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Functional analyses of novel autophagy system in immune responses

Research Project

Project/Area Number 21200067
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)

Allocation TypeSingle-year Grants
Research Field Plant molecular biology/Plant physiology
Plant pathology
Research InstitutionTokyo University of Science

Principal Investigator

KURUSU Takamitsu  東京理科大学, 総合研究機構, プロジェクト研究員 (50422499)

Co-Investigator(Renkei-kenkyūsha) KUCHITSU Kazuyuki  東京理科大学, 理工学部, 教授 (50211884)
TAKAHASHI Akira  独立行政法人農業生物資源研究所, 植物科学研究領域耐病性研究ユニット, 研究員 (20414914)
MITSUHARA Ichiro  独立行政法人農業生物資源研究所, 植物科学研究領域植物微生物間相互作用研究ユニット, 研究員 (80370683)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000)
Fiscal Year 2011: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2010: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2009: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Keywords病害抵抗性 / 環境応答 / オートファジー / 細胞内物流 / 生殖 / イネ / 感染防御 / シグナル伝達 / タンパク質リン酸化 / カルシウムイオン / 免疫活性化剤 / 植物
Research Abstract

Our studies revealed that plant immune responses were regulated by both membrane traffic and degradation system. We also established the real-time monitoring system of autophagy in tobacco BY-2 cells as well as rice, and found the dynamic changes of autophagy during the induction of immune responses in plant cells. In addition, we identified several autophagy mutants (Osatgs) from rice, and functional analyses of mutants revealed that autophagy plays critical roles in during reproductive development in rice. We believe that these findings are useful for improving stress resistance in many crops.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (36 results)

All 2012 2011 2010 2009 Other

All Journal Article (15 results) (of which Peer Reviewed: 14 results) Presentation (11 results) Book (4 results) Remarks (4 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 2 results)

  • [Journal Article] Roles of a putative mechanosensitive plasma membrane Ca^<2+>-permeable channel OsMCA1 in generation of reactive oxygen species and hypo-osmotic signaling in rice2012

    • Author(s)
      来須孝光、飯田秀利、朽津和幸
    • Journal Title

      Plant Signaling & Behavior

      Volume: (In press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of the putative Ca^<2+>-permeable mechanosensitive channels, NtMCA1 and NtMCA2, in Ca^<2+> uptake, Ca^<2+>-dependent cell proliferation and mechanical stress-induced gene expression in tobacco (Nicotiana tabacum) BY-2 cells2012

    • Author(s)
      来須孝光、山中拓哉、中野正貴、瀧口彬子、小笠原よう子、林晃之、飯田和子、花俣繁、篠崎一雄、飯田秀利、朽津和幸
    • Journal Title

      Journal of Plant Research

      Volume: (In press)

    • NAID

      10030803989

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 植物の免疫制御における情報素子とシグナルネットワーク2012

    • Author(s)
      朽津和幸、濱田晴康、来須孝光
    • Journal Title

      量子論から見る情報と生命の研究2011

      Pages: 102-107

    • Related Report
      2011 Final Research Report
  • [Journal Article] Regulation of a proteinaceous elicitor-induced Ca <sup>2+</sup> influx and production of phytoalexins by a putative voltage-gated cation channel, OsTPC1, in cultured rice cells2012

    • Author(s)
      濱田晴康*、来須孝光*(*Co-first authors)、大熊英治、能鹿島央司、清塚正弘、小谷野智子、杉山淑美、岡田憲典、古賀仁一郎、佐治光、宮尾安藝雄、廣近洋彦、山根久和、村田芳行、朽津和幸
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 287 Issue: 13 Pages: 9931

    • DOI

      10.1074/jbc.m111.337659

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasma membrane protein OsMCA1 is involved in regulation of hypo-osmotic shock-induced Ca^<2+> influx and modulates generation of reactive oxygen species in cultured rice cells2012

    • Author(s)
      来須孝光、西川大輔、山崎友香里、後藤真理子、中野正貴、濱田晴康、山中拓哉、飯田和子、中川祐子、佐治光、篠崎一雄、飯田秀利、朽津和幸
    • Journal Title

      BMC Plant Biology

      Volume: 12巻 Issue: 1 Pages: 11-11

    • DOI

      10.1186/1471-2229-12-11

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 植物の免疫力を高め病気に強くする2011

    • Author(s)
      来須孝光、朽津和幸
    • Journal Title

      理大科学フォーラム

      Volume: 328巻 Pages: 15-17

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article]2011

    • Author(s)
      来須孝光、濱田晴康、杉山淑美、矢柄寿一、門田康弘、古市卓也、林晃之、梅村賢司、小松節子、宮尾安藝雄、廣近洋彦、朽津和幸
    • Journal Title

      Negative feedback regulation of microbe-associated molecular pattern-induced cytosolic Ca^<2+> transients by protein phosphorylation

      Volume: 124巻 Issue: 3 Pages: 415-424

    • DOI

      10.1007/s10265-010-0388-4

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic intracellular reorganization of cytoskeletons and the vacuole in defense responses and hypersensitive cell death2011

    • Author(s)
      桧垣匠、来須孝光、馳澤盛一郎、朽津和幸
    • Journal Title

      Journal of Plant Research

      Volume: 124巻 Issue: 3 Pages: 315-324

    • DOI

      10.1007/s10265-011-0408-z

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 植物の免疫制御機構~情報素子としてのカルシウムイオンの役割~2011

    • Author(s)
      来須孝光、朽津和幸
    • Journal Title

      理大科学フォーラム

      Volume: 322巻 Pages: 44-49

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 植物の免疫力を高め病気に強くする2011

    • Author(s)
      来須孝光
    • Journal Title

      理大科学フォーラム

      Volume: 328 Pages: 15-17

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 植物の免疫制御機構~情報素子としてのカルシウムイオンの役割~2011

    • Author(s)
      来須孝光
    • Journal Title

      理大科学フォーラム

      Volume: 322 Pages: 44-49

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of calcineurin B-like protein-interacting protein kinases in plant innate immunity in rice2010

    • Author(s)
      来須孝光、濱田晴康、花俣繁、朽津和幸
    • Journal Title

      Plant Signaling & Behavior

      Volume: 5巻 Issue: 8 Pages: 1045-1047

    • DOI

      10.4161/psb.5.8.12407

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of microbe-associated molecular pattern-induced hypersensitive cell death, phytoalexin production, and defense gene expression by calcineurin B-like protein-interacting protein kinases, OsCIPK14/15, in rice cultured cells2010

    • Author(s)
      来須孝光、濱田淳平、能鹿島央司、北川陽一郎、清塚正弘、高橋章、花俣繁、大野良子、林晃之、岡田憲典、古賀仁一郎、廣近洋彦、山根久和、朽津和幸
    • Journal Title

      Plant Physiology

      Volume: 153 Issue: 2 Pages: 678

    • DOI

      10.1104/pp.109.151852

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of microbe-associated molecular pattern-induced hypersensitive cell death, phytoalexin production and defense gene expression by calcineurin B-like protein-interacting protein kinases, OsCIPK14/15, in rice cultured cells.2010

    • Author(s)
      来須孝光
    • Journal Title

      Plant Physiology

      Volume: 153 Pages: 678-692

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of calcineurin B-like protein-interacting protein kinases in plant innate immunity in rice.2010

    • Author(s)
      来須孝光
    • Journal Title

      Plant Signaling & Behavior

      Volume: 5 Pages: 1045-1047

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] タバコ培養細胞BY-2のcryptogein誘導性感染防御応答におけるS型陰イオンチャネルSLAC1の機能解析2012

    • Author(s)
      来須孝光
    • Organizer
      第53回植物生理学会年会
    • Place of Presentation
      京都産業大学(京都)
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 植物に生殖・受精におけるオートファジーの新たな役割2012

    • Author(s)
      来須孝光
    • Organizer
      第4回領域会議(動植物アロ認証)
    • Place of Presentation
      筑波大学(茨城)
    • Year and Date
      2012-01-11
    • Related Report
      2011 Final Research Report
  • [Presentation] 植物の生殖・受精におけるオートファジーの新たな役割2012

    • Author(s)
      来須孝光
    • Organizer
      新学術領域研究領域第4回領域会議(動植物アロ認証)
    • Place of Presentation
      筑波大学(茨城)
    • Year and Date
      2012-01-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] 植物におけるオートファジーの多面的な生理機能の解析2011

    • Author(s)
      来須孝光
    • Organizer
      RNA科学総合研究センター公開シンポジウム
    • Place of Presentation
      東京理科大学(千葉)
    • Year and Date
      2011-07-11
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] イネにおけるオートファジー機構の役割2011

    • Author(s)
      来須孝光
    • Organizer
      2011年度細胞周期セミナー
    • Place of Presentation
      かんぽの宿山代(福井)
    • Year and Date
      2011-06-17
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 植物の感染防御応答におけるオートファジー動態の解析2011

    • Author(s)
      来須孝光
    • Organizer
      第6回オートファジー研究会
    • Place of Presentation
      ヤマハリゾートつま恋(静岡)
    • Year and Date
      2011-01-13
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] イネ培養細胞の自然免疫応答におけるカルシウム制御型プロテインキナーゼOsCIPK14/15の機能解析2010

    • Author(s)
      来須孝光
    • Organizer
      イネ遺伝学・分子生物学ワークショップ2010
    • Place of Presentation
      つくば国際会議場(茨城)
    • Year and Date
      2010-07-02
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 細胞内物流システムを介した植物免疫の新規制御機構~植物免疫増強と抗菌能を併せ持つ防疫剤の創出に向けて~2010

    • Author(s)
      来須孝光
    • Organizer
      JST Innovation Bridge東京理科大学研究シーズ発表会
    • Place of Presentation
      秋葉原ダイビル(東京)
    • Year and Date
      2010-03-16
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 植物免疫の新規制御機構~植物免疫賦活効果と抗菌活性を併せ持つ防疫剤の創出を目指して~2009

    • Author(s)
      来須孝光
    • Organizer
      東京理科大学SCITEC CLUBセミナー
    • Place of Presentation
      森戸記念館(東京)
    • Year and Date
      2009-11-13
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] DYNAMICS OF AUTOPHAGY DURING PATHOGENIC SIGNAL- TRIGGERED IMMUNE RESPONSES IN TOBACCO BY-2 CELLS2009

    • Author(s)
      来須孝光
    • Organizer
      International Symposium on Autophagy
    • Place of Presentation
      大津プリンスホテル(滋賀)
    • Year and Date
      2009-09-26
    • Related Report
      2011 Final Research Report
  • [Presentation] DYNAMICS OF AUTOPHAGY DURING PATHOGENIC SIGNAL-TRIGGERED IMMUNE RESPONSES IN TOBACCO BY-2 CELLS2009

    • Author(s)
      来須孝光
    • Organizer
      International Symposium on Autophagy
    • Place of Presentation
      大津プリンスホテル(滋賀)
    • Year and Date
      2009-09-26
    • Related Report
      2009 Annual Research Report
  • [Book] Signaling network of environmental sensing and adaptation in plants: key roles of calcium ion. In: QUANTUM BIO-INFORMATICS IV From Quantum Information to Bio-Informatics. (Edited by Accardi, L., Freudenberg, W., Ohya, M.)2011

    • Author(s)
      来須孝光、朽津和幸
    • Publisher
      World Scientific
    • Related Report
      2011 Final Research Report
  • [Book] Signaling network of environmental sensing and adaptation in plants : key roles of calcium ion.In : QUANTUM BIO-INFORMATICS IV From Quantum Information to Bio-Informatics.(Edited by Accardi, L., Freudenberg, W., Ohya, M.)2011

    • Author(s)
      来須孝光
    • Publisher
      World Scientific
    • Related Report
      2010 Annual Research Report
  • [Book] 植物のシグナル伝達-分子と応答-「植物の防御応答におけるカルシウムシグナリング」2010

    • Author(s)
      濱田晴康、来須孝光、朽津和幸
    • Publisher
      共立出版
    • Related Report
      2011 Final Research Report
  • [Book] 植物のシグナル伝達-分子と応答「植物の防御応答におけるカルシウムシグナリング」2010

    • Author(s)
      濱田晴康
    • Publisher
      共立出版
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.tus.ac.jp/tlo/new/pdf/100607.pdf

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.tus.ac.jp/tlo/new/pdf/120216.pdf

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.tus.ac.jp/tlo/new/pdf/120216.pdf

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.tus.ac.jp/tlo/new/pdf/100607.pdf

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] METHOD OF SCREENING FOR PLANT DEFENSE ACTIVATORS, PLANT DEFENSE ACTIVATORS, AND METHOD OF ENHANCING IMMUNE RESPONSE2011

    • Inventor(s)
      来須孝光、朽津和幸
    • Industrial Property Rights Holder
      東京理科大学
    • Filing Date
      2011-08-10
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] METHOD OF SCREENING FOR PLANT DEFENSE ACTIVATORS, PLANT DEFENSE ACTIVATORS, AND METHOD OF ENHANCING IMMUNE RESPONSE2011

    • Inventor(s)
      来須孝光、朽津和幸
    • Industrial Property Rights Holder
      東京理科大学
    • Filing Date
      2011-08-10
    • Related Report
      2011 Annual Research Report
    • Overseas

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Published: 2009-04-01   Modified: 2018-03-28  

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