Elucidation of the molecular mechanisms of muscle atrophy
Project/Area Number |
21200023
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Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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Allocation Type | Single-year Grants |
Research Field |
General medical chemistry
Applied health science
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Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
Principal Investigator |
SHIGEMOTO Kazuhiro 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (40284400)
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Co-Investigator(Kenkyū-buntansha) |
KUBO Sachiho 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 助手 (00280769)
MIYAZAKI Tsuyoshi 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (50376480)
YAMADA Shigeru 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (50508679)
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Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥30,940,000 (Direct Cost: ¥23,800,000、Indirect Cost: ¥7,140,000)
Fiscal Year 2011: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2010: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2009: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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Keywords | 筋萎縮 / 神経筋シナプス / 逆行性シグナル / 運動神経細胞 / 筋線維 / 神経筋接合部 / 疾患モデル動物 / ノックインマウス / 神経細胞栄養因子 |
Research Abstract |
We found that MuSK molecules, which are expressed at post synaptic membrane of NMJs, mediates unknown retrograde signaling which regulate presynaptic functions. We generated mouse expressed-genes database for atrophy-induced muscles to find the retrograde-signaling molecules.
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Report
(4 results)
Research Products
(63 results)
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[Journal Article] 3,4-Diaminopyridine improves neuromuscular transmission in a MuSK antibody-induced mouse model of myasthenia gravis2012
Author(s)
Mori, S. , Kishi, M., Kubo, S., Akiyoshi, T., Yamada, S., Miyazaki, T., Konishi, T., Maruyama, N., and Shigemoto, K.
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Journal Title
Journal of neuroimmunology
Volume: 245
Issue: 1-2
Pages: 75-78
DOI
Related Report
Peer Reviewed
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[Journal Article] Antibodies against muscle-specific kinase impair both presynaptic and postsynaptic functions in a murine model of myasthenia gravis2012
Author(s)
Mori, S., Kubo, S., Akiyoshi, T., Yamada, S., Miyazaki, T., Hotta, H., Desaki, J., Kishi, M., Konishi, T., Nishino, Y., Miyazawa, A., Maruyama, N., and Shigemoto, K.
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Journal Title
The American journal of pathology
Volume: 180
Pages: 798-810
Related Report
Peer Reviewed
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[Journal Article] Divalent and monovalent autoantibodies cause dysfunction of MuSK by distinct mechanisms in a rabbit model of myasthenia gravis2012
Author(s)
Mori, S. , Yamada, S., Kubo, S. , Chen, J., Matsuda, S. , Shudou, M. , Maruyama, N., and Shigemoto, K.
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Journal Title
Journal of neuroimmunology
Volume: 244
Issue: 1-2
Pages: 1-7
DOI
Related Report
Peer Reviewed
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[Journal Article] Antibodies against muscle-specific kinase impair both presynaptic and postsynaptic functions in a murine model of myasthenia gravis2012
Author(s)
Mori S, Kubo S, Akiyoshi T, Yamada S, Miyazaki T, Hotta H, Desaki J, Kishi M, Konishi T, Nishino Y, Miyazawa A, Maruyama N, Shigemoto K
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Journal Title
The American Journal of Pathology
Volume: 180
Issue: 2
Pages: 617-28
DOI
Related Report
Peer Reviewed
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[Journal Article] Establishment and characterization of hepatocytes from an Immortomouse/SMP30/GNL knockout mouse hybrid lacking vitamin C to study vitamin C transport2011
Author(s)
Amano, A., Handa, S., Aigaki, T., Shigemoto, K., Maruyama, N., Ishigami, A.
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Journal Title
Journal of biochemistry
Volume: 150
Issue: 6
Pages: 671-678
DOI
Related Report
Peer Reviewed
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[Journal Article] Muscle weakness and neuromuscular junctions in aging and disease2010
Author(s)
Shigemoto, K., Kubo, S., Mori, S., Yamada, S., Akiyoshi, T., and Miyazaki, T.
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Journal Title
Geriatr Gerontol Int 10 Suppl
Volume: 1
Issue: s1
Pages: 137-147
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Neutrophil CD64 expression as a diagnostic marker for local infection and crystal-induced arthritis.2010
Author(s)
Doi, T., Miyazaki, T., Nishino, J., Tanaka, S., Matsui, T., Komiya, A., Yamamoto, S., Tokimura, F., Mori, T., Nishimura, K., Katoh, N., Hasegawa, J., Omata, Y., Matsushita, T, Tohma, S
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Journal Title
Mod.Rheumatol.
Volume: 20(6)
Pages: 573-579
NAID
Related Report
Peer Reviewed
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[Journal Article] Muscle weakness and neuromuscular junction in aging and disease2010
Author(s)
Shigemoto, K., Kubo, S., Mori, S., Yamada, S., Akiyoshi, T., Miyazaki, T.
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Journal Title
Geriatr.Gerintol.Int.
Volume: 10
NAID
Related Report
Peer Reviewed
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[Journal Article] The role of zinc finger protein 521/early hematopoietic zinc finger protein in erythroid cell differentiation.2009
Author(s)
Matsubara, E., Sakai, I., Yamanouchi, J. , Fujiwara, H., Yakushijin, Y., Hato, T., Shigemoto, K., Yasukawa, M.
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Journal Title
J Biol Chem 284
Pages: 3480-3487
Related Report
Peer Reviewed
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[Journal Article] The antiapoptotic protein Bcl-xL negatively regulates the bone-resorbing activity of osteoclasts in mice.2009
Author(s)
Iwasawa M, Miyazaki T, Nagase Y, Akiyama T, Kadono Y, Nakamura M, Oshima Y, Yasui T, Matsumoto T, Nakamura T, Kato S, Hennighausen L, Nakamura K, Tanaka S
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Journal Title
J Clin Invest 19
Pages: 3149-59
Related Report
Peer Reviewed
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[Presentation] Mouse lacking in intracellular superoxide dismutase increased reactive oxygen spices in osteoblasts and suppressed osteoblastic ability leading to osteoporotic phenotypes in bone.2010
Author(s)
Saita, Y., Mojiri, H., Tsuda, C., Miyazaki, T., Morikawa, D., Kaneko, K, Shimizu, T.
Organizer
IOF World Congress on Osteoporosis & 10^<th> European Congress on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis
Place of Presentation
Italy
Related Report
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[Presentation] New strategy to treatment of myasthenia gravis caused by MuSK antibodies using a synchronized experimental animal model2010
Author(s)
Mori, S., Kubo, S., Akiyoshi, T., Yamada, S., Miyazaki, T., Shigemoto, K.
Organizer
第33回日本神経科学会大会
Place of Presentation
神戸
Related Report
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[Presentation] Intracellular superoxide dismutase deficiency decreased bone mass in vivo by impairment of cell viability and redox balance in osteoblasts.2010
Author(s)
Saita, Y., Nojiri, H., Tsuda, C., Miyazaki, T., Morikawa, D., Kaneko, K, Shimizu, T.
Organizer
32^<nd> Annual Meeting of the American Society for Bone and Mineral Research
Place of Presentation
Toronto
Related Report
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[Presentation] Complement activation is dispensable for myasthenia gravis caused by MuSK antibodies.2010
Author(s)
Shigemoto, K., Mori, S., Kubo, S., Akiyoshi, T., Yamada, S., Miyazaki, T
Organizer
10^<th> International Congress of Neuroimmunology
Place of Presentation
Barcelona
Related Report
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[Presentation] Strategy to treatment of myasthenia gravis caused by MuSK antibodies using a synchronized experimental animal model.2010
Author(s)
Mori, S., Kubo, S., Akiyoshi, T., Yamada, S., Miyazaki, T., Shigemoto, K
Organizer
Society for Neuroscience 2010
Place of Presentation
San Diego
Related Report
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