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Neuronal basis of olfactory antagonism in moths

Research Project

Project/Area Number 20H03293
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 44050:Animal physiological chemistry, physiology and behavioral biology-related
Research InstitutionThe University of Tokyo

Principal Investigator

Namiki Shigehiro  東京大学, 先端科学技術研究センター, 准教授 (40567757)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2020: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Keywords匂い源探索 / 神経回路 / フェロモン / 細胞内記録 / 電気生理学 / 神経行動学 / アンタゴニズム / 嗅覚 / 種分化
Outline of Research at the Start

昆虫の性フェロモンは複数の成分から構成されており,それぞれの成分は種間で重複して使用されていることも多い.多様な種が混在する環境下で,異種のフェロモンによって性フェロモン行動が抑制されるアンタゴニズムの機構は,生殖隔離において重要なプロセスであり,種分化のメカニズムの理解に必要不可欠である.フェロモン情報経路のいずれかにおいて,アンタゴニストによる神経活動の抑制が起こり,行動の抑制を実現するという仮説に基づき,フェロモン情報経路における神経活動抑制の作用点・作用機序を検討することにより,匂いのアンタゴニズムが脳のどこでどのように起こっているかを明らかにする.

Outline of Final Research Achievements

Electrophysiological techniques using silkmoth Bombyx mori revealed that antagonism occurs in the second and later of the four brain regions in the information pathway. The second region in the silkworm moth brain, the lateral protocerebrum, is known to have separate areas for processing sex pheromones and antagonists. We then tested whether similar functional structures exist in insects other than the silkworm moth using a hawkmoth Agrius convolvuli, for which physiological measurements are relatively easy. In Agrius, we identified cells that transmit antagonist information to the lateral protocerebrum. By standardizing the experimental data, we compared the distribution of axonal projections and confirmed that, as in the silkworm moth, sex pheromone information is output inward and antagonist information outward. The commonality among different species suggests that this feature may contribute to antagonism.

Academic Significance and Societal Importance of the Research Achievements

ガ類では性フェロモンによるコミュニケーションの発達に伴い、種の顕著な多様化がみとめられる。多様な信号が混在する実環境下で、異種のフェロモンによって、性フェロモン行動が抑制されるアンタゴニズムの機構は、フェロモン選好性の変化による生殖隔離において必要不可欠なプロセスであり、種分化のメカニズムを理解するうえで重要である。本研究成果はアンタゴニズムの機構について、解剖学的な知見を提供したという点で学術的な価値がある。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • Research Products

    (12 results)

All 2023 2022 2021 2020

All Journal Article (4 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (7 results) (of which Int'l Joint Research: 1 results,  Invited: 6 results) Book (1 results)

  • [Journal Article] Synaptic gradients transform object location to action2023

    • Author(s)
      Dombrovski Mark、Peek Martin Y.、Park Jin-Yong、Vaccari Andrea、Sumathipala Marissa、Morrow Carmen、Breads Patrick、Zhao Arthur、Kurmangaliyev Yerbol Z.、Sanfilippo Piero、Rehan Aadil、Polsky Jason、Alghailani Shada、Tenshaw Emily、Namiki Shigehiro、Zipursky S. Lawrence、Card Gwyneth M.
    • Journal Title

      Nature

      Volume: 613 Issue: 7944 Pages: 534-542

    • DOI

      10.1038/s41586-022-05562-8

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A searchable image resource of Drosophila GAL4 driver expression patterns with single neuron resolution2023

    • Author(s)
      Meissner Geoffrey W、Nern Aljoscha、Dorman Zachary、et al.
    • Journal Title

      eLife

      Volume: 12 Pages: 1-20

    • DOI

      10.7554/elife.80660

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A population of descending neurons that regulates the flight motor of Drosophila2022

    • Author(s)
      Namiki Shigehiro、Ros Ivo G.、Morrow Carmen、Rowell William J.、Card Gwyneth M.、Korff Wyatt、Dickinson Michael H.
    • Journal Title

      Current Biology

      Volume: 32 Issue: 5 Pages: 1189-1196.e6

    • DOI

      10.1016/j.cub.2022.01.008

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Systematic Nomenclature for the Drosophila Ventral Nerve Cord.2020

    • Author(s)
      Court R, Namiki S, Armstrong D, Borner J, Card G, Costa M, Dickinson MH, Duch C, Korff W, Mann R, Merritt D, Murphey R, Seeds A, Shirangi T, Simpson J, Truman J, Tuthill J, Williams D, Shepherd D
    • Journal Title

      Neuron

      Volume: 107 Issue: 6 Pages: 1071-1079

    • DOI

      10.1016/j.neuron.2020.08.005

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Accessible science laboratory environment for students with physical disabilities2023

    • Author(s)
      Shigehiro Namiki
    • Organizer
      4th International Disability Inclusion Symposium
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 大学でのインクルーシブな教育研究環境の構築2023

    • Author(s)
      並木重宏
    • Organizer
      UDXワークショップ基調講演,計測自動制御学会システムインテグレーション部門ユニバーサルデザイン応用システム部会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 科学の多様性を支えるしくみについて2023

    • Author(s)
      並木重宏
    • Organizer
      日本木材学会ダイバーシティ推進委員会公開シンポジウム 「ポストコロナを踏まえた 教育・研究におけるダイバーシティの取り組み」
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 障害と科学/JAASでの取り組み2022

    • Author(s)
      並木重宏
    • Organizer
      すべての人が科学を楽しむ場を作るために,日本科学振興協会第一回総会キックオフミーティング
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] インクルーシブデザインラボの取り組み2022

    • Author(s)
      並木重宏
    • Organizer
      東京都立大学バリアフリー講演会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 科学の多様性に関わる最近の話題2022

    • Author(s)
      並木重宏
    • Organizer
      ワークショップ「動物の生きるしくみを学ぶ仕掛け」,日本比較生理生化学会第44回高知大会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Drosophila connectome based insect brain simulations on Fugaku using multi-compartment Hodgkin-Huxley type neuron models2021

    • Author(s)
      Kazwa T, Higuchi K, Sakai B, Namiki S, Haupt SS, Kanzaki R
    • Organizer
      第43回日本比較生理生化学会大会
    • Related Report
      2021 Annual Research Report
  • [Book] Death-Feigning in Insects: Mechanism and Function of Tonic Immobility2021

    • Author(s)
      Namiki S
    • Total Pages
      312
    • Publisher
      Descending neuron for freezing behavior in Drosophila melanogaster
    • ISBN
      9789813365971
    • Related Report
      2021 Annual Research Report

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Published: 2020-04-28   Modified: 2024-12-25  

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