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Biomarkers of patients with clozapine-resistant schizophrenia

Research Project

Project/Area Number 20K07945
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52030:Psychiatry-related
Research InstitutionOsaka University

Principal Investigator

Fujimoto Michiko  大阪大学, 大学院医学系研究科, 助教 (50647625)

Co-Investigator(Kenkyū-buntansha) 三浦 健一郎  国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所 精神疾患病態研究部, 室長 (20362535)
松本 純弥  国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所 精神疾患病態研究部, 室長 (10635535)
Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords統合失調症 / 眼球運動異常 / 中間表現型 / 生物学的精神医学 / クロザピン / 眼球運動
Outline of Research at the Start

統合失調症の治療薬は抗精神病薬であるが、20-30%程度の患者は十分な効果が得られず、治療抵抗性と診断される。抗精神病薬の一つであるクロザピンは治療抵抗性統合失調症に対する唯一の治療薬であり、60-70%の有効率が示されている。一方で30-40%の治療抵抗性統合失調症患者はクロザピンによっても十分な精神症状の改善が得られない。このようなクロザピン抵抗性統合失調症の患者特性や病態についてはほとんど研究されておらず、そのバイオマーカーも確立されていない。本研究では、眼球運動などの中間表現型を用いてクロザピン抵抗性統合失調症患者のバイオマーカーを確立することを目的とする。

Outline of Final Research Achievements

Clozapine is the most promising antipsychotics for the patients with treatment-resistant schizophrenia. However 30-40% of the patients with treatment-refractory schizophrenia show the resistance to clozapine. Although our study haven't found the biomarkers that characterize the clozapine-resistant schizophrenia, our data showed the possibility of the relationship between the eye movement on patients with schizophrenia and therapeutic outcome.

Academic Significance and Societal Importance of the Research Achievements

統合失調症は多数の遺伝子と環境因子が関連している多因子疾患であり、病態は極めて複雑と考えられる。病因は不明でバイオマーカーも確立されていないため、臨床では特定の検査により診断できるものではなく、問診による精神症状の評価と器質因の除外により診断される。現在、補助診断法として注目されている検査の一つが眼球運動検査であり、クロザピン抵抗性統合失調症について、眼球運動をはじめ認知機能、脳MRI画像など中間表現型との関連はこれまで報告がないため、統合失調症のサブタイプの一つとしてクロザピン抵抗性の生物学的指標を捉えることは、統合失調症の病態メカニズムの理解へつながると期待できる。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (45 results)

All 2024 2023 2022 2021 2020 2019 Other

All Journal Article (34 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 34 results,  Open Access: 29 results) Presentation (5 results) Book (4 results) Remarks (2 results)

  • [Journal Article] Visual salience is affected in participants with schizophrenia during free-viewing2024

    • Author(s)
      Yoshida M, Miura K, Fujimoto M, Yamamori H, Yasuda Y, Iwase M, Hashimoto R
    • Journal Title

      Scientific Reports

      Volume: 14 Issue: 1 Pages: 4606-4606

    • DOI

      10.1038/s41598-024-55359-0

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Longitudinal reduction in brain volume in patients with schizophrenia and its association with cognitive function2024

    • Author(s)
      Yamazaki R, Matsumoto J, Ito S, Nemoto K, Fukunaga M, Hashimoto N, Kodaka F, Takano H, Hasegawa N, Yasuda Y, Fujimoto M, Yamamori H, Watanabe Y, Miura K, Hashimoto R
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: 44 Issue: 1 Pages: 206-215

    • DOI

      10.1002/npr2.12423

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between copy number variations in parkin (PRKN) and schizophrenia and autism spectrum disorder: A case-control study2024

    • Author(s)
      Lo T, Yamamoto M(34人中10番目)
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: 44(1) Issue: 1 Pages: 42-50

    • DOI

      10.1002/npr2.12370

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Better adherence to guidelines among psychiatrists providing pharmacological therapy is associated with longer work hours in patients with schizophrenia2023

    • Author(s)
      Ito Satsuki、Ohi Kazutaka、Yasuda Yuka、Fujimoto Michiko、Yamamori Hidenaga、Matsumoto Junya、Fukumoto Kentaro、Kodaka Fumitoshi、Hasegawa Naomi、Ishimaru Keiichiro、Miura Kenichiro、Yasui-Furukori Norio、Hashimoto Ryota
    • Journal Title

      Schizophrenia

      Volume: 9 Issue: 1

    • DOI

      10.1038/s41537-023-00407-3

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebral cortical structural alteration patterns across four major psychiatric disorders in 5549 individuals.2023

    • Author(s)
      J. Matsumoto,M. Fukunaga,K. Miura,K. Nemoto K,N. Okada, et al.
    • Journal Title

      Mol Psychiatry

      Volume: 28 Issue: 11 Pages: 4915-4923

    • DOI

      10.1038/s41380-023-02224-7

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Discrimination in the clinical diagnosis between patients with schizophrenia and healthy controls using eye movement and cognitive functions.2023

    • Author(s)
      Okazaki K, Miura K, Matsumoto J, Hasegawa N, Fujimoto M, Yamamori H, Yasuda Y, Makinodan M, Hashimoto R.
    • Journal Title

      Psychiatry Clin Neurosci.

      Volume: 77(7) Issue: 7 Pages: 393-400

    • DOI

      10.1111/pcn.13553

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationships Between Adherence to Guideline Recommendations for Pharmacological Therapy Among Clinicians and Psychotic Symptoms in Patients With Schizophrenia2023

    • Author(s)
      Kodaka Fumitoshi、Ohi Kazutaka、Yasuda Yuka、Fujimoto Michiko、Yamamori Hidenaga、Hasegawa Naomi、Ito Satsuki、Fukumoto Kentaro、Matsumoto Junya、Miura Kenichiro、Yasui-Furukori Norio、Hashimoto Ryota
    • Journal Title

      International Journal of Neuropsychopharmacology

      Volume: 26 Issue: 8 Pages: 557-565

    • DOI

      10.1093/ijnp/pyad037

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Longitudinal characteristics of insight and clinical factors in patients with schizophrenia2023

    • Author(s)
      Sakai Yoshie、Ito Satsuki、Matsumoto Junya、Yasuda Yuka、Yamamori Hidenaga、Fujimoto Michiko、Hasegawa Naomi、Ishimaru Keiichiro、Miura Kenichiro、Hashimoto Ryota
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: 43 Issue: 3 Pages: 373-381

    • DOI

      10.1002/npr2.12356

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Subcortical volumetric alterations in four major psychiatric disorders: a mega-analysis study of 5604 subjects and a volumetric data-driven approach for classification.2023

    • Author(s)
      N. Okada,et al.
    • Journal Title

      Mol Psychiatry.

      Volume: 28 Issue: 12 Pages: 5206-5216

    • DOI

      10.1038/s41380-023-02141-9

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association between globus pallidus volume and positive symptoms in schizophrenia2022

    • Author(s)
      Ito S, Miura K, Miyayama M, Matsumoto J, Fukunaga M, Ishimaru K, Fujimoto M, Yasuda Y, Watanabe Y, Hashimoto R
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 76 Issue: 11 Pages: 602-603

    • DOI

      10.1111/pcn.13465

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clozapine Treatment Is Associated With Higher Prescription Rate of Antipsychotic Monotherapy and Lower Prescription Rate of Other Concomitant Psychotropics: A Real-World Nationwide Study2022

    • Author(s)
      Ochi S、Tagata H、Hasegawa N、Yasui-Furukori N、Iga J、Kashiwagi H、Kodaka F、Komatsu H、Tsuboi T、Tokutani A、Numata S、Ichihashi K、Onitsuka T、Muraoka H、Iida H、Ohi K、Atake K、Kishimoto T、Hori H、Takaesu Y、Takeshima M、Usami M、Makinodan M、Hashimoto N、Fujimoto M,et al
    • Journal Title

      International Journal of Neuropsychopharmacology

      Volume: 25 Issue: 10 Pages: 818-826

    • DOI

      10.1093/ijnp/pyac036

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cross-disorder analysis of genetic and regulatory copy number variations in bipolar disorder, schizophrenia, and autism spectrum disorder2022

    • Author(s)
      Kushima Itaru、Nakatochi Masahiro、Aleksic Branko、Okada Takashi、(中略)、Ozaki Norio
    • Journal Title

      Biological Psychiatry

      Volume: - Issue: 5 Pages: 362-374

    • DOI

      10.1016/j.biopsych.2022.04.003

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transdiagnostic comparisons of intellectual abilities and work outcome in patients with mental disorders: multicentre study2022

    • Author(s)
      Sumiyoshi C, Ohi K, Fujino H, Yamamori H, Fujimoto M, Yasuda Y, Uno Y, Takahashi J, Morita K, Katsuki A, Yamamoto M, Okahisa Y, Sata A, Katsumoto E, Koeda M, Hirano Y, Nakataki M, Matsumoto J, Miura K, Hashimoto N, Makinodan M, Takahashi T, Nemoto K, Kishimoto T, Suzuki M, Sumiyoshi T, Hashimoto R.
    • Journal Title

      BJPsych Open .

      Volume: 8(4) Issue: 4 Pages: 1-10

    • DOI

      10.1192/bjo.2022.50

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A dissemination and education programme to improve the clinical behaviours of psychiatrists in accordance with treatment guidelines for schizophrenia and major depressive disorders: the Effectiveness of Guidelines for Dissemination and Education in Psychiatric Treatment (EGUIDE) project2022

    • Author(s)
      Yamada H、Motoyama M、Hasegawa N、Miura K、Matsumoto J、Ohi K、Yasui-Furukori N、Numata S、Takeshima M、Sugiyama N、Nagasawa T、Kubota C、Atake K、Tsuboi T、Ichihashi K、Hashimoto N、Inagaki T、Takaesu Y、Iga J、Hori H、Onitsuka T、Komatsu H、Hishimoto A、Fukumoto K、Fujimoto M, et al.
    • Journal Title

      BJPsych Open

      Volume: 8 Issue: 3

    • DOI

      10.1192/bjo.2022.44

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between autistic traits and social functioning in healthy individuals2022

    • Author(s)
      Demizu Yuria、Matsumoto Junya、Yasuda Yuka、Ito Satsuki、Miura Kenichiro、Yamamori Hidenaga、Fujimoto Michiko、Hasegawa Naomi、Ishimaru Keiichiro、Hashimoto Ryota
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: 42 Issue: 2 Pages: 226-229

    • DOI

      10.1002/npr2.12249

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Subjective assessment of participants in education programs on clinical practice guidelines in the field of psychiatry2022

    • Author(s)
      Ogasawara Kazuyoshi, Ikuo Otsuka, Akitoyo Hishimoto et al.
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: Epub Issue: 2 Pages: 221-225

    • DOI

      10.1002/npr2.12245

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neurocognitive features, personality traits, and social function in patients with schizophrenia with a history of violence2022

    • Author(s)
      Kashiwagi Hiroko、Matsumoto Junya、Miura Kenichiro、Takeda Koji、Yamada Yuji、Fujimoto Michiko、Yasuda Yuka、Yamamori Hidenaga、Ikeda Manabu、Hirabayashi Naotsugu、Hashimoto Ryota
    • Journal Title

      Journal of Psychiatric Research

      Volume: 147 Pages: 50-58

    • DOI

      10.1016/j.jpsychires.2022.01.012

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association Study Between White Matter Microstructure and Intelligence Decline in Schizophrenia2021

    • Author(s)
      Matsumoto Junya、Miura Kenichiro、Fukunaga Masaki、Nemoto Kiyotaka、Koshiyama Daisuke、Okada Naohiro、Morita Kentaro、Yamamori Hidenaga、Yasuda Yuka、Fujimoto Michiko、Ito Satsuki、Hasegawa Naomi、Watanabe Yoshiyuki、Kasai Kiyoto、Hashimoto Ryota
    • Journal Title

      Clinical EEG and Neuroscience

      Volume: in press Issue: 6 Pages: 0-0

    • DOI

      10.1177/15500594211063314

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multiple alterations in glutamatergic transmission and dopamine D2 receptor splicing in induced pluripotent stem cell-derived neurons from patients with familial schizophrenia2021

    • Author(s)
      Yamamoto Kana、Kuriu Toshihiko、Takuma Kazuhiro、Ono Fumihito、Matsumoto Naomichi、Hashimoto Ryota、Hashimoto Hitoshi、Nakazawa Takanobu
    • Journal Title

      Translational Psychiatry

      Volume: 11 Issue: 1 Pages: 548-548

    • DOI

      10.1038/s41398-021-01676-1

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Methylation Analysis in Monozygotic Twins With Treatment-Resistant Schizophrenia and Discordant Responses to Clozapine.2021

    • Author(s)
      Kikuchi M, Nakazawa T, Kinoshita M, Yamamori H, Yasuda Y, Fujimoto M, Hashimoto R, Numata S
    • Journal Title

      Frontiers in Psychiatry

      Volume: 12 Pages: 734606-734606

    • DOI

      10.3389/fpsyt.2021.734606

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] No adverse events were observed in clozapine‐treated patients on extended hematologic monitoring intervals during the coronavirus pandemic in four psychiatric centers in Japan2021

    • Author(s)
      Hata Masahiro、Fujimoto Michiko、Kanai Koji、Yoshiyama Kenji、Nakatani Yoshitaka、et al.
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: 41 Issue: 2 Pages: 179-184

    • DOI

      10.1002/npr2.12166

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of age and sex on the eye movement characteristics2021

    • Author(s)
      Takahashi J, Miura K, Morita K, Fujimoto M, Miyata S, Okazaki K, Matsumoto J, Hasegawa N, Hirano Y, Yamamori H, Yasuda Y, Makinodan M, Kasai K, Ozaki N, Onitsuka T, Hashimoto R.
    • Journal Title

      Neuropsychopharmacological Reports

      Volume: in press Issue: 2 Pages: 1-7

    • DOI

      10.1002/npr2.12163

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Eye Movement Abnormalities in Major Depressive Disorder2021

    • Author(s)
      Junichi Takahashi, Yoji Hirano*, Kenichiro Miura, Kentaro Morita, Michiko Fujimoto, Hidenaga Yamamori, Yuka Yasuda, Noriko Kudo, Emiko Shishido, Kosuke Okazaki, Tomoko Shiino, Tomohiro Nakao, Kiyoto Kasai, Ryota Hashimoto, Toshiaki Onitsuka
    • Journal Title

      Frontiers in Psychiatry

      Volume: 12 Pages: 673443-673443

    • DOI

      10.3389/fpsyt.2021.673443

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impaired inhibition of return during free-viewing behaviour in patients with schizophrenia2021

    • Author(s)
      Okada K, Miura K, Fujimoto M, Morita K, Yoshida M, Yamamori H, Yasuda Y, Iwase M, Shinozaki T, Fujita I, Hashimoto R
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 3237-3237

    • DOI

      10.1038/s41598-021-82253-w

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between white matter microstructure and work hours2021

    • Author(s)
      Matsumoto Junya、Fukunaga Masaki、Miura Kenichiro、Nemoto Kiyotaka、Koshiyama Daisuke、Okada Naohiro、Morita Kentaro、Yamamori Hidenaga、Yasuda Yuka、Fujimoto Michiko、Hasegawa Naomi、Watanabe Yoshiyuki、Kasai Kiyoto、Hashimoto Ryota
    • Journal Title

      Neuroscience Letters

      Volume: 740 Pages: 135428-135428

    • DOI

      10.1016/j.neulet.2020.135428

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] クロザピン投与中の検査間隔は延長できないか? ~新型コロナウイルス感染拡大に伴う緊急事態宣言下の検査間隔延長措置を経験して~2021

    • Author(s)
      畑真弘、藤本美智子、金井講治、吉山顕次、池田学
    • Journal Title

      精神神経学雑誌

      Volume: 123 Pages: 69-74

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between the superior longitudinal fasciculus and perceptual organization and working memory: A diffusion tensor imaging study2020

    • Author(s)
      Koshiyama Daisuke、Fukunaga Masaki、Okada Naohiro、Morita Kentaro、Nemoto Kiyotaka、Yamashita Fumio、Yamamori Hidenaga、Yasuda Yuka、Matsumoto Junya、Fujimoto Michiko、Kudo Noriko、Azechi Hirotsugu、Watanabe Yoshiyuki、Kasai Kiyoto、Hashimoto Ryota
    • Journal Title

      Neuroscience Letters

      Volume: 738 Pages: 135349-135349

    • DOI

      10.1016/j.neulet.2020.135349

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unmet needs of patients with major depressive disorder ? Findings from the ‘Effectiveness of Guidelines for Dissemination and Education in Psychiatric Treatment (EGUIDE)’ project: A nationwide dissemination, education, and evaluation study2020

    • Author(s)
      Iida Hitoshi、Iga Junichi、Hasegawa Naomi、(45番目)Fujimoto Michiko、et al.
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 74 Issue: 12 Pages: 667-669

    • DOI

      10.1111/pcn.13143

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ethnicity-Dependent Effects of Schizophrenia Risk Variants of the OLIG2 Gene on OLIG2 Transcription and White Matter Integrity2020

    • Author(s)
      Komatsu H, Takeuchi H, Kikuchi Y, Ono C, Yu Z, Iizuka K, Takano Y, Kakuto Y, Funakoshi S, Ono T, Ito J, Kunii Y, Hino M, Nagaoka A, Iwasaki Y, Yamamori H, Yasuda Y, Fujimoto M, Azechi H, Kudo N, Hashimoto R, Yabe H, Yoshida M, Saito Y, Kakita A, Fuse N, Kawashima R, Taki Y, Tomita H
    • Journal Title

      Schizophrenia Bulletin

      Volume: - Issue: 6 Pages: 1619-1628

    • DOI

      10.1093/schbul/sbaa049

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes.2020

    • Author(s)
      Matsumura K, (33名中略), Hashimoto R, (37名中35番目),Hashimoto H, Nakazawa T.
    • Journal Title

      Nat. Commun

      Volume: 11(1) Issue: 1 Pages: 859-859

    • DOI

      10.1038/s41467-020-14697-z

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Plasma levels of matrix metalloproteinase‐9 (MMP‐9) are associated with cognitive performance in patients with schizophrenia2020

    • Author(s)
      Kudo Noriko、Yamamori Hidenaga、Ishima Tamaki、Nemoto Kiyotaka、Yasuda Yuka、Fujimoto Michiko、Azechi Hirotsugu、Niitsu Tomihisa、Numata Shusuke、Ikeda Manabu、Iyo Masaomi、Ohmori Tetsuro、Fukunaga Masaki、Watanabe Yoshiyuki、Hashimoto Kenji、Hashimoto Ryota
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: - Issue: 2 Pages: 150-156

    • DOI

      10.1002/npr2.12098

    • NAID

      120007027668

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Brain morphological and functional features in cognitive subgroups of Schizophrenia.2020

    • Author(s)
      Yasuda Y, Okada N, Nemoto K, Fukunaga M, Yamamori H, Ohi K, Koshiyama D, Kudo N, Shiino T, Morita S, Morita K, Azechi H, Fujimoto M, Miura K, Watanabe Y, Kasai K, Hashimoto R.
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 74(3) Issue: 3 Pages: 191-203

    • DOI

      10.1111/pcn.12963

    • NAID

      120007132757

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clozapineによる薬疹を疑われ中止した後に再投与した治療抵抗性統合失調症の1例2020

    • Author(s)
      垰夲 大喜, 藤本 美智子, 近江 翼, 片上 茂樹, 岩瀬 真生, 橋本 亮太, 山森 英長, 安田 由華, 阿古目 純, 中川 幸延, 池田 学
    • Journal Title

      精神神経学雑誌

      Volume: 122 Pages: 424-430

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] White matter microstructural alterations across four major psychiatric disorders: mega-analysis study in 2937 individuals2019

    • Author(s)
      Koshiyama Daisuke、(他38名18番目)Yamamoto Meeri
    • Journal Title

      Molecular Psychiatry

      Volume: 25 Issue: 4 Pages: 883-895

    • DOI

      10.1038/s41380-019-0553-7

    • NAID

      120006980539

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 統合失調症患者における薬物治療ガイドライン適合度と労働時間の関係2023

    • Author(s)
      伊藤 颯姫,大井 一高,安田 由華,藤本 美智子,山森 英長,松本 純弥,福本 健太郎,小高 文聰,長谷川 尚美,石丸 径一郎,三浦 健一郎,古郡 規雄,橋本 亮太、
    • Organizer
      第53回日本神経精神薬理学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] クロザピン使用に関連する脳波変化について2023

    • Author(s)
      平島 温也,畑 真弘,大森 久樹,宮崎 友希,高橋 隼,藤本 美智子,池田 学
    • Organizer
      第25回日本薬物脳波学会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] ミオクローヌスのため抗てんかん薬併用下での修正型電気けいれん療法が奏功した治療抵抗性統合失調症の一例2023

    • Author(s)
      武田 眞一,藤本 美智子,大森 久樹,真殿 花梨,高橋 隼,畑 真弘,岩瀬 真生,池田 学
    • Organizer
      第119回日本精神神経学会学術総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 統合失調症におけるバイオマーカーとしての眼球運動スコアの臨床的意義2021

    • Author(s)
      藤本美智子、三浦健一郎、森田健太郎、工藤紀子、畦地裕統、山森英長、安田由華、池田学、橋本亮太
    • Organizer
      第43回 日本生物学的精神医学会・第51回 日本神経精神薬理学会 合同年会
    • Related Report
      2021 Research-status Report
  • [Presentation] 統合失調症におけるバイオマーカーとしての眼球運動スコアの 臨床的意義2020

    • Author(s)
      藤本美智子、三浦健一郎、森田健太郎、工藤紀子、畦地裕統、山森英長、安田由華、池田学、橋本亮太
    • Organizer
      NPBPPP2020合同年会
    • Related Report
      2020 Research-status Report
  • [Book] Tasman’s Psychiatry2023

    • Author(s)
      Narita, Z., Fujimoto, M., Winter, E., Nestadt, P., Sawa, A
    • Publisher
      Springer Cham
    • ISBN
      9783030513658
    • Related Report
      2023 Annual Research Report
  • [Book] Tasman’s Psychiatry, 5th edition, Chapter 106 Anxiolytic Drugs2023

    • Author(s)
      Zui Narita, Michiko Fujimoto, Elizabeth Winter, Paul Nestadt, Akira Sawa
    • Publisher
      Springer
    • Related Report
      2022 Research-status Report
  • [Book] Tasman’s Psychiatry, 5th edition, Chapter 106 Anxiolytic Drugs.2022

    • Author(s)
      Zui Narita, Michiko Fujimoto, Elizabeth Winter, Paul Nestadt, Akira Sawa
    • Publisher
      Springer
    • Related Report
      2021 Research-status Report
  • [Book] Tasman’s Psychiatry, 5th edition, Chapter 106 Anxiolytic Drugs.2021

    • Author(s)
      Zui Narita, Michiko Fujimoto, Elizabeth Winter, Paul Nestadt, Akira Sawa
    • Publisher
      Springer
    • Related Report
      2020 Research-status Report
  • [Remarks]

    • URL

      https://www.med.osaka-u.ac.jp/pub/psy/laboratories/lab05/

    • Related Report
      2023 Annual Research Report
  • [Remarks] 大阪大学大学院医学系研究科精神医学教室 生物学的精神医学研究グループ

    • URL

      http://www2.med.osaka-u.ac.jp/psy/laboratories/lab05/

    • Related Report
      2022 Research-status Report 2021 Research-status Report 2020 Research-status Report

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Published: 2020-04-28   Modified: 2025-01-30  

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