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Development of an noninvasive liquid assessment technologies for smart home-care

Research Project

Project/Area Number 20H00560
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 58:Society medicine, nursing, and related fields
Research InstitutionIshikawa Prefectural Nursing University (2022-2023)
The University of Tokyo (2020-2021)

Principal Investigator

Sanada Hiromi  石川県立看護大学, 看護学部, 教授 (50143920)

Co-Investigator(Kenkyū-buntansha) 須釜 淳子  藤田医科大学, 社会実装看護創成研究センター, 教授 (00203307)
峰松 健夫  石川県立看護大学, 看護学部, 教授 (00398752)
大貝 和裕  石川県立看護大学, 看護学部, 教授 (40706983)
岡本 成史  大阪大学, 大学院医学系研究科, 教授 (50311759)
仲上 豪二朗  東京大学, 大学院医学系研究科(医学部), 教授 (70547827)
玉井 奈緒  横浜市立大学, 医学部, 教授 (80636788)
下澤 達雄  国際医療福祉大学, 医学部, 主任教授 (90231365)
大江 真琴  金沢大学, 保健学系, 教授 (60389939)
Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥44,850,000 (Direct Cost: ¥34,500,000、Indirect Cost: ¥10,350,000)
Fiscal Year 2023: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2022: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2021: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2020: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Keywordsリキッドアセスメント / スマートホームケア / バイオセンサ / リキッドバイオプシー / バイオマーカー / 高齢者 / リキッド / リキッドアセスメント技術
Outline of Research at the Start

本研究では、高齢者の身体の異変の予兆を捉える「リキッドアセスメント技術」の確立を目指す。
高齢者の療養生活に起因し療養生活を脅かす慢性脱水、誤嚥性肺炎、褥瘡感染、尿路感染を対象として、STEP 1:病態の把握(実態調査)、STEP 2:バイオマーカーの探索・同定(臨床調査)、STEP 3:バイオマーカーと症状の因果関係の証明(動物実験)、STEP 4:バイオマーカーの非侵襲的測定法確立(開発研究)、STEP 5:バイオマーカー測定法の信頼性・妥当性の証明(臨床調査)と研究を進めていく。
これにより、症状出現に先立つ予防行動を促し高齢者の健やかな療養生活の実現、幸福寿命の延伸に寄与する。

Outline of Final Research Achievements

Continuous and timely assessment of pathological conditions is necessary for elderly people with advanced medical needs to be able to care for themselves safely at home. In order to realize the smart home care based on the concepts of "non-invasive”, “non-restrictive," "continuous" and "real-time”, this study aimed to establish liquid assessment technologies using biosensors to capture pathological changes and to predict abnormalities.
This project targeted chronic dehydration, aspiration pneumonia, infection of pressure injury, and urinary tract infection, which are caused by and threaten the daily life of the elderly. The studies were conducted according to the following steps: (1) search for biomarkers, (2) proof of the causal relationship between biomarkers and symptoms, (3) establishment of non-invasive measurement methods for biomarkers, and (4) verification the reliability and validity of the biomarker measurement methods.

Academic Significance and Societal Importance of the Research Achievements

地域包括ケアシステムの時代に、高齢者は複数の疾患を有し複雑な病態を呈するため、高度な医療ニーズを抱えながら在宅で療養している。本研究で実現を目指すスマートホームケアは、ベッドセンサ、環境センサ、およびバイオセンサを用いた継続的かつ適時的な病態アセスメントによる病態の変化や異変の予兆を捉え、適切な医療ケアに繋げる者であり、在宅療養高齢者が安心して日常生活を送ることに繋がり、ひいては地域包括ケアシステムの確立に寄与するものと考えられる。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Comments on the Screening Results   Annual Research Report
  • Research Products

    (15 results)

All 2023 2022 2021 Other

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (10 results) (of which Int'l Joint Research: 5 results) Remarks (2 results)

  • [Journal Article] Expression levels of NPPB, ITGB6, CPNE4, EML5, and ITSN1 in fresh exudates swabbed from critically colonised and infected full-thickness wounds in rats.2023

    • Author(s)
      Takizawa C, Minematsu T, Nakagami G, Kitamura A, Koudounas S, Kunimitsu M, Sanada H.
    • Journal Title

      International Wound Journal

      Volume: 20 Issue: 4 Pages: 1088-1097

    • DOI

      10.1111/iwj.13965

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A pilot epidemiological study on chronic dehydration of older adults in home care setting2022

    • Author(s)
      Shiho Higashimura, Nao Tamai, Gojiro Nakagami, Hiromi Tobe, Hiromi Sanada
    • Journal Title

      Journal of Nursing Science and Engineering

      Volume: 9 Issue: 0 Pages: 123-135

    • DOI

      10.24462/jnse.9.0_123

    • NAID

      130008165190

    • ISSN
      2188-4323, 2432-6283
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibiting effect of synthetic urine on the growth and mobility of <i>Pseudomonas aeruginosa</i>, <i>Escherichia coli</i>, <i>Proteus mirabilis</i> and <i>Klebsiella pneumoniae</i> shifts to a promoting effect during culture2021

    • Author(s)
      Sofoklis Koudounas , Takeo Minematsu , Yuko Mugida , Sanae Tomita , Ayano Nakai , Gojiro Nakagami and Hiromi Sanada
    • Journal Title

      Journal of Nursing Science and Engineering

      Volume: 8 Issue: 0 Pages: 220-229

    • DOI

      10.24462/jnse.8.0_220

    • NAID

      130008081322

    • ISSN
      2188-4323, 2432-6283
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Development and evaluation of a rapid taurine concentration measurement method for skin blot examination for early detection of dehydration.2023

    • Author(s)
      Tsuchiya H, Tomida S, Abe M, Higashimura S, Minematsu T, Sanada H. Nakagami G.
    • Organizer
      26th East Asian Forum of Nursing Scholars
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] おむつ内センサーを用いた尿路感染症アセスメントを目的とした初尿中バイオマーカーの治療反応性検討.2022

    • Author(s)
      板橋みずほ,玉井奈緒,三浦由佳,峰松健夫,仲上豪二朗,下澤達雄,角田誠,鈴木基文,井口靖浩,真田弘美.
    • Organizer
      第10回看護理工学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 高齢者の褥瘡管理におけるドレッシング交換及び創部洗浄の頻度の治癒遅延への影響 ラットクリティカルコロナイゼーション創モデルの作成.2022

    • Author(s)
      滝沢知大,峰松健夫,仲上豪二朗,北村言,國光真生,真田弘美.
    • Organizer
      日本老年看護学会第27回学術集会.
    • Related Report
      2022 Annual Research Report
  • [Presentation] オムツ内における尿路感染症同定を目的とした初尿中バイオマーカーの妥当性検証.2022

    • Author(s)
      板橋みずほ,玉井奈緒,三浦由佳,峰松健夫,仲上豪二朗,下澤達雄,角田誠,鈴木基文,井口靖浩,真田弘美.
    • Organizer
      第31回日本創傷・オストミー・失禁管理学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Development of mRNA markers of wound infection in fresh exudate of rat rull-thickness wounds.2022

    • Author(s)
      Takizawa C, Minematsu T, Nakagami G, Kitamura A, Koudounas S, Kunimitsu M, Sanada H.
    • Organizer
      第31回日本創傷・オストミー・失禁管理学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Urine biomarkers for lower urinary tract infections among diaper-wearing community-dwelling elderly individuals with cognitive impairments: A scoping review.2021

    • Author(s)
      Mizuho Itabashi, Daijiro Haba, Nao Tamai, Yuka Miura, Shiori Nitta, Takeo Minematsu, Masaru Matsumoto, Gojiro Nakagami, Carolina Weller, Hiromi Sanada
    • Organizer
      9th Asia Pacific Enterostomal Therapy Nurse Association
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Does the presence of bacterial urinary infection contribute to the development of incontinence-associated dermatitis? A scoping review.2021

    • Author(s)
      Sofoklis Koudounas, Yuko Mugita, Takeo Minematsu, Gojiro Nakagami, Carolina Weller, Hiromi Sanada
    • Organizer
      9th Asia Pacific Enterostomal Therapy Nurse Association
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Measurement of taurine concentration by skin blotting before and after cycling exercise: Investigation of correlation with dehydration.2021

    • Author(s)
      Shiho Higashimura, Takeo Minematsu, Mitsuo Neya, Nao Tamai, Mari Abe, Sofoklis Koudounas, Gojiro Nakagami, Hiromi Sanada
    • Organizer
      9th Asia Pacific Enterostomal Therapy Nurse Association
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Expression of NPPB, ITGB6, CPNE4, EML5, and ITSN1 in the infected wound tissue of rats.2021

    • Author(s)
      Chihiro Takizawa, Takeo Minematsu, Gojiro Nakagami, Aya Kitamura, Sofoklis Koudounas, Mao Kunimitsu, Hiromi Sanada
    • Organizer
      9th Asia Pacific Enterostomal Therapy Nurse Association
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of mRNA markers of wound infection in fresh exudate of rat rull-thickness wounds.2021

    • Author(s)
      Chihiro Takizawa, Takeo Minematsu, Gojiro Nakagami, Aya Kitamura, Sofoklis Koudounas, Mao Kunimitsu, Hiromi Sanada
    • Organizer
      第31回日本創傷・オストミー・失禁管理学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Remarks] 石川県立看護大学

    • URL

      https://www.ishikawa-nu.ac.jp/

    • Related Report
      2022 Annual Research Report
  • [Remarks] 石川県立看護大学成人看護学領域

    • URL

      https://www.ishikawa-nu.ac.jp/lab/seijin/

    • Related Report
      2021 Annual Research Report

URL: 

Published: 2020-04-28   Modified: 2025-01-30  

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