| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2022: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2021: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2020: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Outline of Final Research Achievements |
The living environment during pregnancy is increasingly known to influence the child's future health and disease risk (DOHaD). The involvement of the maternal gut microbiota, which is influenced by diet, as one of the environmental factors inducing DOHaD has increased concern, but the underlying mechanisms are unknown. This study showed that gut microbiota disruption via decreased α-defensin due to maternal high-fat diet intake prevents maturation of the child's gut microbiota by inducing abnormal Paneth cell development due to epigenetic modifications during the embryonic period. These findings contribute to the establishment of novel disease prevention methods that target α-defensin during the maternal gestation period to reduce the risk of developing a child's disease.
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