Identification and characterization of lncRNAs involved in genetic compensation
| Project/Area Number |
20K15784
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 43060:System genome science-related
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| Research Institution | Waseda University (2021)
National Institute of Advanced Industrial Science and Technology (2020) |
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Principal Investigator |
曽 超 早稲田大学, 理工学術院総合研究所(理工学研究所), 次席研究員(研究院講師) (80822460)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Project Status |
Granted (Fiscal Year 2021)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | RNA-chromatin / GCR / RNA degradation / Genetic compensation / lncRNA / RNA decay / NMD |
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| Outline of Research at the Start |
Understanding the role of long noncoding RNA (lncRNA) in gene regulation expands our knowledge of life and disease. Here, we raise and try to uncover that lncRNA decay (death) may trigger to up-regulate the expression of other genes (birth). This study promises to reveal a novel mechanism of lncRNA.
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| Outline of Annual Research Achievements |
GCRに関わる分子メカニズムを検証するために、対応する細胞株におけるRNA-Chromatin相互作用の実験データを収集し、RNA-クロマチン相互作用部位を定義した。さらに、RNA-クロマチン相互作用に起因すると想定されるGCR関連遺伝子ペアのリストが得られた。
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
GCR関連遺伝子ペアをヒト細胞ではじめて予測し、ヒト細胞でGCR制御に関与する新たなRNA分解因子をはじめて同定できた。
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| Strategy for Future Research Activity |
GCR関連遺伝子の配列特徴を解析する。
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Report
(2 results)
Research Products
(14 results)
