| Co-Investigator(Kenkyū-buntansha) |
NISHIZAWA Masatoyo 新潟大学, 脳研究所, 教授 (80198457)
FUJII Yukihiko 新潟大学, 脳研究所, 教授 (40283014)
IGARASHI Hironaka 新潟大学, 脳研究所, 教授 (20231128)
HUBER Vincent 新潟大学, 脳研究所, 准教授 (40422620)
TSUJITA Mika 新潟大学, 脳研究所, 准教授 (60397180)
SUZUKI Kiyotaka 新潟大学, 脳研究所, 准教授 (40303169)
KAKITA Akiyoshi 新潟大学, 脳研究所, 教授 (80281012)
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| Budget Amount *help |
¥213,720,000 (Direct Cost: ¥164,400,000、Indirect Cost: ¥49,320,000)
Fiscal Year 2013: ¥29,120,000 (Direct Cost: ¥22,400,000、Indirect Cost: ¥6,720,000)
Fiscal Year 2012: ¥29,120,000 (Direct Cost: ¥22,400,000、Indirect Cost: ¥6,720,000)
Fiscal Year 2011: ¥29,120,000 (Direct Cost: ¥22,400,000、Indirect Cost: ¥6,720,000)
Fiscal Year 2010: ¥29,120,000 (Direct Cost: ¥22,400,000、Indirect Cost: ¥6,720,000)
Fiscal Year 2009: ¥97,240,000 (Direct Cost: ¥74,800,000、Indirect Cost: ¥22,440,000)
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| Research Abstract |
The research project was one of the most ambitious proposals aiming to develop ligand based MRI molecular imaging, a goal that has eluded world scientists for more than 30 years. Our research team successfully developed such a "dream" imaging method as we promised. The technique utilized O17, a stable isotope of oxygen, labeled specific ligand and its JJ vicinal coupling to its covalent proton. The method was termed JJ Vicinal Coupling Proton Exchange (JJVCPE) imaging by the project director. We applied this method to study water molecule dynamics utilizing H2O17, and beta-amyloid imaging utilizing O17-PiB in vivo. The studies showed that aquaporin-4 (AQP-4), abundant in glia in brain, plays a major role in the interstitional flow through the Virchow-Robin space. The disturbance in this system, which is critical for beta-amyloid clearance, plays a major role in the pathogentesis of Alzheimer disease.
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