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Development of a lymphatic drug delivery system for local control of metastatic lymph nodes to systemic metastatic therapy

Research Project

Project/Area Number 20H00655
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 90:Biomedical engineering and related fields
Research InstitutionTohoku University

Principal Investigator

Kodama Tetsuya  東北大学, 医工学研究科, 教授 (40271986)

Co-Investigator(Kenkyū-buntansha) 志賀 清人  岩手医科大学, 医学部, 教授 (10187338)
伊藤 康一  東北大学, 情報科学研究科, 准教授 (70400299)
森 菜緒子  東北大学, 医学系研究科, 助教 (90535064)
加藤 茂樹  山口大学, 大学院医学系研究科, 助教 (90790767)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥45,630,000 (Direct Cost: ¥35,100,000、Indirect Cost: ¥10,530,000)
Fiscal Year 2022: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Fiscal Year 2021: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Fiscal Year 2020: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Keywordsリンパ節 / 転移 / リンパ節内投与 / DDS / 治療 / 診断 / がん / 薬物送達法 / リンパ行性
Outline of Research at the Start

本研究ではリンパ節介在血行性転移理論の普遍性を検証し, この概念を根拠に臨床的N0センチネルリンパ節のLDDSの局所制御が全身転移の治療にも有効であることを立証するものである. この目的を達成するために, 以下の3つの課題に取り組む. (A)リンパ節介在血行性転移理論の普遍性の検証, (B) LDDSの溶媒特性と抗腫瘍効果の検証, (C) 免疫チェックポイント阻害剤を併用したLDDSの抗腫瘍効果の検証, である.

Outline of Final Research Achievements

In this study, lymph nodes removed from head and neck cancer patients and breast cancer patients were analyzed histologically to clarify the universality of the lymph node-mediated hematogenous metastasis theory. In addition, the solvent properties of lymphatic drug delivery system (LDDS) and the antitumor effect of LDDS in combination with immune checkpoint inhibitors on clinical N0 lymph nodes were demonstrated from mouse experiments. This study clarifies the clinical significance of LDDS and suggests the possibility of controlling distant metastases from metastatic lymph nodes by LDDS.

Academic Significance and Societal Importance of the Research Achievements

(1) リンパ節転移初期段階において, 腫瘍細胞は遠隔臓器に転移することが示唆された. (2) リンパ行性薬物送達法の溶媒には, 粘度と浸透圧で定まる最適な値が存在する. (3) リンパ行性薬物送達法は転移リンパ節の局所制御から遠隔転移の制御も可能な手法となり得る.
本研究は, リンパ節転移に関する新たな概念を提唱し, この概念に基づく新たな転移リンパ節の治療法を提唱するものである.

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Comments on the Screening Results   Annual Research Report
  • Research Products

    (63 results)

All 2022 2021 2020 Other

All Journal Article (8 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 8 results,  Open Access: 8 results) Presentation (51 results) (of which Int'l Joint Research: 19 results,  Invited: 2 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Combination therapy of lymphatic drug delivery and total body irradiation in a metastatic lymph node and lung mouse model2022

    • Author(s)
      Sora Shota、Sukhbaatar Ariunbuyan、Fukushige Shinichi、Mori Shiro、Sakamoto Maya、Kodama Tetsuya
    • Journal Title

      Cancer Science

      Volume: 114 Issue: 1 Pages: 227-235

    • DOI

      10.1111/cas.15562

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Drug formulation augments the therapeutic response of carboplatin administered through a lymphatic drug delivery system2022

    • Author(s)
      Mishra Radhika、Sukhbaatar Ariunbuyan、Dorai Arunkumar、Mori Shiro、Shiga Kiyoto、Kodama Tetsuya
    • Journal Title

      Cancer Science

      Volume: 114 Issue: 1 Pages: 259-270

    • DOI

      10.1111/cas.15599

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intranodal delivery of modified docetaxel: Innovative therapeutic method to inhibit tumor cell growth in lymph nodes2022

    • Author(s)
      Sukhbaatar A, Mori S, Kodama T.
    • Journal Title

      Cancer Sci

      Volume: - Issue: 4 Pages: 1125-1139

    • DOI

      10.1111/cas.15283

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Perfusion defects in non-enlarged metastatic lymph nodes using vessel wall magnetic resonance imaging: Detection performance and diagnostic value2022

    • Author(s)
      Sakamoto Maya、Kojima Ikuho、Iikubo Masahiro、Ito Koichi、Aoki Takafumi、Mori Shiro、Ogawa Takenori、Katori Yukio、Murata Takaki、Ito Daisuke、Kodama Tetsuya
    • Journal Title

      Clinical & Experimental Metastasis

      Volume: - Issue: 3 Pages: 421-431

    • DOI

      10.1007/s10585-022-10147-w

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] haracterizing perfusion defects in metastatic lymph nodes at an early stage using high-frequency ultrasound and micro-CT imaging.2021

    • Author(s)
      T. Yamaki, A. Sukhbaatar, R. Radhika, R. Kikuchi, M. Sakamoto, S. Mori, T. Kodama
    • Journal Title

      Clin Exp Metastasis

      Volume: 14 Issue: 6 Pages: 539-549

    • DOI

      10.1007/s10585-021-10127-6

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Study of the physicochemical properties of drugs suitable for administration using a lymphatic drug delivery system2021

    • Author(s)
      Fukumura Ryoichi、Sukhbaatar Ariunbuyan、Mishra Radhika、Sakamoto Maya、Mori Shiro、Kodama Tetsuya
    • Journal Title

      Cancer Science

      Volume: - Issue: 5 Pages: 1-11

    • DOI

      10.1111/cas.14867

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Optimization of the delivery of molecules into lymph nodes using a lymphatic drug delivery system with ultrasound2021

    • Author(s)
      Kato Shigeki、Yoshiba Shota、Mori Shiro、Kodama Tetsuya
    • Journal Title

      International Journal of Pharmaceutics

      Volume: 597 Pages: 120324-120324

    • DOI

      10.1016/j.ijpharm.2021.120324

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intranodal pressure of a metastatic lymph node reflects the response to lymphatic drug delivery system2020

    • Author(s)
      Kato Shigeki、Takeda Kazu、Sukhbaatar Ariunbuyan、Sakamoto Maya、Mori Shiro、Shiga Kiyoto、Kodama Tetsuya
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 11 Pages: 4232-4241

    • DOI

      10.1111/cas.14640

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] CTLA4 targeted therapy using LDDS for the treatment of metastatic lymph nodes2022

    • Author(s)
      Mishra R, Sukhbaatar A, Mori S, Kodama T
    • Organizer
      the AACR Special Conference: Precision Prevention, early detection and interception of Cancer
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparing the pharmacokinetic parameters of ICG via lymphatic drug delivery and the intravenous injection2022

    • Author(s)
      Namugga B, Sukhbaatar A, Kodama T
    • Organizer
      19th International Conference on Flow Dynamics
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Acquisition of anti-tumor immunity by local irradiation and its application to radioimmunotherapy2022

    • Author(s)
      Kuriu S, Mishra R, Sukhbaatar A, Mori S, Kodama T
    • Organizer
      19th International Conference on Flow Dynamics
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Docetaxel facilitates improved treatment effect for lymph node metastasis by LDDS administration2022

    • Author(s)
      Sukhbaatar A, Sakamoto M, Mori S, Kodama T
    • Organizer
      Interface summer seminar 2022 (The 17th International Workshop on Biomaterials in Interface Science)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Activation of Anti-tumor Immunity by Local Irradiation2022

    • Author(s)
      Kuriu S, Mishra R, Sukhbaatar A, Mori S, Kodama T
    • Organizer
      Interface summer seminar 2022 (The 17th International Workshop on Biomaterials in Interface Science)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ultrasonographic analysis of enhanced intra lymphatic drug delivery by high osmotic pressure and high viscosity solvent in lymphatic drug delivery2022

    • Author(s)
      Shimizu K, Sukhbaatar A, Mori S, Kodama T
    • Organizer
      Interface summer seminar 2022 (The 17th International Workshop on Biomaterials in Interface Science)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lymphatic drug delivery system: an efficient drug delivery strategy for treatment of metastatic lymph nodes using immune checkpoint inhibitors2022

    • Author(s)
      Mishra R, Sukhbaatar A, Sakamoto M, Mori S, Kodama T
    • Organizer
      SelectScience;Virtual Cancer & Immunology Research Summit 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel drug formulation for potentiation of therapeutic response using the lymphatic drug delivery system2022

    • Author(s)
      Mishra R, Sukhbaatar A, Sakamoto M, Mori S, Kodama T
    • Organizer
      第40回札幌国際がんシンポジウム(SICS2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Targeting lymph node metastasis through lymphatic drug delivery system by administration of docetaxel2022

    • Author(s)
      Sukhbaatar A, Mori S, Kodama T
    • Organizer
      第40回札幌国際がんシンポジウム(SICS2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] リンパ行性薬物送達法における薬物動態に関する研究2022

    • Author(s)
      前田一伎,Bridget Namugga,Radhika Mishra,Ariunbuyan Sukhbaatar,小玉哲也
    • Organizer
      日本機械学会第33回バイオフロンティア講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] リンパ行性薬物送達法を用いた転移リンパ節に対する新たな治療戦略2022

    • Author(s)
      小玉哲也
    • Organizer
      第24回SNNS研究会学術集会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] リンパ行性薬剤送達法に最適な溶媒特性に関する考察2022

    • Author(s)
      小玉哲也,Ariunbuyan Sukhbaatar, 森士朗,志賀清人
    • Organizer
      第60回日本癌治療学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] リンパ節転移に対する新たな治療法-LDDS(lymphatic drug delivery system)の開発.2022

    • Author(s)
      志賀清人,日下尚裕,片桐克則,齋藤大輔,Ariunbuyan Sukhbaatar,森士朗,小玉哲也
    • Organizer
      第60回日本癌治療学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] リンパ節介在血行性転移理論の実験的検証2022

    • Author(s)
      志水洸太,Radhika Mishra, Ariunbuyan Sukhbaatar, 森士朗,小玉哲也
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 放射線局所照射による遠隔転移の抑制2022

    • Author(s)
      栗生晏暉,Radhika Mishra, Ariunbuyan Sukhbaatar, 森士朗, 小玉哲也
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Lymph node resection induces metastases in the lung2022

    • Author(s)
      Sukhbaatar A, Mori S, Kodama T
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Immune checkpoint inhibitor delivered via lymphatic drug delivery system: a curative therapy for metastatic lymph nodes2022

    • Author(s)
      Mishra R, Sukhbaatar A, Mori S, Sakamoto M, Kodama T
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 抗CTLA-4抗体のリンパ節直接投与がもたらす遠隔転移治療効果の検討2022

    • Author(s)
      髙木洸樹,宮津美里有,Radhika Mishra, Ariunbuyan Sukhbaatar, 森士朗,小玉哲也
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] リンパ行性薬剤送達法および浸透圧・粘度調整溶媒を用いたカルボプラチンによる転移リンパ節に対する抗腫瘍効果の評価2022

    • Author(s)
      宮津美里有,髙木洸樹,Radhika Mishra, Ariunbuyan Sukhbaatar, 森士朗,小玉哲也
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ドキソルビシンを用いたリンパ行性薬剤送達法(LDDS)による転移性リンパ節の治療2022

    • Author(s)
      田中菜生,Radhika Mishra,Ariunbuyan Sukhbaatar, 森士朗,小玉哲也
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] リンパ行性薬剤送達法における高浸透圧・高粘度溶媒によるリンパ節内薬剤貯留性の向上に関する超音波画像による解析2022

    • Author(s)
      志水洸太,Ariunbuyan Sukhbaatar, 森士朗, 小玉哲也
    • Organizer
      日本超音波医学会第64回東北地方会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] リンパ行性薬剤送達法と浸透圧・粘度調整溶媒を用いたカルボプラチンによる転移リンパ節に対する抗腫瘍効果の評価2022

    • Author(s)
      宮津美里有, 髙木洸樹, 栗生晏暉, 志水洸太,Radhika Mishra, Ariunbuyan Sukhbaatar, 阪本真弥,森士朗, 小玉哲也
    • Organizer
      第38回日本DDS学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] リンパ節転移介在遠隔転移マウスモデルの樹立2022

    • Author(s)
      髙木洸樹, 宮津美里有, Radhika Mishra, Ariunbuyan Sukhbaatar, 森士朗, 小玉哲也
    • Organizer
      第38回日本DDS学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] リンパ行性薬剤送達法および粘度・浸透圧調整溶媒を用いたカルボプラチンによる転移リンパ節に対する抗腫瘍効果の評価2022

    • Author(s)
      宮津美里有, 髙木洸樹, Radhika Mishra, Ariunbuyan Sukhbaatar, 森士朗, 小玉哲也
    • Organizer
      日本機械学会第34回バイオエンジニアリング講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 抗CTLA-4抗体のリンパ節投与がもたらす遠隔転移治療効果の検討2022

    • Author(s)
      髙木洸樹, 宮津美里有, Radhika Mishra, Ariunbuyan Sukhbaatar, 森士朗, 小玉哲也
    • Organizer
      日本機械学会第34回バイオエンジニアリング講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 転移性リンパ節の治療を目指したドキソルビシンを用いたリンパ行性薬物送達法の開発2022

    • Author(s)
      田中菜生, Radhika Mishra, Ariunbuyan Sukhbaatar, 森士朗, 小玉哲也
    • Organizer
      日本機械学会第34回バイオエンジニアリング講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 早期転移リンパ節の診断と治療2022

    • Author(s)
      小玉哲也
    • Organizer
      第46回日本頭頸部癌学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Optimization of drug physicochemical parameters for enhanced anti-tumor response using LDDS.2021

    • Author(s)
      Mishra R, Ariunbuyan S, Sakamoto M, Mori S, Kodama T
    • Organizer
      The 11th Asian-Pacific Conference on Biomechanics (AP Biomech 2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Can radiation therapy for total body including tumor-bearing lymph nodes control metastasis?2021

    • Author(s)
      Sora S, Ariunbuyan S, Mori S, Kodama T.
    • Organizer
      The 11th Asian-Pacific Conference on Biomechanics (AP Biomech 2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of Lymphatic Delivery Capacity of ICG Liposomes after X-Ray Irradiation.2021

    • Author(s)
      Kuriu S, Sora S, Ariunbuyan S, Mishra R, Sakamoto M, Mori S, Kodama T
    • Organizer
      The 11th Asian-Pacific Conference on Biomechanics (AP Biomech 2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of total body irradiation for metastatic lymph node anf lung metastasis in early stage.2021

    • Author(s)
      Shouta Sora, Shizuki Kuriu, Radhika Mishra, Ariunbuyan Sukhbaatar, Maya Sakamoto, Shiro Mori, Tetsuya Kodama.
    • Organizer
      International Conference on Cancer Detection and Radiology Research 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Possibility of total body irradiations for lymph node metastasis and lung metastasis.2021

    • Author(s)
      Shouta Sora, Radhika Mishra, Ariunbuyan Sukhbaatar, Maya Sakamoto, Shiro Mori, Tetsuya Kodama.
    • Organizer
      AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lymph node metastasis targeted intranodal delivery of docetaxel improves treatment outcome.2021

    • Author(s)
      Ariunbuyan Sukhbaatar, Shouta Sora, Shiro Mori, Tetsuya Kodama
    • Organizer
      AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Importance of drug osmotic pressure and viscosity for efficient drug delivery using the Lymphatic Drug Delivery System.2021

    • Author(s)
      Radhika MISHRA, Ariunbuyan SUKHBAATAR, Shota SORA, Shiro MORI, Maya SAKAMOTO, Tetsuya KODAMA.
    • Organizer
      AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics
    • Related Report
      2021 Annual Research Report
  • [Presentation] Manipulation of drug physicochemical parameters for efficient drug delivery using lymphatic drug delivery system.2021

    • Author(s)
      Mishra R, S Ariunbuyan, Sora S, Sakamoto M, Mori S, Kodama T.
    • Organizer
      The 16th International Workshop on Biomaterials in Interface Science, Sep 28, 2021
    • Related Report
      2021 Annual Research Report
  • [Presentation] Optimized window of drug physicochemical parameters for the Lymphatic Drug Delivery System.2021

    • Author(s)
      Mishra R, S Ariunbuyan, Sora S, Mori S, Sakamoto M, Kodama T.
    • Organizer
      1st JCA-AACR Precision Cancer Medicine International Conference
    • Related Report
      2021 Annual Research Report
  • [Presentation] Micro-CT analysis of lung vascularization in a mouse model of metastatic lung cancer.2021

    • Author(s)
      S Ariunbuyan, Kuriu S, Mori S, Kodama T.
    • Organizer
      1st JCA-AACR Precision Cancer Medicine International Conference
    • Related Report
      2021 Annual Research Report
  • [Presentation] Lymph node metastasis mouse model and its treatment2020

    • Author(s)
      S Ariunbuyan, Sakamoto M, Mori S, Kodama T
    • Organizer
      International Joint Symposium 2020(The 15th International Workshop on Biomaterials in Interface Science, The 11th Symposium on Innovative Dental-Engineering Alliance (IDEA))
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Imaging of the mouse lymphatic sinus during lymphatic administration of high osmotic pressure solutions using a contrast-enhanced high-frequency ultrasound imaging system2020

    • Author(s)
      Fukumura R, Mishra R, S Ariunbuyan, Mori S, Kodama T
    • Organizer
      World Molecular Imaging Congress (WMIC) virtual 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Optimized fluid parameters for enhanced treatment efficacy for drug delivery using the Lymphatic Drug Delivery System2020

    • Author(s)
      Mishra R, Fukumura R, S Ariunbuyan, Mori S, Kodama T
    • Organizer
      World Molecular Imaging Congress (WMIC) virtual 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Does radiotherapy metastatic lymph nodes induce an abscopal effect?2020

    • Author(s)
      Sora S, S Ariunbuyan, Sakamoto M, Mori S, Kodama T
    • Organizer
      World Molecular Imaging Congress (WMIC) virtual 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 浸透圧にともなうリンパ節の形態変化に関する研究2020

    • Author(s)
      福村凌一,Radhika Mishra, Ariunbuyan Sukhbaatar, 森士朗,小玉哲也
    • Organizer
      日本超音波医学会第93回学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Improvement of chemotherapy for the lymph node metastasis2020

    • Author(s)
      S Ariunbuyan,Kodama T, Mori S
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Importance of drug osmotic pressure and viscosity for enhancing treatment effect using lymphatic drug delivery system2020

    • Author(s)
      Mishra R, Fukumura R, S Ariunbuyan, Mori S, Kodama T
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] マウスの転移リンパ節治療における超選択的放射線治療2020

    • Author(s)
      空翔太,スフバートル アリウンブヤン,森士朗,小玉哲也
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 複数の転移リンパ節モデルマウスの開発2020

    • Author(s)
      永松大輝,アリウンブヤン スフバートル,ラディカ ミシュラ,森士朗,小玉哲也
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] リンパ行性薬物送達法におけるリンパ節への分子集積の定量解析2020

    • Author(s)
      鈴木健大,アリウンブヤン スフバートル,森士朗,伊藤明宏,小玉哲也
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] リンパ行性薬剤送達法を用いた抗がん剤投与時における浸透圧の治療依存性2020

    • Author(s)
      福村凌一,ミシュラ ラディカ,スフバートル アリウンブヤン,永松大輝,森士朗,小玉哲也
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] リンパ行性薬剤送達法における薬剤浸透圧変化にともなう転移リンパ節の治療評価に関する研究2020

    • Author(s)
      福村凌一,Radhika Mishra,Ariunbuyan Sukhbaatar,森士朗,小玉哲也
    • Organizer
      日本超音波医学会第60回東北地方会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 深層学習を用いた乳癌造影超音波定量解析における客観的病変範囲評価2020

    • Author(s)
      樋口賢一, 森菜緒子, 伊藤康一, 小玉哲也, 高瀬圭
    • Organizer
      日本超音波医学会第93回学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] リンパ節転移モデルマウスの3次元in vivo超音波定量評価の基礎検討2020

    • Author(s)
      大村眞朗, 永松大輝, 小玉哲也, 佐藤悠佑, 吉田憲司, 山口匡
    • Organizer
      日本超音波医学会第93回学術集会
    • Related Report
      2020 Annual Research Report
  • [Book] Methods Molecular Biology2022

    • Author(s)
      Sukhbaatar A, Kodama T
    • Total Pages
      4
    • Publisher
      Methods Molecular Biology
    • Related Report
      2022 Annual Research Report
  • [Remarks] 小玉研究室ウェブサイト

    • URL

      https://web.tohoku.ac.jp/kodama/achievement/

    • Related Report
      2022 Annual Research Report
  • [Remarks] 小玉研究室

    • URL

      https://web.tohoku.ac.jp/kodama/achievement/

    • Related Report
      2021 Annual Research Report
  • [Remarks] 小玉研究室ホームページ

    • URL

      https://web.tohoku.ac.jp/kodama/

    • Related Report
      2020 Annual Research Report

URL: 

Published: 2020-04-28   Modified: 2024-01-30  

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