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Racial differences in neural networks related to understanding others

Research Project

Project/Area Number 20KK0206
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
Research InstitutionKanazawa University

Principal Investigator

Nakada Mitsutoshi  金沢大学, 医学系, 教授 (20334774)

Co-Investigator(Kenkyū-buntansha) 木下 雅史  金沢大学, 医学系, 講師 (50525045)
中嶋 理帆  金沢大学, 保健学系, 助教 (60614865)
Project Period (FY) 2020-10-27 – 2025-03-31
Project Status Completed (Fiscal Year 2024)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2024: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2023: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2022: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords覚醒下手術 / 感情理解 / メンタライジング / 社会的認知機能 / 画像統計解析 / 脳機能局在
Outline of Research at the Start

他者の感情や考え、行動を相手の表情やしぐさ、声の調子、さらに社会的背景などを加味して推測する能力を社会的認知機能という。 脳神経外科において、社会的認知機能を温存する手術法の確立が世界的課題となっている。本研究では、異なる人種間の“他者を理解する”脳内ネットワークの共通点と差異を明らかにし、世界標準の社会的認知機能温存型覚醒下手術を確立する。

Outline of Final Research Achievements

This study aimed to elucidate interethnic similarities and differences in the brain networks underlying social cognition and to establish a globally standardized awake brain surgery that preserves these functions. Through a combination of statistical neuroimaging, resting-state functional MRI, and intraoperative monitoring, we identified specific brain regions and subcortical networks involved in the understanding of joy and sadness. Notably, a trade-off relationship between the posterior prefrontal cortex and medial orbitofrontal cortex was revealed. We also developed an Asian version of the "Reading the Mind in the Eyes Test (RME-T)" in collaboration with international partners. Comparative analysis showed significantly lower performance in the Western version among Japanese participants. These findings underscore the importance of culturally adapted intraoperative assessments and support the development of surgical strategies tailored to diverse populations.

Academic Significance and Societal Importance of the Research Achievements

本研究は、社会的認知機能に関わる脳内ネットワークの人種間差異を明らかにし、脳機能を守る新たな手術法の確立に貢献した。感情理解に関与する脳領域を特定し、アジア版術中評価法も開発することで、国際的にも汎用可能な術式の基盤を築いた。これにより、脳腫瘍などの治療後も患者の社会性を保つ手術が可能となり、医療の質向上と国際医療の標準化に寄与する成果を上げた。

Report

(6 results)
  • 2024 Annual Research Report   Final Research Report ( PDF )
  • 2023 Research-status Report
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (68 results)

All 2024 2023 2022 2021 2020 Other

All Int'l Joint Research (4 results) Journal Article (16 results) (of which Peer Reviewed: 14 results,  Open Access: 12 results) Presentation (43 results) (of which Int'l Joint Research: 4 results,  Invited: 22 results) Book (2 results) Remarks (3 results)

  • [Int'l Joint Research] モンペリエ大学(フランス)

    • Related Report
      2024 Annual Research Report
  • [Int'l Joint Research] モンペリエ大学(フランス)

    • Related Report
      2023 Research-status Report
  • [Int'l Joint Research] モンペリエ大学(フランス)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] モンペリエ大学(フランス)

    • Related Report
      2021 Research-status Report
  • [Journal Article] 覚醒下手術2024

    • Author(s)
      中田光俊
    • Journal Title

      日本臨床 増刊号 臨床脳腫瘍学

      Volume: 増刊号 Pages: 351-355

    • Related Report
      2024 Annual Research Report
  • [Journal Article] 覚醒下手術による脳機能マッピングのコンセンサスと発展性2024

    • Author(s)
      中田光俊、中嶋理帆、木下雅史
    • Journal Title

      脳神経外科ジャーナル

      Volume: 33 Pages: 664-673

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed
  • [Journal Article] More widespread functionality of posterior language area in patients with brain tumors2024

    • Author(s)
      Nakajima R, Osada T, Kinoshita M, Ogawa A, Okita H, Konishi S, Nakada M
    • Journal Title

      Human Brain Mapping

      Volume: 45 Issue: 11

    • DOI

      10.1002/hbm.26801

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Postsurgical motor function and processing speed as predictors of quality of life in patients with chronic-phase glioblastoma2024

    • Author(s)
      Nakajima Riho、Kinoshita Masashi、Okita Hirokazu、Nakada Mitsutoshi
    • Journal Title

      Acta Neurochirurgica

      Volume: 166 Issue: 1 Pages: 357-357

    • DOI

      10.1007/s00701-024-06245-1

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predicting Postoperative Motor Function After Brain Tumor Resection With Motor Evoked Potential Monitoring Using Decision Tree Analysis2024

    • Author(s)
      Yuno Takeo、Nakade Yusuke、Nakada Mitsutoshi、Kinoshita Masashi、Nakata Masako、Nakagawa Shiori、Oe Hiroyasu、Mori Mika、Wada Takashi、Kanamori Hajime
    • Journal Title

      Cureus

      Volume: 16

    • DOI

      10.7759/cureus.74155

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mentalizing can be Impaired in Patients with Meningiomas Originating in the Anterior Skull Base2024

    • Author(s)
      Demura Munehiro、Nakajima Riho、Tanaka Shingo、Kinoshita Masashi、Nakada Mitsutoshi
    • Journal Title

      World Neurosurgery

      Volume: 182 Pages: e872-e881

    • DOI

      10.1016/j.wneu.2023.12.067

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 高次脳機能を温存する覚醒下手術―臨床的意義と神経科学―2023

    • Author(s)
      中田光俊
    • Journal Title

      医学のあゆみ

      Volume: 286 Pages: 714-717

    • Related Report
      2023 Research-status Report
  • [Journal Article] Glioblastomas at the white matter of temporo-parietal junction cause a poor postoperative independence level2023

    • Author(s)
      Nakajima Riho、Kinoshita Masashi、Okita Hirokazu、Nakada Mitsutoshi
    • Journal Title

      Journal of Neuro-Oncology

      Volume: 165 Issue: 1 Pages: 191-199

    • DOI

      10.1007/s11060-023-04479-0

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Two different subcortical language networks supporting distinct Japanese orthographies: morphograms and phonograms2022

    • Author(s)
      Tamai Sho、Kinoshita Masashi、Nakajima Riho、Okita Hirokazu、Nakada Mitsutoshi
    • Journal Title

      Brain Structure and Function

      Volume: 227 Issue: 3 Pages: 1145-1154

    • DOI

      10.1007/s00429-022-02454-5

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Posterior-prefrontal and medial orbitofrontal regions play crucial roles in happiness and sadness recognition2022

    • Author(s)
      Nakajima Riho、Kinoshita Masashi、Okita Hirokazu、Nakada Mitsutoshi
    • Journal Title

      NeuroImage: Clinical

      Volume: 35 Pages: 103072-103072

    • DOI

      10.1016/j.nicl.2022.103072

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recovery of Visual Field After Awake Stimulation Mapping of the Optic Pathway in Glioma Patients2022

    • Author(s)
      Ichinose Toshiya、Kinoshita Masashi、Nakajima Riho、Tanaka Shingo、Nakada Mitsutoshi
    • Journal Title

      Brain Topography

      Volume: 36 Issue: 1 Pages: 87-98

    • DOI

      10.1007/s10548-022-00922-z

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Simultaneous Damage of the Cingulate Cortex Zone II and Fronto-Striatal Circuit Causes Prolonged Selective Attentional Deficits2021

    • Author(s)
      Nakajima Riho、Kinoshita Masashi、Nakada Mitsutoshi
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 15 Pages: 762578-762578

    • DOI

      10.3389/fnhum.2021.762578

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quality of life following awake surgery depends on ability of executive function, verbal fluency, and movement2021

    • Author(s)
      Nakajima Riho、Kinoshita Masashi、Okita Hirokazu、Nakada Mitsutoshi
    • Journal Title

      Journal of Neuro-Oncology

      Volume: 156 Issue: 1 Pages: 173-183

    • DOI

      10.1007/s11060-021-03904-6

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Disconnection of posterior part of the frontal aslant tract causes acute phase motor functional deficit2021

    • Author(s)
      Nakajima Riho、Kinoshita Masashi、Okita Hirokazu、Shinohara Harumichi、Nakada Mitsutoshi
    • Journal Title

      Brain and Cognition

      Volume: 151 Pages: 105752-105752

    • DOI

      10.1016/j.bandc.2021.105752

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 左下頭頂小葉腫瘍に対する摘出術後に相貌変形視を呈した左利きの1例2021

    • Author(s)
      沖田浩一、福永真哉、中嶋理帆、木下雅史、中田光俊、八幡徹太郎
    • Journal Title

      高次脳機能研究

      Volume: 41 Pages: 368-376

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preserving Right Pre-motor and Posterior Prefrontal Cortices Contribute to Maintaining Overall Basic Emotion2021

    • Author(s)
      Nakajima Riho、Kinoshita Masashi、Okita Hirokazu、Liu Zhanwen、Nakada Mitsutoshi
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 15 Pages: 612890-612890

    • DOI

      10.3389/fnhum.2021.612890

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Awake surgery preserving higher cognitive function for brain tumors2024

    • Author(s)
      Nakada M
    • Organizer
      67th anniversary conference of Yonsei Neurosurgery
    • Related Report
      2024 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 覚醒下手術でモニタリング可能な脳機能2024

    • Author(s)
      中田光俊
    • Organizer
      山口脳腫瘍カンファレンスセミナー
    • Related Report
      2024 Annual Research Report
    • Invited
  • [Presentation] 脳腫瘍外科医による脳科学への挑戦2024

    • Author(s)
      中田光俊
    • Organizer
      第30回河田町脳神経外科懇話会
    • Related Report
      2024 Annual Research Report
    • Invited
  • [Presentation] 覚醒下手術の現在知2024

    • Author(s)
      中田光俊
    • Organizer
      Brain Tumor Expert Meeting
    • Related Report
      2024 Annual Research Report
    • Invited
  • [Presentation] 脳腫瘍外科から脳機能を考察する2024

    • Author(s)
      中田光俊
    • Organizer
      Neurosurgery Sharing Session
    • Related Report
      2024 Annual Research Report
    • Invited
  • [Presentation] Awake surgeryを起点とする脳科学研究2024

    • Author(s)
      中田光俊
    • Organizer
      第22回日本Awake Surgery学会
    • Related Report
      2024 Annual Research Report
    • Invited
  • [Presentation] 脳神経外科が解き明かす神経回路の特徴2024

    • Author(s)
      中田光俊
    • Organizer
      Neurosurgery Web Seminar
    • Related Report
      2024 Annual Research Report
    • Invited
  • [Presentation] Postoperative motor function and processing speed predict quality of life in patients with glioblastoma at chronic-phase2024

    • Author(s)
      Nakada M, Nakajima R, Kinoshita M
    • Organizer
      29th Annual Meeting and Education Day of the Society for Neuro-Oncology
    • Related Report
      2024 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 後方言語野ネットワークにおける機能シフトの解析2024

    • Author(s)
      中田光俊、中嶋理帆、木下雅史、長田貴宏、小川昭利、沖田浩一、小西清貴
    • Organizer
      第47回日本脳神経CI学会総会
    • Related Report
      2024 Annual Research Report
  • [Presentation] 覚醒下手術中の視空間認知機能マッピング陽性所見を認める脳内ネットワークの特徴2024

    • Author(s)
      中田光俊、中嶋理帆、木下雅史
    • Organizer
      第29回日本脳腫瘍の外科学会
    • Related Report
      2024 Annual Research Report
  • [Presentation] 高次脳機能温存型覚醒下手術の適応2024

    • Author(s)
      中田光俊、中嶋理帆、木下雅史
    • Organizer
      日本脳神経外科学会 第83回学術総会
    • Related Report
      2024 Annual Research Report
  • [Presentation] 高次脳機能局在と大脳ネットワーク研究のすすめ2023

    • Author(s)
      中田光俊
    • Organizer
      第37回臨床高次脳機能研究会えひめ
    • Related Report
      2023 Research-status Report
    • Invited
  • [Presentation] 高次脳機能局在と大脳ネットワーク2023

    • Author(s)
      中田光俊
    • Organizer
      第7回脳腫瘍学会Webinar講演会
    • Related Report
      2023 Research-status Report
    • Invited
  • [Presentation] 機能温存のための大脳機能ネットワークの理解2023

    • Author(s)
      中田光俊
    • Organizer
      東北大学講演会『脳内ネットワーク -臨床と研究の最前線-』
    • Related Report
      2023 Research-status Report
    • Invited
  • [Presentation] 脳神経外科医に必要な大脳機能局在の理解2023

    • Author(s)
      中田光俊
    • Organizer
      兵庫脳神経外科手術手技セミナー
    • Related Report
      2023 Research-status Report
    • Invited
  • [Presentation] 悪性脳腫瘍の最先端手術:脳機能の可視化と機能温存2023

    • Author(s)
      中田光俊
    • Organizer
      第130回慶應義塾大学医学部生涯教育研修セミナー
    • Related Report
      2023 Research-status Report
    • Invited
  • [Presentation] 脳神経外科医が紡ぎだす脳科学と大脳の理解2023

    • Author(s)
      中田光俊
    • Organizer
      北海道脳腫瘍セミナー
    • Related Report
      2023 Research-status Report
    • Invited
  • [Presentation] 脳腫瘍外科から神経ネットワークを考える2023

    • Author(s)
      中田光俊
    • Organizer
      第24回Skill-building Neurosurgical Conference
    • Related Report
      2023 Research-status Report
    • Invited
  • [Presentation] グリオーマと高次脳機能障害2023

    • Author(s)
      中田光俊
    • Organizer
      第7回日本脳神経外科認知症学会学術総会
    • Related Report
      2023 Research-status Report
    • Invited
  • [Presentation] 脳機能ネットワークの新しい理解と脳腫瘍手術2023

    • Author(s)
      中田光俊
    • Organizer
      第12回 劒ニューロオンコロジーセミナー
    • Related Report
      2023 Research-status Report
    • Invited
  • [Presentation] Glioblastomas located in the right inferior parietal lobe causes a poor postoperative performance level.2023

    • Author(s)
      Nakada M, Nakajima R, Okita H, Kinoshita M
    • Organizer
      Society for Neuro-Oncology 28th Annual Meeting 2023
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] 覚醒下手術による脳機能マッピングのコンセンサスと発展性2023

    • Author(s)
      中田光俊
    • Organizer
      第43回日本脳神経外科コングレス総会
    • Related Report
      2023 Research-status Report
  • [Presentation] 右前頭葉グリオーマに対する高次脳機能温存を狙った覚醒下手術2023

    • Author(s)
      中田光俊、中嶋理帆、沖田浩一、木下雅史
    • Organizer
      日本脳神経外科学会 第82回学術総会
    • Related Report
      2023 Research-status Report
  • [Presentation] 高次脳機能を温存する前頭葉グリオーマの摘出術2022

    • Author(s)
      中田光俊
    • Organizer
      第31回脳神経外科手術と機器学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 現代脳神経外科医療の進歩2022

    • Author(s)
      中田光俊
    • Organizer
      第37回小矢部川メディカルカンファレンス
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 白質神経ネットワークの規則性と可塑性2022

    • Author(s)
      中田光俊
    • Organizer
      第42回日本脳神経外科コングレス総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 脳機能局在と機能シフトの理解に基づく脳腫瘍手術2022

    • Author(s)
      中田光俊
    • Organizer
      第35回多摩脳腫瘍研究会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 脳腫瘍摘出術後の高次脳機能低下に対する認知予備力の影響2022

    • Author(s)
      中田光俊、中嶋理帆、木下雅史、松井三枝
    • Organizer
      第6回日本脳神経外科認知症学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 非優位半球grade 2, 3グリオーマに対する高次脳機能温存を目的とした覚醒下手術:手術の工夫と有用性の検証2022

    • Author(s)
      中田光俊、中嶋理帆、沖田浩一,木下雅史
    • Organizer
      第20回日本Awake Surgery学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 意識の局在はどこか2022

    • Author(s)
      中田光俊、中嶋理帆
    • Organizer
      第30回日本意識障害学会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 背側上縦束の圧迫変位を認める右前頭葉グリオーマ症例では視空間認知機能温存に覚醒下モニタリングが有用である2022

    • Author(s)
      中田光俊、中嶋理帆、沖田浩一、木下雅史
    • Organizer
      第27回日本脳腫瘍の外科学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 脳機能マッピング・覚醒下手術最前線2022

    • Author(s)
      中田光俊、中嶋理帆、沖田浩一、木下雅史
    • Organizer
      第27回日本脳腫瘍の外科学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 右前頭葉グリオーマ摘出に起因する視空間認知機能障害を回避するための方策2022

    • Author(s)
      中田光俊、中嶋理帆、沖田浩一、木下雅史
    • Organizer
      日本脳神経外科学会 第81回学術総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 覚醒下手術を起点とする脳科学研究2022

    • Author(s)
      中田光俊
    • Organizer
      e-casebook Web lecture
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 高次脳機能温存のための白質解剖2021

    • Author(s)
      中田光俊
    • Organizer
      第41回日本脳神経外科コングレス総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 脳腫瘍治療における脳機能を守り抜く戦い2021

    • Author(s)
      中田光俊
    • Organizer
      最新のグリオーマの治療戦略
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 視空間認知と作業記憶の温存を意図した右前頭葉グリオーマ摘出時の不可侵領域の策定2021

    • Author(s)
      中田光俊、中嶋理帆、沖田浩一、木下雅史
    • Organizer
      第26回日本脳腫瘍の外科学会
    • Related Report
      2021 Research-status Report
  • [Presentation] Preservation of deep posterior part of the middle frontal gyrus and cingulate gyrus zone II prevents visuospatial cognition and working memory impairment during right frontal glioma surgery2021

    • Author(s)
      Nakada M, Nakajima R, Kinoshita M
    • Organizer
      2021 CNS Annual Meeting
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 右前頭葉グリオーマ摘出術後に視空間認知機能障害をきたす背側上縦束責任領域の同定2021

    • Author(s)
      中田光俊、中嶋理帆、沖田浩一、木下雅史
    • Organizer
      日本脳神経外科学会 第80回学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 覚醒下マッピングによる言語機能シフトの特徴と解剖学的メカニズムに関する考察2021

    • Author(s)
      中田光俊、中嶋理帆、沖田浩一、木下雅史、篠原治道
    • Organizer
      日本脳神経外科学会 第80回学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 術後経過にみるグリオーマ手術のありかた2021

    • Author(s)
      中田光俊
    • Organizer
      第39回日本脳腫瘍学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 悪性グリオーマに対する臨床の光と影2020

    • Author(s)
      中田光俊
    • Organizer
      第23回日本臨床脳神経外科学会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 右前頭葉グリオーマに対する高次脳機能温存型覚醒下手術の機能予後2020

    • Author(s)
      中田光俊
    • Organizer
      日本脳神経外科学会第79回学術総会
    • Related Report
      2020 Research-status Report
  • [Book] 脳機能 入門2023

    • Author(s)
      中田光俊
    • Total Pages
      255
    • Publisher
      メディカ出版
    • Related Report
      2023 Research-status Report
  • [Book] Intraoperative Mapping of Cognitive Networks2021

    • Author(s)
      Emmanuel MandonnetGuillaume Herbet
    • Publisher
      Springer
    • ISBN
      9783030750701
    • Related Report
      2021 Research-status Report
  • [Remarks] 金沢大学脳神経外科

    • URL

      https://neurosurgery.w3.kanazawa-u.ac.jp/j/

    • Related Report
      2024 Annual Research Report 2020 Research-status Report
  • [Remarks]

    • URL

      https://neurosurgery.w3.kanazawa-u.ac.jp/j/

    • Related Report
      2023 Research-status Report
  • [Remarks]

    • URL

      https://neurosurgery.w3.kanazawa-u.ac.jp/j/

    • Related Report
      2021 Research-status Report

URL: 

Published: 2020-10-29   Modified: 2026-01-16  

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