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Prebirth cohort studies on the relationship between perinatal environmental factors and allergic diseases: from the view point of hygiene hypothesis

Research Project

Project/Area Number 20K23135
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section 0908:Society medicine, nursing, and related fields
Research InstitutionEhime University

Principal Investigator

Tokinobu Akiko  愛媛大学, 医学系研究科, 助教 (10758212)

Project Period (FY) 2020-09-11 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords小児アレルギー / 環境要因 / 出生前コーホート研究 / 衛生仮説 / 出生前コホート研究 / アレルギー疾患 / 疫学
Outline of Research at the Start

本研究では、1,757名の妊婦が参加し生まれた子を追跡している「九州・沖縄母子保健研究」(出生前コーホート研究)のデータを用いて、衛生仮説と関連する胎児期及び2歳時までの乳幼児期環境要因曝露と3歳時及び7歳時におけるアレルギー疾患(喘鳴、アトピー性皮膚炎、アレルギー性鼻炎、喘息、食物アレルギー)リスクとの関連について「衛生仮説」の視点から検討する。

Outline of Final Research Achievements

This study investigated the association between environmental factors during fetal or infant period and health outcomes of the children, using data from the Kyushu Okinawa Maternal and Child Health Study. We investigated the following three associations during the study period.
(1) Maternal use of induction heating cookers during pregnancy and birth outcomes (preterm birth, Low birth weight, small-for-gestational age, and birth weight), (2) Perinatal maternal hair dye use and risk of wheeze and asthma in 5-year-old children, (3) Bathing or showering frequency during infancy and risk of eczema and atopic dermatitis in 3-year-old children.
We have written and submitted the original articles in each study. As of 6 May 2022, the study (1) is already published, and the remaining two studies are under review.

Academic Significance and Societal Importance of the Research Achievements

本研究で調査した3つの環境要因曝露(①妊娠中のIHクッキングヒーターの使用(中間周波電磁界への曝露)、②周産期における母親の染髪の有無(染髪剤への曝露)、③乳児期の入浴頻度)と子の健康アウトカムとの関連についてはいずれも先行研究が少なくエビデンスが十分蓄積されていないため、影響の程度がよく分かっていなかった。我々の研究は、出生前コーホート研究のデータを用いた疫学研究であり、周産期の環境要因曝露とその影響に関する貴重なエビデンスとなり得る。

Report

(3 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • Research Products

    (4 results)

All 2021 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Remarks (1 results)

  • [Journal Article] Maternal Use of Induction Heating Cookers During Pregnancy and Birth Outcomes: The Kyushu Okinawa Maternal and Child Health Study2021

    • Author(s)
      Tokinobu Akiko、Tanaka Keiko、Arakawa Masashi、Miyake Yoshihiro
    • Journal Title

      Bioelectromagnetics

      Volume: - Issue: 4 Pages: 329-335

    • DOI

      10.1002/bem.22339

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Maternal consumption of soy and isoflavones during pregnancy and risk of childhood behavioural problems: the Kyushu Okinawa Maternal and Child Health Study2021

    • Author(s)
      Miyake Yoshihiro、Tanaka Keiko、Okubo Hitomi、Sasaki Satoshi、Tokinobu Akiko、Arakawa Masashi
    • Journal Title

      International Journal of Food Sciences and Nutrition

      Volume: 72 Issue: 8 Pages: 1118-1127

    • DOI

      10.1080/09637486.2021.1904844

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Maternal metal intake during pregnancy and childhood behavioral problems in Japan: the Kyushu Okinawa Maternal and Child Health Study2021

    • Author(s)
      Miyake Yoshihiro、Tanaka Keiko、Okubo Hitomi、Sasaki Satoshi、Tokinobu Akiko、Arakawa Masashi
    • Journal Title

      Nutritional Neuroscience

      Volume: - Issue: 8 Pages: 1-9

    • DOI

      10.1080/1028415x.2021.1885241

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Remarks] 愛媛大学大学院医学系研究科疫学・予防医学講座 主な実績

    • URL

      https://www.m.ehime-u.ac.jp/course/%e7%96%ab%e5%ad%a6%e3%83%bb%e4%ba%88%e9%98%b2%e5%8c%bb%e5%ad%a6/

    • Related Report
      2020 Research-status Report

URL: 

Published: 2020-09-29   Modified: 2023-01-30  

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