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Brain connectivity changes related to age-induced decline in visuomotor control

Research Project

Project/Area Number 20K19708
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionHiroshima University

Principal Investigator

Watanabe Tatsunori  広島大学, 医系科学研究科(保), 助教 (20868400)

Project Period (FY) 2020-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords視覚運動制御 / 脳律動 / 脳内ネットワーク / 脳波 / 経頭蓋磁気刺激 / 加齢 / 脳機能ネットワーク
Outline of Research at the Start

高齢ドライバーによる交通死亡事故が社会問題となっており、運転技能低下の要因として、視覚情報を用いた動作の制御機能の加齢低下が挙げられる。本研究では、大脳皮質運動野と他の脳領域のネットワーク機構に着目して、この機能低下のメカニズムを検証する。そして、機能が低下した高齢者に対して介入を行う際に重要となる神経生理学的ターゲットの同定を目指す。

Outline of Final Research Achievements

Control of movements based on visual information, which is known as visuomotor control, plays an important role in daily life. In this study, we found that theta oscillations increase in the midfrontal area of the brain when precise visuomotor control is required. Furthermore, we found that the supplementary motor area - contralateral primary motor cortex interaction tends to become excitatory, and the ipsilateral premotor area - contralateral primary motor cortex interaction becomes inhibitory when precise visuomotor control is required.

Academic Significance and Societal Importance of the Research Achievements

近年、高齢ドライバーによる交通死亡事故が社会問題となっており免許の自主返納が助言されている。しかし、公共交通機関の充実していない地方に暮らす高齢者にとって自動車は生活の足であり、不安ながらも運転を継続しているのが現状である。よって、安全に運転することができる期間(安全運転寿命)を延伸することが重要となるが運転時に必要となる視覚情報を用いた動作の制御機構や機能低下に関わる生理学的機序は解明されていない。本研究では、脳の中前頭の脳波律動、補足運動野や運動前野の活動が視覚運動制御に関わることを示した。本研究の一連の成果は視覚運動制御機能の加齢低下に対する新たな介入手段の確立に繋がることが期待される。

Report

(3 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • Research Products

    (52 results)

All 2022 2021 2020 Other

All Int'l Joint Research (4 results) Journal Article (18 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 18 results,  Open Access: 17 results) Presentation (30 results) (of which Int'l Joint Research: 11 results)

  • [Int'l Joint Research] University of Florida(米国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Hospital Nacional de Paraple'jicos(スペイン)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Hospital Nacional de Paraple’jicos(スペイン)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] University of Florida(米国)

    • Related Report
      2020 Research-status Report
  • [Journal Article] Repetitive training of contralateral limb through reconsolidation strengthens motor skills2022

    • Author(s)
      Gyoda Tomoya、Ishida Kazuto、Watanabe Tatsunori、Nojima Ippei
    • Journal Title

      Neuroscience Letters

      Volume: 766 Pages: 136306-136306

    • DOI

      10.1016/j.neulet.2021.136306

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Two-Month Individually Supervised Exercise Therapy Improves Walking Speed, Step Length, and Temporal Gait Symmetry in Chronic Stroke Patients: class FormattedString { value: A before–after Trial }2022

    • Author(s)
      Yoshioka Kiyoshi、Watanabe Tatsunori、Maruyama Norikazu、Yoshioka Mizuki、Iino Keita、Honda Kimikazu、Hayashida Koshiro
    • Journal Title

      Healthcare

      Volume: 10 Issue: 3 Pages: 527-527

    • DOI

      10.3390/healthcare10030527

    • URL

      https://localhost/en/publications/8c90f28b-50d1-4ab5-b6c1-466d95ec0f11

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of transcranial static magnetic stimulation over the primary motor cortex on local and network spontaneous electroencephalogram oscillations2021

    • Author(s)
      Shibata Sumiya、Watanabe Tatsunori、Yukawa Yoshihiro、Minakuchi Masatoshi、Shimomura Ryota、Ichimura Sachimori、Kirimoto Hikari、Mima Tatsuya
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 1-7

    • DOI

      10.1038/s41598-021-87746-2

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Null Effect of Transcranial Static Magnetic Field Stimulation over the Dorsolateral Prefrontal Cortex on Behavioral Performance in a Go/NoGo Task2021

    • Author(s)
      Watanabe T, Kubo N, Chen X, Yunoki K,Matsumoto T, Kuwabara T, Sunagawa T, Date S, Mima T, Kirimoto H
    • Journal Title

      Brain Sciences

      Volume: 11(4) Issue: 4 Pages: 483-483

    • DOI

      10.3390/brainsci11040483

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Modulation of sensorimotor cortical oscillations in athletes with yips2021

    • Author(s)
      Watanabe Tatsunori、Yoshioka Kiyoshi、Matsushita Kojiro、Ishihara Shin
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 1-10

    • DOI

      10.1038/s41598-021-89947-1

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Effect of Prior Knowledge of Color on Behavioral Responses and Event-Related Potentials During Go/No-go Task2021

    • Author(s)
      Kubo Nami、Watanabe Tatsunori、Chen Xiaoxiao、Matsumoto Takuya、Yunoki Keisuke、Kuwabara Takayuki、Kirimoto Hikari
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 15 Pages: 1-11

    • DOI

      10.3389/fnhum.2021.674964

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transient Modulation of Working Memory Performance and Event-Related Potentials by Transcranial Static Magnetic Field Stimulation over the Dorsolateral Prefrontal Cortex2021

    • Author(s)
      Chen Xiaoxiao、Watanabe Tatsunori、Kubo Nami、Yunoki Keisuke、Matsumoto Takuya、Kuwabara Takayuki、Sunagawa Toru、Date Shota、Mima Tatsuya、Kirimoto Hikari
    • Journal Title

      Brain Sciences

      Volume: 11 Issue: 6 Pages: 739-739

    • DOI

      10.3390/brainsci11060739

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Midfrontal theta as moderator between beta oscillations and precision control2021

    • Author(s)
      Watanabe Tatsunori、Mima Tatsuya、Shibata Sumiya、Kirimoto Hikari
    • Journal Title

      NeuroImage

      Volume: 235 Pages: 118022-118022

    • DOI

      10.1016/j.neuroimage.2021.118022

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Event-related potentials evoked by skin puncture reflect activation of Aβ fibers: comparison with intraepidermal and transcutaneous electrical stimulations2021

    • Author(s)
      Shiroshita Yui、Kirimoto Hikari、Watanabe Tatsunori、Yunoki Keisuke、Sobue Ikuko
    • Journal Title

      PeerJ

      Volume: 9 Pages: e12250-e12250

    • DOI

      10.7717/peerj.12250

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Can Event-Related Potentials Evoked by Heel Lance Assess Pain Processing in Neonates? A Systematic Review2021

    • Author(s)
      Shiroshita Yui、Kirimoto Hikari、Ozawa Mio、Watanabe Tatsunori、Uematsu Hiroko、Yunoki Keisuke、Sobue Ikuko
    • Journal Title

      Children

      Volume: 8 Issue: 2 Pages: 58-58

    • DOI

      10.3390/children8020058

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Excitability of the Ipsilateral Primary Motor Cortex During Unilateral Goal-Directed Movement2021

    • Author(s)
      Matsumoto Takuya、Watanabe Tatsunori、Kuwabara Takayuki、Yunoki Keisuke、Chen Xiaoxiao、Kubo Nami、Kirimoto Hikari
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 15 Pages: 1-10

    • DOI

      10.3389/fnhum.2021.617146

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Age-associated increase in postural variability relate to greater low-frequency center of pressure oscillations2021

    • Author(s)
      Delmas Stefan、Watanabe Tatsunori、Yacoubi Basma、Christou Evangelos A.
    • Journal Title

      Gait & Posture

      Volume: 85 Pages: 103-109

    • DOI

      10.1016/j.gaitpost.2020.12.019

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Transcranial static magnetic stimulation over the motor cortex can facilitate the contralateral cortical excitability in human.2021

    • Author(s)
      Takamatsu, Y., Koganemaru, S., Watanabe, T., Shibata, S., Yukawa, Y., Minakuchi, M., Shimomura, R., & *Mima, T.
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 5370-5370

    • DOI

      10.1038/s41598-021-84823-4

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The effects of transcranial static magnetic fields stimulation over the supplementary motor area on anticipatory postural adjustments2020

    • Author(s)
      Daisuke Tsuru, Tatsunori Watanabea, Xiaoxiao Chen, Nami Kubo, Toru Sunagawa, Tatsuya Mima, Hikari Kirimoto
    • Journal Title

      Neuroscience Letters

      Volume: 723 Pages: 1-6

    • DOI

      10.1016/j.neulet.2020.134863

    • NAID

      120007002545

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of transcranial static magnetic stimulation on intracortical excitability in the contralateral primary motor cortex2020

    • Author(s)
      Sumiya Shibata, Tatsunori Watanabe, Yoshihiro Yukawa, Masatoshi Minakuchi, Ryota Shimomura, Tatsuya Mima
    • Journal Title

      Neuroscience Letters

      Volume: 723 Pages: 1-5

    • DOI

      10.1016/j.neulet.2020.134871

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Magnification of visual feedback modulates corticomuscular and intermuscular coherences differently in young and elderly adults2020

    • Author(s)
      Watanabe Tatsunori、Nojima Ippei、Mima Tatsuya、Sugiura Hideshi、Kirimoto Hikari
    • Journal Title

      NeuroImage

      Volume: 220 Pages: 117089-117089

    • DOI

      10.1016/j.neuroimage.2020.117089

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Direction-specific Disruption of Paretic Arm Movement in Post-stroke Patients2020

    • Author(s)
      Yoshioka Kiyoshi、Watanabe Tatsunori、Yoshioka Mizuki、Iino Keita、Honda Kimikazu、Hayashida Koshiro、Kuninaka Yuji
    • Journal Title

      Progress in Rehabilitation Medicine

      Volume: 5 Issue: 0 Pages: n/a

    • DOI

      10.2490/prm.20200009

    • NAID

      130007833136

    • ISSN
      2432-1354
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of static magnetic field stimulation on the accuracy of tachystoscopically presented line bisection.2020

    • Author(s)
      *Kirimoto, H., Watanabe, T., Kubo, N., Date, S., Sunagawa, T., Mima, T., Ogata, K., Nakazono, H., Tobimatsu, S., & Oliviero, A.
    • Journal Title

      Brain Sci.

      Volume: 10 Issue: 12 Pages: 1006-1006

    • DOI

      10.3390/brainsci10121006

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 色の先行知識がGo/No-go課題の反応時間に与える影響-異なる視覚モダリティを用いた検討-2022

    • Author(s)
      堀之内 峻之,松本 卓也,柚木 啓輔,桑原 貴之,伊藤 佳奈実,石田 晴輝,渡邊 龍憲,桐本光
    • Organizer
      生理研研究会 スポーツからみる日常と非日常の神経生理学
    • Related Report
      2021 Annual Research Report
  • [Presentation] ピアノ演奏経験者が行う外的ペースタッピングの同期安定性は視聴覚複合刺激で顕在化する2021

    • Author(s)
      伊藤 佳奈実,松本 卓也,柚木 啓輔,陳 瀟瀟,桑原 貴之,石田 晴輝,堀之内 峻之,渡邊 龍憲,桐本 光
    • Organizer
      第15回Motor control研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 静的筋収縮では錘を牽引する時より不動の物体を押す時に皮膚感覚情報が必要とされる2021

    • Author(s)
      柚木 啓輔,松本 卓也,桑原 貴之,陳 瀟瀟,石田 晴輝,伊藤 佳奈実,堀之内 峻之,渡邊 龍憲,桐本 光
    • Organizer
      第15回Motor control研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 運動前野への経頭蓋静磁場刺激が単純および選択反応時間に及ぼす影響2021

    • Author(s)
      松本 卓也,伊藤 佳奈実,石田 晴輝,堀之内 峻之,桑原 貴之,柚木 啓輔,陳 瀟瀟,渡邊 龍憲,桐本 光
    • Organizer
      第76回日本体力医学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 一定の筋力保持に関与する皮膚感覚情報の処理過程は運動負荷形式によって異なる ―筋力制御と肢位制御―2021

    • Author(s)
      柚木 啓輔,松本 卓也,桑原 貴之,陳 瀟瀟,石田 晴輝,伊藤 佳奈実,堀之内 峻之,渡邊 龍憲,桐本 光
    • Organizer
      第76回日本体力医学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 静的筋収縮時の負荷形式の違いが皮膚感覚情報の処理過程に及ぼす影響-筋力制御と肢位制御-2021

    • Author(s)
      柚木 啓輔,松本 卓也,桑原 貴之,陳 瀟瀟,石田 晴輝,伊藤 佳奈実,堀之内 峻之,渡邊 龍憲,桐本 光
    • Organizer
      第26回日本基礎理学療法学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 楽器演奏経験がrepeated bout rate enhancementへ与える影響2021

    • Author(s)
      堀之内 峻之,宇野 七海,伊藤 佳奈実,松本 卓也,柚木 啓輔,陳 瀟瀟,桑原 貴之,石田 晴輝,渡邊 龍憲,桐本光
    • Organizer
      第51回日本臨床神経生理学会学術大会
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  • [Presentation] ピアノ演奏者のタッピングの同期安定性は視聴覚複合刺激で向上する2021

    • Author(s)
      伊藤 佳奈実,松本 卓也,柚木 啓輔,陳 瀟瀟,桑原 貴之,石田 晴輝,堀之内 峻之,渡邊 龍憲,桐本光
    • Organizer
      第51回日本臨床神経生理学会学術大会
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  • [Presentation] 運動前野に対する経頭蓋静磁場刺激の効果-視覚反応課題を用いたpilot study-2021

    • Author(s)
      松本 卓也,伊藤 佳奈実,石田晴輝,堀之内 峻之,桑原 貴之,柚木 啓輔,陳 瀟瀟,渡邊 龍憲,桐本 光
    • Organizer
      第15回日本作業療法研究学会学術大会
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      2021 Annual Research Report
  • [Presentation] 静的筋収縮時の運動負荷形式の違いが皮膚感覚情報の処理過程に及ぼす影響-不動の物体を押すか,錘を牽引するか-2021

    • Author(s)
      柚木 啓輔,松本 卓也,桑原 貴之,堀之内 峻之,石田 晴輝,伊藤 佳奈実,渡邊 龍憲,桐本 光
    • Organizer
      第15回日本作業療法研究学会学術大会
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      2021 Annual Research Report
  • [Presentation] ピアノ演奏者の外的ペースタッピングにおける同期安定性は音楽学習環境に近似した刺激提示で顕在化する2021

    • Author(s)
      伊藤 佳奈実,松本 卓也,柚木 啓輔,陳 瀟瀟,桑原 貴之,石田 晴輝,堀之内 峻之,渡邊 龍憲,桐本光
    • Organizer
      第15回日本作業療法研究学会学術大会
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      2021 Annual Research Report
  • [Presentation] ピアノ演奏経験の有無が外的ペースタッピング課題時の同期の正確性および運動制御様式に与える影響2021

    • Author(s)
      松本 卓也,桑原 貴之,柚木 啓輔,渡邊 龍憲,桐本 光
    • Organizer
      第55回日本作業療法学会
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  • [Presentation] Cutaneous stimulus registration and information processing differ during constant finger force and position2021

    • Author(s)
      Yunoki K, Watanabe T, Matsumoto T, Kuwabara T, Chen X, Ito K, Ishida H, Horinouchi T, Kirimoto H
    • Organizer
      The 2nd International Electronic Conference on Brain Sciences
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effect of piano playing experience on tapping synchronization to different sensory modalities2021

    • Author(s)
      Ito K, Watanabe T, Matsumoto T, Yunoki K, Chen X, Kubo N, Kuwabara T, Ishida H, Horinouchi T, Kirimoto H
    • Organizer
      The 2nd International Electronic Conference on Brain Sciences
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Repeated bout rate enhancement of finger tapping does not occur in musicians2021

    • Author(s)
      Ito K, Watanabe T, Yunoki K, Matsumoto T, Chen X, Kubo N, Kuwabara T, Ishida H, Horinouchi T, Kirimoto H
    • Organizer
      The 2nd International Electronic Conference on Brain Sciences
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 背外側前頭前野への経頭蓋静磁場刺激がワーキングメモリ及び事象関連電位に与える影響2021

    • Author(s)
      渡邊龍憲,陳瀟瀟,柚木啓輔,松本卓也,桑原貴之,伊藤佳奈実,石田晴輝,堀之内峻之,桐本光
    • Organizer
      第26回日本基礎理学療法学会学術大会
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  • [Presentation] Transcranial static magnetic field stimulation over the supplementary motor area modulates function of anticipatory postural adjustments2020

    • Author(s)
      Kuwabara T, Watanabe T, Matsumoto T, Yunoki K, Kubo N, Chen X, Mima T, Kirimoto H
    • Organizer
      Federation of European neuroscience society
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Excitability of the ipsilateral primary motor cortex during unilateral finger movment: the effect of hand dominance2020

    • Author(s)
      Matsumoto T, Watanabe T, Kuwabara T, Yunoki K, Chen X, Kubo N, Kirimoto H
    • Organizer
      Federation of European neuroscience society
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Greater amount of visual information increases corticomuscular coherence in elderly but not in young adults2020

    • Author(s)
      Watanabe T, Matsumoto T, Yunoki K, Kuwabara T, Kubo N, Chen X, Mima T, Kirimoto H
    • Organizer
      Federation of European neuroscience society
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Transcranial static magnetic stimulation over the temporal lobe induces plastic changes in the accuracy of tachystoscopically presented line bisection2020

    • Author(s)
      Yunoki K, Watanabe T, Matsumoto T, Kuwabara T, Kubo N, Chen X, Mima T, Kirimoto H
    • Organizer
      Federation of European neuroscience society
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] The effects of transcranial static magnetic field stimulation over the supplementary motor area on the function of anticipatory postural adjustments2020

    • Author(s)
      Kuwabara T, Watanabe T, Matsumoto T, Yunoki K, Kubo N, Chen X, Mima T, Kirimoto H
    • Organizer
      14th ICME International Conference on Complex Medical Engineering
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Laterality of intracortical inhibition in the ipsilateral primary motor cortex during unilateral finger movement2020

    • Author(s)
      Matsumoto T, Watanabe T, Kuwabara T, Yunoki K, Chen X, Kubo N, Kirimoto H
    • Organizer
      14th ICME International Conference on Complex Medical Engineering
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Changes in corticomuscular and intermuscular coherences associated with visuomotor control2020

    • Author(s)
      Watanabe T, Matsumoto T, Yunoki K, Kuwabara T, Kubo N, Chen X, Mima T, Kirimoto H
    • Organizer
      14th ICME International Conference on Complex Medical Engineering
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] The effects of transcranial static magnetic field stimulation on the accuracy of tachystoscopically presented line bisection2020

    • Author(s)
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Published: 2020-04-28   Modified: 2023-01-30  

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