Influence of caesarean section on susceptibility to allergy

• Project/Area Number: 20K22788
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0803:Pathology, infection/immunology, and related fields
• Research Institution: Keio University
• Principal Investigator: YAMADA TAKAHIRO 慶應義塾大学, 薬学部(芝共立), 特任助教 (50881207)
• Project Period (FY): 2020-09-11 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 帝王切開 / アレルギー / 腸内細菌 / 免疫 / 共生細菌

Outline of Research at the Start

帝王切開または自然分娩により出生したマウスに対しアレルギー喘息を誘導する。これにより帝王切開がアレルギー感受性に与える影響を調べる。さらに発症前、過程における免疫系を精査することによって、帝王切開がアレルギー感受性に影響するメカニズムを調べる。帝王切開によるアレルギー感受性への影響が、帝王切開に伴う新生仔腸内細菌の異常によるものか検証する。

Outline of Final Research Achievements

Accumulating studies have suggested that caesarean section increases the risk of allergic diseases, however, the causal relationship and the mechanism are unknown. In this study, by taking advantages of our caesarean section model mice, we investigated influences of caesarean section on gut microbiota and immune system development.

Academic Significance and Societal Importance of the Research Achievements

帝王切開とアレルギー感受性の関連が明らかになることで、有効な疾患制御法の開発に繋がる。例えば腸内細菌のバランス異常が原因であった場合、帝王切開出生児の腸内細菌のモニタリング、必要に応じてアレルギー感受性低下につながる細菌を投与することで発症を防ぐことができる可能性がある。また本研究によって、出生時点での環境が長期的な免疫系の発達に及ぼす影響の一端が明らかになった。

Research Products

• [Journal Article] Diet diurnally regulates SI microbiome-epithelial-immune homeostasis and enteritis (2020)
  • Author(s): Tuganbaev T, Mor U, Bashiardes S, Liwinski T, Nobs SP, Leshem A, Dori-Bachash M, Pinker EY, Ratiner K, Adlung L, Federici S, Kleimeyer C, Moresi C, Yamada T, Cohen Y, Massalha H, Massasa E, Kuperman Y, Koni PA, Harmelin A, Gao N, Itzkovitz S, Honda K, Shapiro H, Elinav E
  • Journal Title: Cell Volume: 182 Issue: 6 Pages: 1441-1459
  • DOI: 10.1016/j.cell.2020.08.027
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Mucin-Derived O-Glycans Act as Endogenous Fiber and Sustain Mucosal Immune Homeostasis via Short-Chain Fatty Acid Production in Rat Cecum (2020)
  • Author(s): Hino S, Mizushima T, Kaneko K, Kawai E, Kondo T, Genda T, Yamada T, Hase K, Nishimura N, Morita T
  • Journal Title: Journal of Nutrition Volume: 150 Issue: 10 Pages: 2656-2665
  • DOI: 10.1093/jn/nxaa097
  • Peer Reviewed
• [Journal Article] Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells (2020)
  • Author(s): Daisuke Takahashi, Naomi Hoshina, Yuma Kabumoto, Yuichi Maeda, Akari Suzuki, Hiyori Tanabe, Junya Isobe, Takahiro Yamada, Kisara Muroi, Yuto Yanagisawa, Atsuo Nakamura, ... Koji Hase
  • Journal Title: EBioMedicine Volume: 58 Pages: 102913-102913
  • DOI: 10.1016/j.ebiom.2020.102913
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 帝王切開が腸管免疫応答に与える影響の解明 (2021)
  • Author(s): 白鳥 弘明, 山田恭央, 永井基慈, 中村有孝, 木梨祐輔, 大貫公義, 大川拓眞, 河村由紀, 長谷耕二
  • Organizer: 第45回日本女性・栄養代謝学会学術集会／第10回日本DOHaD学会学術集会