Non-standard peptide-probe discovery

• Project/Area Number: 21000005
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering; Chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: SUGA Hiroaki 東京大学, 大学院・理学系研究科, 教授 (00361668)
• Co-Investigator(Kenkyū-buntansha): 内匠 透 広島大学, 医歯(薬)学総合研究科, 教授 (00222092)
• Project Period (FY): 2009 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥314,080,000 (Direct Cost: ¥241,600,000、Indirect Cost: ¥72,480,000); Fiscal Year 2013: ¥78,520,000 (Direct Cost: ¥60,400,000、Indirect Cost: ¥18,120,000); Fiscal Year 2012: ¥78,520,000 (Direct Cost: ¥60,400,000、Indirect Cost: ¥18,120,000); Fiscal Year 2011: ¥78,520,000 (Direct Cost: ¥60,400,000、Indirect Cost: ¥18,120,000); Fiscal Year 2010: ¥78,520,000 (Direct Cost: ¥60,400,000、Indirect Cost: ¥18,120,000)
• Keywords: 天然物有機化学 / 生理活性物質 / 生体高分子 / 生化学 / ケミカルバイオロジー / ペプチド / RNA / タンパク質合成 / 特殊ペプチド / 創薬 / 翻訳 / 遺伝暗号 / リボザイム / 天然物 / 生合成

Research Abstract

This research project aims at developing the genetic code reprogramming technology based on the flexizyme system and expressing natural product-like macrocyclic peptides from mRNA libraries. Moreover, an in vitro display system, referred to RaPID (Random nonstandard Peptide Integrated Discovery) system, has been established to apply for massive screenings of macrocyclic peptides generated by the above technology. This has enabled us to discover molecular probes against various drug targets, leading to a new era of chemical biology.

Assessment Rating

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Research Products

• [Journal Article] One-pot synthesis of azoline-containing peptides in a cell-free translation system integrated with a posttranslational cyclodehydratase SIRT2 (2014)
  • Author(s): Y. Goto, Y. Ito, Y. Kato, S. Tsunoda, H. Suga
  • Journal Title: Chemistry and Biology Volume: (in press)
  • Peer Reviewed
• [Journal Article] An orthogonal ribosome-tRNAs pair via the engineering of peptidyl transferase center (2014)
  • Author(s): N. Terasaka, G. Hayashi1, T. Katoh, and H. Suga
  • Journal Title: Nature Chemical Biology Volume: (in press)
  • NAID: 120006348461
  • Peer Reviewed
• [Journal Article] Selection-based discovery of druglike macrocyclic peptides (2014)
  • Author(s): T. Passioura, T. Katoh, Y. Goto, H. Suga
  • Journal Title: Selection-based discovery of druglike macrocyclic peptides Volume: (in press)
  • Peer Reviewed
• [Journal Article] Protein cocrystallization molecules originating from in vitro selected macrocyclic peptides (2014)
  • Author(s): C.J. Hipolito, N.K. Bashiruddin, H. Suga
  • Journal Title: Current Opinion in Structural Biology Volume: 26 Pages: 24-31
  • DOI: 10.1016/j.sbi.2014.03.001
  • Peer Reviewed
• [Journal Article] Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog (2014)
  • Author(s): A. Kodan, T. Yamaguchi, T. Nakatsu, K. Sakiyama, C.J. Hipolito, A. Fujioka, R. Hirokane, K. Ikeguchi, B. Watanabe,J. Hiratake, Y. Kimura, H. Suga, K. Ueda, H. Kato
  • Journal Title: Pro. Nat. Acad. Sci Volume: 111 Pages: 4049-4054
  • Peer Reviewed
• [Journal Article] Structural Basis for Potent Inhibition of SIRT2 Deacetylase by a Macrocyclic Peptide Inducing Dynamic Structural Change (2014)
  • Author(s): K. Yamagata, Y. Goto, H. Nishimasu, J. Morimoto, R. Ishitani, N. Dohmae, N. Takeda, R. Nagai, I. Komuro, H. Suga, O. Nureki
  • Journal Title: Structure Volume: 22 Pages: 345-352
  • Peer Reviewed
• [Journal Article] Flexizymes-facilitated genetic code reprogramming leading to the discovery of drug-like peptides (2014)
  • Author(s): N. Terasaka, H. Suga
  • Journal Title: Chemistry Letters Volume: 43 Pages: 11-19
  • NAID: 130004427082
  • Peer Reviewed
• [Journal Article] One-pot synthesis of azoline-containing peptides in a cell-free translation system integrated with a posttranslational cyclodehydratase (2014)
  • Author(s): Y. Goto, Y. Ito, Y. Kato, S. Tsunoda, H. Suga*
  • Journal Title: Chemistry and Biology Volume: (in press)(未確定)
  • Peer Reviewed
• [Journal Article] An orthogonal ribosome-tRNAs pair via the engineering of peptidyl transferase center (2014)
  • Author(s): N. Terasaka, G. Hayashil, T. Katoh, and H. Suga
  • Journal Title: Nature Chemical Biology Volume: (in press)(未確定)
  • NAID: 120006348461
  • Peer Reviewed
• [Journal Article] Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog (2014)
  • Author(s): A. Kodan, T. Yamaguchi, T. Nakatsu, K. Sakiyama, C. J. Hipolito, A. Fujioka, R. Hirokane, K. Ikeguchi, B. Watanabe, J. Hiratake, Y. Kimura, H. Suga, K. Ueda, H. Kato
  • Journal Title: Pro. Nat. Acad. Sci. Volume: 111(未確定) Pages: 4049-4054
  • Peer Reviewed
• [Journal Article] Selection-based discovery of druglike macrocyclic peptides (2014)
  • Author(s): T. Passioura, T. Katoh, Y. Goto, H. Suga
  • Journal Title: Annual Review in Biochemistry Volume: (in press)(未確定)
  • Peer Reviewed
• [Journal Article] Non-standard peptide expression under the genetic code consisting of reprogrammed dual sense codons (2013)
  • Author(s): Y. Goto, M. Iseki, A. Hitomi, H. Murakami, and H. Suga
  • Journal Title: ACS Chemical Biology Volume: 8 Issue: 12 Pages: 266-719
  • DOI: 10.1021/cb400549p
  • Peer Reviewed
• [Journal Article] A macrocyclic peptide that serves as a cocrystallization ligand and inhibits the function of a MATE family transporte (2013)
  • Author(s): C・J・ Hipolito, Y・Tanaka, T・ Katoh, O・ Nureki, H・ Suga
  • Journal Title: Molecules Volume: 18 Issue: 9 Pages: 10514-30
  • DOI: 10.3390/molecules180910514
  • Peer Reviewed
• [Journal Article] Structural basis for the drug extrusion mechanism by a MATE multidrug transporter (2013)
  • Author(s): Y. Tanaka, C.J. Hipolito, A.D. Maturana, K. Ito, T. Kuroda, T. Higuchi, T. Katoh, H.E. Kato, M. Hattori, K. Kumazaki, T. Tsukazaki, R. Ishitani, H. Suga, O. Nureki
  • Journal Title: Nature Volume: 496 Issue: 21 Pages: 247-251
  • DOI: 10.1002/chem.201300247
  • NAID: 120005716854
  • Peer Reviewed
• [Journal Article] In Vitro Selection of Multiple Libraries Created by Genetic Code Reprogramming To Discover Macrocyclic Peptides That Antagonize VEGFR2 Activity in Living Cells (2013)
  • Author(s): T. Kawakami, T. Ishizawa, T. Fujino, P.C. Reid, H. Suga, H. Murakami
  • Journal Title: ACS Chemical Biology Volume: 8 Issue: 6 Pages: 1205-1514
  • DOI: 10.1021/cb300697h
  • Peer Reviewed
• [Journal Article] Technologies for the Synthesis of mRNA-Encoding Libraries and Discovery of Bioactive Natural Product-Inspired Non-Traditional Macrocyclic Peptides (2013)
  • Author(s): Kenichiro Ito, Toby Pass ioura. Hiroaki Suga
  • Journal Title: Molecules Volume: 18 Issue: 3 Pages: 3502-3528
  • DOI: 10.3390/molecules18033502
  • Peer Reviewed
• [Journal Article] Reevaluation of the D-amino acid compatibility with the elongation event in translation (2013)
  • Author(s): T. Fujino, Y. Goto, H. Suga, H. Murakami
  • Journal Title: Journal of American Chemical Society Volume: 135 Issue: 5 Pages: 1830-1837
  • DOI: 10.1021/ja309570x
  • Peer Reviewed
• [Journal Article] Distinct tRNA recognition strategies used by a homologous family of editing domains prevent mistranslation (2013)
  • Author(s): M. Das, O. Vargas-Rodriguez, Y. Goto, H. Suga, K. Museir-Forsyth
  • Journal Title: Nucleic Acids Research Volume: 未確定 Issue: 6 Pages: 3943-3953
  • DOI: 10.1093/nar/gkt1332
  • Peer Reviewed
• [Journal Article] Structural basis for the drug extrusion mechanism by a MATE multidrug transporter (2013)
  • Author(s): Y・ Tanaka, C・J・ Hipolito, A・D・ Maturana, K・ Ito, T・ Kuroda, T・ Higuchi, T・ Katoh, H・E・ Kato, M・ Hattori, K・ Kumazaki, T・ Tsukazaki, R・ Ishitani, H・ Suga, O・ Nureki
  • Journal Title: Nature Volume: 496 Issue: 7444 Pages: 247-51
  • DOI: 10.1038/nature12014
  • Peer Reviewed
• [Journal Article] In Vitro Selection of Anti-Akt2 Thioether-Macrocyclic Peptides Leading to Isoform- Selective Inhibitors (2012)
  • Author(s): Y. Hayashi, J. Morimoto, H. Suga*
  • Journal Title: ACS Chemical Biology Volume: 7 Pages: 607-613
• [Journal Article] Discovery of Macrocyclic Peptides Armed with a Mechanism-Based Warhead : Isoform-Selective Inhibition of Human Deacetylase SIRT2 (2012)
  • Author(s): Morimoto, J.: Hayashi, Y., Suga, H.
  • Journal Title: Angewandte Chemie International Edition Volume: (In press) Issue: 14 Pages: 3423-3427
  • DOI: 10.1002/anie.201108118
  • Peer Reviewed
• [Journal Article] Ribosomal production and in vitro selection of natural product-like peptidomimetics: The FIT and RaPID systems (2012)
  • Author(s): C. J. Hipolito, H. Suga*
  • Journal Title: Current Opinion in Chemical Biology Volume: 16 Pages: 196-203
• [Journal Article] Selective thioether macrocyclization of peptides having the N-terminal 2-chloroacetyl group and competing two or three cysteine residues in translation (2012)
  • Author(s): Kazuhiro Iwasaki, Yuki Goto, Takayuki Katoh, Hiroaki Suga
  • Journal Title: Org.Biomol.Chem. Volume: 10 Issue: 30 Pages: 5783-5786
  • DOI: 10.1039/c2ob25306b
  • Peer Reviewed
• [Journal Article] In Vitro Selection of Anti-Akt2 Thioether-Macrocyclic Peptides Leading to Isoform-Selective Inhibitors (2012)
  • Author(s): Hayashi, Y.; Morimoto, J.: Suga, H.
  • Journal Title: ACS Chemical Biology Volume: 7 Issue: 3 Pages: 607-613
  • DOI: 10.1021/cb200388k
  • Peer Reviewed
• [Journal Article] Flexizymes for genetic code reprogramming (2011)
  • Author(s): Y.Goto, T.Katoh, H.Suga
  • Journal Title: Nature Protocols Volume: 6 Issue: 6 Pages: 779-790
  • DOI: 10.1038/nprot.2011.331
  • Peer Reviewed
• [Journal Article] Ribosomal synthesis of backbone-macrocyclic peptides containing γ-amino acids (2011)
  • Author(s): Y.Ohshiro, E.Nakajima, Y.Goto, S.Fuse, T.Takahashi, T.Doi, H.Suga
  • Journal Title: ChemBioChem Volume: 12 Issue: 8 Pages: 1183-1187
  • DOI: 10.1002/cbic.201100104
  • Peer Reviewed
• [Journal Article] Small-molecule inhibitor binding to an N-acyl-homoserine lactone synthase (2011)
  • Author(s): J.Chung, E.Goo, S.Yu, O.Choi, J.Lee, J.Kim, H.Kim, J.Igarashi, H.Suga
  • Journal Title: Pro.Nat.Acad.Sci. Volume: 108(29) Issue: 29 Pages: 12089-12094
  • DOI: 10.1073/pnas.1103165108
  • Peer Reviewed
• [Journal Article] Apolar surface area determines the efficiency of translocon-mediated membrane-protein integration into the endoplasmic reticulum (2011)
  • Author(s): K.Ojemalm, T.Higuchi, Y.Jiang, U.Langel, I.Nilsson, S.H.White, H.Suga*, G.von Heijne
  • Journal Title: Pro.Nat.Acad.Sci. Volume: 108(31) Issue: 31
  • DOI: 10.1073/pnas.1100120108
  • Peer Reviewed
• [Journal Article] Flexizymes : Their Evolutionary History and the Origin of Catalytic Function (2011)
  • Author(s): Morimoto, J.; Hayashi, Y.; K.Iwasaki, K.; Suga, H.
  • Journal Title: Accounts of Chemical Research Volume: 44 Issue: 12 Pages: 1359-1368
  • DOI: 10.1021/ar2000953
  • Peer Reviewed
• [Journal Article] Ribosomal synthesis of backbone macrocyclic peptides (2011)
  • Author(s): T.Katoh, Y.Goto, S.Raza, H.Suga*
  • Journal Title: Chemical Communication Volume: 47 Issue: 36 Pages: 9946-9958
  • DOI: 10.1039/c1cc12647d
  • Peer Reviewed
• [Journal Article] Natural product-like macrocyclic N-methyl-peptide inhibitors against a ubiquitin ligase uncovered from a ribosome-expressed de novo library (2011)
  • Author(s): Y.Yamagishi, I.Shoji, S.Miyagawa, T.Kawakami, T.Katoh, Y.Goto, H.Suga*
  • Journal Title: Chemistry & Biology Volume: 18 Issue: 12 Pages: 1562-1570
  • DOI: 10.1016/j.chembiol.2011.09.013
  • Peer Reviewed
• [Journal Article] Synthesis of a backbone-cyclic peptide SFTI-1 promoted by the induced peptidyl-tRNA drop-off (2011)
  • Author(s): T.-J.Kang, Y.Hayashi, H.Suga
  • Journal Title: Angewandte Chemie International Edition Volume: 50 Pages: 2159-2161
  • Peer Reviewed
• [Journal Article] ペプチド医薬品開発の新基盤技術『RaPIDシステム』 (2011)
  • Author(s): 下舞大・後藤佑樹・菅裕明
  • Journal Title: 化学工業 Volume: 62 Pages: 109-115
• [Journal Article] Ribosome evolution for two artificial amino acids in E.coli (2010)
  • Author(s): G.Hayashi, Y.Goto, H.Suga
  • Journal Title: Chemistry&Biology Volume: 17 Pages: 320-321
• [Journal Article] Engineering of the redox ribozyme for the determination of its architechure. (2010)
  • Author(s): S.B.Pattnaik, K.Jin, K.Futai, H.Suga
  • Journal Title: Chemistry Letters Volume: 39 Pages: 786-787
  • Peer Reviewed
• [Journal Article] RaPIDシステムが拓く新創薬戦略 (2010)
  • Author(s): 後藤佑樹、伊東利紗、菅裕明
  • Journal Title: MEDCHEM NEWS Volume: 4 Pages: 26-31
  • NAID: 130007944543
• [Journal Article] RaPIDシステムによる特殊ペプチド薬剤の探索 (2010)
  • Author(s): 飯田健夫・菅裕明
  • Journal Title: フロンティア22:生命現象を理解する分子ツール Pages: 71-76
• [Journal Article] 特殊環状ペプチドの翻訳合成と医薬品探索への展開 (2010)
  • Author(s): 林剛介・大城幸紀・菅裕明
  • Journal Title: 生化学 Volume: 6 Pages: 505-514
  • NAID: 10026899979
• [Journal Article] 擬天然物特殊ペプチドのプログラム翻訳合成と応用 (2010)
  • Author(s): 菅裕明・樋口岳
  • Journal Title: 有機合成化学協会誌 Volume: 68 Pages: 217-227
  • NAID: 10026868150
• [Journal Article] Diverse backbone-cyclized peptides via codon reprogramming (2009)
  • Author(s): T.Kawakami, A.Ohta, M.Ohuchi, H.Ashigai, H.Murakami, H.Suga
  • Journal Title: Nature Chemical Biology 5 Pages: 888-890
  • Peer Reviewed
• [Journal Article] A flexizyme that selectively charges amino acids activated by a water-friendly leaving group (2009)
  • Author(s): N.Niwa, Y.Yamagishi, H.Murakami, H.Suga
  • Journal Title: Bioorganic Medicinal Chemistry Letter 19 Pages: 3892-3894
  • Peer Reviewed
• [Journal Article] Ribosomal synthesis of dehydrobutyrine- and methyllanthionine-containing peptides (2009)
  • Author(s): Y.Goto, K.Iwasaki, K.Torikai, H.Murakami, H.Suga
  • Journal Title: Chemical Communication Pages: 3419-3421
  • Peer Reviewed
• [Journal Article] Ribosomal synthesis of cyclic peptides with a fluorogenic oxidative coupling reaction (2009)
  • Author(s): Y.Yamagishi, H.Ashigai, Y.Goto, H.Murakami, H.Suga
  • Journal Title: ChemBioChem 10 Pages: 1469-1472
  • Peer Reviewed
• [Journal Article] Ribosomal synthesis of peptides with C-terminal lactams, thiolactones, and alkylamides (2009)
  • Author(s): E.Nakajima, Y.Goto, Y.Sako, H.Murakami, H.Suga
  • Journal Title: ChemBioChem 10 Pages: 1186-1192
  • Peer Reviewed
• [Journal Article] Translation initiation with initiator tRNA charged with exotic peptides (2009)
  • Author(s): Y.Goto, H.Suga
  • Journal Title: Journal of the American Chemical Society 131 Pages: 5040-5041
  • Peer Reviewed
• [Journal Article] Bases in the anticodon loop of tRNA(GGC)(Ala)prevent misreading (2009)
  • Author(s): H.Murakami, A.Ohta, H.Suga
  • Journal Title: Nature Structural & Molecular Biology 16 Pages: 353-358
  • Peer Reviewed
• [Presentation] 擬天然物の新機能創出分子技術 (2014)
  • Author(s): 菅 裕明
  • Organizer: 日本化学会第94春期年会「社会持続的発展のための分子技術」
  • Place of Presentation: 名古屋大学東山キャンパス(名古屋市)(招待講演)
  • Year and Date: 2014-03-29
• [Presentation] 擬天然物の新機能創出分子技術 (2014)
  • Author(s): Hiroaki Suga
  • Organizer: 日本化学会第94春期年会「社会持続的発展のための分子技術」
  • Place of Presentation: 名古屋大学東山キャンパス(名古屋市)
  • Year and Date: 2014-03-29
  • Invited
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2014)
  • Author(s): 菅 裕明
  • Organizer: AsiaTIDES, 2.Plenary Lecture
  • Place of Presentation: シェラトン都ホテル東京(東京都港区)(招待講演)
  • Year and Date: 2014-02-25
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2014)
  • Author(s): Hiroaki Suga
  • Organizer: AsiaTIDES, 2. Plenary Lecture
  • Place of Presentation: シェラトン都ホテル東京(東京都港区)
  • Year and Date: 2014-02-25
  • Invited
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): 菅 裕明
  • Organizer: Korean Peptide Protein Society Meeting
  • Place of Presentation: Seoul National University (Seoul, Korea)(招待講演)
  • Year and Date: 2013-11-29
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): Hiroaki Suga
  • Organizer: Korean Peptide Protein Society Meeting
  • Place of Presentation: Seoul National University (Seoul, Korea)
  • Year and Date: 2013-11-29
  • Invited
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): 菅 裕明
  • Organizer: Basel Chemical Society Lectureship
  • Place of Presentation: Medicinal Chemistry Navartis Institute (Basel, Switzerland)(招待講演)
  • Year and Date: 2013-10-24
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): Hiroaki Suga
  • Organizer: Basel Chemical Society Lectureship
  • Place of Presentation: Medicinal Chemistry Navartis Institute (Basel, Switzerland)
  • Year and Date: 2013-10-24
  • Invited
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): 菅 裕明
  • Organizer: RiboClub
  • Place of Presentation: Hotel Cheribourg (Quebec,Canada)(招待講演)
  • Year and Date: 2013-09-22
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): Hiroaki Suga
  • Organizer: RiboClub
  • Place of Presentation: Hotel Cheribourg (Quebec, Canada)
  • Year and Date: 2013-09-22
  • Invited
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): 菅 裕明
  • Organizer: Biochemistry Seminar of University of Colorado BioFrontier Institute
  • Place of Presentation: Univerity of Colorado (Boulder, USA)(招待講演)
  • Year and Date: 2013-09-11
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): Hiroaki Suga
  • Organizer: Biochemistry Seminar of University of Colorado, BioFrontier Institute
  • Place of Presentation: Univerity of Colorado (Boulder, USA)
  • Year and Date: 2013-09-11
  • Invited
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): 菅 裕明
  • Organizer: Lilly Distinguished Lecturer at Colorado State University
  • Place of Presentation: Colorado State University (Fort Collins, US)(招待講演)
  • Year and Date: 2013-09-10
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): Hiroaki Suga
  • Organizer: Lilly Distinguished Lecturer at Colorado State University
  • Place of Presentation: Colorado State University (Fort Collins, US)
  • Year and Date: 2013-09-10
  • Invited
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): 菅 裕明
  • Organizer: ACS National Meeting
  • Place of Presentation: Indiana Convention Center (Indianapolis, USA)(招待講演)
  • Year and Date: 2013-09-09
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): Hiroaki Suga
  • Organizer: ACS National Meeting
  • Place of Presentation: Indiana Convention Center (Indianapolis, USA)
  • Year and Date: 2013-09-09
  • Invited
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): 菅 裕明
  • Organizer: American Peptide Symposium 2013
  • Place of Presentation: Hilton Waikoloa Village (Hawaii, USA)(招待講演)
  • Year and Date: 2013-06-23
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): Hiroaki Suga
  • Organizer: American Peptide Symposium 2013
  • Place of Presentation: Hilton Waikoloa Village (Hawaii, USA)
  • Year and Date: 2013-06-23
  • Invited
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): 菅 裕明
  • Organizer: Gordon Research Conference, Bioorganic Chemistry
  • Place of Presentation: Proctor Academy (New Hampshire, USA)(招待講演)
  • Year and Date: 2013-06-13
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): Hiroaki Suga
  • Organizer: Gordon Research Conference, Bioorganic Chemistry
  • Place of Presentation: Proctor Academy (New Hampshire, USA)
  • Year and Date: 2013-06-13
  • Invited
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): 菅 裕明
  • Organizer: 5th Gratama Workshop
  • Place of Presentation: 東京工業大学大岡山キャンパス(東京都目黒区)(招待講演)
  • Year and Date: 2013-05-30
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): Hiroaki Suga
  • Organizer: 5th Gratama Workshop
  • Place of Presentation: 東京工業大学大岡山キャンパス(東京都目黒区)
  • Year and Date: 2013-05-30
  • Invited
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): 菅 裕明
  • Organizer: RIKEN-Max Planc Joint Symposium
  • Place of Presentation: 理化学研究所和光研究所(埼玉県和光市)(招待講演)
  • Year and Date: 2013-04-16
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): Hiroaki Suga
  • Organizer: RIKEN-Max Planc Joint Symposium
  • Place of Presentation: 理化学研究所和光研究所(埼玉県和光市)
  • Year and Date: 2013-04-16
  • Invited
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): 菅 裕明
  • Organizer: Symposium on Foldamers
  • Place of Presentation: Les Cordeliers Conference Centre(Paris, France)(招待講演)
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): 菅 裕明
  • Organizer: Keynote Lecture Symposium on Chemoselective Reactions for the Synthesis and Application
  • Place of Presentation: Max Planc Institute (Dortmund, Germany)(招待講演)
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): 菅 裕明
  • Organizer: International Conference on Structural Genomics2013, Structural Life Science
  • Place of Presentation: 京王プラザホテル(北海道札幌)(招待講演)
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): 菅 裕明
  • Organizer: Current Strategy for Development of Biopharmaceuticals and Small Molecule Drugs
  • Place of Presentation: 北海道大学(北海道札幌)(招待講演)
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): 菅 裕明
  • Organizer: "Jokichi Takamine" 130 years of Glasgow-Japan Collaboration
  • Place of Presentation: University of Glasgow (Glasgow, UK)(招待講演)
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): 菅 裕明
  • Organizer: Solvay Conference of "New Chemistry and New Opportunities from the Expanding Protein Universe"
  • Place of Presentation: International Solvay Institute (Brussels, Belgium)(招待講演)
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): Hiroaki Suga
  • Organizer: Symposium on Foldamers
  • Place of Presentation: Les Cordeliers Conference Centre (Paris, France)
  • Invited
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): Hiroaki Suga
  • Organizer: Keynote Lecture, Symposium on Chemoselective Reactions for the Synthesis and Application
  • Place of Presentation: Max Planc Institute (Dortmund, Germany)
  • Invited
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): Hiroaki Suga
  • Organizer: International Conference on Structural Genomics 2013, Structural Life Science
  • Place of Presentation: 京王プラザホテル(北海道札幌)
  • Invited
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): Hiroaki Suga
  • Organizer: Current Strategy for Delopment of Biopharmaceuticals and Small Molecule Drugs
  • Place of Presentation: 北海道大学(北海道札幌)
  • Invited
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): Hiroaki Suga
  • Organizer: "Jokichi Takamine" 130 years of Glasgow-Japan Collaboration
  • Place of Presentation: University of Glasgow (Glasgow, UK)
  • Invited
• [Presentation] Discovery of natural product-like petides accerelated by RaPID system (2013)
  • Author(s): Hiroaki Suga
  • Organizer: Solvay Conference of "New Chemistry and New Opportunities from the Expanding Protein Universe"
  • Place of Presentation: International Solvay Institute (Brussels, Belgium)
  • Invited
• [Presentation] The non-traditional peptide therapeutics (2013)
  • Author(s): 菅 裕明
  • Organizer: Discovery Chemistry Congress
  • Place of Presentation: Munich, Germany
  • Invited
• [Presentation] Genetic code reprogramming : Its concept and applications for drug discovery (2012)
  • Author(s): 菅裕明
  • Organizer: 北海道大学GCQE国際会議
  • Place of Presentation: 札幌(招待講演)
  • Year and Date: 2012-02-22
• [Presentation] 特殊ペプチドが起こす構造生命科学と創薬の飛躍 (2012)
  • Author(s): 菅裕明
  • Organizer: 学術会議公開シンポジウム「構造生命科学」
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2012-01-09
• [Presentation] Flexizyme, FIT and RaPID: The enabling technologies for probes discovery (2012)
  • Author(s): 菅 裕明
  • Organizer: XXIV tRNA Conference
  • Place of Presentation: Olmue, Chile
  • Invited
• [Presentation] The non-traditional peptide therapeutics (2012)
  • Author(s): 菅 裕明
  • Organizer: 13th Tetrahedron Symposium
  • Place of Presentation: Taipei, Taiwan
  • Invited
• [Presentation] The non-traditional peptide therapeutics (2012)
  • Author(s): 菅 裕明
  • Organizer: 13th FAOBMB International Congress of Biochemistry and Molecular Biology
  • Place of Presentation: Bangkok, Thailand
  • Invited
• [Presentation] The non-traditional peptide therapeutics (2012)
  • Author(s): 菅 裕明
  • Organizer: ICCP2012-International Conference on Circular Proteins
  • Place of Presentation: Heron island, Australia
  • Invited
• [Presentation] The non-traditional peptide therapeutics (2012)
  • Author(s): 菅 裕明
  • Organizer: EFMC-ISMC 2012 22nd International Symposium on Medicinal Chemistry
  • Place of Presentation: Berlin, Germany
  • Invited
• [Presentation] RaPID system: A new discovery tool of natural product-like peptides from de novo libraries (2012)
  • Author(s): 菅 裕明
  • Organizer: 3rd International Symposium on DNA-encoded chemical libraries
  • Place of Presentation: Zurich, Switzerland
  • Invited
• [Presentation] Non-Traditional Peptide Therapeutic Leads (2012)
  • Author(s): 菅 裕明
  • Organizer: Gordon Research Conference Medicinal Chemistry
  • Place of Presentation: Colby-Sawyer College New London, NH USA
  • Invited
• [Presentation] RaPID Discovery of Natural Product-Like Peptides against Therapeutic Targets (2012)
  • Author(s): 菅 裕明
  • Organizer: Asia TIDES Oligonucleotide and Peptide Research, Technology and Product Development
  • Place of Presentation: Las Vegas, NV USA
  • Invited
• [Presentation] Genetic code reprogramming : Its concept and applications for drug discovery (2011)
  • Author(s): 菅裕明
  • Organizer: 名古屋大学GCOE国際会議
  • Place of Presentation: 名古屋(招待講演)
  • Year and Date: 2011-11-30
• [Presentation] Genetic code reprogramming : Its concept and applications for drug discovery (2011)
  • Author(s): 菅裕明
  • Organizer: 日本分子生物学会年会「Leading Edge seminar」
  • Place of Presentation: 横浜(招待講演)
  • Year and Date: 2011-11-13
• [Presentation] Genetic code reprogramming : Its concept and applications for drug discovery (2011)
  • Author(s): 菅裕明
  • Organizer: The 38th International Symposium of Nucleic Acid Chemistry
  • Place of Presentation: Sapporo, Hokkaido, Japan(招待講演)
  • Year and Date: 2011-11-11
• [Presentation] Genetic code reprogramming : Its concept and applications for drug discovery (2011)
  • Author(s): 菅裕明
  • Organizer: 細胞を創る会
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2011-10-28
• [Presentation] Genetic code reprogramming : Its concept and applications for drug discovery (2011)
  • Author(s): 菅裕明
  • Organizer: The 9th Australian Peptide Conference
  • Place of Presentation: Hamilton Island, Australia(招待講演)
  • Year and Date: 2011-10-18
• [Presentation] Genetic code reprogramming : Its concept and applications for drug discovery (2011)
  • Author(s): 菅裕明
  • Organizer: The 2011 International Symposium on Aminoacyl-tRNA synthetases
  • Place of Presentation: Snowbird, Salt Lake City, USA(招待講演)
  • Year and Date: 2011-09-28
• [Presentation] Genetic code reprogramming : Its concept and applications for drug discovery (2011)
  • Author(s): 菅裕明
  • Organizer: 5th International Symposium on Advancing the Chemical Sciences on Challenges in Chemical Biology
  • Place of Presentation: Manchester, UK(招待講演)
  • Year and Date: 2011-07-27
• [Presentation] Genetic code reprogramming : Its concept and applications for drug discovery (2011)
  • Author(s): 菅裕明
  • Organizer: The 22nd American Peptide Symposium
  • Place of Presentation: San Diego, USA(招待講演)
  • Year and Date: 2011-06-27
• [Presentation] Genetic code reprogramming : Its concept and applications for drug discovery (2011)
  • Author(s): 菅裕明
  • Organizer: The 11th Tetrahedron Symposium "Frontiers in Organic and Bioorganic Chemistry"
  • Place of Presentation: Sitges, Barcelona, Spain(招待講演)
  • Year and Date: 2011-06-22
• [Presentation] Genetic code reprogramming : Its concept and applications for drug discovery (2011)
  • Author(s): 菅裕明
  • Organizer: International RNA Society Meeting
  • Place of Presentation: Kyoto, Japan(招待講演)
  • Year and Date: 2011-06-16
• [Presentation] Genetic code reprogramming : Its concept and applications for drug discovery (2011)
  • Author(s): 菅裕明
  • Organizer: European Protein Society Meeting
  • Place of Presentation: Stockholm, Sweden(招待講演)
  • Year and Date: 2011-05-25
• [Presentation] Genetic code reprogramming : Its concept and applications for drug discovery (2011)
  • Author(s): 菅裕明
  • Organizer: PepTalk, Cambrige Health Institute
  • Place of Presentation: Boston, Massachusetts, USA(招待講演)
  • Year and Date: 2011-05-10
• [Presentation] Genetic code reprogramming : Its concept and applications for drug discovery (2011)
  • Author(s): 菅裕明
  • Organizer: AsiaTIDES : Oligonucleotide and Peptide Research, Technology and Product Development
  • Place of Presentation: Tokyo, Japan(招待講演)
  • Year and Date: 2011-02-28
• [Presentation] Genetic code reprogramming for the discovery of a novel class of peptide, drug leads (2011)
  • Author(s): 菅裕明
  • Organizer: Royal Society discussion meeting : Chemical Origins and Early Evolution
  • Place of Presentation: London, UK
  • Year and Date: 2011-02-21
• [Presentation] Genetic code reprogramming for the discovery of a novel class of peptide drug leads (2011)
  • Author(s): 菅裕明
  • Organizer: 22^<nd> Enzyme Mechanisms Conference
  • Place of Presentation: St.Pete beach FL, USA
  • Year and Date: 2011-01-04
• [Presentation] Genetic code reprogramming for the discovery of a novel class of peptide drug leads (2010)
  • Author(s): 菅裕明
  • Organizer: PacifiChem 2010
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 2010-12-18
• [Presentation] Genetic code reprogramming for the discovery of a novel class of peptide drug lead (2010)
  • Author(s): 菅裕明
  • Organizer: 5^<th> International Peptide Symposium
  • Place of Presentation: 京都、京都国際コンファレンスセンター
  • Year and Date: 2010-12-08
• [Presentation] 特殊ペプチド創薬 (2010)
  • Author(s): 菅裕明
  • Organizer: 第29回メディシナルケミストリーシンポジウム
  • Place of Presentation: 京都、京都テレサホール
  • Year and Date: 2010-11-18
• [Presentation] Genetic code reprogramming for the discovery of a novel class of peptide drug lead (2010)
  • Author(s): 菅裕明
  • Organizer: RIKEN Chemical Biology Symposium
  • Place of Presentation: 和光、理研 和光研究所
  • Year and Date: 2010-10-29
• [Presentation] Genetic code reprogramming for the discovery of a novel class of peptide drug lead (2010)
  • Author(s): 菅裕明
  • Organizer: 国際構造エピゲノムシンポジウム
  • Place of Presentation: 横浜、理研 横浜研究所
  • Year and Date: 2010-10-01
• [Presentation] 特殊ペプチド創薬 (2010)
  • Author(s): 菅裕明
  • Organizer: 日本生物物理学会年会
  • Place of Presentation: 仙台、東北大学
  • Year and Date: 2010-09-20
• [Presentation] 特殊ペプチド創薬 (2010)
  • Author(s): 菅裕明
  • Organizer: 日本RNA学会年会
  • Place of Presentation: 東京、一橋記念講堂
  • Year and Date: 2010-07-07
• [Presentation] 特殊ペプチド創薬 (2010)
  • Author(s): 菅裕明
  • Organizer: 仙台万有シンポジウム
  • Place of Presentation: 仙台、仙台国際センター
  • Year and Date: 2010-06-05
• [Presentation] Genetic code reprogramming for the discovery of a novel class of peptide drug lead (2010)
  • Author(s): 菅裕明
  • Organizer: Yale University, Symposium of Chemical Biology
  • Place of Presentation: Connecticut, USA
  • Year and Date: 2010-05-14
• [Presentation] Genetic code reprogramming for the discovery of a novel class of peptide drug lead (2010)
  • Author(s): 菅裕明
  • Organizer: The 2010 Annual Meeting of the American Society for Biochemistry and Molecular Biology
  • Place of Presentation: Los Angels, California, USA
  • Year and Date: 2010-04-27
• [Presentation] 特殊ペプチド創薬 (2010)
  • Author(s): 菅裕明
  • Organizer: 日本化学会年会、ATPプログラム
  • Place of Presentation: 大阪
  • Year and Date: 2010-03-27
• [Presentation] Genetic Code reprogramming and its application for the discovery of a new class of peptide drugs (2010)
  • Author(s): 菅裕明
  • Organizer: 2010 Chemistry & Biology of Peptides Gordon Research Conference
  • Place of Presentation: Ventura, USA
  • Year and Date: 2010-03-01
• [Presentation] Genetic Code reprogramming and its application for the discovery of a new class of peptide drugs (2010)
  • Author(s): 菅裕明
  • Organizer: AsiaTide
  • Place of Presentation: 東京
  • Year and Date: 2010-02-23
• [Presentation] Genetic Code reprogramming and its application for the discovery of a new class of peptide drugs (2010)
  • Author(s): 菅裕明
  • Organizer: The 75^<th> Israel Chemical Society Meeting, Israel
  • Place of Presentation: Tel Aviv, Israel
  • Year and Date: 2010-01-29
• [Presentation] 特殊ペプチド創薬 (2009)
  • Author(s): 菅裕明
  • Organizer: 日本発生学会年会
  • Place of Presentation: 三島
  • Year and Date: 2009-11-27
• [Presentation] Genetic Code reprogramming and its application for the discovery of a new class of peptide drugs (2009)
  • Author(s): 菅裕明
  • Organizer: The 3rd Asia-Pacific International Peptide Symposium
  • Place of Presentation: Jeju Island, Korea
  • Year and Date: 2009-11-09
• [Presentation] Genetic Code reprogramming and its application for the discovery of a new class of peptide drugs (2009)
  • Author(s): 菅裕明
  • Organizer: Nottingham 'New Horizons' meeting 2009
  • Place of Presentation: Nottingham, UK
  • Year and Date: 2009-11-04
• [Presentation] Genetic Code reprogramming and its application for the discovery of a new class of peptide drugs (2009)
  • Author(s): 菅裕明
  • Organizer: Peptide Engineering : Therapeutic Peptide" Fifth Peptide Engineering Meeting
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2009-10-26
• [Presentation] Genetic Code reprogramming and its application for the discovery of a new class of peptide drugs (2009)
  • Author(s): 菅裕明
  • Organizer: The 1^<st> International Conference for Circular Protein
  • Place of Presentation: Heron Island, Australia
  • Year and Date: 2009-10-16
• [Presentation] Genetic Code reprogramming and its application for the discovery of a new class of peptide drugs (2009)
  • Author(s): 菅裕明
  • Organizer: Naito Foundation Conference in Chemical Biology
  • Place of Presentation: 札幌
  • Year and Date: 2009-09-08
• [Presentation] Genetic Code reprogramming and its application for the discovery of a new class of peptide drugs (2009)
  • Author(s): 菅裕明
  • Organizer: 第5回日韓天然物化学談話会
  • Place of Presentation: 湯河原
  • Year and Date: 2009-08-28
• [Presentation] Genetic Code reprogramming and its application for the discovery of a new class of peptide drugs (2009)
  • Author(s): 菅裕明
  • Organizer: Burugenstock Conference
  • Place of Presentation: Lucerne, Switzerland
  • Year and Date: 2009-05-17
• [Book] Methods in Molecular Biology 805: Ribosome Display and Related Technologies “Charging of tRNAs using ribozymes and selection of cyclic peptides containing thioethers” (2012)
  • Author(s): P. Reid, Y. Goto, T. Katoh, H. Suga
  • Publisher: Humana Press
• [Book] Methods in Molecular Biology 848: Ribozymes Methods and Protocols “Flexizymes as a tRNA acylation tool facilitating genetic code reprogramming” (2012)
  • Author(s): Y. Goto, H. Suga
  • Publisher: Humana Press
• [Book] Metal Ions in Life Sciences: Structural and Catalytic Roles of Metal Ions in RNA “Metal ion requirements in artificial ribozymes that catalyze aminoacylation and red-ox reactions” (2012)
  • Author(s): H. Suga, K. Futai, K. Jin
  • Publisher: RSC Publishing
• [Book] Methods in Molecular Biology 805 : Ribosome Display and Related Technologies "Charging of tRNAs using ribozymes and selection of cyclic peptides containing thioethers" (2012)
  • Author(s): P.Reid, Y.Goto, T.Katoh, H.Suga
  • Publisher: Humana Press
• [Book] Methods in Molecular Biology 848 : Ribozymes Methods and Protocols "Flexizymesas a tRNA acylation tool facilitating genetic code reprogramming" (2012)
  • Author(s): Y.Goto, H.Suga
  • Publisher: Humana Press
• [Book] Metal Ions in Life Sciences : Structural and Catalytic Roles of Metal Ions in RNA "Metal ion requirements in artificial ribozymes that catalyze aminoacylation and redox reactions" (2012)
  • Author(s): H.Suga, K.Futai, K.Jin
  • Publisher: RSC Publishing
• [Book] 最新ペプチド合成技術とその創薬研究への応用 (2012)
  • Author(s): 伊藤悠美、後藤佑樹、菅裕明
  • Publisher: メディカルドゥ
• [Book] 核酸化学のニュートレンド (2011)
  • Author(s): 後藤佑樹、菅裕明
  • Publisher: 化学同人
• [Book] Quorum Sensing : Chapter 19 "Custom synthesis of antoinducers and their analogues" (2010)
  • Author(s): J.Igarashi, H.Suga
  • Publisher: Humane Press
• [Remarks]
  • URL: http://www.chem.s.u-tokyo.ac.jp/users/biorig/index.html
• [Remarks]
  • URL: http://www.chem.s.u-tokyo.ac.jp/users/bioorg/index.html
• [Remarks]
  • URL: http://www.chem.s.u-tokyo.ac.jp/users/bioorg/index.html
• [Remarks]
  • URL: http://www.cbl.rcast.u-tokyo.ac.jp/
• [Remarks]
  • URL: http://www.cbl.rcast.u-tokyo.ac.jp/
• [Patent(Industrial Property Rights)] MATE 活性阻害ペプチド (2013)
  • Inventor(s): 菅裕明、濡木理、ヒポリト クリストファー、田中良樹
  • Industrial Property Rights Holder: 東京大学
  • Filing Date: 2013-07-28
  • Overseas
• [Patent(Industrial Property Rights)] 大環状ペプチド、その製造方法、及び大環状ペプチドライブラリを用いるスクリーニング方法 (2013)
  • Inventor(s): 菅裕明
  • Industrial Property Rights Holder: 東京大学
  • Filing Date: 2013-08-26
• [Patent(Industrial Property Rights)] C-Metタンパク質アゴニスト (2013)
  • Inventor(s): 菅裕明、伊藤健一郎
  • Industrial Property Rights Holder: 東京大学
  • Filing Date: 2013-10-15
• [Patent(Industrial Property Rights)] MATE活性阻害ペプチド (2013)
  • Inventor(s): 菅裕明、濡木理、クリストファージェイ ヒポライト、田中良樹
  • Industrial Property Rights Holder: 東京大学
  • Filing Date: 2013-07-28
  • Overseas
• [Patent(Industrial Property Rights)] 大環状ペプチド、その製造方法、及び大環状ペプチドライブラリを用いるスクリーニング方法 (2013)
  • Inventor(s): 菅裕明
  • Industrial Property Rights Holder: 東京大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-08-26
• [Patent(Industrial Property Rights)] c-Metタンパク質アゴニスト (2013)
  • Inventor(s): 菅裕明, 伊藤健一郎
  • Industrial Property Rights Holder: 東京大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-10-15
• [Patent(Industrial Property Rights)] MATE活性阻害ペプチド (2012)
  • Inventor(s): 菅裕明、濡木理、クリストファー ヒポリト、田中良樹
  • Industrial Property Rights Holder: 菅裕明、濡木理、クリストファー ヒポリト、田中良樹
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-170144
  • Filing Date: 2012-07-31
• [Patent(Industrial Property Rights)] pH依存的に標的分子に結合するペプチドのスクリーニング方法 (2012)
  • Inventor(s): 菅裕明、飯田健夫
  • Industrial Property Rights Holder: 菅裕明、飯田健夫
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-129056
  • Filing Date: 2012-06-06
• [Patent(Industrial Property Rights)] アゾリン化合物及びアゾール化合物のライブラリー、並びにその製造方法 (2012)
  • Inventor(s): 菅裕明・後藤佑樹・伊藤悠美
  • Industrial Property Rights Holder: 国立大学法人東京大学
  • Filing Date: 2012-03-09
  • Overseas
• [Patent(Industrial Property Rights)] 安定化された二次構造を有するペプチド、及びペプチドライブラリー、それらの製造方法 (2011)
  • Inventor(s): 菅裕明、樋口岳
  • Industrial Property Rights Holder: 東京大学
  • Acquisition Date: 2011-12-05
  • Overseas
• [Patent(Industrial Property Rights)] 安定化された二次構造を有するペプチド、及びペプチドライブラリー、それらの製造方法 (2011)
  • Inventor(s): 菅裕明、樋口岳
  • Industrial Property Rights Holder: 東京大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2011-12-05
• [Patent(Industrial Property Rights)] 新規人工翻訳合成系 (2011)
  • Inventor(s): 菅裕明・村上裕・後藤佑樹
  • Industrial Property Rights Holder: 国立大学法人東京大学
  • Filing Date: 2011-08-26
  • Overseas
• [Patent(Industrial Property Rights)] N-メチルアミノ酸おびその他の特殊アミノ酸を含む特殊ペプチド化合物ライブラリーの翻訳構築と活性種探索法 (2011)
  • Inventor(s): 菅裕明, 山岸祐介
  • Industrial Property Rights Holder: 国立大学法人東京大学
  • Filing Date: 2011-09-08
  • Overseas
• [Patent(Industrial Property Rights)] ペプチドライブラリーの製造方法、ペプチドライブラリー、およびスクリーニング方法 (2011)
  • Inventor(s): 菅裕明, 森本淳平
  • Industrial Property Rights Holder: 国立大学法人東京大学
  • Filing Date: 2011-12-05
  • Overseas
• [Patent(Industrial Property Rights)] 安定化された二次構造を有するペプチド、およびペプチドライブラリー、それらの製造方法 (2011)
  • Inventor(s): 菅裕明, 樋口岳
  • Industrial Property Rights Holder: 国立大学法人東京大学
  • Filing Date: 2011-12-05
  • Overseas
• [Patent(Industrial Property Rights)] アゾリン化合物およびアゾール化合物のライブラリー、並びにその製造方法 (2011)
  • Inventor(s): 菅裕明, 後藤佑樹, 伊藤悠美
  • Industrial Property Rights Holder: 東京大学
  • Industrial Property Number: 2010-190315
  • Filing Date: 2011-03-19
• [Patent(Industrial Property Rights)] 新規人工翻訳合成系 (2010)
  • Inventor(s): 菅裕明・村上裕・後藤佑樹
  • Industrial Property Rights Holder: 東京大学
  • Industrial Property Number: 2010-190315
  • Filing Date: 2010-08-27
• [Patent(Industrial Property Rights)] N・メチルアミノ酸およびその他の特殊アミノ酸を含む特殊ペプチド化合物ライブラリーの翻訳構築と活性種探索法 (2010)
  • Inventor(s): 菅裕明, 山岸祐介
  • Industrial Property Rights Holder: 東京大学
  • Industrial Property Number: 2010-202012
  • Filing Date: 2010-09-09
• [Patent(Industrial Property Rights)] 特異的機能低分子化合物含有特殊ペプチドのライブラリーの合成法と活性種探索法 (2010)
  • Inventor(s): 菅裕明, 森本淳平
  • Industrial Property Rights Holder: 東京大学
  • Industrial Property Number: 2010-270507
  • Filing Date: 2010-12-03
• [Patent(Industrial Property Rights)] αヘリックス2次元構造を固定した特殊ペプチド化合物ライブラリーの合成法と活性種探索法 (2010)
  • Inventor(s): 菅裕明, 樋口岳
  • Industrial Property Rights Holder: 東京大学
  • Industrial Property Number: 2010-270958
  • Filing Date: 2010-12-03