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The Brain of Musicians: A Cross Sectional Functional Neuroimaging Study with MRS, TMS and EEG

Research Project

Project/Area Number 20H04092
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59030:Physical education, and physical and health education-related
Research InstitutionKeio University

Principal Investigator

FUJII Shinya  慶應義塾大学, 環境情報学部(藤沢), 准教授 (40773817)

Co-Investigator(Kenkyū-buntansha) 中島 振一郎  慶應義塾大学, 医学部(信濃町), 講師 (60383866)
野田 賀大  慶應義塾大学, 医学部(信濃町), 特任准教授 (20807226)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2022: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2021: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2020: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywords音楽家 / 脳機能 / 音楽機能 / 認知機能 / リズム / TMS-EEG / MRS / MMN / 統合失調症 / 脳波 / 脳 / ドラマー / MRI / TMS / EEG
Outline of Research at the Start

近年、音楽経験を豊富に積んだ高齢者は、音楽経験の少ない高齢者に比べて、ワーキングメモリーや実行機能など、認知課題の成績が優れていると報告された。これらの先行研究を踏まえると、音楽はヒトの認知機能の改善や維持、長寿健康社会の実現に有用であると示唆されるが、その神経生理メカニズムは十分に解明されていない。そこで本研究では、核磁気共鳴スペクトロスコピー(MRS)と、経頭蓋磁気刺激と高解像度脳波の同時計測手法(TMS-EEG)を用いて、音楽家と非音楽家の前頭前野グルタミン酸・γアミノ酪酸(GABA)神経機能を横断比較し、音楽機能・認知機能との関連性を解明する。

Outline of Final Research Achievements

The aim of this study was to investigate the neurophysiological foundations of musical and cognitive functions in musicians, with a particular focus on their interrelationships. Through a TMS-EEG study, we elucidated the relationship between cognitive function, TMS-elicited alpha band power in the prefrontal cortex, and time spent practicing a musical instrument in groups with and without extensive music learning experience. Further, our MRS study shed light on the association between glutamate concentration in the caudate nucleus and musical rhythm generation capabilities. Additionally, we identified a link between rhythm perception-generation function and mismatch negativity potentials in patients with schizophrenia. These findings contribute to our understanding of the neurocognitive mechanisms underlying musical ability and cognition, offering novel perspectives for future research.

Academic Significance and Societal Importance of the Research Achievements

音楽は太古の昔から世界中に普遍的に存在したが、音楽がヒトの認知機能に与える影響についてはまだ科学的に十分に理解されていない。本研究は、音楽機能と認知機能の関連性やその神経基盤について、現在不足している科学的エビデンスを着実に補った点で意義がある。統合失調症患者の音楽リズム知覚生成機能や認知機能・神経評価指標との関連を明らかにした成果は、精神医学と音楽療法の関係に新たな洞察を与えうる点で学術的意義がある。音楽学習経験と認知機能の関連、前頭前皮質機能と認知機能・楽器練習時間の関連性を明らかにした成果は、音楽が人々の健康と長寿にどのように貢献するかについて、科学的な理解を深めた点で社会的意義がある。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • Research Products

    (49 results)

All 2023 2022 2021 2020

All Journal Article (21 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 2 results) Presentation (28 results) (of which Int'l Joint Research: 23 results,  Invited: 1 results)

  • [Journal Article] Impaired mismatch negativity reflects the inability to perceive beat interval in patients with schizophrenia2023

    • Author(s)
      Takahashi Yuichi, Fujii Shinya, Osakabe Yusuke, Hoshino Hiroshi, Konno Rei, Kakamu Takeyasu, Fukushima Tetsuhito, Matsumoto Takatomo, Yoshida Kumi, Aoki Shuntaro, Kanno Kazuko, Oi Naoyuki, Ueda Yuka, Suzutani Ken, Sato Aya, Mori Yuhei, Wada Tomohiro, Shiga Tetsuya, Itagaki Shuntaro, Miura Itaru, Yabe Hirooki
    • Journal Title

      Schizophrenia Research

      Volume: 254 Pages: 40-41

    • DOI

      10.1016/j.schres.2023.02.014

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Music rhythm perception and production relate to treatment response in schizophrenia2023

    • Author(s)
      Honda S, Matsushita K, Noda Y, Tarumi R, Nomiyama N, Tsugawa S, Nakajima S, Mimura M, Fujii S
    • Journal Title

      Schizophrenia Research

      Volume: 252 Pages: 69-76

    • DOI

      10.1016/j.schres.2022.12.040

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Decrease in Gamma-band Auditory Steady-State Response in Patients with Treatment-resistant Schizophrenia: Schizophrenia Research2023

    • Author(s)
      Kamiyu Ogyu, Karin Matsushita, Shiori Honda, Masataka Wada, Shunsuke Tamura, Kazumasa Takenouchi, Yui Tobari, Keisuke Kusudo, Hideo Kato, Teruki Koizumi, Naohiro Arai, Akihiro Koreki, Mie Matsui, Hiroyuki Uchida, Shinya Fujii, Mitsumoto Onaya, Yoji Hirano, Masaru Mimura, Shinichiro Nakajima, Yoshihiro Noda
    • Journal Title

      Schizophrenia Research

      Volume: 252 Pages: 129-137

    • DOI

      10.1016/j.schres.2023.01.011

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] マイクロタイミングに着目したグルーヴ研究の展望2023

    • Author(s)
      惠谷隆英、三浦哲都、河瀬諭、工藤和俊、藤井進也
    • Journal Title

      心理学評論

      Volume: 66

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Towards a cross-cultural framework for predictive coding of music2022

    • Author(s)
      Savage Patrick E.、Fujii Shinya
    • Journal Title

      Nature Reviews Neuroscience

      Volume: 23 Issue: 10 Pages: 641-641

    • DOI

      10.1038/s41583-022-00622-4

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transition between individually different and common features in skilled drumming movements2022

    • Author(s)
      Takiyama Ken, Hirashima Masaya, Fujii Shinya
    • Journal Title

      Frontiers in Sports and Active Living

      Volume: 4 Pages: 923180-923180

    • DOI

      10.3389/fspor.2022.923180

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tapping Performance of Professional and Amateur Darbuka Players2022

    • Author(s)
      Honda Kazuaki, Fujii Shinya
    • Journal Title

      Frontiers in Psychology

      Volume: 13

    • DOI

      10.3389/fpsyg.2022.861821

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anticipatory regulation of cardiovascular system on the emergence of auditory‐motor interaction in young infants2022

    • Author(s)
      Yuta Shinya, Kensuke Oku, Hama Watanabe, Gentaro Taga, Shinya Fujii
    • Journal Title

      Experimental Brain Research

      Volume: - Issue: 6 Pages: 1661-1671

    • DOI

      10.1007/s00221-022-06379-7

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 音楽リズムと身体の共鳴-その光と影-2022

    • Author(s)
      小嶺美月、本田一暁、佐田静香、山口智史、柏野牧夫、藤井進也
    • Journal Title

      体育の科学

      Volume: 第72巻7号 Pages: 487-495

    • Related Report
      2022 Annual Research Report
  • [Journal Article] 音楽リズムの普遍性と多様性2022

    • Author(s)
      藤井進也
    • Journal Title

      体育の科学

      Volume: 第72巻6号 Pages: 423-428

    • Related Report
      2022 Annual Research Report
  • [Journal Article] リズム知覚同期の生物学的起源2022

    • Author(s)
      藤井進也
    • Journal Title

      体育の科学

      Volume: 第72巻5号 Pages: 355-359

    • Related Report
      2022 Annual Research Report
  • [Journal Article] グルーヴ感と脳の予測性2022

    • Author(s)
      藤井進也
    • Journal Title

      体育の科学

      Volume: 第72巻4号 Pages: 285-289

    • Related Report
      2022 Annual Research Report
  • [Journal Article] 音楽リズムを知覚する脳2022

    • Author(s)
      藤井進也
    • Journal Title

      体育の科学

      Volume: 第72巻3号 Pages: 211-215

    • Related Report
      2022 Annual Research Report
  • [Journal Article] 音楽リズムと身体運動2022

    • Author(s)
      藤井進也
    • Journal Title

      体育の科学

      Volume: 第72巻2号 Pages: 135-138

    • Related Report
      2022 Annual Research Report
  • [Journal Article] 音楽リズムと身体の共鳴(2)音楽リズムを知覚する脳2022

    • Author(s)
      藤井 進也
    • Journal Title

      体育の科学

      Volume: 72(3) Pages: 211-215

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 音楽リズムと身体の共鳴(1)音楽リズムと身体運動2022

    • Author(s)
      藤井 進也
    • Journal Title

      体育の科学

      Volume: 72(2) Pages: 135-138

    • NAID

      40022817032

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 精神疾患と音楽機能の関連性:精神医学分野における音楽神経科学の発展可能性2021

    • Author(s)
      本多 栞, 野田 賀大, 中島 振一郎, 藤井 進也
    • Journal Title

      KEIO SFC JOURNAL

      Volume: 20 (2) Pages: 70-82

    • NAID

      120007053307

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Urban Composition -都市の現象を応用することによる音楽・サウンドアート表現の探求2021

    • Author(s)
      田中 堅大, 藤井 進也
    • Journal Title

      KEIO SFC JOURNAL

      Volume: 20 (2) Pages: 108-129

    • NAID

      120007053322

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 歌の科学2021

    • Author(s)
      北山 陽一, パトリック サベジ, 藤井 進也
    • Journal Title

      KEIO SFC JOURNAL

      Volume: 20 (2) Pages: 22-33

    • NAID

      120007053304

    • Related Report
      2020 Annual Research Report
  • [Journal Article] コロナ時代の音楽の実学2021

    • Author(s)
      村井 純, 真鍋 大度, 藤井 進也
    • Journal Title

      KEIO SFC JOURNAL

      Volume: 44 (4) Pages: 8-20

    • NAID

      120007053303

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 巧みな音楽家の演奏にみられる時間のゆらぎとグルーヴ2020

    • Author(s)
      藤井 進也
    • Journal Title

      バイオメカニズム学会誌

      Volume: 44 (4) Pages: 217-222

    • Related Report
      2020 Annual Research Report
  • [Presentation] The relationship between the experience in learning instruments, cognitive performance, and TMS-elicited EEG from the dorsolateral prefrontal cortex2023

    • Author(s)
      Etani T., Takano M., Wada M., Honda S., Taniguchi K., Tobari Y., Mimura M., Nakajima S., Noda Y., & Fujii S.
    • Organizer
      The Joint Conference of the 17th International Conference on Music Perception and Cognition and the 7th Conference of the Asia-Pacific Society for the Cognitive Sciences of Music (ICMPC17-APSCOM7)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Music-evoked nostalgia with and without prior listening experience2023

    • Author(s)
      Sakakibara Y., Mori M., & Fujii S.
    • Organizer
      The Joint Conference of the 17th International Conference on Music Perception and Cognition and the 7th Conference of the Asia-Pacific Society for the Cognitive Sciences of Music (ICMPC17-APSCOM7)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Music reward in patients with psychiatric disorders2023

    • Author(s)
      Honda S., Noda S., Tobari Y., Matsushita K., Wada M., Tarumi R., Ogyu K., Mimura M., Nakajima S., & Fujii S.
    • Organizer
      The Joint Conference of the 17th International Conference on Music Perception and Cognition and the 7th Conference of the Asia-Pacific Society for the Cognitive Sciences of Music (ICMPC17-APSCOM7)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pitch perception and cognitive function in patients with mild cognitive impairment2023

    • Author(s)
      Tobari Y., Mimura Y., Nakajima S., Honda S., Mimura M., Noda Y., & Fujii S.
    • Organizer
      The Joint Conference of the 17th International Conference on Music Perception and Cognition and the 7th Conference of the Asia-Pacific Society for the Cognitive Sciences of Music (ICMPC17-APSCOM7)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of Background Music on Moods and Feelings of Users and Staff in Senior Day Care2023

    • Author(s)
      Homma S., Etani T., Takata Y., Okawa R., Morizumi K., Matsumoto S., Shindo K., Shindo Y., & Fujii S.
    • Organizer
      The Joint Conference of the 17th International Conference on Music Perception and Cognition and the 7th Conference of the Asia-Pacific Society for the Cognitive Sciences of Music (ICMPC17-APSCOM7)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of recalling positive and negative music performance memories on subjective performance achievement and heart-rate variability: A pilot study2023

    • Author(s)
      Watanabe A., Samma T., & Fujii S.
    • Organizer
      The Joint Conference of the 17th International Conference on Music Perception and Cognition and the 7th Conference of the Asia-Pacific Society for the Cognitive Sciences of Music (ICMPC17-APSCOM7)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Rating of Perceived Exertion in Runners Listening to Adaptive Music Feedback Providing Integer Ratio of Heart Rate2023

    • Author(s)
      Nakamura T., Beijaert T., Yumoto R., Ueda K., Samma T., Anzai R., Tanaka K., Uno Y., Kikukawa Y., & Fujii S.
    • Organizer
      The Joint Conference of the 17th International Conference on Music Perception and Cognition and the 7th Conference of the Asia-Pacific Society for the Cognitive Sciences of Music (ICMPC17-APSCOM7)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Muscle Synergy of A Lower Limb in Drummer’s Dystonia: A Case Study2023

    • Author(s)
      Sata S., Honda K., Yamaguchi S., Komine M., Yoshida K., Kim S., Kashino M., Hagio S., & Fujii S.
    • Organizer
      The Joint Conference of the 17th International Conference on Music Perception and Cognition and the 7th Conference of the Asia-Pacific Society for the Cognitive Sciences of Music (ICMPC17-APSCOM7)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Drummer’s Dystonia: Incidence and Affected Limb in 1003 Japanese Drummers2023

    • Author(s)
      Yamaguchi S., Honda K., Sata S., Komine M., Kashino M., & Fujii S.
    • Organizer
      The Joint Conference of the 17th International Conference on Music Perception and Cognition and the 7th Conference of the Asia-Pacific Society for the Cognitive Sciences of Music (ICMPC17-APSCOM7)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cross-recurrence quantification analysis of bimanual finger coordination in professional and amateur darbuka players2023

    • Author(s)
      Honda K., & Fujii S.
    • Organizer
      The Joint Conference of the 17th International Conference on Music Perception and Cognition and the 7th Conference of the Asia-Pacific Society for the Cognitive Sciences of Music (ICMPC17-APSCOM7)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Foot Tapping Speed of Drummers, Non-drummer Musicians, and Non-musicians2022

    • Author(s)
      Sata S., Honda K., & Fujii S.
    • Organizer
      The 2022 Meeting of the Society for Music Perception and Cognition (SMPC 2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synchronization Error and Sound Amplitude during Drum-kit Playing with A Metronome in A Professional Drummer with Musician’s Dystonia2022

    • Author(s)
      Honda K., Sata S., Komine K., Yamaguchi S., Kashino M., & Fujii S.
    • Organizer
      The 2022 Meeting of the Society for Music Perception and Cognition (SMPC 2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Replicability of Sight-over-sound Effect in Performance Judgement of Japanese Brass Ensemble Competition2022

    • Author(s)
      Samma T., Savage P. E., & Fujii S.
    • Organizer
      The 2022 Meeting of the Society for Music Perception and Cognition (SMPC 2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pitch perception and production ability in patients with schizophrenia2022

    • Author(s)
      Tobari Y., Ogyu K., Noda Y., Honda S., Matsushita K.,Koizumi T., Koreki A., Mimura M., Nakajima S., & Fujii S.
    • Organizer
      The 2022 Meeting of the Society for Music Perception and Cognition (SMPC 2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ドラマーの最速下肢タッピング速度-非ドラマー音楽家及び非楽家との比較-2022

    • Author(s)
      佐田 静香, 本田 一暁, 藤井 進也
    • Organizer
      第12回東京若手心理学者の会. オンライン
    • Related Report
      2021 Annual Research Report
  • [Presentation] ドラムパターン演奏中のメトロノーム同期誤差 -右下肢音楽家ジストニアの症例-2022

    • Author(s)
      本田 一暁, 佐田 静香, 小嶺 美月, 山口 智史, 柏野 牧夫, 藤井 進也.
    • Organizer
      第12回東京若手心理学者の会. オンライン
    • Related Report
      2021 Annual Research Report
  • [Presentation] Dissociation of Rhythm Perception and Production Abilities in Patients with Treatment-Response Schizophrenia: A Behavioral and Voxel-Based Morphometry Study2021

    • Author(s)
      Honda S., Tarumi R., Noda Y., Matsushita K., Nomiyama N., Ochi R., Tsugawa S., Uchida H., Nakajima S., Mimura M., Fujii S.
    • Organizer
      The Neurosciences and Music VII: Connecting with Music across the Lifespan. Online/Virtual from Aarhus, Denmark
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The neural basis of consonance preferences in chronic stroke patients: A resting-state fMRI study2021

    • Author(s)
      Kasashima-Shindo Y., Tsuchimoto S., Shindo K., Imai E., Kikuchi Y., Matsugi Y., Toyoda A., Honda S., Savage P. E., Fujii S.
    • Organizer
      The Neurosciences and Music VII: Connecting with Music across the Lifespan. Online/Virtual from Aarhus, Denmark
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Single, double, and triple tonguing speeds of professional and amateur trombone players2021

    • Author(s)
      Honda K., Ikemoto S., Savage P. E., Fujii S.
    • Organizer
      The Neurosciences and Music VII: Connecting with Music across the Lifespan. Online/Virtual from Aarhus, Denmark
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Replicability of Sight-over-sound Effect in the Judgement of Brass Ensemble Competition in Japan.2021

    • Author(s)
      Samma T., Savage P. E., Fujii S.
    • Organizer
      The Neurosciences and Music VII: Connecting with Music across the Lifespan. Online/Virtual from Aarhus, Denmark
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Uncertainty Resolution and Anticipation of Pleasure in Chord Progression: An EEG Study2021

    • Author(s)
      Sakamoto S., Aoyama A., Fujii S.
    • Organizer
      The Neurosciences and Music VII: Connecting with Music across the Lifespan. Online/Virtual from Aarhus, Denmark
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Motion Analysis of Finger-bowing Skill in Violin Playing with A High Speed Camera: A Case Study2021

    • Author(s)
      Fukatsu H., Honda K, Ishizuka T., Ohgi Y., Fujii S.
    • Organizer
      ICMPC16-ESCOM11: The 16th International Conference on Music Perception and Cognition / The 11th Triennial Conference of ESCOM. Online.
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Generalizability Of Sight Vs. Sound Effect: Evidence From Brass Ensemble Competition In Japan2021

    • Author(s)
      Samma T., Savage P. E., & Fujii S.
    • Organizer
      The 17th Annual McMaster NeuroMusic Conference: Rhythm And Interpersonal Coordination. Virtual from McMaster University, Hamilton, Ontario, Canada
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lower-Limb EMG Activity During Drum-Kit Playing In A Professional Drummer With Dystonia2021

    • Author(s)
      Honda K., Sata S., Komine K., Yamaguchi S., Kim S.H., & Fujii S.
    • Organizer
      The 17th Annual McMaster NeuroMusic Conference: Rhythm And Interpersonal Coordination. Virtual from McMaster University, Hamilton, Ontario, Canada.
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 音楽と科学の超越的融合の可能性:ドラマー研究者の視点から2021

    • Author(s)
      藤井 進也
    • Organizer
      合同学術シンポジウム「音楽科学の意義と展望」, 東京大学/オンライン
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 動作特異性ジストニアに罹患したドラム奏者の演奏動作中の下肢筋活動に関する症例報告2021

    • Author(s)
      本田 一暁, 佐田 静香, 小嶺 美月, 山口 智史, 金 承革, 藤井 進也
    • Organizer
      第15回 Motor Control研究会, オンライン
    • Related Report
      2021 Annual Research Report
  • [Presentation] Music science in Japan vs. North America2021

    • Author(s)
      Fujii S.
    • Organizer
      CLaME Event: Building sustainable global collaborative research networks
    • Related Report
      2020 Annual Research Report
  • [Presentation] Heartbeat of infant drummer: Allostatic regulation of cardiovascular system in auditory-motor integration at three-month-old2020

    • Author(s)
      Shinya Y., Oku K., Watanabe H., Taga G., Fujii S.
    • Organizer
      vICIS 2020: The International Congress of Infant Studies
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research

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Published: 2020-04-28   Modified: 2024-01-30  

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