi、Kokubo Yasumasa、Okano Hideyuki
    • Journal Title

      Neurological Sciences

      Volume: 44 Issue: 12 Pages: 4511-4516

    • DOI

      10.1007/s10072-023-07000-7

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Induced pluripotent stem cells‐based disease modeling, drug screening, clinical trials, and reverse translational research for amyotrophic lateral sclerosis2023

    • Author(s)
      Okano Hideyuki、Morimoto Satoru、Kato Chris、Nakahara Jin、Takahashi Shinichi
    • Journal Title

      Journal of Neurochemistry

      Volume: 167 Issue: 5 Pages: 603-614

    • DOI

      10.1111/jnc.16005

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] iPS細胞を用いたドラッグ・リポジショニングによるALS治療の探索 ―ロピニロール塩酸塩の作用とメカ ニズム―2023

    • Author(s)
      髙橋愼一, 森本悟, 加藤玖里純, 岡野栄之
    • Journal Title

      難病と在宅ケア

      Volume: 29 Pages: 41-47

    • Related Report
      2023 Annual Research Report
  • [Journal Article] ロピニロール塩酸塩2023

    • Author(s)
      森本悟、髙橋愼一、岡野栄之
    • Journal Title

      CLINICAL NEUROSCIENCE

      Volume: 41 Pages: 404-407

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Pathogenic Mutation of TDP-43 Impairs RNA Processing in a Cell Type-Specific Manner: Implications for the Pathogenesis of ALS/FTLD2022

    • Author(s)
      Imaizumi Kent、Ideno Hirosato、Sato Tsukika、Morimoto Satoru、Okano Hideyuki
    • Journal Title

      eneuro

      Volume: 9 Issue: 3 Pages: ENEURO.0061-22.2022

    • DOI

      10.1523/eneuro.0061-22.2022

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] DNA damage stress-induced translocation of mutant FUS proteins into cytosolic granules and screening for translocation inhibitors2022

    • Author(s)
      Nogami Masahiro、Sano Osamu、Adachi-Tominari Keiko、Hayakawa-Yano Yoshika、Furukawa Takako、Iwata Hidehisa、Ogi Kazuhiro、Okano Hideyuki、Yano Masato
    • Journal Title

      Frontiers in Molecular Neuroscience

      Volume: 15 Pages: 01-14

    • DOI

      10.3389/fnmol.2022.953365

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Isoform-specific mutation in Dystonin-b gene causes late-onset protein aggregate myopathy and cardiomyopathy2022

    • Author(s)
      Yoshioka Nozomu、Kurose Masayuki、Yano Masato、Tran Dang Minh、Okuda Shujiro、Mori-Ochiai Yukiko、Horie Masao、Nagai Toshihiro、Nishino Ichizo、Shibata Shinsuke、Takebayashi Hirohide
    • Journal Title

      eLife

      Volume: 11 Pages: 78419-78419

    • DOI

      10.7554/elife.78419

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] RNA結合蛋白質解析の利と美-柔軟かつ堅牢性の高い脳の組織、細胞機能を包括的に理解する-2022

    • Author(s)
      矢野真人
    • Journal Title

      神経化学

      Volume: 61 Pages: 1-1

    • Related Report
      2022 Annual Research Report
    • Open Access
  • [Journal Article] iPSC-based disease modeling and drug discovery in cardinal neurodegenerative disorders2022

    • Author(s)
      Okano Hideyuki、Morimoto Satoru
    • Journal Title

      Cell Stem Cell

      Volume: 29 Issue: 2 Pages: 189-208

    • DOI

      10.1016/j.stem.2022.01.007

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of hub molecules of FUS-ALS by Bayesian gene regulatory network analysis of iPSC model: iBRN2021

    • Author(s)
      Nogami Masahiro、Ishikawa Mitsuru、Doi Atsushi、Sano Osamu、Sone Takefumi、Akiyama Tetsuya、Aoki Masashi、Nakanishi Atsushi、Ogi Kazuhiro、Yano Masato、Okano Hideyuki
    • Journal Title

      Neurobiology of Disease

      Volume: 155 Pages: 105364-105364

    • DOI

      10.1016/j.nbd.2021.105364

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of ferroptosis in human motor neuron cell death2021

    • Author(s)
      Matsuo Tsuyoshi、Adachi-Tominari Keiko、Sano Osamu、Kamei Takayuki、Nogami Masahiro、Ogi Kazuhiro、Okano Hideyuki、Yano Masato
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 566 Pages: 24-29

    • DOI

      10.1016/j.bbrc.2021.05.095

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DGCR8-dependent efficient pri-miRNA processing of human pri-miR-9-22021

    • Author(s)
      Nogami Masahiro、Miyamoto Kazumasa、Hayakawa-Yano Yoshika、Nakanishi Atsushi、Yano Masato、Okano Hideyuki
    • Journal Title

      Journal of Biological Chemistry

      Volume: 296 Pages: 100409-100409

    • DOI

      10.1016/j.jbc.2021.100409

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] ヒトiPS細胞技術とAI解析による神経変性疾患の分子病態予測2024

    • Author(s)
      矢野真人
    • Organizer
      第23回日本再生医療学会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] RNA binding protein taxonomy in neurodevelopment and disease2024

    • Author(s)
      Masato Yano
    • Organizer
      第 14 回 新潟大学脳研究所共同研究拠点国際シンポジウム 14th BRI_International_Symposium ~ALS/FTD: in-depth understanding and up-to-date~
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 昭和小学校からiPS細胞研究まで2024

    • Author(s)
      岡野栄之
    • Organizer
      昭和女子大学キャリア教育講演会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 中枢神経系の再生医療と疾患・創薬研究2024

    • Author(s)
      岡野栄之
    • Organizer
      第2回 神経化学会 若手KYOUEN
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 中枢神経系の再生医療と創薬研究2024

    • Author(s)
      岡野栄之
    • Organizer
      立命館大学「再生医療・遺伝子治療と薬学」シンポジウム
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] iPS細胞技術を用いた中枢神経系の再生医療と創薬研究2024

    • Author(s)
      岡野栄之
    • Organizer
      グローバルヘルスケア財団第15回記念 GHIC勉強会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] iPS 細胞を活用した神経疾患の克服2024

    • Author(s)
      岡野栄之
    • Organizer
      藤田医科大学 地域中核・特色ある研究大学 合同シンポジウム
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 幹細胞技術を用いた神経再生と疾患・創薬研究2024

    • Author(s)
      岡野栄之
    • Organizer
      第10回 再生医療EXPO大阪
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] これまでの100 年の医学研究とこれから100年の医学研究2024

    • Author(s)
      岡野栄之
    • Organizer
      第23回日本再生医療学会総会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 幹細胞生物学に基盤をおいた中枢神経系の再生医療と創薬研究2024

    • Author(s)
      岡野栄之
    • Organizer
      日本薬学会第144回年会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] DNA damage stress-induced translocation of mutant FUS proteins into cytosolic granules and screening for translocation inhibitors2023

    • Author(s)
      Masahiro Nogami, Osamu Sano, Keiko Adachi-Tominari, Yoshika Hayakawa-Yano, Takako Furukawa, Hidehisa Iwata, Kazuhiro Ogi, Hideyuki Okano and Masato Yano
    • Organizer
      CSHL-Asia ~The Now and Future of RNA therapeutics~
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 神経変性へ至る分子経路に共通するRNA制御ハブ分子群同定の試み2023

    • Author(s)
      矢野真人、古川貴子、矢野佳芳、岡野栄之
    • Organizer
      第46回日本神経科学大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] An RNA-binding protein Quaking safeguards motor neurons through pre-mRNA processing2023

    • Author(s)
      矢野佳芳、岡野栄之、矢野真人
    • Organizer
      第46回日本分子生物学会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 未来の再生医療および医学/科学技術を担う皆様へ2023

    • Author(s)
      矢野真人
    • Organizer
      新潟大学オープンキャンパス2023
    • Related Report
      2023 Annual Research Report
  • [Presentation] RNA結合蛋白質解析の成せる用と美~再生医学との合流点を考える~2023

    • Author(s)
      矢野真人
    • Organizer
      令和5年度日本医師会生涯教育講座【新潟会場】
    • Related Report
      2023 Annual Research Report
  • [Presentation] ALS患者体液由来細胞外小胞におけるmiRNAプロファイルと経時的変化2023

    • Author(s)
      森本悟, 加藤玖里純, 髙橋愼一, 中村志穂, 小澤史子, 伊東大介, 伊達悠岳, 岡田健佑, 中原仁, 岡野栄之
    • Organizer
      第64回日本神経学会総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 筋萎縮性側索硬化症患者体液由来細胞外小胞におけるmiRNAプロファイルの特徴と経時的変化2023

    • Author(s)
      森本悟, 加藤玖里純, 髙橋愼一, 中村志穂, 小澤史子, 伊東大介, 伊達悠岳, 岡田健佑, 中原仁, 岡野栄之
    • Organizer
      第41回日本神経治療学会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] iPSCs-based on regenerative medicine of CNS diseases2023

    • Author(s)
      Hideyuki Okano
    • Organizer
      Lund Stem Cell Center's Anniversary Conference
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Modeling Neurological diseases using iPS cell technologies and Genetically Modified Non-human primates2023

    • Author(s)
      Hideyuki Okano
    • Organizer
      SBME seminar
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPSCs-based modeling, drug development, and clinical trial for ALS2023

    • Author(s)
      Hideyuki Okano
    • Organizer
      Keystone Symposia, Neurodegeneration: New Biology Guiding the Next Generation of Therapeutic Development
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Supercentenarian Study: the quest for biological determinants of healthy longevity2023

    • Author(s)
      Hideyuki Okano
    • Organizer
      IAGG Asia / Oceania Regional Congress 2023 (IAGG 2023)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPS cell-based Regenerative Medicine and Drug Development for CNS Disorders2023

    • Author(s)
      Hideyuki Okano
    • Organizer
      17th Meeting of the Asian-Pacific Society for Neurochemistry (APSN 2023)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPSCs-based Regenerative Medicine and Drug Development of CNS disorders2023

    • Author(s)
      Hideyuki Okano
    • Organizer
      Neuroscience & Behavioural Disorders (NBD) Seminar
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Modeling Neurological Diseases using iPS cell technologies and Genetically Modified Non-human Primates2023

    • Author(s)
      Hideyuki Okano
    • Organizer
      Whitehead Institute seminar
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPSCs-based disease modeling/drug development for ALS and Alzheimer's disease2023

    • Author(s)
      Hideyuki Okano
    • Organizer
      G2D2 (Eisai Center for Genetics Guided Dementia Discovery)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPSCs-based regenerative medicine, drug development, and clinical trial for neurological disorders2023

    • Author(s)
      Hideyuki Okano
    • Organizer
      Massachusetts General Hospital (MGH) seminar
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Modeling Neurological Diseases using genetically modified non-human Primates and patients-specific iPSCs2023

    • Author(s)
      Hideyuki Okano
    • Organizer
      Boston University seminar
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPS cell-based Regenerative Medicine and Drug Development for CNS Disorders2023

    • Author(s)
      Hideyuki Okano
    • Organizer
      UCSD seminar
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPSCs-based Regenerative Medicine and Drug Development for CNS Disorders2023

    • Author(s)
      Hideyuki Okano
    • Organizer
      Stemson Therapeutics seminar
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Modeling Neurological diseases using iPS cell technologies and Genetically Modified Non-human primates2023

    • Author(s)
      Hideyuki Okano
    • Organizer
      AHA-Allen Team meeting
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPS cell-based Regenerative Medicine and Drug Development for CNS Disorders2023

    • Author(s)
      Hideyuki Okano
    • Organizer
      BIOHK2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 幹細胞生物学に基盤をおいた中枢神経系の再生医療と創薬の研究とその臨床応用2023

    • Author(s)
      岡野栄之
    • Organizer
      第112回日本病理学会総会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 中枢神経系の疾患の再生医療と創薬研究2023

    • Author(s)
      岡野栄之
    • Organizer
      第31回日本医学会総会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 幹細胞生物学に基盤をおいた中枢神経系の再生医療と創薬研究2023

    • Author(s)
      岡野栄之
    • Organizer
      長崎大学大学院セミナー
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 中枢神経系の再生医療と疾患・創薬研究2023

    • Author(s)
      岡野栄之
    • Organizer
      2023年医学振興銀杏会総会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] iPS細胞技術を用いた神経疾患の病態解析と創薬研究2023

    • Author(s)
      岡野栄之
    • Organizer
      第64回日本神経学会学術大会シンポジウム
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] iPS 細胞を用いたALS 創薬と臨床研究2023

    • Author(s)
      岡野栄之
    • Organizer
      日本ALS協会静岡県支部特別講演会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] iPS細胞技術を用いた中枢神経系の再生医療と疾患・創薬研究2023

    • Author(s)
      岡野栄之
    • Organizer
      Seminar for Open Innovation by Shonan iPark x AstraZeneca
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] iPS細胞関連技術を用いた難治性疾患の再生医療・創薬研究への挑戦2023

    • Author(s)
      岡野栄之
    • Organizer
      第59回日本小児循環器学会総会・学術集会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] iPS開発からALS治験まで2023

    • Author(s)
      岡野栄之
    • Organizer
      第64回日本神経病理学会総会学術研究会/第66回日本神経化学会大会 合同大会シンポジウム
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] iPSCs-based Regenerative Medicine and Drug Development for CNS Disorders2023

    • Author(s)
      岡野栄之
    • Organizer
      【AMED再生】国際関連 カナダSCNとの共同イベント
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] iPS細胞技術と健康長寿2023

    • Author(s)
      岡野栄之
    • Organizer
      有馬朗人記念「第 17 回創造性の育成塾」
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 小型霊長類マーモセットとiPS細胞を用いた神経疾患研究2023

    • Author(s)
      岡野栄之
    • Organizer
      第9回Kyoto Neurology Forum
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 幹細胞生物学に基盤をおいた中枢神経系疾患の再生医療と創薬の研究とその臨床応用2023

    • Author(s)
      岡野栄之
    • Organizer
      事業構想大学院大学第二回研究会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] iPS 細胞技術を用いた神経難病・神経感染症の病態解析と創薬研究2023

    • Author(s)
      岡野栄之
    • Organizer
      第27回日本神経感染症学会総会・学術大会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] iPS細胞技術を用いた難病の病態解析・創薬・臨床試験2023

    • Author(s)
      岡野栄之
    • Organizer
      第4回シロリムス新作用研究会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 遺伝子改変霊長類とiPS細胞技術を用いた中枢神経系疾患の病態解析と治療法の開発2023

    • Author(s)
      岡野栄之
    • Organizer
      岐阜大学 第2回COMITセミナー
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] iPS細胞技術を用いた中枢神経系の再生医療と創薬研究2023

    • Author(s)
      岡野栄之
    • Organizer
      アステラス製薬(株)社内講演会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] iPSCs-based Regenerative Medicine for CNS Disorders2023

    • Author(s)
      岡野栄之
    • Organizer
      日韓合同シンポジウム「Japan-Korea Joint Symposium on Translational Research in Regenerative Medicine and Genome Editing」
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] iPS 細胞を活用した神経疾患の克服2023

    • Author(s)
      岡野栄之
    • Organizer
      令和5年日本医師会生涯教育講座
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Investigation of ALS and Frontotemporal Dementia Using iPSC Technologies2023

    • Author(s)
      岡野栄之
    • Organizer
      第42回日本認知症学会学術集会 大会長企画シンポジウム
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Brain Science using genetically modified non-human primate and iPSC technologies2023

    • Author(s)
      岡野栄之
    • Organizer
      藤田医科大学ICBS国際シンポジウム
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] iPSCs-based Regenerative Medicine and Drug Development of CNS disorders2023

    • Author(s)
      岡野栄之
    • Organizer
      京都大学大学院医学研究科 教育コース 再生医療・臓器再建医学コース講義
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 幹細胞生物学に基盤をおいた中枢神経系の再生医療と創薬研究2023

    • Author(s)
      岡野栄之
    • Organizer
      第36回日本放射線腫瘍学会学術大会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Roles of Glial Cells in Neurodegenerative Diseases: A Study via iPSC-Derived Models2023

    • Author(s)
      岡野栄之
    • Organizer
      第27回グリア研究会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] iPS細胞創薬と医療ビッグデータ が導く神経疾患の新たな治療薬開発2023

    • Author(s)
      岡野栄之
    • Organizer
      日本再生医療学会 法人正会員限定講演会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] iPS細胞技術を用いた脊髄損傷とALSの治療法の開発2022

    • Author(s)
      岡野栄之
    • Organizer
      第51回日本脊椎脊髄病学会学術集会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] iPS細胞技術を用いたALSの疾患モデリング、薬剤開発、臨床試験、リバーストランスレーショナルリサーチ2022

    • Author(s)
      岡野栄之
    • Organizer
      第63回日本神経学会学術大会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 昭和小学校からIPS細胞研究まで2022

    • Author(s)
      岡野栄之
    • Organizer
      昭和女子大学・女性教養講座
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] iPS細胞技術を用いた精神・神経疾患の病態解析と創薬研究2022

    • Author(s)
      岡野栄之
    • Organizer
      第118回日本精神神経学会学術総会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] iPS cells-based drug development for CNS disorders. iPS細胞技術を用いた神経疾患に対する創薬研究2022

    • Author(s)
      岡野栄之
    • Organizer
      LINK-J 6月の大規模シンポジウム「創薬のフロンティア2022」
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] iPS細胞技術を用いた神経系の再生医療と創薬研究2022

    • Author(s)
      岡野栄之
    • Organizer
      第241回生命科学フォーラム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] iPS細胞技術を用いた神経系の再生医療と創薬研究2022

    • Author(s)
      岡野栄之
    • Organizer
      日本神経化学会フラッグシップ・プロジェクトシンポジウム ~分子・グリア・病態と他分野を結集した一点突破の疾患研究
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Breakthrough for conquering Neurological/Psychiatric diseases using iPSCs and Genetically Modified Non-human primates2022

    • Author(s)
      岡野栄之
    • Organizer
      Boston Children's Hospital, Boston, USA
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPSCs-based Regenerative Medicine and Drug development for CNS diseases2022

    • Author(s)
      岡野栄之
    • Organizer
      第2回ロート再生医療フォーラム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Modeling Neurological diseases using iPS cell technologies and Genetically Modified Non-human primates2022

    • Author(s)
      岡野栄之
    • Organizer
      Picower Institute’s Aging Brain Initiative seminar
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPSCs-based Regenerative Medicine and Drug Development of CNS disorders2022

    • Author(s)
      岡野栄之
    • Organizer
      Special Seminar in Stem Cells at MGH
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPS細胞技術を用いたALSの病態解析・創薬研究・臨床試験2022

    • Author(s)
      岡野栄之
    • Organizer
      第33回日本末梢神経学会学術集会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Modeling Neurological/Psychiatric diseases using iPS cell technologies and Genetically Modified Non-human primates2022

    • Author(s)
      岡野 栄之
    • Organizer
      4th Japan-UK Neuroscience Symposium 2022
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] iPS細胞技術を用いた中枢神経系の再生医療と疾患・創薬研究2022

    • Author(s)
      岡野 栄之
    • Organizer
      関西医科大学
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Walking Again 2022開催にあたって2022

    • Author(s)
      岡野 栄之
    • Organizer
      Walk Again2022
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] iPS細胞を用いた中枢神経系の再生医療と創薬研究2022

    • Author(s)
      岡野 栄之
    • Organizer
      福井県立高志高等学校・講演会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Applications of human induced pluripotent stem cells (hiPSCs) in treatment of ALS (Amyotrophic lateral sclerosis)2022

    • Author(s)
      岡野 栄之
    • Organizer
      The 5th Vinmec International Conference on Cell & Gene Therapy
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Modeling Neurological diseases using iPS cell technologies and Genetically Modified Non-human primates2022

    • Author(s)
      岡野 栄之
    • Organizer
      Fujita international Symposium on Brain Science シンポジウム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Modeling Neurological/Psychiatric diseases using iPS cell technologies and Genetically Modified Non-human primates2022

    • Author(s)
      岡野 栄之
    • Organizer
      The 37th International Kumamoto Medical Bioscience Symposium
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 神経変性疾患ALSに対するiPS細胞創薬と医師指導治験2022

    • Author(s)
      岡野 栄之
    • Organizer
      第43回日本臨床薬理学会学術総会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] iPSCs-based modeling and drug development for neurodegenerative diseases2022

    • Author(s)
      岡野 栄之
    • Organizer
      2022 International Conference of Brain Science and Life Health Technology
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 「神経疾患の再生医療と創薬研究」2022

    • Author(s)
      岡野 栄之
    • Organizer
      第43回メディコピア教育講演シンポジウム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] iPS細胞技術を用いた精神・神経疾患の研究2022

    • Author(s)
      岡野 栄之
    • Organizer
      SCBR(Schizophrenia Clinical and Basic Research)FORUM
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Modeling Neurological diseases using Human iPS cell technologies and Genetically Modified Non-human primates2022

    • Author(s)
      岡野 栄之
    • Organizer
      第21回武田科学振興財団生命科学シンポジウム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] iPS細胞を用いた神経変性疾患の治療法の開発2022

    • Author(s)
      岡野 栄之
    • Organizer
      第58回 広島神経医科学研究会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] iPS細胞技術を用いた中枢神経系疾患の再生医療と創薬研究2022

    • Author(s)
      岡野 栄之
    • Organizer
      日本生理学会第100回記念大会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Deficiency of Quaking results in the dysregulation of RNA metabolism and motor neuron degeneration2022

    • Author(s)
      Masato Yano, Hideyuki Okano, Hirohide Takebayashi, Osamu Onodera, Kenji Sakimura, Takako Furukawa and Yoshika Hayakawa-Yano
    • Organizer
      日本RNA学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Deficiency of Quaking results in the dysregulation of RNA metabolism and motor neuron degeneration2022

    • Author(s)
      Yoshika Hayakawa-Yano, Takako Furukawa, Kenji Sakimura, Hirohide Takebayashi, Osamu Onodera, Hideyuki Okano, Masato Yano
    • Organizer
      日本神経科学学会-Neuro2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] An RNA-binding protein Quaking safeguards motor neuron function through pre-mRNA processing2021

    • Author(s)
      Yano M, Yano Y
    • Organizer
      第44回日本分子生物学会大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] An RNA-binding protein Quaking safeguards motor neuron function through pre-mRNA processing2021

    • Author(s)
      Hayakawa-Yano Y, Furukawa T, Koyama A, Nakamoto C, Sakimura K, Onodera O, Takebayashi H, Okano H and Yano M
    • Organizer
      第64回日本神経化学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] iPSCs-based stratification, drug development and clinical trial for ALS2021

    • Author(s)
      Okano H
    • Organizer
      第62回日本神経学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Investigation of human neurological diseases using iPSCs and GM Non-human Primates2021

    • Author(s)
      岡野 栄之
    • Organizer
      第18回幹細胞シンポジウム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] iPSCs-based drug development for ALS and clinical trial2021

    • Author(s)
      Okano H
    • Organizer
      Mechanistic Insights into the Pathophysiology of ALS
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 幹細胞技術を用いた神経疾患の病態解析・創薬・臨床試験2021

    • Author(s)
      岡野 栄之
    • Organizer
      第6回 Neuroscience Expert Seminar
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] iPS細胞技術を用いた精神・神経疾患の研究2021

    • Author(s)
      岡野 栄之
    • Organizer
      第5回日本臨床薬理学会 九州・沖縄地方会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 遺伝子と細胞:基礎から再生医療・創薬へ2021

    • Author(s)
      岡野 栄之
    • Organizer
      "慶應義塾大学グローバルサイエンス事業「医学・医療の学際的修学、半学半教」プログラム 2021年度キックオフミーティング"
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] iPSCs-based New Therapy for Spinal Cord Injury and ALS.2021

    • Author(s)
      Okano H
    • Organizer
      28th ASNTR annual conference
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 幹細胞生物学に基づく中枢神経系の再生医療と疾患研究2021

    • Author(s)
      岡野 栄之
    • Organizer
      新適塾「難病への挑戦」 第47回
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] iPS細胞を用いた再生医療と創薬研究2021

    • Author(s)
      岡野 栄之
    • Organizer
      慶應義塾大学病院・三四会・慶應医学会 100年合同記念式典・シンポジウム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] iPSCs-based modelling, drug development and clinical trials for ALS.2021

    • Author(s)
      Okano H
    • Organizer
      PACTALS 2021 NAGOYA
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPS細胞技術を用いた精神・神経疾患の研究2021

    • Author(s)
      岡野 栄之
    • Organizer
      第117回日本精神神経学会学術総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] iPS細胞技術を用いたALSの創薬・治験とリバース・トランスレーション研究2021

    • Author(s)
      岡野 栄之
    • Organizer
      第3回ALS Frontier seminar
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] iPS 細胞創薬のリアリティー2021

    • Author(s)
      岡野 栄之
    • Organizer
      第10回大阪大学健康・医療クロスイノベーションフォーラム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] IPSCS-BASED MODELING, DRUG DEVELOPMENT AND CLINICAL TRIALS FOR ALS2021

    • Author(s)
      Okano H
    • Organizer
      ISSCR/JSRM International Symposium Virtual , “Stem Cells: From Basic Science to Clinical Translation”
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPS細胞技術を用いた精神・神経疾患の研究2021

    • Author(s)
      岡野 栄之
    • Organizer
      第47回日本神経内分泌学会・学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] iPSCs-Based Regenerative Medicine for Spinal Cord Injury2021

    • Author(s)
      Okano H
    • Organizer
      31st Annual Meeting of NECTAR and 16th INTR
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPSCs-based Cell Therapy and Disease modeling, drug development and clinical trial2021

    • Author(s)
      Okano H
    • Organizer
      2021 Global Hybrid Conference【The Clinical Development and Integration Strategies of Key Manufacturing Process of Regenerative Medicine in Japan】
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPS cells-based Modelling of Neural Development and Diseases2021

    • Author(s)
      Okano H
    • Organizer
      第16回生命医科学研究所ネットワーク国際シンポジウム、KEY FORUM 2021 International Symposium on "The front lines of biomedical researches on the nervous system"
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 疾患特異的iPS細胞を用いた認知症・神経変性疾患研究2021

    • Author(s)
      岡野 栄之
    • Organizer
      第40回日本認知症学会学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] iPS細胞研究の進捗・医療応用2021

    • Author(s)
      岡野 栄之
    • Organizer
      第6回DIA再生医療製品・遺伝子治療用製品シンポジウム 医療現場で使いこなせる再生・遺伝子治療に向けて ~産業化ステージでの課題を解決する~
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] iPS細胞技術を用いた認知症を含むヒト神経変性疾患の研究2021

    • Author(s)
      岡野 栄之
    • Organizer
      慶應・健康長寿連携大学院記念シンポジウム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] iPS細胞と遺伝子改変霊長類技術を用いた医学研究2021

    • Author(s)
      岡野 栄之
    • Organizer
      筑波大学生命科学動物資源センター20周年記念シンポジウム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] iPS細胞技術を用いた神経変性疾患の病態解析・創薬・臨床試験2021

    • Author(s)
      岡野 栄之
    • Organizer
      第126回慶應義塾大学医学部生涯教育研修セミナー
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] iPS cells-based Regenerative Medicine and Drug Development2021

    • Author(s)
      Okano H
    • Organizer
      日中医学協会・2021年度さくらサイエンス オンライン交流プログラム
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPS細胞を用いた神経系の再生医療と創薬研究2021

    • Author(s)
      岡野 栄之
    • Organizer
      第8回再生医療EXPO[大阪]
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] iPSCs-based modeling, drug development and Clinical Trials for ALS2021

    • Author(s)
      岡野 栄之
    • Organizer
      The 1st Keio-Stanford Webinar
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPSCs-based modeling, drug development and Clinical Trials for ALS2021

    • Author(s)
      岡野 栄之
    • Organizer
      11th Annual California (virtual) ALS Research Summit
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPSCs-Based Regenerative Medicine and Drug Development2021

    • Author(s)
      岡野 栄之
    • Organizer
      1st Keio Cedars-Sinai Meeting
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPSCs-Based Regenerative Medicine and Drug Development for CNS diseases2021

    • Author(s)
      岡野 栄之
    • Organizer
      Japan Healthcare Update Conference in UAE
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPSCs-Based Regenerative Medicine and Drug Development2021

    • Author(s)
      岡野 栄之
    • Organizer
      3rd Annual Cell & Gene Therapy Manufacturing Asia 2021
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Disease Modeling and Brain Science using Stem Cells and GM Non-Human Primates2020

    • Author(s)
      岡野 栄之
    • Organizer
      Neurozoom
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 中枢神経系の再生医療と疾患研究2020

    • Author(s)
      岡野 栄之
    • Organizer
      第41回日本炎症・再生医学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Neurological Disease Modeling and Brain Science using Stem Cells and GM Non-Human Primates2020

    • Author(s)
      岡野 栄之
    • Organizer
      第43回日本神経科学大会/Neuroscience2020
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] iPS細胞技術を用いた神経変性疾患の病態解析と創薬研究2020

    • Author(s)
      岡野 栄之
    • Organizer
      第31回日本末梢神経学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] iPS 細胞技術を用いた神経変性疾患研究の最前線2020

    • Author(s)
      岡野 栄之
    • Organizer
      第63回日本脳循環代謝学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] iPSCs-based drug development of ALS and Clinical Trails2020

    • Author(s)
      岡野 栄之
    • Organizer
      CSHL Virtual Conference: Neurodegenerative Diseases-Biology & Therapeutics
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] iPSCs-based Regenerative Medicine and Drug Development for CNS Diseases2020

    • Author(s)
      岡野 栄之
    • Organizer
      SCSS―JSRM Symposium 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] Medical Science Digest :FUS 蛋白質の細胞質顆粒移行の分子機序とその阻害低分子化合物の同定2023

    • Author(s)
      矢野 真人・矢野(早川)佳芳
    • Publisher
      ニュー・サイエンス社
    • Related Report
      2023 Annual Research Report
  • [Book] カンデル神経科学2022

    • Author(s)
      宮下 保司(矢野真人、岡野栄之 共訳:2章 遺伝子と行動)
    • Total Pages
      1704
    • Publisher
      メディカル・サイエンス・インターナショナル
    • ISBN
      9784815730550
    • Related Report
      2022 Annual Research Report
  • [Book] Annual Review 神経 20222022

    • Author(s)
      鈴木則宏、荒木信夫、宇川義一、桑原聡、塩川芳昭(森本悟、髙橋愼一、岡野栄之:筋萎縮性側索硬化症(ALS)患者を対象としたロピニロール塩酸塩(ropinirole)投与による医師主導治験)
    • Total Pages
      331
    • Publisher
      中外医学社
    • ISBN
      9784498328822
    • Related Report
      2022 Annual Research Report
  • [Remarks] 岡野研 Weblog

    • URL

      http://www.okano-lab.com/

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
  • [Remarks] 変異型 FUS 蛋白質が細胞質顆粒へ移行する分子機構と その移行を阻害する低分子化合物を発見

    • URL

      https://www.niigata-u.ac.jp/wp-content/uploads/2022/12/20221220rs1.pdf

    • Related Report
      2022 Annual Research Report

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Published: 2020-04-28   Modified: 2025-01-30  

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