| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
In this study, we generated the intestinal organoids from human iPS cells and were able to develop the method in which the cells were able to be cultured with maintaining crypt-villus structures by the two-dimensional culture of the intestinal organoids. We could obtain preliminary findings to be suggested that the intestinal mucosal damage could be able to be evaluated by using the two-dimensional cultured cells. Additionally, we were able to develop the differentiation method into the endodermal cells from human iPS cells efficiently and the culture method in which the two-dimensional intestinal organoids can be cultured for a relatively long term with keeping crypt-villus structures.
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