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Development of statistical analysis methods for visualizing nonlinear activity of large-scale neural populations

Research Project

Project/Area Number 20K11709
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 60030:Statistical science-related
Research InstitutionKyoto University (2022-2023)
Hokkaido University (2020-2021)

Principal Investigator

SHIMAZAKI HIDEAKI  京都大学, 情報学研究科, 准教授 (50587409)

Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2023: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords神経スパイクデータ / イジングモデル / 状態空間モデル / キネティック・イジングモデル / 非平衡系 / 情報幾何 / 平均場近似 / 神経符号化 / 非線形ダイナミクス
Outline of Research at the Start

脳は神経ネットワークを用いて外界のモデルを構築し,これに基づいて感覚刺激の原因を推測する器官であるという考え方(ベイズ脳仮説)が提案されている.この仮説を検証するために,本研究では脳が有する外界のモデルを実験データから明らかにする基盤的な統計解析技術を開発する.このために,我々がこれまでに構築してきた時間変動する神経細胞集団の発火頻度と相関構造を逐次推定する技術【状態空間-イジングモデル】を発展させ,大規模な神経細胞集団活動の非線形ダイナミクスの解析を可能にする技術を開発する.この技術に基づいて,大規模・非線形データから神経細胞集団が有する外界のモデルを明らかにする手法を開発する.

Outline of Final Research Achievements

We studied the nonequilibrium kinetic Ising model to analyze and visualize large-scale, nonlinear neuronal population activity. We developed a theory that unifies various mean-field approximation methods and proposed a new method that outperforms previous ones in conditions where neurons exhibit diverse patterns. We also conducted theoretical analyses on this model using a path-integral approach to elucidate the behavior of large-scale networks. Furthermore, we extended the nonequilibrium kinetic Ising model within the state-space framework. This model enabled us to estimate fluctuating asymmetric couplings from experimentally obtained spiking time-series data. In conclusion, we successfully developed novel theories and statistical analysis methods for understanding and visualizing large-scale neuronal population activity.

Academic Significance and Societal Importance of the Research Achievements

非平衡キネティック・イジングモデルに対する新しい理論と統計解析技術は,神経科学分野における基礎研究だけでなく,機械学習分野にも応用可能である.提案した平均場近似法によって機械学習による大規模データ解析の精度が向上が見込まれる.さらに,提案した平均場近似の統一的枠組みに基づいて,機械学習モデルのトランスフォーマーの解析が海外の研究者によって行われるなど,学習機械の理論的な理解にも一定の貢献がある.また,理論解析により求めた大規模ネットワークの厳密解は他の複雑系の解析にも適用できるため,物理学,生物学,経済学など多岐にわたる分野で観測されるネットワーク現象への応用が期待される.

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (31 results)

All 2023 2022 2021 2020 Other

All Int'l Joint Research (9 results) Journal Article (5 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (16 results) (of which Int'l Joint Research: 6 results,  Invited: 9 results) Book (1 results)

  • [Int'l Joint Research] Basque Center for Applied Mathematics(スペイン)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] Basque Center for Applied Mathematics/IKERBASQUE(スペイン)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] IPM/University of Tehran/University of Guilan(イラン)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] Sussex University/University College London(英国)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] CMAT(メキシコ)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] Sussex University(英国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] University of the Basque Country/University of Zaragoza(スペイン)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] Brown University(米国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] IPM/University of Guilan(イラン)

    • Related Report
      2020 Research-status Report
  • [Journal Article] Nonequilibrium thermodynamics of the asymmetric Sherrington-Kirkpatrick model2023

    • Author(s)
      Aguilera Miguel、Igarashi Masanao、Shimazaki Hideaki
    • Journal Title

      Nature Communications

      Volume: 14 Issue: 1 Pages: 3685-3685

    • DOI

      10.1038/s41467-023-39107-y

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Uncovering hidden network architecture from spiking activities using an exact statistical input-output relation of neurons2023

    • Author(s)
      Shomali Safura Rashid、Rasuli Seyyed Nader、Ahmadabadi Majid Nili、Shimazaki Hideaki
    • Journal Title

      Communications Biology

      Volume: 6 Issue: 1 Pages: 1-18

    • DOI

      10.1038/s42003-023-04511-z

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Canonical neural networks perform active inference2022

    • Author(s)
      Isomura Takuya、Shimazaki Hideaki、Friston Karl J.
    • Journal Title

      Communications Biology

      Volume: 5 Issue: 1 Pages: 1-15

    • DOI

      10.1038/s42003-021-02994-2

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A unifying framework for mean-field theories of asymmetric kinetic Ising systems2021

    • Author(s)
      Aguilera Miguel、Moosavi S. Amin、Shimazaki Hideaki
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 1197-1197

    • DOI

      10.1038/s41467-021-20890-5

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hunger Potentiates the Habenular Winner Pathway for Social Conflict by Orexin-Promoted Biased Alternative Splicing of the AMPA Receptor Gene2020

    • Author(s)
      Nakajo Haruna、Chou Ming-Yi、Kinoshita Masae、Appelbaum Lior、Shimazaki Hideaki、Tsuboi Takashi、Okamoto Hitoshi
    • Journal Title

      Cell Reports

      Volume: 31 Issue: 12 Pages: 107790-107790

    • DOI

      10.1016/j.celrep.2020.107790

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 非定常・非対称な機能的結合の推定に基づく神経スパイク活動の不可逆性の検証2023

    • Author(s)
      石原憲, 島崎秀昭
    • Organizer
      第33回日本神経回路学会全国大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 神経符号化研究の歴史と最前線2023

    • Author(s)
      島崎秀昭
    • Organizer
      第33回日本神経回路学会全国大会 サテライトシンポジウム
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 脳の計算論概説:効率的符号化仮説からベイズ脳・自由エネルギー原理まで2023

    • Author(s)
      島崎秀昭
    • Organizer
      第46回日本神経科学会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 状態空間ーキネティックイジングモデルによる非平衡神経スパイク時系列の解析2023

    • Author(s)
      石原憲, 島崎秀昭
    • Organizer
      ニューロコンピューティング研究会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Winter Workshop on Mechanism of Brain and Mind 20232023

    • Author(s)
      Ken Ishihara, Hideaki Shimazaki
    • Organizer
      Mechanism of Brain and Mind
    • Related Report
      2022 Research-status Report
  • [Presentation] State-space analysis for neural population dynamics2022

    • Author(s)
      Hideaki Shimazaki, Ken Ishihara, Ulises Rodriguez Dominguez, Sai Sumedh Hindupur, Miguel Aguilera, S. Amin Moosavi, Magalie Tatischeff, Jimmy Gaudreault, Christian Donner
    • Organizer
      NEURO2022
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] The state-space kinetic Ising model for nonequilibrium neuronal dynamics2022

    • Author(s)
      Ken Ishihara, Hideaki Shimazaki
    • Organizer
      NEURO2022
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Consciousness and the thermodynamics of the Bayesian brain.2022

    • Author(s)
      Hideaki Shimazaki
    • Organizer
      International Symposium on Artificial Intelligence and Brain Science 2022
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 神経細胞集団活動の数理とデータ解析2022

    • Author(s)
      島崎秀昭
    • Organizer
      日本応用数理学会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 脳の認識のダイナミクスと時間遅れ2022

    • Author(s)
      島崎秀昭
    • Organizer
      2022年度 RIMS 共同研究(公開型)「時間遅れ系と数理科学:理論と応用の新たな展開に向けて」
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 標準リカレントネットワークモデルでつなぐ皮質回路の構造・機能・作動原理2021

    • Author(s)
      島崎秀昭
    • Organizer
      生理学研究所研究会「大脳皮質を中心とした神経回路:構造と機能、その作動原理」
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Bayesian Computation of Generic Neural Binary Code by Local Competition2021

    • Author(s)
      Ulises Rodriguez Dominguez, Hideaki Shimazaki
    • Organizer
      The 44th Annual Meeting of the Japan Neuroscience Society (Neuro 2021)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] An information geometry approach for unifying mean field theories of asymmetric kinetic Ising systems2021

    • Author(s)
      Miguel Aguilera, S. Amin Moosavi, Hideaki Shimazaki
    • Organizer
      Entropy 2020: The Scientific Tool of the 21st Century
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 非定常・非平衡イジングモデルによる神経細胞集団活動の解明2021

    • Author(s)
      島崎秀昭
    • Organizer
      データ駆動生物学ワークショップ
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Revealing hidden microcircuits using higher-order interactions of neuronal activity2021

    • Author(s)
      Safura Rashid Shomali, S. Nader Rasuli, Hideaki Shimazaki
    • Organizer
      The 3rd Sharif Neuroscience Symposium
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 脳への計算論的アプローチ概説: 視覚野の理論を中心に2021

    • Author(s)
      島崎秀昭
    • Organizer
      日本視覚学会2021年冬季大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Book] イベント時系列解析入門2023

    • Author(s)
      小山慎介, 島崎秀昭
    • Total Pages
      160
    • Publisher
      近代科学社
    • Related Report
      2023 Annual Research Report

URL: 

Published: 2020-04-28   Modified: 2025-01-30  

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