| Project/Area Number |
21221009
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Kanagawa University (2011-2012)
Keio University (2009-2010) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHNO Osamu 慶應義塾大学, 理工学部, 助教 (20436992)
SUENAGA Kiyotake 慶應義塾大学, 理工学部, 准教授 (60273215)
ARIMOTO Hirokazu 東北大学, 生命科学研究科, 教授 (60262789)
MIYAMOTO Kenji 慶應義塾大学, 理工学部, 准教授 (60360111)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥147,810,000 (Direct Cost: ¥113,700,000、Indirect Cost: ¥34,110,000)
Fiscal Year 2012: ¥37,440,000 (Direct Cost: ¥28,800,000、Indirect Cost: ¥8,640,000)
Fiscal Year 2011: ¥39,000,000 (Direct Cost: ¥30,000,000、Indirect Cost: ¥9,000,000)
Fiscal Year 2010: ¥38,350,000 (Direct Cost: ¥29,500,000、Indirect Cost: ¥8,850,000)
Fiscal Year 2009: ¥33,020,000 (Direct Cost: ¥25,400,000、Indirect Cost: ¥7,620,000)
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| Keywords | 天然物有機化学 / 巨大炭素鎖有機分子 / 生物活性 / 海洋生物共生鞭毛藻 / 生物学的存在意義 / 生体内動態 / メタゲノム / バックライブラリー / 分子量2,169 / 分子量1,242 / 分子量8,245 / 生合成遣伝子 / シンビオジノリド |
|---|
| Research Abstract |
We refer to marine organism-derived long carbon chain molecules without repeating motifs as super-carbon-chain molecules. They have extraordinary chemical structures and exhibit strong biological activities. In this study, we endeavored to identify novel super-carbon-chain molecules by a new approach: the large-scale cultivation of symbiotic bacteria or a meta-genomic method. We also studied the biological significance, biological activities, biosynthesis, and unique chemical reactivities of these molecules. As a result, we successfully identified several important molecules and determined their biological activities. Our findings should help to establish the concept of super-carbon-chain molecules.
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| Assessment Rating |
Verification Result (Rating)
A
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