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Investigation of the critical period for audio-visual integration in CI users

Research Project

Project/Area Number 20K09709
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56050:Otorhinolaryngology-related
Research InstitutionKobe City Medical Center General Hospital(First Clinical Division, Second Clinical Division, Third

Principal Investigator

Yamazaki Hiroshi  地方独立行政法人神戸市民病院機構神戸市立医療センター中央市民病院(第1診療部、第2診療部、第3診療部, 中央市民病院, 難聴研究部 部長 (80536243)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2021: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords人工内耳 / 脳機能 / 難聴 / 聴覚中枢 / 視聴覚統合 / 脳波 / 聴覚 / 聴覚野 / 光トポグラフィー / 発達
Outline of Research at the Start

健聴者では視覚入力と聴覚入力は協調して語音聴取に寄与してると考えられている。一方、先天性難聴を持つ人工内耳装用者の聴覚野では、視覚入力と聴覚入力が拮抗しており、十分な聴覚入力が得られなければ聴覚野は視覚情報を処理するようになる。しかし、低年齢から人工内耳を介した聴覚入力が得られた際に、視聴覚入力が協調するか、拮抗するかは不明である。本研究では、視聴覚統合の結果乗じる錯覚であるマガーク効果を用い、人工内耳装用者の視覚野と聴覚野活動がどのように同期するかを多チャンネル脳波計を用いて検証する。申請者は視覚野と聴覚野の協調した活動の発達には臨界期があると考えており、この仮説を脳波を用いて検証する。

Outline of Final Research Achievements

the beta-band power in the EEG between -150 ms and -25 ms of the audiovisual integration task (audio stimulus onset = 0 ms) was compared. The results showed that the beta band power of Cz was significantly smaller in the PreLing_visual group and the beta band power of Oz tended to be smaller in the PreLing_visual group, but not significantly different.

Academic Significance and Societal Importance of the Research Achievements

先天性難聴を有する人工内耳装用者の中で、人工内耳による聴覚活用が良好で音声言語を用いたコミュニケーションが可能なものは、言語獲得後失聴と同様の脳波のパターンを示したのに対し、聴覚活用が不良でコミュニケーションに視覚言語が不可欠な装用者はCzのβバンドパワーが有意に低い結果となった。この結果は先天性難聴を有する人工内耳装用者の聴覚活用を評価する他覚的検査所見として、Czのβバンドパワーが有用である事が示唆している。今後、人工内耳装用者ごとに術後のCzにおけるβバンドパワーの経時変化を評価することで、言語発達との関連を検証すると同時に、適切なリハビリテーション手法の選択に活用できる可能性がある。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (13 results)

All 2023 2022 2021 2020

All Journal Article (9 results) (of which Peer Reviewed: 8 results,  Open Access: 2 results) Presentation (4 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results)

  • [Journal Article] Remote Mapping of Cochlear Implants Using Custom Sound<sup>®</sup> Pro for Patients at Home.2023

    • Author(s)
      Tamaya Rinko、Yamazaki Hiroshi、Yamazaki Tomoko、Fujii Naoko、Moroto Saburo、Fujiwara Keizo、Naito Yasushi
    • Journal Title

      AUDIOLOGY JAPAN

      Volume: 66 Issue: 1 Pages: 40-48

    • DOI

      10.4295/audiology.66.40

    • NAID

      130008119066

    • ISSN
      0303-8106, 1883-7301
    • Year and Date
      2023-02-28
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A multicenter study to investigate the positive rate of SARS-CoV-2 in middle ear and mastoid specimens from otologic surgery patients2023

    • Author(s)
      Yamazaki Hiroshi、Yamamoto Norio、Sonoyama Toru、Maruoka Hayato、Nasu Seiko、Makino Akiko、Tomonaga Keizo、Shigemoto Norifumi、Ohge Hiroki、Fujiwara Keizo、Shinohara Shogo、Takeno Sachio、Omori Koichi、Naito Yasushi
    • Journal Title

      Auris Nasus Larynx

      Volume: 50 Issue: 2 Pages: 285-291

    • DOI

      10.1016/j.anl.2022.07.007

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Management of Already Inserted Ventilation Tubes During Pediatric Cochlear Implantation: To Remove or Leave the Tube?2023

    • Author(s)
      Tobe Yota、Yamazaki Hiroshi、Shirakawa Chigusa、Shinohara Shogo、Fujiwara Keizo、Naito Yasushi
    • Journal Title

      Otology &amp; Neurotology

      Volume: 44

    • DOI

      10.1097/mao.0000000000003797

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 当院における EAS 症例と残存聴力を有する人工内耳症例の検討2022

    • Author(s)
      山崎 博司、藤井 直子、玉谷 輪子、山崎 朋子、諸頭 三郎、藤原 敬三、内藤 泰
    • Journal Title

      Nippon Jibiinkoka Tokeibugeka Gakkai Kaiho(Tokyo)

      Volume: 125 Issue: 1 Pages: 18-23

    • DOI

      10.3950/jibiinkotokeibu.125.1_18

    • NAID

      130008150769

    • ISSN
      2436-5793, 2436-5866
    • Year and Date
      2022-01-20
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early Cochlear Implantation Allows Deaf Children to Control Voice Pitch and Loudness independently2022

    • Author(s)
      Yamazaki Hiroshi、Suehiro Atsushi、Ueda Yuko、Kondo Kanako、Ishida Ai、Yamamoto Norio、Takagi Akira、Omori Koichi
    • Journal Title

      Otology &amp; Neurotology

      Volume: 43 Issue: 1 Pages: e56-e63

    • DOI

      10.1097/mao.0000000000003388

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] High Riding Jugular Bulb Protruding Into Tympanic Cavity: Longitudinal Radiologic Study in a Deaf Child2022

    • Author(s)
      Ueda K, Yamazaki H, Michida T, Shinohara S, Naito Y.
    • Journal Title

      Ear Nose Throat J

      Volume: - Issue: 11 Pages: 707-710

    • DOI

      10.1177/01455613221079494

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sensorineural hearing loss and hypoplastic cochlea in Axenfeld-Rieger syndrome with FOXC1 mutation2021

    • Author(s)
      Yamazaki Hiroshi、Nakamura Takeshi、Hosono Katsuhiro、Yamaguchi Tomoya、Hiratsuka Yasuyuki、Hotta Yoshihiro、Takahashi Makio
    • Journal Title

      Auris Nasus Larynx

      Volume: 48 Issue: 6 Pages: 1204-1208

    • DOI

      10.1016/j.anl.2020.07.006

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Advantages of double density alignment of fNIRS optodes to evaluate cortical activities related to phonological short-term memory using NIRS-SPM2020

    • Author(s)
      Yamazaki Hiroshi、Kanazawa Yuji、Omori Koichi
    • Journal Title

      Hearing Research

      Volume: 395 Pages: 108024-108024

    • DOI

      10.1016/j.heares.2020.108024

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive Evaluation of Children with Cochlear Implants Using Objective Measurements2020

    • Author(s)
      Yamazaki Hiroshi
    • Journal Title

      Practica Oto-Rhino-Laryngologica

      Volume: 113 Issue: 11 Pages: 692-693

    • DOI

      10.5631/jibirin.113.692

    • NAID

      130007933804

    • ISSN
      0032-6313, 1884-4545
    • Related Report
      2020 Research-status Report
  • [Presentation] EAS in Japan - Current status & Future2022

    • Author(s)
      Hiroshi Yamazaki
    • Organizer
      18th Japan-Korea Joint Meeting of Otorhinolaryngology Head and Neck Surgery
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 内耳・内耳道奇形症例における術中EABR結果と術後の人工内耳刺激電荷量との関連2022

    • Author(s)
      山崎博司, 内藤 泰, 諸頭三郎, 山崎朋子, 玉谷輪子, 藤井直子, 藤原敬三
    • Organizer
      第67回日本聴覚医学会総会・学術講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 内耳・内耳道奇形人工内耳症例における光トポグラフィー(fNIRS)を用いた聴性皮質反応の評価2022

    • Author(s)
      山崎博司, 内藤 泰, 藤原敬三, 濵口清海, 道田哲彦, 安本眞美, 上田啓史
    • Organizer
      第32回日本耳科学会総会・学術講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] The Abnormal Cochlea; Objective measurements of auditory nerve responses in CI children with inner ear malformations.2021

    • Author(s)
      1.Yamazaki H, Naito Y, Moroto S, Yamazaki T, Tamaya R, Fujii N
    • Organizer
      The 13th Asia Pacific Symposium on Cochlear Implants and Related Sciences
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2020-04-28   Modified: 2024-01-30  

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