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Exploration of neuromodulators that control overcoming dissapointment

Research Project

Project/Area Number 20K20862
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 10:Psychology and related fields
Research InstitutionKyoto University

Principal Investigator

Ogawa Masaaki  京都大学, 医学研究科, 特定准教授 (00716186)

Project Period (FY) 2020-07-30 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2021: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2020: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywordsニューロモジュレーター
Outline of Research at the Start

ヒトは常日頃、将来の目標を高く設定し、現実との間に「期待外れ」が生まれても、それを「乗り越えよう」とする。社会的にも、諦めるよりは、乗り越えようとする方が賞賛され、その姿勢が強化される傾向にすらある。この心理が不足すると、社会的に成功できず、挫折を味わった後の抑うつや不登校などの問題につながる。本研究は、神経伝達を修飾する様々なニューロモジュレーターの役割に焦点を当て、これらが期待外れを乗り越える心理に果たす役割を探索する。

Outline of Final Research Achievements

Humans routinely set goals that are higher than the present situation. Even in cases of "disappointment" when things do not go as expected, they try to overcome them, which leads to success in the future. Lack of this mentality leads to inability to succeed socially and to problems such as depression after a setback. Despite this universal and important function, the neural mechanisms underlying the mentality of "overcoming disappointment" have been unclear. This study explored the role of multiple neuromodulators that control the mentality of overcoming reward-related disappointment and found brain regions in which their concentration increases at the moment of unexpected reward omission. We also found causal roles of the neural circuits in the mentality of overcoming disappointment.

Academic Significance and Societal Importance of the Research Achievements

本研究は、心理学分野と神経科学分野の技術の融合を達成し、将来的に不確実な報酬に対する多面的な心理を担う多層的な神経機構の解明に発展させるための基礎となる成果を得た。本研究成果は、複数の神経伝達調節因子の異常が深く関わるうつ、依存症、統合失調症などの精神疾患症状の理解やそれらの心理的介入などの治療、不登校などの教育心理、社会的成功などの社会心理の神経機構の理解を変える潜在性がある。

Report

(3 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • Research Products

    (7 results)

All 2022 2021 Other

All Int'l Joint Research (1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Remarks (2 results)

  • [Int'l Joint Research] Peking University(中国)

    • Related Report
      2021 Annual Research Report
  • [Presentation] The neural basis for overcoming failure: a dopamine circuit facilitates switching toward new goals2022

    • Author(s)
      小川正晃
    • Organizer
      The international symposium on development and plasticity of neural systems
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A potential role of mesolimbic dopamine system in overcoming omission of expected reward2021

    • Author(s)
      石野誠也、鎌田泰輔、Gideon Sarpong、司玲央、向平妃沙、Yulong Li、小林憲太、本田直樹、大石直也、小川正晃
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 不確実な報酬を求め続けるための中脳辺縁ドーパミン回路の潜在的役割2021

    • Author(s)
      石野誠也、鎌田泰輔、Gideon Sarpong、司玲央、向平妃沙、Yulong Li、小林憲太、本田直樹、大石直也、小川正晃
    • Organizer
      第113回近畿生理学談話会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 報酬予測誤差に対する相反するドーパミン信号伝達2021

    • Author(s)
      小川正晃
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Remarks] 京都大学医学研究科 小川正晃 研究室

    • URL

      https://sites.google.com/view/ogawagroup/

    • Related Report
      2021 Annual Research Report
  • [Remarks] 京都大学医学研究科 小川正晃 研究室

    • URL

      https://sites.google.com/view/ogawagroup

    • Related Report
      2020 Research-status Report

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Published: 2020-08-03   Modified: 2023-01-30  

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