• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Examination of ischemic tolerance exercise and microRNA in hippocampus

Research Project

Project/Area Number 20K19449
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionKagawa University

Principal Investigator

Takata Tadayuki  香川大学, 医学部, 寄附講座教員 (10714272)

Project Period (FY) 2020-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
KeywordsMicro RNA / 海馬 / 虚血再灌流 / 短期記憶 / 虚血耐性運動 / 乳酸 / microRNA / Hippocampus / Reperfusion / Short-term memory / Ischemic tolerance / Lactate / micro RNA / 運動 / 一過性全脳虚血 / スナネズミ
Outline of Research at the Start

microRNA(miRNA)はタンパク質をコードしない小型一本鎖RNAである.このmiRNAが標的messenger RNAの翻訳の中断あるいは遺伝子発現を制御していることが明らかとなってきた.脳虚血における神経細胞障害の機序においてもmiRNAが重要な役割を担う可能性が指摘されている.
本研究は,スナネズミの脳虚血モデルにおける,海馬のエクソソーム中のmiRNAを解析し,脳虚血作成前に行う運動負荷が,どのようにmiRNAのprofilingに影響をもたらすか追及する.運動負荷の程度は,乳酸値を指標とし,軽運動後のmiRNAの変化から,虚血耐性や認知と関連するmiRNAを明確にする.

Outline of Final Research Achievements

In an ischemia-reperfusion injury model in gerbils, light exercise loading without lactate elevation protected hippocampal neurons and maintained short-term memory. Among several miRNAs whose expression was changed by ischemia-reperfusion, 14 miRNAs whose expression was increased and 6 miRNAs whose expression was decreased were suppressed by light exercise before ischemia-reperfusion. In other words, these miRNAs may regulate multiple biological processes such as inflammation, metabolism, and cell death, and these findings suggest that light exercise without elevated lactate may reduce neuronal cell death and behavioral deficits after transient ischemia by regulating miRNAs in the hippocampus.

Academic Significance and Societal Importance of the Research Achievements

本研究では乳酸上昇を伴わない軽運動は,miRNAの分子レベルにおいても虚血耐性を得たことが示された.miR-181c-5pの発現を維持したことは虚血負荷時にペナンブラに移行することの予防が可能であったことが示された.また,miR-455-3pはアミロイドβ(Aβ)前駆体蛋白のプロセッシングを調整し,虚血による機能不全では,Aβの蓄積が誘発されることが予想されたが,本研究では軽運動よりmiR-455-3pの発現も維持できたことから,Aβの蓄積を予防できる可能性も判明した.乳酸上昇を伴わない軽運動は,急性の虚血障害のメカニズムのみではなく,Aβ蓄積による長期的な認知機能の低下も防ぐ可能性がある.

Report

(3 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • Research Products

    (2 results)

All 2020

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] Light exercise without lactate elevation induces ischemic tolerance through the modulation of microRNA in the gerbil hippocampus2020

    • Author(s)
      Takata Tadayuki、Nonaka Wakako、Iwama Hisakazu、Kobara Hideki、Deguchi Kazushi、Masugata Hisashi、Touge Tetsuo、Miyamoto Osamu、Nakamura Takehiro、Itano Toshifumi、Masaki Tsutomu
    • Journal Title

      Brain Research

      Volume: 1732 Pages: 146710-146710

    • DOI

      10.1016/j.brainres.2020.146710

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Presentation] Light exercise induces ischemic tolerance through modulation of microRNAs in the gerbil hippocampus2020

    • Author(s)
      Tadayuki Takata, Wakako Nonaka, Hisakazu Iwama, Hideki Kobara, Kazushi Deguchi, Hisashi Masugata, Tetsuo Touge, Osamu Miyamoto, Takehiro Nakamura, Toshifumi Itano, Tsutomu Masaki
    • Organizer
      第61回日本神経学会学術大会
    • Related Report
      2020 Research-status Report

URL: 

Published: 2020-04-28   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi