Investigating the relationship between the conformation of nuclear membrane and the functions of chromatin
| Project/Area Number |
21200040
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
Applied genomics
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| Research Institution | Hosei University (2011)
Tohoku University (2009-2010) |
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Principal Investigator |
OHBA Tomoyuki 法政大学, 企画戦略本部, 特任准教授 (80380666)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥29,510,000 (Direct Cost: ¥22,700,000、Indirect Cost: ¥6,810,000)
Fiscal Year 2011: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2010: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2009: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
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| Keywords | 染色体構造 / 転写因子 / シグナル伝達 / 核構造 / 染色体 / IκB-ζ |
|---|
| Research Abstract |
In order to control the activity of signal transduction components, they were expressed as mutated hormone binding domain of human estrogen receptor fusion proteins, whose activity is regulated by the addition of a small synthetic compound, 4-hydroxytamoxifen. These components show that the signaling pathway leading to nuclear factor-kB activation and the post-transcriptional activation bifurcates at IRAK1, suggesting a new pathway activated by IRAK1.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article]2012
Author(s)
Tomoyuki Ohba, Yujiro Ariga, Takashi Maruyama, Nha K. Truong, Jun-ichiro Inoue, Tatsushi Muta
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Journal Title
FEBS Journal
Volume: 279(2)
Pages: 211-222
Related Report
Peer Reviewed
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