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Fundamental study on bioelectronic chip for diagnosis of pathologic conditions based on specific and ultrahighly sensitive detection of prion-like protein

Research Project

Project/Area Number 20H00663
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 90:Biomedical engineering and related fields
Research InstitutionKyoto Institute of Technology

Principal Investigator

Noda Minoru  京都工芸繊維大学, 電気電子工学系, 教授 (20294168)

Co-Investigator(Kenkyū-buntansha) 山門 穂高  京都大学, 医学研究科, 特定准教授 (10378771)
澤村 正典  京都大学, 医学研究科, 助教 (60852423)
島内 寿徳  岡山大学, 環境生命自然科学学域, 准教授 (10335383)
寒川 雅之  新潟大学, 自然科学系, 准教授 (70403128)
福澤 理行  京都工芸繊維大学, 情報工学・人間科学系, 准教授 (60293990)
Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥44,980,000 (Direct Cost: ¥34,600,000、Indirect Cost: ¥10,380,000)
Fiscal Year 2023: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2022: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2021: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2020: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Keywords診断用チップ / プリオン様タンパク質 / バイオセンサ / 脂質膜 / αシヌクレイン / リポソーム / アミロイドβ / 統計解析 / 診断チップ / 機械学習 / パーキンソン病
Outline of Research at the Start

申請者らは、人間の脳髄液中、さらには血液中で異なる各種のプリオン様タンパク質を特異的・超高感度に検出するため、その生化学的機序を明らかにするとともに、特異的・超高感度に検出できるバイオセンサ技術を創成することが大きな目的である。そのために本研究では、プリオン様タンパク質との相互作用性を格段に向上しうる脂質膜関連技術、高感度検出と同時に異なる複数種プリオン様タンパク質を検出できる電気電子的物理センサ基盤技術を検討する。さらにセンシング認識分子となる各種脂質膜リポソームとの最適な反応条件を検討するために機械学習の適用を進める。

Outline of Final Research Achievements

This study aims to realize ultra-early diagnosis of various dementias and diagnosis using easily obtained body fluids (blood), and conducted basic studies on highly reproducible diagnostic markers for diagnosis and treatment effectiveness evaluation, and new pathological diagnostic sensor systems that enable ultra-early diagnosis using these markers. By specific detection of dementia-causing protein a-synuclein, Ab, we confirmed the effectiveness of a lipid membrane with gangliosides of controlled composition, increased the sensitivity by about two orders of magnitude (equivalent to ~10 fM) with a cantilever, examined the dimensions and shape of nanostructures with an LSPR sensor, and increased the sensitivity to detect the fibril at 27 pM against the target ~1 pM by using the self-template effect. We also collected data using the LSPR multi-cell compatible scanning spectroscopic measurement system, and investigated a system that can comprehensively verify statistical learning models.

Academic Significance and Societal Importance of the Research Achievements

本研究は、様々な認知症の原因とされるアミロイドを高感度に超早期に検出して、診断、治療に活用するために、その生化学的機序、それに応じた最適な測定技術・条件の導出から実用化研究に至る学術的な基盤を得ることを目指した。そのために従来の分子生物学的研究の手法のみを用いた研究展開に留まらず、同法に有効なマイクロセンサ工学技術を具体的に融合させた我々独自の新しい技術を考察、実施して得られた研究成果には十分な学術的意義があると考える。認知症の原因物質を高感度に超早期に検出し、診断・治療に役立たせ得る本研究で得られた基礎的な研究基盤・成果は、更なる実用化を目指す現時点でおいて有意な社会的意義を有すると考える。

Report

(4 results)
  • 2023 Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Comments on the Screening Results   Annual Research Report
  • Research Products

    (47 results)

All 2022 2021 2020 Other

All Journal Article (14 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 14 results,  Open Access: 4 results) Presentation (32 results) (of which Int'l Joint Research: 4 results) Remarks (1 results)

  • [Journal Article] Rapid Induction of Dopaminergic Neuron Loss Accompanied by Lewy Body-Like Inclusions in A53T BAC-SNCA Transgenic Mice2021

    • Author(s)
      Okuda Shinya、Uemura Norihito、Sawamura Masanori、Taguchi Tomoyuki、Ikuno Masashi、Uemura Maiko T.、Yamakado Hodaka、Takahashi Ryosuke
    • Journal Title

      Neurotherapeutics

      Volume: 0 Issue: 1 Pages: 0-0

    • DOI

      10.1007/s13311-021-01169-5

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial dysfunction in a mouse model of prodromal Parkinson’s disease: A metabolomic analysis2021

    • Author(s)
      Ikuno Masashi、Yamakado Hodaka、Amano Ikuko、Hatanaka Yusuke、Uemura Norihito、Matsuzawa Shu-ichi、Takahashi Ryosuke
    • Journal Title

      Neuroscience Letters

      Volume: 765 Pages: 136267-136267

    • DOI

      10.1016/j.neulet.2021.136267

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Membranes and Organelle in Lewy Bodies: The Mastermind or the Bystander?2021

    • Author(s)
      Ishimoto Tomoyuki、Yamakado Hodaka
    • Journal Title

      Movement Disorders

      Volume: 36 Issue: 9 Pages: 2026-2026

    • DOI

      10.1002/mds.28747

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The stimulator of interferon genes (STING) pathway is upregulated in striatal astrocytes of patients with multiple system atrophy2021

    • Author(s)
      Inoue Yutaka、Ayaki Takashi、Ishimoto Tomoyuki、Yamakado Hodaka、Maki Takakuni、Matsuzawa Shuichi、Sawamoto Nobukatsu、Takahashi Ryosuke
    • Journal Title

      Neuroscience Letters

      Volume: 757 Pages: 135972-135972

    • DOI

      10.1016/j.neulet.2021.135972

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of Gba2 on neuronopathic Gaucher’s disease and α-synuclein accumulation in medaka (Oryzias latipes)2021

    • Author(s)
      Nakanishi Etsuro、Uemura Norihito、Akiyama Hisako、Kinoshita Masato、Masanori Sawamura、Taruno Yosuke、Yamakado Hodaka、Matsuzawa Shu-ichi、Takeda Shunichi、Hirabayashi Yoshio、Takahashi Ryosuke
    • Journal Title

      Molecular Brain

      Volume: 14 Issue: 1 Pages: 0-0

    • DOI

      10.1186/s13041-021-00790-x

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Perampanel Inhibits α-Synuclein Transmission in Parkinson's Disease Models2021

    • Author(s)
      Ueda J, Uemura N, Sawamura M, Taguchi T, Ikuno M, Kaji S, Taruno Y, Matsuzawa S, Yamakado H, Takahashi R.
    • Journal Title

      Mov Disord. 2021 Apr 4. doi: 10.1002/mds.28558. Epub ahead of print. PMID: 33813737.

      Volume: 4 Issue: 7 Pages: 28558-28558

    • DOI

      10.1002/mds.28558

    • NAID

      120007030224

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] α-Synuclein Spread from Olfactory Bulb Causes Hyposmia, Anxiety, and Memory Loss in BAC-SNCA Mice2021

    • Author(s)
      Uemura N, Ueda J, Yoshihara T, Ikuno M, Uemura MT, Yamakado H, Asano M, Trojanowski JQ, Takahashi R
    • Journal Title

      Mov Disord. 2021 Feb 6. doi: 10.1002/mds.28512. Epub ahead of print. PMID: 33547846

      Volume: 2 Issue: 9 Pages: 28512-28512

    • DOI

      10.1002/mds.28512

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Mice with cleavage-resistant N-cadherin exhibit synapse anomaly in the hippocampus and outperformance in spatial learning tasks2021

    • Author(s)
      M. Asada-Utsugi, K. Uemura, M. Kubota, Y. Noda, Y. Tashiro, T. M. Uemura, H. Yamakado, M. Urushitani, R. Takahashi, S. Hattori, T. Miyakawa, N. Ageta-Ishihara, K. Kobayashi, M. Kinoshita, A. Kinoshita
    • Journal Title

      Molecular Brain

      Volume: 14 Issue: 1 Pages: 23-23

    • DOI

      10.1186/s13041-021-00738-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Label‐free, chronological and selective detection of aggregation and fibrillization of amyloid β protein in serum by microcantilever sensor immobilizing cholesterol‐incorporated liposome2020

    • Author(s)
      Tomoya Taniguchi, Toshinori Shimanouchi, Masayuki Sohgawa, Minoru Noda
    • Journal Title

      Biotechnology and Bioengineering , Volume117, Issue8, 2469-2478, (2020).

      Volume: Volume117, Issue8 Issue: 8 Pages: 2469-2478

    • DOI

      10.1002/bit.27380

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Developmental Changes in Dendritic Spine Morphology in the Striatum and Their Alteration in an A53T α-Synuclein Transgenic Mouse Model of Parkinson’s Disease2020

    • Author(s)
      Parajuli Laxmi Kumar、Wako Ken、Maruo Suiki、Kakuta Soichiro、Taguchi Tomoyuki、Ikuno Masashi、Yamakado Hodaka、Takahashi Ryosuke、Koike Masato
    • Journal Title

      eneuro

      Volume: 7 Issue: 4 Pages: 0072-20

    • DOI

      10.1523/eneuro.0072-20.2020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] BCAS1-positive immature oligodendrocytes are affected by the α-synuclein-induced pathology of multiple system atrophy2020

    • Author(s)
      Kaji S, Maki T, Ueda J, Ishimoto T, Inoue Y, Yasuda K, Sawamura M, Hikawa R, Ayaki T, Yamakado H, Takahashi R
    • Journal Title

      Acta Neuropathol Commun. 2020 Jul 29;8(1):120. doi: 10.1186/s40478-020-00997-4. PMID: 32727582; PMCID: PMC7391509

      Volume: 8 Issue: 1 Pages: 120-120

    • DOI

      10.1186/s40478-020-00997-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Susceptibility to erastin- induced ferroptosis decreases during maturation in a human oligodendrocyte cell line2020

    • Author(s)
      Hoshino T, Yamakado H, Takahashi R, Matsuzawa SI
    • Journal Title

      FEBS Open Bio. 2020 Sep;10(9):1758-1764. doi: 10.1002/2211-5463.12923. Epub 2020 Jul 30. PMID: 32608563; PMCID: PMC7459400

      Volume: 10 Issue: 9 Pages: 1758-1764

    • DOI

      10.1002/2211-5463.12923

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Portable Spectrometric System for Quantitative Prediction of the Soluble Solids Content of Apples with a Pre-calibrated Multispectral Sensor Chipset2020

    • Author(s)
      N.-T. Tran, M. Fukuzawa
    • Journal Title

      Sensors, Vol. 20 (20), 5883, 11 pages, 2020, DOI: 10.3390/s20205883

      Volume: 20 Issue: 20 Pages: 5883-5893

    • DOI

      10.3390/s20205883

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Precise Sweetness Grading of Mango (Mangifera indica L.) Based on Random Forest Technique with Low-Cost Multispectral Sensors2020

    • Author(s)
      C.-N. Nguyen, Q.-T. Phan, N.-T. Tran, M. Fukuzawa, P.-L. Nguyen, C.-N. Nguyen
    • Journal Title

      IEEE Access, Vol. 8, pp. 212371-212382, 2020, DOI:10.1109/ACCESS.2020.3040062

      Volume: 8 Pages: 212371-212382

    • DOI

      10.1109/access.2020.3040062

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] カンチレバーアレイバイオセンサ用マイクロ流体デバイスの検討2022

    • Author(s)
      高橋 悠矢, 紙谷 虎太郎, Carl Frederik Werner1, 寒川 雅之, 野田 実
    • Organizer
      第69回応用物理学会春季学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Investigation of the cross-talk behavior of a multi measurement cell LAPS2022

    • Author(s)
      Carl Frederik Werner, Yuya Takahashi, Ko-ichiro Miyamoto, Tatsuo Yoshinobu, Minoru Noda
    • Organizer
      第69回応用物理学会春季学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] バイオセンサ・触覚センサ応用に向けたカンチレバーアレイチップの設計と試作評価2022

    • Author(s)
      水戸部龍介, 長谷川拓海, 高橋悠矢, 紙谷虎太郎, 安部 隆, 野田 実, 寒川雅之
    • Organizer
      電気学会交通・電気鉄道/マイクロマシン・センサシステム合同研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 二つのひずみゲージを搭載したカンチレバー型MEMS触覚センサ2022

    • Author(s)
      岡固 創, 髙橋佑司, 安部 隆, 野間春生, 寒川雅之
    • Organizer
      電気学会全国大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] A highly sensitive and specific detection of biomarker of Parkinson's disease by liposome immobilized cantilever sensor2021

    • Author(s)
      Kotaro Kamitani, Masanori Sawamura, Hodaka Yamakado, Masayuki Sohgawa,Minoru Noda
    • Organizer
      IEEE EDSK IMFEDK 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] バイオセンサアレイ化に向けた3Dプリンターによるマイクロ流体デバイスの開発2021

    • Author(s)
      高橋 悠矢, 紙谷 虎太郎, Werner Carl Frederik, 野田 実
    • Organizer
      応用物理学会2021秋季講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] パーキンソン病患者血清中αシヌクレインのリポソーム 固定化センサにおける高感度検出の検討2021

    • Author(s)
      紙谷 虎太郎, 高橋 悠矢, Werner Carl Frederik, 澤村 正典, 山門 穂高, 寒川 雅之, 野田 実
    • Organizer
      応用物理学会2021秋季講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Real-time chemical imaging sensor based on the light-addressable potentiometric sensors principle2021

    • Author(s)
      WERNER Carl Frederik, WAGNER Torsten, SCHOENING Michael J., 宮本 浩一郎, 吉信 達夫, 野田 実
    • Organizer
      Sensor Symposium 2021, 電気学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Multi analyte sensor with individual measurement cells based on the LAPS principle2021

    • Author(s)
      Carl Frederik Werner, Yuya Takahashi, Ko-ichiro Miyamoto, Tatsuo Yoshinobu, Minoru Noda
    • Organizer
      電気学会全国大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Prodromal DLB/synucleinopathy - 動物モデルからみた prodromal synucleinopathy2021

    • Author(s)
      山門 穂高
    • Organizer
      1.第40回日本認知症学会(シンポジウム)
    • Related Report
      2021 Annual Research Report
  • [Presentation] レヴィ小体病の病態と治療:update 2021 -シヌクレイノパチーの病態仮説とその前駆期動物モデルの作製2021

    • Author(s)
      山門 穂高
    • Organizer
      2.第39回日本神経治療学会(シンポジウム)
    • Related Report
      2021 Annual Research Report
  • [Presentation] 神経変性疾患の新知見-未来に向けて 疾患修飾療法開発のための新しいパーキンソン病動物モデル2021

    • Author(s)
      山門 穂高
    • Organizer
      3.第44回日本神経科学大会 (シンポジウム)
    • Related Report
      2021 Annual Research Report
  • [Presentation] Braakモデル再考 ーαシヌクレイン凝集体伝播に焦点を当てたアプローチー2021

    • Author(s)
      山門 穂高
    • Organizer
      4.第15回パーキンソン病・運動障害疾患コングレス(シンポジウム)
    • Related Report
      2021 Annual Research Report
  • [Presentation] RBDを呈する新しい前駆期パーキンソン病モデルの開発2021

    • Author(s)
      山門 穂高
    • Organizer
      5.第62回 日本神経学会学術大会 (シンポジウム)
    • Related Report
      2021 Annual Research Report
  • [Presentation] 非ヒト霊長類におけるα-synuclein嗅覚系伝播とレム睡眠行動異常症2021

    • Author(s)
      澤村 正典
    • Organizer
      6.第15回パーキンソン病・運動障害疾患コングレス(シンポジウム)
    • Related Report
      2021 Annual Research Report
  • [Presentation] “Benign” amyotrophic lateral sclerosis with slow progression harboring homozygous D92G SOD12021

    • Author(s)
      澤村 正典
    • Organizer
      7.第62回 日本神経学会学術大会 (シンポジウム)
    • Related Report
      2021 Annual Research Report
  • [Presentation] 亜臨界水乳化法と溶媒拡散法を用いたリン脂質ベシクル調製2021

    • Author(s)
      多井駿介,島内寿徳, 木村幸敬
    • Organizer
      中四国若手CE合宿@徳島大
    • Related Report
      2021 Annual Research Report
  • [Presentation] 酸化グラフェン薄膜を用いた intact なリポソーム固定化法の開発2021

    • Author(s)
      島内寿徳,小川雄河,林啓太,木村幸敬
    • Organizer
      膜学会年会@早稲田大学
    • Related Report
      2021 Annual Research Report
  • [Presentation] マイクロカンチレバー触覚センサにおけるひずみゲージ用NiCr薄膜特性のスパッタリング成膜温度依存性評価2021

    • Author(s)
      GONG LIQIANG, 安部 隆, 寒川 雅之
    • Organizer
      日本機械学会2021年度年次大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Sensitivity Enhancement of MEMS Tactile Sensor by Redesign of Microcantilever and Strain Gauge2021

    • Author(s)
      Ren Kaneta, Takumi Hasegawa, Takashi Abe, Masayuki Sohgawa
    • Organizer
      IEEE Sensors 2021
    • Related Report
      2021 Annual Research Report
  • [Presentation] 触覚センサ感度のマイクロカンチレバーサイズおよびひずみゲージ形状・材料依存性評価2021

    • Author(s)
      長谷川 拓海, 金田 蓮, 安部 隆, 丹羽 英二, 寒川 雅之
    • Organizer
      第12回マイクロ・ナノ工学シンポジウム
    • Related Report
      2021 Annual Research Report
  • [Presentation] リポソームセンシングにおけるNaCl添加によるパーキンソン病原因物質αシヌクレイン凝集体検出感度向上2021

    • Author(s)
      紙谷 虎太郎, 小林 亮子, 澤村 正典, 山門 穂高, 野田 実
    • Organizer
      16p-Z21-7. 第68回応用物理学会春季学術講演会. オンライン開催. 3月16-19日 (2021) 11-126
    • Related Report
      2020 Annual Research Report
  • [Presentation] Machine Learning-Based Classification of Apple Sweetness with Multispectral Sensor2021

    • Author(s)
      N.-T. Tran, Q.-T. Phan, C.-N. Nguyen, M. Fukuzawa
    • Organizer
      Proceedings of 21st ACIS International Winter Conference on Software Engineering, Artificial Intelligence, Networking and Parallel/Distributed Computing (SNPD2021-Winter), pp. 30-34, 2021 (国際学会)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] AN ULTRASENSITIVE DETECTION OF AGGREGATED α-SYNUCLEIN AS A BIOMARKER MOLECULE FOR PARKINSON DISEASE BY LIPOSOME-IMMOBILIZED CANTILEVER BIOSENSOR USING SELF-TEMPLATING PHENOMENA OF PRIONOID PROTEIN2020

    • Author(s)
      Ryoko Kobayashi, Masanori Sawamura, Hodaka Yamakado, Masayuki Sohgawa, Minoru Noda
    • Organizer
      C3L-A-2, MicroTAS 2020, Online Conference, October. 4-9 (2020) 1274.(国際学会)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A Novel Detection Method of Biomarker Molecule of α-Synuclein for Parkinson Disease by Liposome-Immobilized Cantilever Biosensor Using Self-Templating Phenomena of Prionoid Protein2020

    • Author(s)
      Ryoko Kobayashi, Masanori Sawamura, Hodaka Yamakado, Masayuki Sohgawa, Minoru Noda
    • Organizer
      G-8-03, The 2020 International Conference on Solid State Devices and Materials (SSDM2020), Virtual Conference, Septmber. 27- 30 (2020) 463-464.(国際学会)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] リポソーム固定化カンチレバーセンサを用いたパーキンソン病原因物質αシヌクレイン凝集体の超高感度検出2020

    • Author(s)
      小林亮子, 澤村正典, 山門穂高, 寒川雅之, 野田実
    • Organizer
      28A3-SS3-6, 第37回「センサ・マイクロマシンと応用システム」シンポジウム, オンライン開催, 10月26-28日 (2020)
    • Related Report
      2020 Annual Research Report
  • [Presentation] リン脂質リポソーム固定化カンチレバーセンサを用いたパーキンソン病患者血清中αシヌクレインの検出2020

    • Author(s)
      小林 亮子, 澤村 正典, 山門 穂高, 寒川 雅之, 野田 実
    • Organizer
      9a-Z12-2, 第81回応用物理学会秋季学術講演会, オンライン開催, 9月8日-11日 (2020) 11-075.
    • Related Report
      2020 Annual Research Report
  • [Presentation] Au電極上固定化リポソーム表面でのαシヌクレインの凝集・線維化の液中AFM観察2020

    • Author(s)
      小林 亮子, 澤村 正典, 山門 穂高, 野田 実
    • Organizer
      11a-Z12-1, 第81回応用物理学会秋季学術講演会, オンライン開催, 9月8-11日 (2020) 11-225
    • Related Report
      2020 Annual Research Report
  • [Presentation] 早期パーキンソン病のモデルの開発と治療の可能性2020

    • Author(s)
      山門穂高
    • Organizer
      第38回日本神経治療学会学術集会(シンポジウム) 2020年10月30日
    • Related Report
      2020 Annual Research Report
  • [Presentation] Animal model for disease-modifying therapies in Parkinson's disease2020

    • Author(s)
      山門穂高
    • Organizer
      第61回 日本神経学会学術大会 (シンポジウム) 2020年9月1日
    • Related Report
      2020 Annual Research Report
  • [Presentation] 高ゲージ率Cr-N薄膜及び設計改良によるMEMS触覚センサの感度向上2020

    • Author(s)
      金田 蓮, 安部 隆, 丹羽 英二, 寒川雅之
    • Organizer
      令和2年度電気学会A部門大会 2020年度
    • Related Report
      2020 Annual Research Report
  • [Presentation] マイクロカンチレバーの設計改良によるMEMS触覚センサの感度向上2020

    • Author(s)
      金田蓮, 安部隆, 寒川雅之
    • Organizer
      ロボティクス・メカトロニクス講演会2020, 2020年
    • Related Report
      2020 Annual Research Report
  • [Remarks] 京都工芸繊維大学 大学院工芸科学研究科 電子システム工学専攻 電子デバイス工学研究室 研究業績リスト

    • URL

      http://www.cis.kit.ac.jp/~led/worklist/worklist_index.html

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report

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Published: 2020-04-28   Modified: 2025-01-30  

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