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Molecular mechanism underlying sexual development of male germ cells

Research Project

Project/Area Number 21227008
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Developmental biology
Research InstitutionNational Institute of Genetics

Principal Investigator

SAGA Yumiko  国立遺伝学研究所, 系統生物研究センター, 教授 (50221271)

Co-Investigator(Kenkyū-buntansha) KOKUBO Hiroki  国立遺伝学研究所, 系統生物研究センター, 助教 (10270480)
Co-Investigator(Renkei-kenkyūsha) SUZUKI Atsushi  横浜国立大学, 工学研究院, 准教授 (60467058)
Project Period (FY) 2009-05-11 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥208,000,000 (Direct Cost: ¥160,000,000、Indirect Cost: ¥48,000,000)
Fiscal Year 2013: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2012: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2011: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2010: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2009: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Keywords生殖細胞 / RNA結合タンパク質 / 性分化 / 精子幹細胞 / CNOT複合体 / Nanos2 / Smad / ERK / Nodal / Smad4 / Smad2/3 / Dnd1 / Soh1h / 精子形成 / GDNF / セルトリ細胞
Research Abstract

In mouse germ cell development, the activation of an RNA binding protein Nanos2 is a critical step for male germ cell differentiation. We found that TGF-b signal (nodal/activin) mediated by Smad2 signaling is required for the Nanos2 induction. Once Nanos2 is induced, it localizes to P-bodies and interacts with CNOT complex, by which target RNAs are degraded. Nanos2 suppresses female pathway and promotes male pathway by repressing RNAs involved in the maintenance of PGCs, meiosis and mitosis in embryonic gonads. Nanos2 is also expressed in spermatogonial stem cells and plays an important role for the maintenance of stem cells. In the absence of Nanos2, stem cells can not maintain the stem cell property and quickly differentiate. We found that coordination of stem cells between self-renewal and differentiation is regulated by both extrinsic niche signals such as GDNF, FGF, RA and stem cell intrinsic factors such as Nanos2.

Assessment Rating
Verification Result (Rating)

A

Report

(6 results)
  • 2014 Research Progress Assessment (Verification Result) ( PDF )
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (64 results)

All 2014 2013 2012 2011 2010 2009 Other

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (47 results) (of which Invited: 21 results) Remarks (1 results)

  • [Journal Article] CYP26B1 promotes male germ cell differentiation by suppressing STRA8-dependent meiotic and STRA8-independent mitotic pathways2014

    • Author(s)
      Saba R, Wu Q, Saga Y
    • Journal Title

      Dev Biol

      Volume: 389 Issue: 2 Pages: 173-81

    • DOI

      10.1016/j.ydbio.2014.02.013

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] NANOS2 promotes male germ cell development independent of meiosis suppression2014

    • Author(s)
      Saba R, Kato Y, Saga Y
    • Journal Title

      Dev Biol

      Volume: 385 Issue: 1 Pages: 32-40

    • DOI

      10.1016/j.ydbio.2013.10.018

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] MEK/ERK Signaling Directly and Indirectly Contributes to the Cyclical Self-Renewal of Spermatogonial Stem Cells2013

    • Author(s)
      Hasegawa K, Namekawa SH, Saga Y
    • Journal Title

      StemCells

      Volume: 31 Issue: 11 Pages: 2517-27

    • DOI

      10.1002/stem.1486

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nodal/activin signaling promotes male germ cell fate and suppresses female programming in somatic cells2013

    • Author(s)
      Wu Q, Kanata K, Saba R, Deng CX, Hamada H, Saga Y
    • Journal Title

      Development

      Volume: 140(2) Issue: 2 Pages: 291-300

    • DOI

      10.1242/dev.087882

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mice stage-specific claudin 3 expression regulates progression of meiosis in early stage spermatocytes2013

    • Author(s)
      Chihara M, Ikebuchi R, Otsuka S, Ichii O, Hashimoto Y, Suzuki A, Saga Y, Kon Y.
    • Journal Title

      Biology of Reproduction

      Volume: 89 Issue: 1 Pages: 1-12

    • DOI

      10.1095/biolreprod.113.107847

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Posttranscriptional Regulation of Histone Lysine Methyltransferase GLP in Embryonic Male Mouse Germ Cells.2013

    • Author(s)
      Deguchi K, Nagamatsu G, Miyachi H, Kato Y, Morita S, Kimura H, Kitano S, Hatada I, Saga Y, Tachibana M, Shinkai Y.
    • Journal Title

      Biol Reprod

      Volume: 88 Issue: 2 Pages: 36-36

    • DOI

      10.1095/biolreprod.112.103572

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retinoic acid signaling in Sertoli cells regulates organization of the blood-testis barrier through cyclical changes in gene expression2012

    • Author(s)
      Hasegawa K, Saga Y
    • Journal Title

      Development

      Volume: 139 Issue: 23 Pages: 4347-55

    • DOI

      10.1242/dev.080119

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction between NANOS2 and the CCR4-NOT deadenylation complex is essential for male germ cell development in mouse2012

    • Author(s)
      Suzuki A, Saba R, MiyoshiK, Morita, Saga Y
    • Journal Title

      PLos One

      Volume: 7(3) Issue: 3 Pages: 1-12

    • DOI

      10.1371/journal.pone.0033558

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NANOS2 acts downstream of glial cell line-derived neurotrophic factor signaling to suppress differentiation of spermatogonial stem cells2012

    • Author(s)
      Sada A, Hasegawa K, Pin PH, Saga Y
    • Journal Title

      Stem Cells

      Volume: 30 Issue: 2 Pages: 280-91

    • DOI

      10.1002/stem.790

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Notch signaling in Sertoli cells regulates cyclical gene expression of Hes1 but is dispensable for mouse spermatogenesis2012

    • Author(s)
      Hasegawa K, Okamura Y, Saga Y
    • Journal Title

      Mol Cell Biol

      Volume: 32 Issue: 1 Pages: 206-15

    • DOI

      10.1128/mcb.06063-11

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rhox13 Is Translated in Premeiotic Germ Cells in Male and Female Mice and Is Regulated by NANOS2 in the Male.2012

    • Author(s)
      Geyer CB, Saba R, Kato Y, Anderson AJ, Chappell VK, Saga Y, Eddy EM.
    • Journal Title

      Biol Reprod.

      Volume: 86 Issue: 4 Pages: 127-127

    • DOI

      10.1095/biolreprod.111.094938

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Nanos3-3'UTR is required for germ cell specific NANOS3 expression in mouse embryos2010

    • Author(s)
      Suzuki H, Saba R, Sada A, Saga Y
    • Journal Title

      PLoS One

      Volume: 18 ; 5(2) Issue: 2 Pages: e9300-e9300

    • DOI

      10.1371/journal.pone.0009300

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] NANOS2 interacts with the CCR4-NOT deadenylation complex and leads to suppression of specific RNAs2010

    • Author(s)
      Suzuki A, Igarashi K, Aisaki K, Kanno J, Saga Y
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 107 Issue: 8 Pages: 3594-9

    • DOI

      10.1073/pnas.0908664107

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Function of Nanos2 in the male germ cell lineage in mice.2010

    • Author(s)
      Saga Y.
    • Journal Title

      Cell Mol Life Sci.

      Volume: 67 Pages: 3815-3822

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The heterogeneity of spermatogonia is revealed by their topology and expression of marker proteins including the germ cell-specific proteins Nanos2 and Nanos32009

    • Author(s)
      H.Suzuki, A.Sada, S.Yoshida and Y.Saga
    • Journal Title

      Dev Biol

      Volume: 336 Issue: 2 Pages: 222-231

    • DOI

      10.1016/j.ydbio.2009.10.002

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The RNA-binding protein NANOS2 is required to maintain murine spermatogonial stem cells2009

    • Author(s)
      Sada A, Suzuki A, Suzuki H, Saga Y
    • Journal Title

      Science

      Volume: 325(5946) Issue: 5946 Pages: 1394-8

    • DOI

      10.1126/science.1172645

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Germ cell specific factors, NANOS2 and NANOS3 interact with distinct components of the CNOT complex2013

    • Author(s)
      相賀 裕美子
    • Organizer
      Meeting of Japanese Society of Molecular Biology
    • Place of Presentation
      Kobe
    • Year and Date
      2013-12-04
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Maintenance of spermatogonial stem cell(SSCs) via Nanos2-mediated mechanism2013

    • Author(s)
      相賀 裕美子
    • Organizer
      Meeting of Japanese Society of Biochemistry
    • Place of Presentation
      Yokohama
    • Year and Date
      2013-09-11
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] The molecular mechanism of NANOS2-mediated RNA regulation in germ cell differentiation2012

    • Author(s)
      相賀 裕美子
    • Organizer
      Meeting of Japanese Society of Molecular Biology
    • Place of Presentation
      Fukuoka
    • Year and Date
      2012-12-15
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] NANOS2 and NANOS3 contribute to germ cell differentiation via interacting with different components2012

    • Author(s)
      相賀 裕美子
    • Organizer
      Meeting of Japanese Society of Biochemistry
    • Place of Presentation
      Fukuoka
    • Year and Date
      2012-12-12
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] NANOS2-mediated RNA regulation in germ cell differentiation2012

    • Author(s)
      相賀 裕美子
    • Organizer
      CSH-meeting, germ cells
    • Place of Presentation
      NY
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Genetic pathways leading to sexual fate decision in mouse germ cells2012

    • Author(s)
      相賀 裕美子
    • Organizer
      The 58th/60th NIBB conference
    • Place of Presentation
      Okazaki
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] NANOS2-mediated RNA regulation in germ cell differentiation2012

    • Author(s)
      相賀 裕美子
    • Organizer
      ISSCR
    • Place of Presentation
      Yokohama
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Genetic Pathways Leading to Sexual Fate Decision in Mouse Germ Cells2012

    • Author(s)
      Yumiko Saga
    • Organizer
      The 58th/60th NIBB Conference
    • Place of Presentation
      Okazaki
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Identification of Authentic Nanos2 Targets in Fetal Male Germ Cells2012

    • Author(s)
      Yuzuru Kato
    • Organizer
      The 58th/60th NIBB Conference
    • Place of Presentation
      Okazaki
    • Related Report
      2012 Annual Research Report
  • [Presentation] Retinoic Acid Activates Mitosis and Interferes Male Gonocyte Differentiation via stra8-independent Pathway in the CYP26B1-null Mutant2012

    • Author(s)
      Rie Saba
    • Organizer
      The 58th/60th NIBB Conference
    • Place of Presentation
      Okazaki
    • Related Report
      2012 Annual Research Report
  • [Presentation] Nodal/Activin Promotes Sex Differentiation of Male Germ Cells through MAPK P38 Signaling Pathway2012

    • Author(s)
      Quan Wu
    • Organizer
      The 58th/60th NIBB Conference
    • Place of Presentation
      Okazaki
    • Related Report
      2012 Annual Research Report
  • [Presentation] Nodal/Activin promotes sex differentiation of male germ cells through2012

    • Author(s)
      Quan Wu, Rie Saba, Kohei
    • Organizer
      第45回発生生物学会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] NANOS2 promotes male germ cell program independent of the2012

    • Author(s)
      Yuzuru Kato, Rie Saba, Yumiko Saga.
    • Organizer
      第45回発生生物学会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] NANOS2-mediated RNA regulation in germ cell differentiation2012

    • Author(s)
      Yumiko Saga
    • Organizer
      Cold Spring Harbor meeting (Germ cells)
    • Place of Presentation
      New York,USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Identification of Authentic Nanos2 Targets in Fetal Male Germ Cells2012

    • Author(s)
      Yuzuru Kato, Yumiko Saga
    • Organizer
      Cold Spring Harbor meeting (Germ cells)
    • Place of Presentation
      New York,USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] NANOS2 and NANOS3 contribute to germ cell differentiation via2012

    • Author(s)
      Yumiko Saga, Atsushi Suzuki.
    • Organizer
      第85回 日本生化学会大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Post-transcriptional regulation in the sexual differentiation of mouse male germ cells2012

    • Author(s)
      Atsushi Suzuki, Yumiko Saga
    • Organizer
      第85回 日本生化学会大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] The Molecular Mechanism of NANOS2-Mediated RNA Regulation in2012

    • Author(s)
      Yumiko Saga, Atsushi Suzuki,YuzuruKato.
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] The mechanism leading to sexual differentiation of male germ cells2011

    • Author(s)
      相賀 裕美子
    • Organizer
      The Cold Spring Harbor Asia conference
    • Place of Presentation
      Suzhou, China
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Male germ cell development in mice2011

    • Author(s)
      相賀 裕美子
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      Andover, NH
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Male germ cell development in mice2011

    • Author(s)
      Yumiko Saga
    • Organizer
      Gordon Research Conference (Developmental Biology)
    • Place of Presentation
      Andover,NH,USA
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] The mechanism leading to sexual differentiation of male germ cells.2011

    • Author(s)
      Yumiko Saga
    • Organizer
      The Cold Spring Harbor Asia conference
    • Place of Presentation
      Suzhou,China
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] TGFb signaling is essential for sex differentiation of male germ cells.2011

    • Author(s)
      Quan Wu
    • Organizer
      The Cold Spring Harbor Asia conference
    • Place of Presentation
      Suzhou,China
    • Related Report
      2011 Annual Research Report
  • [Presentation] NANOS2 suppresses premature meiosis in the CYP26B1-null male gonad2011

    • Author(s)
      Rie Saba, Yumiko Saga
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] マウス胎児期雄性生殖細胞のP-body形成におけるNANOS2 zinc finger motif の機能解析2011

    • Author(s)
      中島優紀、相賀裕美子、鈴木敦
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Fgf signaling is required to maintain spermatogonial stem cells in mouse testes2011

    • Author(s)
      Kazuteru Hasegawa,.Yumiko Saga.
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Analyses of small amount RNAs via next generation sequencer2011

    • Author(s)
      Rie Saba, Masafumi Muraoka,
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Analyses of the regulation of transcriptome in embryonic male germ cells via next generation sequencer2011

    • Author(s)
      Masafumi Muraoka, Rie Saba, Yuzuru Kato, Katsuhiko Shirahige, Yumiko Saga.
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Functions of NANOS2 in the maintenance and differentiation of male germ lineage in mice2010

    • Author(s)
      相賀 裕美子
    • Organizer
      CSH-meeting : Mouse development, Genetics and Genomics
    • Place of Presentation
      Cold Spring Harbor, New York
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Function of NANOS2 in the embryonic germ cells and spermatogonial stem cells in mice2010

    • Author(s)
      相賀 裕美子
    • Organizer
      OzBio2010
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Molecular functions of Nanos2 as a switcher of sexual differentiation of germ cells2010

    • Author(s)
      相賀 裕美子
    • Organizer
      SDB-JSDB Joint Meeting
    • Place of Presentation
      Albuquerque, New Mexico, United States
    • Related Report
      2013 Final Research Report 2010 Annual Research Report
    • Invited
  • [Presentation] Interaction between Nanos2 and CCR4-NOT deadenylation comples is essential for male germ cell development in mouse2010

    • Author(s)
      Atsushi Suzuki
    • Organizer
      CSH symposium : Germ cells
    • Place of Presentation
      Cold Spring Harbor, New York
    • Related Report
      2010 Annual Research Report
  • [Presentation] molecular functions of Nanos2 as a switcher of sexual differentiation of germ cells2010

    • Author(s)
      Yumiko Saga
    • Organizer
      International Symposium on "Epigenome Network, Development and Reprogramming of Germ Cells"
    • Place of Presentation
      Fukuoka
    • Related Report
      2010 Annual Research Report
  • [Presentation] Nanos2 is an intrinsic regulator for maintaining an undifferentiated state of spermatogonial stem cells2010

    • Author(s)
      Aiko Sada
    • Organizer
      SDB-JSDB Joint Meeting
    • Place of Presentation
      Albuquerque, New Mexico, United States
    • Related Report
      2010 Annual Research Report
  • [Presentation] Functions of NANOS2 in the maintenance and differentiation of male germ lineage in mice2010

    • Author(s)
      Yumiko Saga
    • Organizer
      CSH symposium : Mouse development, Genetics and Genomics
    • Place of Presentation
      Cold Spring Harbor, New York
    • Related Report
      2010 Annual Research Report
  • [Presentation] Function of NANOS2 in the embryonic germ cells and spermatogonial stem cells in mice2010

    • Author(s)
      Yumiko Saga
    • Organizer
      OzBio20101
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2010 Annual Research Report
  • [Presentation] Periodic activation of retinoic acid signaling creates stage-dependent gene expression in Sertoli cells during mouse spermatogenesis2010

    • Author(s)
      Kazuteru Hasegawa
    • Organizer
      CSH symposium : Germ cells
    • Place of Presentation
      Cold Spring Harbor, New York
    • Related Report
      2010 Annual Research Report
  • [Presentation] Functions of NANOS2 in the Maintenance of Embryonic Germ Cells and Spermatogonial Stem Cells in Mice2010

    • Author(s)
      Yumiko Saga
    • Organizer
      The First SKLRB Symposia on Frontiers in Periimplantation Biology
    • Place of Presentation
      Beijing
    • Related Report
      2010 Annual Research Report
  • [Presentation] Functions of NANOS2 in the maintenance and differentiation of male germ lineage in mice2010

    • Author(s)
      Yumiko Saga
    • Organizer
      43rd Annual Meeting of the Japanese Society of Developmental Biologists
    • Place of Presentation
      Kyoto
    • Related Report
      2010 Annual Research Report
  • [Presentation] Periodic activation of retinoic acid signaling creates stage-dependent gene expression in Sertoli cells during mouse spermatogenesis2010

    • Author(s)
      Kazuteru Hasegawa
    • Organizer
      43rd Annual Meeting of the Japanese Society of Developmental Biologists
    • Place of Presentation
      Kyoto
    • Related Report
      2010 Annual Research Report
  • [Presentation] Functions of NANOS2 in the Maintenance of Embryonic Germ Cells and Spermatogonial Stem Cells in Mice2009

    • Author(s)
      相賀 裕美子
    • Organizer
      The First SKLRB Symposia on Frontiers in Periimplantation Biology
    • Place of Presentation
      Beijing
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] BMP Signaling Determines XX Germ Cell Fate independently of Retinoic Acid-induced Meiotic Initiation

    • Author(s)
      Quan Wu., Chu-Xia,Deng., Yumiko Saga.
    • Organizer
      日本発生生物学会
    • Place of Presentation
      松江
    • Related Report
      2013 Annual Research Report
  • [Presentation] 生殖細胞特異的タンパク質NANOS2, NANOS3とCNOTの相互作用によるRNA制御機構

    • Author(s)
      鈴木敦, 櫻井隆順, 山本雅,相賀 裕美子
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Identification of a Nanos target in the mouse

    • Author(s)
      Yuzuru Kato, Yumiko Saga.
    • Organizer
      日本発生生物学会
    • Place of Presentation
      松江
    • Related Report
      2013 Annual Research Report
  • [Presentation] The mechanism of the establishment of murine spermatogonial stem cells

    • Author(s)
      Han Pin Pui, Yumiko Saga
    • Organizer
      日本発生生物学会
    • Place of Presentation
      松江
    • Related Report
      2013 Annual Research Report
  • [Presentation] Identification of a Nanos target in the mouse

    • Author(s)
      Yuzuru Kato, Yumiko Saga.
    • Organizer
      Mouse molecular Genetics
    • Place of Presentation
      Hinxton (英国)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Maintenance of spermatogonial stem cells(SSCs) viaNanos2-mediated mechanism

    • Author(s)
      Yumiko Saga, Zhou-zhi
    • Organizer
      日本生化学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Remarks]

    • URL

      http://www.nig.ac.jp/labs/MamDev/home-j.html

    • Related Report
      2013 Final Research Report

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Published: 2009-04-01   Modified: 2023-03-16  

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