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Exploring neurodevelopmental indicators evaluating the development of executive functioning in school-age children

Research Project

Project/Area Number 20K02628
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 09030:Childhood and nursery/pre-school education-related
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

Harada Taeko  浜松医科大学, 子どものこころの発達研究センター, 特任助教 (60525963)

Co-Investigator(Kenkyū-buntansha) 星 詳子  浜松医科大学, 光尖端医学教育研究センター, 特任教授 (50332383)
土屋 賢治  浜松医科大学, 子どものこころの発達研究センター, 特任教授 (20362189)
武井 教使  浜松医科大学, 子どものこころの発達研究センター, 教授 (80206937)
Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords認知機能 / 発達 / fNIRS / 実行機能 / fNIRS / 前頭前野 / fNRIS / 発達トラジェクトリー / 複合ルール課題 / 高次機能発達 / 神経発達 / 早期指標
Outline of Research at the Start

学童期(10歳)に低い実行機能を示す児を予測する、乳幼児期の神経発達の徴候を、縦断的な見地から見出すことを目的とする。
本研究は、浜松母と子の出生コホート(HBC)のプラットフォームを利用し、10歳時の知能検査の結果をもとに、2群に分け(知能検査のうちの一つの指標の成績の低い群と平均以上群)、実行機能発達の指標(課題の成績と課題に関与する脳賦活パターンの結果)と、生後1ヵ月~32ヵ月までの神経発達指標(Mullen Scales of Early Learningで得られたスコア)との関連を検討する研究である。

Outline of Final Research Achievements

The present study aimed to examine the development of executive function in school-aged children (7-10 years old) using a multiple-rule selection task to examine the effects of age on task performance and changes in task- related prefrontal cortical activity. The results showed that the accuracy to multiple-rule selection tasks increased significantly with age. In addition, there was a significant age-related shortening of reaction time in this task. Furthermore, the age-related changes in cortical activity specifically related to the multiple-rule selection task were observed only in the right dorsolateral prefrontal cortex. These results suggest that performance on multiple-rule selection tasks may be a useful indicator of the development of executive function in school-aged children. On the other hand, it is necessary to further examine the development of the functional brain network involved in multiple-rule selection tasks, including older children.

Academic Significance and Societal Importance of the Research Achievements

低い実行機能の発達は、学業の遅れや問題行動(Morganら 2017;Hughesら 2006)と関連し、将来の健康や所得、犯罪傾向等の社会的状況を予測するため(Caseyら 2011; Moffittら 2011)、生涯にわたる重要な問題となる可能性が示唆される。よって、実行機能発達の問題をより早期に発見できれば、医学的にもその意義は大きいといえる。また、実行機能を段階的に評価する課題やそれに関連する脳機能が明らかになれば、認知発達研究における本研究の意義は大きい。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (20 results)

All 2024 2023 2022 2021 2020

All Journal Article (17 results) (of which Int'l Joint Research: 12 results,  Peer Reviewed: 17 results,  Open Access: 15 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] The association between screen time and genetic risks for neurodevelopmental disorders in children2023

    • Author(s)
      Takahashi Nagahide、Tsuchiya Kenji J.、Okumura Akemi、Harada Taeko、Iwabuchi Toshiki、Rahman Md Shafiur、Kuwabara Hitoshi、Nomura Yoko、Nishimura Tomoko
    • Journal Title

      Psychiatry Research

      Volume: 327 Pages: 115395-115395

    • DOI

      10.1016/j.psychres.2023.115395

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Interaction of genetic liability for attention deficit hyperactivity disorder (ADHD) and perinatal inflammation contributes to ADHD symptoms in children2023

    • Author(s)
      Takahashi Nagahide、Nishimura Tomoko、Harada Taeko、Okumura Akemi、Iwabuchi Toshiki、Rahman Md Shafiur、Kuwabara Hitoshi、Takagai Shu、Usui Noriyoshi、Makinodan Manabu、Matsuzaki Hideo、Ozaki Norio、Itoh Hiroaki、Nomura Yoko、Newcorn Jeffrey H.、Tsuchiya Kenji J.
    • Journal Title

      Brain, Behavior, & Immunity - Health

      Volume: 30 Pages: 100630-100630

    • DOI

      10.1016/j.bbih.2023.100630

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sex differences in neurodevelopmental trajectories in children with different levels of autistic traits2023

    • Author(s)
      Nishimura Tomoko、Takahashi Nagahide、Okumura Akemi、Harada Taeko、Iwabuchi Toshiki、Nakayasu Chikako、Rahman Mohammad Shafiur、Uchiyama Satoshi、Wakuta Manabu、Nomura Yoko、Takei Nori、Senju Atsushi、Tsuchiya Kenji J.
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: - Issue: 5 Pages: 282-289

    • DOI

      10.1111/pcn.13529

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Outdoor Play as a Mitigating Factor in the Association Between Screen Time for Young Children and Neurodevelopmental Outcomes2023

    • Author(s)
      Sugiyama Mika、Tsuchiya Kenji J.、Okubo Yusuke、Rahman Mohammad Shafiur、Uchiyama Satoshi、Harada Taeko、Iwabuchi Toshiki、Okumura Akemi、Nakayasu Chikako、Amma Yuko、Suzuki Haruka、Takahashi Nagahide、Kinsella-Kammerer Barbara、Nomura Yoko、Itoh Hiroaki、Nishimura Tomoko
    • Journal Title

      JAMA Pediatrics

      Volume: 177 Issue: 3 Pages: 303-303

    • DOI

      10.1001/jamapediatrics.2022.5356

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Autism symptoms, functional impairments, and gaze fixation measured using an eye-tracker in 6-year-old children2023

    • Author(s)
      Mori Toko、Tsuchiya Kenji J.、Harada Taeko、Nakayasu Chikako、Okumura Akemi、Nishimura Tomoko、Katayama Taiichi、Endo Masayuki
    • Journal Title

      Frontiers in Psychiatry

      Volume: 14 Pages: 1250763-1250763

    • DOI

      10.3389/fpsyt.2023.1250763

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lower Availability of Mitochondrial Complex I in Anterior Cingulate Cortex in Autism: A Positron Emission Tomography Study2023

    • Author(s)
      Kato Yasuhiko、Yokokura Masamichi、Iwabuchi Toshiki、Murayama Chihiro、Harada Taeko、Goto Takafumi、Tamayama Taishi、Kameno Yosuke、Wakuda Tomoyasu、Kuwabara Hitoshi、Benner Seico、Senju Atsushi、Tsukada Hideo、Nishizawa Sadahiko、Ouchi Yasuomi、Yamasue Hidenori
    • Journal Title

      American Journal of Psychiatry

      Volume: 180 Issue: 4 Pages: 277-284

    • DOI

      10.1176/appi.ajp.22010014

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neural mechanisms underlying rule selection based on response evaluation: a near-infrared spectroscopy study2022

    • Author(s)
      Harada Taeko、Iwabuchi Toshiki、Senju Atsushi、Nakayasu Chikako、Nakahara Ryuji、Tsuchiya Kenji J、Hoshi Yoko
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 20696-20696

    • DOI

      10.1038/s41598-022-25185-3

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of a novel nasal oxytocin spray with enhanced bioavailability on autism: a randomized trial2022

    • Author(s)
      Yamasue H, Kojima M, Kuwabara H, ..Hirano Y, Onitsuka T, Kosaka H, Okada T
    • Journal Title

      Brain

      Volume: 145 Issue: 2 Pages: 490-499

    • DOI

      10.1093/brain/awab291

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exploration of Sleep Parameters, Daytime Hyperactivity/Inattention, and Attention-Deficit/Hyperactivity Disorder Polygenic Risk Scores of Children in a Birth Cohort in Japan2022

    • Author(s)
      Takahashi Nagahide、Okumura Akemi、Nishimura Tomoko、Harada Taeko、Iwabuchi Toshiki、Rahman Md Shafiur、Tsuchiya Kenji J.
    • Journal Title

      JAMA Network Open

      Volume: 5 Issue: 1 Pages: e2141768-e2141768

    • DOI

      10.1001/jamanetworkopen.2021.41768

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Trajectories of Adaptive Behaviors During Childhood in Females and Males in the General Population2022

    • Author(s)
      Nishimura Tomoko、Kato Takeo、Okumura Akemi、Harada Taeko、Iwabuchi Toshiki、Rahman Md. Shafiur、Hirota Tomoya、Takahashi Michio、Adachi Masaki、Kuwabara Hitoshi、Takagai Shu、Nomura Yoko、Takahashi Nagahide、Senju Atsushi、Tsuchiya Kenji J.
    • Journal Title

      Frontiers in Psychiatry

      Volume: 13 Pages: 817383-817383

    • DOI

      10.3389/fpsyt.2022.817383

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Long-term effect of persistent postpartum depression on children's psychological problems in childhood2022

    • Author(s)
      Tainaka Hanae、Takahashi Nagahide、Nishimura Tomoko、Okumura Akemi、Harada Taeko、Iwabuchi Toshiki、Rahman Md Shafiur、Nomura Yoko、Tsuchiya Kenji J.
    • Journal Title

      Journal of Affective Disorders

      Volume: 305 Pages: 71-76

    • DOI

      10.1016/j.jad.2022.02.061

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of neurodevelopmental transition patterns from infancy to early childhood and risk factors predicting descending transition2022

    • Author(s)
      Kato Takeo、Nishimura Tomoko、Takahashi Nagahide、Harada Taeko、Okumura Akemi、Iwabuchi Toshiki、Nomura Yoko、Senju Atsushi、Tsuchiya Kenji J.、Takei Nori
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 4822-4822

    • DOI

      10.1038/s41598-022-08827-4

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Extrastriatal dopamine D2/3 receptor binding, functional connectivity, and autism socio-communicational deficits: a PET and fMRI study2022

    • Author(s)
      Murayama C, Iwabuchi T, Kato Y, Yokokura M, Harada T, Goto T, Tamayama T, Kameno Y, Wakuda T, Kuwabara H, Senju A, Nishizawa S, Ouchi Y, Yamasue H.
    • Journal Title

      Mol Psychiatry

      Volume: - Issue: 4 Pages: 2106-2113

    • DOI

      10.1038/s41380-022-01464-3

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Early temperament as a predictor of language skills at 40th months2022

    • Author(s)
      Ishikawa-Omori Yuuka、Nishimura Tomoko、Nakagawa Atsuko、Okumura Akemi、Harada Taeko、Nakayasu Chikako、Iwabuchi Toshiki、Amma Yuko、Suzuki Haruka、Rahman Mohammad Shafiur、Nakahara Ryuji、Takahashi Nagahide、Nomura Yoko、Tsuchiya Kenji J.
    • Journal Title

      BMC Pediatrics

      Volume: 22 Issue: 1 Pages: 56-56

    • DOI

      10.1186/s12887-022-03116-5

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Diagnosing Autism Spectrum Disorder Without Expertise: A Pilot Study of 5- to 17-Year-Old Individuals Using Gazefinder2021

    • Author(s)
      Tsuchiya Kenji J.、Hakoshima Shuji、Hara Takeshi、Ninomiya Masaru、Saito Manabu、Fujioka Toru、Kosaka Hirotaka、Hirano Yoshiyuki、Matsuo Muneaki、Kikuchi Mitsuru、Maegaki Yoshihiro、Harada Taeko、Nishimura Tomoko、Katayama Taiichi
    • Journal Title

      Frontiers in Neurology

      Volume: 11 Pages: 603085-603085

    • DOI

      10.3389/fneur.2020.603085

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Polygenic risk score analysis revealed shared genetic background in attention deficit hyperactivity disorder and narcolepsy2020

    • Author(s)
      Takahashi Nagahide、Nishimura Tomoko、Harada Taeko、Okumura Akemi、Choi Damee、Iwabuchi Toshiki、Kuwabara Hitoshi、Takagai Shu、Nomura Yoko、Newcorn Jeffrey. H.、Takei Nori、Tsuchiya Kenji J.
    • Journal Title

      Translational Psychiatry

      Volume: 10 Issue: 1 Pages: 284-284

    • DOI

      10.1038/s41398-020-00971-7

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association of Genetic Risks With Autism Spectrum Disorder and Early Neurodevelopmental Delays Among Children Without Intellectual Disability2020

    • Author(s)
      Takahashi Nagahide、Harada Taeko、Nishimura Tomoko、Okumura Akemi、Choi Damee、Iwabuchi Toshiki、Kuwabara Hitoshi、Takagai Shu、Nomura Yoko、Takei Nori、Tsuchiya Kenji J.
    • Journal Title

      JAMA Network Open

      Volume: 3 Issue: 2 Pages: 1921644-1921644

    • DOI

      10.1001/jamanetworkopen.2019.21644

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Frontopolar cortex is associated with the development of the ability to select complex rules: An fNIRS study2024

    • Author(s)
      T. Harada , T. Iwabuchi , C. Nakayasu , M. Shimizu , R. Nakahara , K. Tsuchiya , A. Senju , Y. Hosh
    • Organizer
      FENS Forum 2024
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Age-related development of appropriate rule selection in children: An fNIRS study2024

    • Author(s)
      Taeko Harada, Toshiki Iwabuchi, Chikako Nakayasu, Mikihiro Shimizu, Ryuji Nakahara, Kenji Tsuchiya, Atsushi Senju, Yoko Hoshi
    • Organizer
      NEURO2024
    • Related Report
      2023 Annual Research Report
  • [Presentation] 小児の応答判断の事前評価に基づくルール選択の神経機構の解明に向けて ‐ 機能的近赤外分光法(fNIRS)による検討 ー2022

    • Author(s)
      原田妙子 岩渕俊樹 中安智香子 中原竜治 千住淳 土屋賢治 星詳子
    • Organizer
      日本ヒト脳機能マッピング学会
    • Related Report
      2021 Research-status Report

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Published: 2020-04-28   Modified: 2025-11-21  

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