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Experimental and epidemiological examination of the exercise effects on the communication between gut environment and skeletal muscle metabolism

Research Project

Project/Area Number 20H04080
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59020:Sports sciences-related
Research InstitutionKyoto Prefectural University

Principal Investigator

Aoi Wataru  京都府立大学, 生命環境科学研究科, 准教授 (60405272)

Co-Investigator(Kenkyū-buntansha) 内藤 裕二  京都府立医科大学, 医学(系)研究科(研究院), 教授 (00305575)
小山 晃英  京都府立医科大学, 医学(系)研究科(研究院), 講師 (40711362)
井上 亮  摂南大学, 農学部, 教授 (70443926)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Fiscal Year 2022: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywords骨格筋 / エネルギー代謝 / 腸内細菌 / 臓器連関 / 血液中因子 / 代謝 / 胆汁酸
Outline of Research at the Start

本研究は、運動習慣によりエネルギー代謝が高まる仕組みについて、腸内細菌の働きに着目して解明することを目的としている。
実験動物モデルや培養細胞を利用して、骨格筋、腸内細菌、血液成分の働きや変化を実験的に検討する。また、健常者を対象とした試験・調査によって、運動習慣と腸内細菌の関連を検討する。
一連の研究から、腸内細菌や血液成分の改善を考慮した健康長寿のための運動処方、栄養処方の確立を目指す。

Outline of Final Research Achievements

This study examined the relationship between gut environment and skeletal muscle metabolism in experimental animals, cultured cells, and humans. In recipient mice transplanted with gut microbiota from exercise-acclimated mice, energy metabolism in skeletal muscle was enhanced, indicating that deconjugation of bile acids by gut microbiota was involved in the activated metabolism. A cross-sectional study in middle-aged and elderly subjects also showed associations of physical activity and dietary habits with circulating bile acid composition. These results indicate that metabolic benefits of exercise involve communication between gut environment and skeletal muscle metabolism via changes in blood metabolites.

Academic Significance and Societal Importance of the Research Achievements

本研究により,腸内細菌叢の変化が,骨格筋のエネルギー代謝,ひいては全身の耐糖能や体組成を調整することが示された。また,運動習慣による代謝疾患の予防や体力の向上には,腸内細菌の働きによる血液中代謝物濃度の調整が関与することが示唆された。適切な運動習慣,食習慣は,健全な腸内環境ならびに骨格筋栄養素代謝を支え,両者のコミュニケーションが健康づくりに寄与すると考えられる。

Report

(4 results)
  • 2023 Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • Research Products

    (30 results)

All 2024 2023 2022 2021 2020 Other

All Int'l Joint Research (3 results) Journal Article (12 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 12 results,  Open Access: 7 results) Presentation (14 results) (of which Int'l Joint Research: 3 results,  Invited: 10 results) Book (1 results)

  • [Int'l Joint Research] カロリンスカ研究所(スウェーデン)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] Karolinska Institutet(スウェーデン)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Karolinska Institutet(スウェーデン)

    • Related Report
      2020 Annual Research Report
  • [Journal Article] High-intensity exercise impairs intestinal barrier function by generating oxidative stress2024

    • Author(s)
      Takami, M., Aoi, W., Matsumoto, K., Kato, Y., Kobayashi, Y., Kuwahata, M.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 74 Issue: 2 Pages: 136-140

    • DOI

      10.3164/jcbn.23-96

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exercise-acclimated microbiota improves skeletal muscle metabolism via circulating bile acid deconjugation2023

    • Author(s)
      Aoi, W., Inoue, R., Mizushima, K., Honda, A., Bjornholm, M., Takagi, T., Naito, Y.
    • Journal Title

      iScience

      Volume: 26 Issue: 3 Pages: 106251-106251

    • DOI

      10.1016/j.isci.2023.106251

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Matcha green tea beverage moderates fatigue and supports resistance training-induced adaptation2023

    • Author(s)
      Shigeta Mizuho、Aoi Wataru、Morita Chiharu、Soga Kurumi、Inoue Ryo、Fukushima Yoichi、Kobayashi Yukiko、Kuwahata Masashi
    • Journal Title

      Nutrition Journal

      Volume: 22 Issue: 1 Pages: 32-32

    • DOI

      10.1186/s12937-023-00859-4

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-intensity exercise training induces the oxidative modification of malate dehydrogenase 2 in skeletal muscles2023

    • Author(s)
      Takami Maki、Aoi Wataru、Ando Chinatsu、Kato Yoji、Kobayashi Yukiko、Kuwahata Masashi
    • Journal Title

      Advances in Redox Research

      Volume: 9 Pages: 100076-100076

    • DOI

      10.1016/j.arres.2023.100076

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of Metabolism and Exercise Functions Associated with Skeletal Muscle and Gut Crosstalk2023

    • Author(s)
      青井渉
    • Journal Title

      Nippon Eiyo Shokuryo Gakkaishi

      Volume: 76 Issue: 5 Pages: 305-312

    • DOI

      10.4327/jsnfs.76.305

    • ISSN
      0287-3516, 1883-2849
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lactococcus cremoris?subsp.?cremoris FC-fermented milk activates protein synthesis and increases skeletal muscle mass in middle-aged mice2022

    • Author(s)
      Aoi, W., Iwasa, M., Aiso, C., Tabata, Y., Gotoh, Y., Kosaka, H., Suzuki, T.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 612 Pages: 176-180

    • DOI

      10.1016/j.bbrc.2022.04.097

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intensive, prolonged exercise seemingly causes gut dysbiosis in female endurance runners2021

    • Author(s)
      Morishima, S., Aoi, W., Kawamura, A., Kawase, T., Takagi, T., Naito, Y., Tsukahara, T., and Inoue, R.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 68 Issue: 3 Pages: 253-258

    • DOI

      10.3164/jcbn.20-131

    • NAID

      130008033290

    • ISSN
      0912-0009, 1880-5086
    • Year and Date
      2021-05-01
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of skeletal muscle-derived exosomes in organ metabolic and immunological communication2021

    • Author(s)
      Aoi, W. and Tanimura, Y.
    • Journal Title

      Front in Endocrinol (Lausanne)

      Volume: 12 Pages: 1-7

    • DOI

      10.3389/fendo.2021.697204

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metabolic functions of flavonoids: From human epidemiology to molecular mechanism2021

    • Author(s)
      Aoi, W., Iwasa, M., and Marunaka, Y.
    • Journal Title

      Neuropeptides

      Volume: 88 Pages: 1-8

    • DOI

      10.1016/j.npep.2021.102163

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Astaxanthin-, β-Carotene-, and Resveratrol-Rich Foods Support Resistance Training-Induced Adaptation2021

    • Author(s)
      Kawamura, A., Aoi, W., Abe, R., Kobayashi, Y., Kuwahata, M., and Higashi, A.
    • Journal Title

      Antioxidants

      Volume: 10 Issue: 1 Pages: 1-11

    • DOI

      10.3390/antiox10010113

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A milk casein hydrolysate‐derived peptide enhances glucose uptake through the AMP‐activated protein kinase signalling pathway in skeletal muscle cells2021

    • Author(s)
      Iwasa, M., Takezoe, S., Kitaura, N., Sutani, T., Miyazaki, H., and Aoi, W.
    • Journal Title

      Experimental Physiology

      Volume: 106 Issue: 2 Pages: 496-505

    • DOI

      10.1113/ep088770

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polysorbate 80‐induced leaky gut impairs skeletal muscle metabolism in mice2020

    • Author(s)
      Nishimura Saho、Aoi Wataru、Kodani Hinako、Kobayashi Yukiko、Wada Sayori、Kuwahata Masashi、Higashi Akane
    • Journal Title

      Physiological Reports

      Volume: 8 Issue: 20 Pages: 1-8

    • DOI

      10.14814/phy2.14629

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 高強度運動による腸管透過性亢進と酸化ストレスの検討2023

    • Author(s)
      髙見真,青井渉,垣内晴菜,松本果倫,小林ゆき子,桑波田雅士
    • Organizer
      第77回日本栄養・食糧学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] The Potential Role of Astaxanthin in Metabolic Health and Exercise Performance2023

    • Author(s)
      Aoi, W.
    • Organizer
      The 19th International Symposium on Carotenoids
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] スポーツ栄養からみる腸バリア・免疫・代謝の機能連関2023

    • Author(s)
      青井渉
    • Organizer
      スポーツ栄養学会第9回大会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 腸シグナルによる骨格筋代謝制御2023

    • Author(s)
      青井渉
    • Organizer
      第10回日本サルコペニア・フレイル学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 腸管透過性亢進モデルマウスにおける骨格筋糖代謝の検討2022

    • Author(s)
      平田樹子,青井渉,小林ゆき子,桑波田雅士
    • Organizer
      第76回日本栄養・食糧学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Immune-metabolic Interaction between Skeletal Muscle and Gut2022

    • Author(s)
      Aoi, W.
    • Organizer
      The 8th Asian Conference for Frailty and Sarcopenia
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] サルコペニア予防のための運動の効果-マイオカインに注目して2021

    • Author(s)
      青井渉
    • Organizer
      第63回日本老年医学会学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 骨格筋と腸の臓器連関からみた運動ベネフィット2021

    • Author(s)
      青井渉
    • Organizer
      第21回日本抗加齢医学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] サルコペニア予防における運動効果の分子メカニズム2021

    • Author(s)
      青井渉
    • Organizer
      第8回日本サルコペニア・フレイル学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 臓器連関からみた骨格筋と腸の機能制御2021

    • Author(s)
      青井渉
    • Organizer
      第7回日本筋学会学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] SPARC, a Muscle-secreted Protein, Improves Glucose Tolerance via AMP-activated Protein Kinase in Skeletal Muscle.2020

    • Author(s)
      Aoi, W., Sakuma, K., and Krook, A.
    • Organizer
      Experimental Biology 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 腸内環境に依存する液性因子による骨格筋代謝修飾作用2020

    • Author(s)
      青井渉
    • Organizer
      第75回日本体力医学会大会 シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] 骨格筋の分泌機能とサルコペニア・フレイル2020

    • Author(s)
      青井渉
    • Organizer
      第7回日本サルコペニア・フレイル学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 骨格筋機能におけるフードサイエンス2020

    • Author(s)
      青井渉
    • Organizer
      第7回日本サルコペニア・フレイル学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Book] Myokines: A Potential Key Factor in Development, Treatment, and Biomarker of Sarcopenia. In Sakuma K. ed. Sarcopenia: Molecular Mechanism and Treatment Strategies2021

    • Author(s)
      Aoi, W.
    • Total Pages
      344
    • Publisher
      Elsevier
    • ISBN
      9780128221464
    • Related Report
      2021 Annual Research Report

URL: 

Published: 2020-04-28   Modified: 2025-01-30  

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