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Mechanisms and physiological roles of electro-chemical Coupling mediated by voltage-sensor domain proteins

Research Project

Project/Area Number 21229003
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field General physiology
Research InstitutionOsaka University

Principal Investigator

YASUSHI Okamura  大阪大学, 医学(系)研究科(研究院), 教授 (80201987)

Co-Investigator(Kenkyū-buntansha) SAKIMURA Kenji  新潟大学, 脳研究所, 教授 (40162325)
YOSHIDA Manabu  東京大学, 大学院理学系研究科, 准教授 (60301785)
NAKAGAWA Atsushi  大阪大学, たんぱく質研究所, 教授 (20188890)
FUJIWARA Yuichiro  大阪大学, 大学院医学系研究科, 准教授 (20532980)
TSUTSUI Hidekazu  大阪大学, 大学院医学系研究科, 特任講師 (30392038)
OUKOUCHI Yoshifumi  大阪大学, 大学院医学系研究科, 助教 (90435818)
Co-Investigator(Renkei-kenkyūsha) MIYAWAKI Atsushi  理化学研究所, 細胞機能探索技術開発チーム, シニア・リーダー (80251445)
Project Period (FY) 2009-05-11 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥143,130,000 (Direct Cost: ¥110,100,000、Indirect Cost: ¥33,030,000)
Fiscal Year 2012: ¥32,240,000 (Direct Cost: ¥24,800,000、Indirect Cost: ¥7,440,000)
Fiscal Year 2011: ¥31,460,000 (Direct Cost: ¥24,200,000、Indirect Cost: ¥7,260,000)
Fiscal Year 2010: ¥35,490,000 (Direct Cost: ¥27,300,000、Indirect Cost: ¥8,190,000)
Fiscal Year 2009: ¥43,940,000 (Direct Cost: ¥33,800,000、Indirect Cost: ¥10,140,000)
Keywords生体膜 / チャネル / トランスポーター / 能動輸送 / 電位センサー / プロトン / 膜電位 / ホスホイノシチド
Research Abstract

Molecular mechanisms of voltage sensor domain proteins, including voltage-sensing phosphatase and voltage-gated proton channels, were studied by X-ray crystallography, electrophysiology, fluorescence imaging or fluorometry. We also exploited advantages of molecular mechanisms to develop efficient voltage-reporter protein and applied them in zebrafish heart and mouse auditory cortex and were convinced that these probes serve as efficient reporter. Knock out mice were establsihed for VSP, VSOP/Hv1 and VSOP2 and physiological functions of these voltage-signaling molecules have been revealed.

Assessment Rating
Verification Result (Rating)

A

Report

(6 results)
  • 2014 Research Progress Assessment (Verification Result) ( PDF )
  • 2013 Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (141 results)

All 2014 2013 2012 2011 2010 2009 Other

All Journal Article (43 results) (of which Peer Reviewed: 27 results,  Open Access: 7 results) Presentation (87 results) (of which Invited: 12 results) Book (5 results) Remarks (4 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Rapid evaluation of a protein-based voltage probe using a field-induced membrane potential change2014

    • Author(s)
      Tsutsui H, Jinno Y, Tomita A & Okamura Y
    • Journal Title

      Biochim. Biophys. Acta

      Volume: 1838(7) Issue: 7 Pages: 1730-7

    • DOI

      10.1016/j.bbamem.2014.03.002

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] X-ray crystal structure of voltage-gated proton channel2014

    • Author(s)
      Takeshita K, Sakata S, Yamashita E, Fujiwara Y, Kawanabe A, Kurokawa T, Okochi Y, Matsuda M, Narita H, Okamura Y & Nakagawa A
    • Journal Title

      Nat. Strucl. & Mol. Biol.

      Volume: (4) Issue: 4 Pages: 352-7

    • DOI

      10.1038/nsmb.2783

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PLC-mediated PI(4,5)P2 hydrolysis regulates activation and inactivation of TRPC6/7 channels2014

    • Author(s)
      Itsuki K, Imai Y, Hase H, Okamura Y, Inoue R & Mori M
    • Journal Title

      J. Gen. Physiol

      Volume: 143(2) Pages: 183-201

    • Related Report
      2013 Final Research Report
  • [Journal Article] Phosphatase activity of the voltage-sensing phosphatase, VSP, shows graded dependence on the extent of activation of the voltage sensor2014

    • Author(s)
      Sakata S & Okamura Y
    • Journal Title

      J. Physiol.

      Volume: 592(Pt 5) Issue: 5 Pages: 899-914

    • DOI

      10.1113/jphysiol.2013.263640

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mapping of sites facing aqueous environment of voltage-gated proton channel at resting state: A study with PEGylation protection2013

    • Author(s)
      Kurokawa T & Okamura Y
    • Journal Title

      Biochem. Biophys. Acta

      Volume: 1838(1 Pt B) Issue: 1 Pages: 382-7

    • DOI

      10.1016/j.bbamem.2013.10.001

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Potential role of voltage-sensing phosphatases in regulation of cell structure through the production of PI(3,4)P<sub>2</sub>2013

    • Author(s)
      Yamaguchi S, Kurokawa T, Taira I, Aoki N, Sakata S, Okamura Y & Homma KJ
    • Journal Title

      J. Cell Physiol.

      Volume: 229 Issue: 4 Pages: 422

    • DOI

      10.1002/jcp.24463

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Improved detection of electrical activity with a voltage probe based on a voltage-sensing phosphatase2013

    • Author(s)
      Tsutsui H, Jinno Y, Tomita A, Niino Y, Yamada Y, Mikoshiba K, Miyawaki A & Okamura Y
    • Journal Title

      J. Physiol. , Epub 2013 Jul 8

      Volume: 591(Pt 18) Issue: 18 Pages: 4427-37

    • DOI

      10.1113/jphysiol.2013.257048

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Optically detected structural change in the N-terminal region of the voltage-sensor domain2013

    • Author(s)
      Tsutsui H, Jinno Y, Tomita A & Okamura Y
    • Journal Title

      Biophys. J.

      Volume: 105(1) Pages: 108-15

    • Related Report
      2013 Final Research Report
  • [Journal Article] Structural characteristics of the redox-sensing coiled coil in the voltage-gated H+ channel2013

    • Author(s)
      Fujiwara Y, Takeshita K, Nakagawa A & Okamura Y
    • Journal Title

      J. Biol. Chem.

      Volume: 288(25) Pages: 17968-75

    • Related Report
      2013 Final Research Report
  • [Journal Article] Optically detected structural change in the N-terminal region of the voltage-sensor domain.2013

    • Author(s)
      Tsutsui H, Jinno Y, Tomita A, Okamura.Y
    • Journal Title

      Biophys. J.

      Volume: 105(1) Issue: 1 Pages: 108-115

    • DOI

      10.1016/j.bpj.2013.05.051

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural characteristics of the redox-sensing coiled coil in the voltage-gated H+ channel.2013

    • Author(s)
      Fujiwara Y, Takeshita K, Nakagawa A, Okamura Y
    • Journal Title

      J Biol Chem.

      Volume: 288(25) Issue: 25 Pages: 17968-75

    • DOI

      10.1074/jbc.m113.459024

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The cytoplasmic coiled-coil mediates cooperative gating temperature sensitivity in the voltage-gated H+ channel Hv12012

    • Author(s)
      Fujiwara Y, Kurokawa T, Takeshita K, Kobayashi M, Okochi Y, Nakagawa A & Okamura Y
    • Journal Title

      Nat. Communi.

      Volume: 3 Issue: 1 Pages: 816-816

    • DOI

      10.1038/ncomms1823

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autoimmune disorder phenotypes in HVCN1 gene deficient mice2012

    • Author(s)
      Sasaki M, Tojo A, Okochi Y, Miyawaki N, Kamimura D, Yamaguchi A, Murakami M & Okamura Y
    • Journal Title

      Biochem. J.

      Volume: 450(2) Pages: 295-301

    • Related Report
      2013 Final Research Report
  • [Journal Article] Gating of the Designed Trimeric/Tetrameric Voltage-Gated H+ Channel2012

    • Author(s)
      Fujiwara Y, Kurokawa T, Takeshita K, Nakagawa A, Larsson HP & Okamura Y
    • Journal Title

      J. Physiol.

      Volume: 591(Pt 3) Pages: 627-40

    • Related Report
      2013 Final Research Report
  • [Journal Article] 3′ Phosphatase activity toward phosphatidylinositol 3,4-bisphosphate [PI(3,4)P <sub>2</sub>] by voltage-sensing phosphatase (VSP)2012

    • Author(s)
      Kurokawa T, Takasuga S, Sakata S, Yamaguchi S, Horie S, Homma KJ, Sasaki T & Okamura Y
    • Journal Title

      VSP. Proc. Natl. Acad. Sci. U.S.A.

      Volume: 109 Issue: 25 Pages: 10089

    • DOI

      10.1073/pnas.1203799109

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of the cytoplasmic PTEN-like region of Ci-VSP provides insight into substrate specificity and redox regulation of the phosphoinositide phosphatase activity2011

    • Author(s)
      Matsuda M, Takeshita K, Kurokawa T, Sakata S, Suzuki M, Yamashita E, Okamura Y & Nakagawa A
    • Journal Title

      J. Biol. Chem.

      Volume: 286(26) Pages: 23368-77

    • Related Report
      2013 Final Research Report
  • [Journal Article] Coupling of the phosphatase activity of Ci-VSP to its voltage sensor activity over the entire range of voltage sensitivity2011

    • Author(s)
      Sakata S, Hossain MI & Okamura Y
    • Journal Title

      J. Physiol.

      Volume: 589(11) Pages: 2687-705

    • Related Report
      2013 Final Research Report
  • [Journal Article] Voltage-sensing phosphatase: its molecular relationship with PTEN2011

    • Author(s)
      Okamura Y & Dixon JE
    • Journal Title

      Physiology

      Volume: 26(1) Pages: 6-13

    • Related Report
      2013 Final Research Report
  • [Journal Article] Coupling of the phosphatase activity of Ci-VSP to its voltage sensor activity over the entire range of voltage sensitivity.2011

    • Author(s)
      Sakata S, Hossain MI, Okamura Y
    • Journal Title

      The Journal of Physiology

      Volume: 589 Issue: 11 Pages: 2687-2705

    • DOI

      10.1113/jphysiol.2011.208165

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of the cytoplasmic PTEN-like region of Ci-VSP provides insight into substrate specificity and redox regulation of the phosphoinositide phosphatase activity.2011

    • Author(s)
      Matsuda M, Takeshita K, Kurokawa T, Sakata S, Suzuki M, Yamashita E, Okamura Y, Nakagawa A
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 286 Issue: 26 Pages: 23368-23377

    • DOI

      10.1074/jbc.m110.214361

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Voltage-sensing phosphatase: its molecular relationship with PTEN.2011

    • Author(s)
      OkamuraY, Dixon JE
    • Journal Title

      Physiology

      Volume: 26 Issue: 1 Pages: 6-13

    • DOI

      10.1152/physiol.00035.2010

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Gene expression profile of Ci-VSP in juveniles and adult blood cells of ascidian.2011

    • Author(s)
      Ogasawara M, Sasaki M, Nakazawa N, Nishino A, OkamuraY
    • Journal Title

      Gene Expression Pattern

      Volume: 11 Issue: 3-4 Pages: 233-238

    • DOI

      10.1016/j.gep.2010.12.004

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Voltage sensitive phosphoinositide phosphatases of Xenopus: their tissue distribution and voltage dependence.2011

    • Author(s)
      Ratzan WJ, Evsikov AV, Okamura Y, Jaffe LA
    • Journal Title

      Journal of Cellular Physiology

      Volume: 226 Issue: 11 Pages: 2740-2746

    • DOI

      10.1002/jcp.22854

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] KCNQ1 subdomains involved in KCNE modulation revealed by an invertebrate KCNQ1 orthologue.2011

    • Author(s)
      Nakajo K, Nishino A, Okamura Y, Kubo Y
    • Journal Title

      J Gen Physiol.

      Volume: 138 Issue: 5 Pages: 521-535

    • DOI

      10.1085/jgp.201110677

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A self-limiting regulation of TRPC3/C6/C7 channels coupled with PI(4,5)P2-diacylglycerol signalling.2011

    • Author(s)
      Imai Y, Itsuki K, Okamura Y, Inoue R, Mori MX
    • Journal Title

      The Journal of Physiology

      Volume: 590 Issue: 5 Pages: 1101-1119

    • DOI

      10.1113/jphysiol.2011.221358

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression profile of Ci-VSP in juveniles and adult blood cells of ascidian2011

    • Author(s)
      Ogasawara M, Sasaki M, Nakazawa N, Nishino A, Okamura Y
    • Journal Title

      Gene Expr Patterns

      Volume: Dec 21 Pages: 233-238

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A mechanism for graded motor control encoded in the channel properties of the muscle ACh receptor2011

    • Author(s)
      Nishino A, Baba SA, Okamura Y
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 108 Pages: 2599-604

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 電位依存性プロトンチャネルに見る膜電位センサーの謎:細胞膜中に存在する電荷2011

    • Author(s)
      黒川竜紀, 岡村康司
    • Journal Title

      生物物理Vol51 No.2

      Volume: 2 Pages: 72-72

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Voltage-Sensing Phosphatase : Its Molecular Relationship With PTEN2011

    • Author(s)
      Yasushi Okamura, Jack E.Dixon
    • Journal Title

      Physiology

      Volume: 26 Pages: 6-13

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualizing voltage dynamics in zebrafish heart2010

    • Author(s)
      Tsutsui H, Higashijima S, Miyawaki A & Okamura Y
    • Journal Title

      J. Physiol.

      Volume: 588(12) Pages: 2017-21

    • NAID

      10030455833

    • Related Report
      2013 Final Research Report
  • [Journal Article] VSOP/Hv1 proton channels sustain calcium entry, neutrophil migration, and superoxide production by limiting cell depolarization and acidification2010

    • Author(s)
      El Chemaly A, Okochi Y, Sasaki M, Arnaudeau S, Okamura Y & Demaurex N
    • Journal Title

      J. Exp. Med.

      Volume: 207(1) Pages: 129-39

    • Related Report
      2013 Final Research Report
  • [Journal Article] Functionality of the voltage-gated proton channel truncated in S42010

    • Author(s)
      Sakata S, Kurokawa T, Norholm MH, Takagi M, Okochi Y, von Heijne G & Okamura Y
    • Journal Title

      Proc. Natl. Acad. Sci. U.S.A.

      Volume: 107(5) Issue: 5 Pages: 2313-8

    • DOI

      10.1073/pnas.0911868107

    • Related Report
      2013 Final Research Report
  • [Journal Article] A glycine receptor is involved in the organization of swimming movements in an invertebrate chordate2010

    • Author(s)
      Nishino A, Okamura Y, Piscopo S, Brown ER
    • Journal Title

      BMC Neurosci

      Volume: 6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lipids : PI couples voltage to catalysis2010

    • Author(s)
      Okamura Y
    • Journal Title

      Nat Chem Biol

      Volume: 6 Pages: 315-6

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Visualizing voltage dynamics in zebrafish heart2010

    • Author(s)
      Tsutsui H, Higashijima S, Miyawaki A, Okamura Y
    • Journal Title

      J Physiol

      Volume: 588 Pages: 2017-21

    • NAID

      10030455833

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single or double? Think zinc!2010

    • Author(s)
      Okamura Y
    • Journal Title

      J Physiol

      Volume: 588 Pages: 1803-4

    • Related Report
      2010 Annual Research Report
  • [Journal Article] A global synergy of ions and voltage?2010

    • Author(s)
      Okamura Y
    • Journal Title

      J Physiol

      Volume: 588 Pages: 4649-4649

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Functionality of the Voltage-gated proton channel truncated in S4.2010

    • Author(s)
      Sakata S, Kurokawa T, Norholm MH, Takagi M, Okochi Y, von Heijne G, Okamura Y.
    • Journal Title

      Proc.Natl.Acad.Sci.U.S.A. 107

      Pages: 845-855

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] VSOP/Hv1 proton channels sustain calcium entry, neutrophil migration, and superoxide production by limiting cell depolarization and acidification2010

    • Author(s)
      El Chemaly A, Okochi Y, Sasaki M, Arnaudeau S, okamura Y, Demaurex N.
    • Journal Title

      Journal of Experimental Medicine 207

      Pages: 129-139

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A glycine receptor is involved in the organization of swimming movements in an invertebrate chordate.2010

    • Author(s)
      Nishino A, Okamura Y, Piscopo S, Brown ER.
    • Journal Title

      BMC Neurosci. 11

      Pages: 6-6

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Voltage-sensing phosphatease : actions and polentials2009

    • Author(s)
      Okamura Y, Murata Y, Iwasaki H.
    • Journal Title

      Journal of Physiology 587

      Pages: 513-520

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Another story of arginines in voltage sensing : the role of phosphoinositides in coupling voltage sensing to enzyme activity2009

    • Author(s)
      Okamura Y.
    • Journal Title

      Journal of Physiology 134

      Pages: 1-4

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Voltage-gated proton channel is expressed on phagosomes2009

    • Author(s)
      Okochi Y, Sasaki M, Iwasaki H, Okamura Y.
    • Journal Title

      Biochem Biophys Res Commun. 382(2) : 274-9. 382

      Pages: 274-279

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 電位依存性プロトンチャネルVSOP1/H1の動作原理2014

    • Author(s)
      岡村康司 藤原祐一郎 川鍋陽 坂田宗平 黒川竜紀
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島県鹿児島市
    • Year and Date
      2014-03-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Voltage-sensor domain proteins: phosphonositide signal, proton permeation and molecular tools2014

    • Author(s)
      Okamura Y
    • Organizer
      Biophysical Society 58th Annual Meetingシンポジウム
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2014-02-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 電位依存性H+チャネルの膜電位感知機能2014

    • Author(s)
      藤原祐一郎、岡村康司
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島県鹿児島市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 電位依存性H+チャネルのゲーティングに対するS4領域の構造基盤2014

    • Author(s)
      奥田裕子、岡村康司 、藤原祐一郎
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島県鹿児島市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 活性化速度の異なるウニおよびマウスVSOP1/Hv1の比較による電位依存的ゲート機構2014

    • Author(s)
      坂田宗平、宮脇奈那、黒川竜紀、オズカーヌルダン、岡村康司
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島県鹿児島市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 電位依存性プロトンチャネルにおける閉状態のトポロジー解析2014

    • Author(s)
      黒川竜紀、岡村康司
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島県鹿児島市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 電位依存性プロトンチャネルへの不飽和脂肪酸による活性増強効果の定量的解析2014

    • Author(s)
      川鍋陽、岡村康司
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島県鹿児島市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 電位依存性プロトンチャネル欠損マウスはメタボリックシンドロームの表現型を呈する2014

    • Author(s)
      河合喬文、大河内善史、井村誉史雄、古川祐子、宮脇那奈、崎村建司、小泉修一、岡村康司
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島県鹿児島市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 光学的に検出された電位センサーN末領域の構造変化2014

    • Author(s)
      筒井秀和、神野有香、富田亜希子、岡村康司
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島県鹿児島市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 発現系を用いたCi-CatSperチャネルの機能解析2014

    • Author(s)
      有馬大貴、岡村康司 、筒井秀和
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島県鹿児島市
    • Related Report
      2012 Annual Research Report
  • [Presentation] PI(4,5)P2-DAGシグナルによって制御されるPCL共役方TRPC電流のモデルシュミレーション2014

    • Author(s)
      森誠之、斎恭平、今井裕子、岡村康司 、井上隆司、長谷英治、森泰生
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島県鹿児島市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 電位依存性プロトンチャネルVSOP/H1の動作原理2014

    • Author(s)
      岡村康司 、藤原祐一郎、川鍋陽、坂田宗平、黒川竜紀
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島県鹿児島市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Voltage-sensor domain proteins: phosphonositide signal, proton permeation and molecular tools.2014

    • Author(s)
      Yasushi Okamura
    • Organizer
      Biophsical Society 58th Annual Meeting
    • Place of Presentation
      San Francisco, CA, USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Inhibitation by reduction of PIP2 accelerates inactivation of receptor-operated TRPC6/7 currents.2014

    • Author(s)
      Mori Masayuki, Kyohei Itsuki, Yuko Imai, Hideharu Hase, Yasushi Okamura, Ryuji Inoue
    • Organizer
      Biophsical Society 58th Annual Meeting
    • Place of Presentation
      San Francisco, CA, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] The activation kinetics of the voltage-gated proton channels is drastically accelerated by unsaturated fatty acide.2014

    • Author(s)
      Akira Kawanabe, Yasushi Okamura
    • Organizer
      Biophsical Society 58th Annual Meeting
    • Place of Presentation
      San Francisco, CA, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Enzyme activity of voltage-sensing phosphatase (VSP) is graded dependent of the magnitude of movements of the voltage sensor?2014

    • Author(s)
      Souhei Sakata, Yasushi Okamura
    • Organizer
      The 4th International Ion Channel Conference.
    • Place of Presentation
      Shijiazhuang, China
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Voltage-sensing phosphatase -it's structure and portability2013

    • Author(s)
      Sakata S, Okamura Y, Tsutsui H
    • Organizer
      The 1st Awaji International Workshop on Electron Spin Science & Technology: Biological and Materials Sciences Oriented Applications
    • Place of Presentation
      兵庫県淡路市
    • Year and Date
      2013-06-17
    • Related Report
      2013 Final Research Report
  • [Presentation] How excited to talk with PI?: Lesson from voltage-sensing phosphatase.2013

    • Author(s)
      Okamura Y
    • Organizer
      日本生理学会第90回大会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 電位依存性ホスファターゼの動作原理と分子ツールへの応用2013

    • Author(s)
      岡村康司 、筒井秀和、坂田宗平
    • Organizer
      第86回日本生化学会大会プログラム
    • Place of Presentation
      神奈川県横浜市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 不飽和脂肪酸による電位依存性プロトンチャネルへの活性増強効果2013

    • Author(s)
      川鍋陽、岡村康司
    • Organizer
      第51回日本生物物理学会年会
    • Place of Presentation
      京都府京都市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 電位依存性ホスファターゼ(VSP)の酵素活性は、電位センサーの動いた大きさに従い段階的に発揮される2013

    • Author(s)
      坂田宗平、岡村康司
    • Organizer
      平成25年度生理学研究所研究会
    • Place of Presentation
      愛知県岡崎市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 電位センサー蛋白機能の多様性:イオン透過からホスファターゼまで2013

    • Author(s)
      岡村康司 、藤原祐一郎、坂田宗平、河合 喬文、筒井秀和、大河内善史
    • Organizer
      Neuro2013(第36回神経科学学大会)
    • Place of Presentation
      京都府京都市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Voltage-sensing phosphatase - its structure and portability.2013

    • Author(s)
      Yasushi Okamura, Souhei Sakata, Hidekazu Tsutsui
    • Organizer
      The 1st Awaji International Workshop on Electron Spin Science & Technology: Biological and Materials Sciences Oriented Applications. (1st AWEST 2013)
    • Place of Presentation
      兵庫県淡路市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Secret lives of voltage-sensing phosphatases,"Bioelectrochemistry"2012

    • Author(s)
      Okamura Y
    • Organizer
      ゴードンカンファレンス
    • Place of Presentation
      Lucca, Italy
    • Year and Date
      2012-07-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Gating Mechanisms of Voltage-Gated Proton Channels2012

    • Author(s)
      Okamura Y
    • Organizer
      ゴードンカンファレンス
    • Place of Presentation
      米国ベンチュラ
    • Year and Date
      2012-02-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Cytoplasmic Coiled-Coil Mediates the Gating Coupling and the Temperature Sensitivity in the Voltage-gated H+ Channel.2012

    • Author(s)
      藤原祐一郎、黒川竜紀、竹下浩平、小林恵、中川敦史、岡村康司
    • Organizer
      HD Physiology国際シンポジウム
    • Place of Presentation
      東大武田ホール(東京)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 細胞膜たんぱく質による膜電位変化のセンシングと情報転換2012

    • Author(s)
      岡村康司
    • Organizer
      ナノ・バイオ ICTシンポジウム2012
    • Place of Presentation
      東京ビッグサイト(東京)
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Gating Mechanisms of Voltage-Gated Proton Channels.2012

    • Author(s)
      岡村康司
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      Ventura CA USA
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Unusual features of chick vsp and its potential role in regulation of cell structure.2012

    • Author(s)
      Yasushi Okamura, Tatsuki Kurokawa, Shinji Yamaguchi, Naoya Aoki, Ikuko Taira, Souhei Sakata, Koichi Homma
    • Organizer
      第55回生物物理学会大会(米国)
    • Place of Presentation
      サンディエゴ CA (米国)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Ci-KCNQ1, an Ortholog of Vertebrate KCNQ1 from Ciona Intestinalis, has Revealed that KCNE1 and KCNE3 Utilize Different Domains of KCNQ1 for the Modulation of Gating.2012

    • Author(s)
      Koichi Nakajo, Atsuo Nishino, Yasushi Okamura, Yoshihiro Kubo
    • Organizer
      第55回生物物理学会大会(米国)
    • Place of Presentation
      サンディエゴ CA(米国)
    • Related Report
      2011 Annual Research Report
  • [Presentation] A Self-limiting Regulation of TRPC3/C6/C7 channels linked with PI(4,5)P2-Diacylglycerol Signaling.2012

    • Author(s)
      Yuko Imai, Kyohei Itsuki, Yasushi Okamura, Ryuji Inoue, Mori X. Masayuki
    • Organizer
      第55回生物物理学会大会(米国)
    • Place of Presentation
      サンディエゴ CA(米国)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Gating of Trimerized or Tetramerized Voltage-Gated H+ Channels.2012

    • Author(s)
      藤原祐一郎、マルタペレス、黒川竜紀、ピータラルソン、岡村康司
    • Organizer
      第55回生物物理学会大会(米国)
    • Place of Presentation
      サンディエゴ CA(米国)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 電位依存性プロトンチャネル.. (VSOP)の構造と機能2012

    • Author(s)
      岡村康司、藤原祐一郎、大河内善史、筒井秀和、坂田宗平、川鍋陽、中川敦史、竹下浩平、松田真
    • Organizer
      ターゲットタンパク研究プログラムシンポジウム
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 生命における電気信号の秘密を探る2012

    • Author(s)
      岡村康司、藤原祐一郎、大河内善史、坂田宗平、筒井秀和、中川敦史、竹下浩平、松田真
    • Organizer
      ターゲットタンパク研究プログラムシンポジウム
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 電位感受性ホスファターゼ (VSP)の構造と機能2012

    • Author(s)
      岡村康司、藤原祐一郎、大河内善史、筒井秀和、坂田宗平、川鍋陽、中川敦史、竹下浩平、松田真
    • Organizer
      ターゲットタンパク研究プログラムシンポジウム
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 電位センサードメイン蛋白の構造基盤:モジュールの共役による分子機能2012

    • Author(s)
      岡村康司、藤原祐一郎、大河内善史、筒井秀和、坂田宗平、川鍋陽、中川敦史、竹下浩平、松田真
    • Organizer
      ターゲットタンパク研究プログラムシンポジウム
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] 3,4量体型へ人工的にデザインした電位依存性プロトンチャネルのゲーティング2012

    • Author(s)
      藤原祐一郎、黒川竜紀、岡村康司
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本文化会館(長野県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 電位依存性ホスファターゼ(VSP)の電位センサーの変異体における電位依存的酵素活性の計測2012

    • Author(s)
      坂田宗平、ホサインモハマド、岡村康司
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      2012年3月29日松本文化会館(長野県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] KCNE3によるゲーティング修飾におけるKCNQ1チャネル.. S1セグメントの機能的役割2012

    • Author(s)
      中條浩一、西野敦雄、岡村康司、久保義弘
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本文化会館(長野県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 人工膜に再構成した電位依存性プロトンチャネルVSOPのチャネル活性2012

    • Author(s)
      川鍋陽、岡村康司
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本文化会館(長野県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] DAG活性化型.. TRPCチャネルにおける電流、細胞内Ca2+と PI(4,5)P2の相関2012

    • Author(s)
      齊郷平、今井裕子、岡村康司、井上隆司、森誠之
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本文化会館(長野県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 感染防御機構における電位依存性プロトンチャネル.. VSOPの役割の解析2012

    • Author(s)
      大河内善史、荒谷康昭、宮脇奈那、佐々木真理、鈴木和男、岡村康司
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本文化会館(長野県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] VSPによる細胞形態制御2012

    • Author(s)
      岡村康司、山口真二、黒川竜紀、坂田宗平、青木直哉、平郁子、本間光一
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本文化会館(長野県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] PIP2-PLC-DAGシグナルと連動したTRPC3/C6/C7チャネルの自律的制御機構2012

    • Author(s)
      森誠之、今井裕子、齋郷平、岡村康司、井上隆司
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本文化会館(長野県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 電位依存性ホスファターゼVSPの基質特異性:PTENとの違い2011

    • Author(s)
      岡村康司、黒川竜紀、松田真、坂田宗平、本間光一、中川敦史
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      神奈川(横浜)(招待講演)
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 構造に基づいた電位感受性ホスファターゼの其質特異性の解析2011

    • Author(s)
      黒川竜紀、岡村康司
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      神奈川(横浜)
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] PI(4,5)P_2の可視化と数理モデルの適用による電位依存性ホスファターゼCi-VSPの酵素活性の計測2011

    • Author(s)
      坂田宗平、岡村康司
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      神奈川(横浜)
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 貧食細胞における電位依存性プロトンチャネルVSOPによる活性酸素産生制御の解析2011

    • Author(s)
      大河内善史、岡村康司、河原司
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      神奈川(横浜)
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 電位依存性プロトンチャネルの温度感受性ゲーティングは2量体会合構造安定性により決定する2011

    • Author(s)
      藤原祐一郎、黒川竜紀、竹下浩平、小林恵、中川敦史、岡村康司
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      神奈川(横浜)
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Voltage-sensing phosphatase : mechanism and applications2011

    • Author(s)
      岡村康司
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      神奈川(横浜)(招待講演)
    • Year and Date
      2011-03-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Stability of the Cytoplasmic Dimer Assembly Regulates the Thermosensitive Gating of the Voltage-gated H+ Channel2011

    • Author(s)
      藤原祐一郎、黒川竜紀、竹下浩平、小林恵、中川敦史、岡村康司
    • Organizer
      第55回生物物理学会大会(米国)
    • Place of Presentation
      ボルチモア(米国)
    • Year and Date
      2011-03-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 電位センサータンパクから見た、膜電位-化学関連の機構と役割2011

    • Author(s)
      岡村康司
    • Organizer
      岡崎統合バイオサイエンスセンター10周年シンポジウム
    • Place of Presentation
      愛知(岡崎)(招待講演)
    • Year and Date
      2011-02-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 電位依存性プロトンチャネルの2量体会合はチャネルの温度感受性を制御する2011

    • Author(s)
      藤原祐一郎、黒川竜紀、竹下浩平、小林恵、中川敦史、岡村康司
    • Organizer
      第10回蛋白質科学会大会
    • Place of Presentation
      ホテル阪急エキスポパーク(大阪府)
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] 電位依存性プロトンチャネルVSOPの物理化学的手法を用いた解析2011

    • Author(s)
      Akira Kawanabe, Tetsuya Fukuda, Hideki Kandori, Yasushi Okamura
    • Organizer
      日本生物物理学会
    • Place of Presentation
      姫路(兵庫県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Characterizations of chick voltage-sensing phosphatase.2011

    • Author(s)
      Yasushi Okamura, Tatsuki Kurokawa, Souhei Sakata, Shinji Yamaguchi, Naoya Aoki, Taira Ikuko, Kouichi Homma
    • Organizer
      7th FAOPS Congress
    • Place of Presentation
      台北(台湾)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 電位依存性ホスファターゼVSPの作動原理:基質特異性とオルソログ分子の解析2011

    • Author(s)
      黒川竜紀、坂田宗平、岡村康司
    • Organizer
      生理学研究所研究会
    • Place of Presentation
      岡崎(愛知県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Characterizations of chick voltage-sensing phosphatase and its possible role in regulation of cell structure.2011

    • Author(s)
      Yasushi Okamura, Tatsuki Kurokawa, Souhei Sakata, Shinji Yamaguchi, Naoya Aoki, Ikuko Taira, Kouichi Homma
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜(神奈川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] ホヤ幼生の尾の運動制御機構2011

    • Author(s)
      西野敦雄、馬場昭次、岡村康司
    • Organizer
      日本動物学会 第82回旭川大会
    • Place of Presentation
      旭川(北海道)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 電位依存性プロトンチャネル VSOPのチャネル活性の定量解析2011

    • Author(s)
      川鍋陽、岡村康司
    • Organizer
      第104回近畿生理学会談話会
    • Place of Presentation
      高槻(大阪府)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 感染防御機構における電位依存性プロトンチャネルVSOPの役割の解析2011

    • Author(s)
      大河内善史、荒谷康昭、宮脇奈那、佐々木真理、鈴木和男、岡村康司
    • Organizer
      第104回近畿生理学会談話会
    • Place of Presentation
      高槻(大阪府)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Molecular mechanisms of voltage-sensor domain proteins.2011

    • Author(s)
      Yasushi Okamura , Tatsuki Kurokawa , Morten H.H. Norholm, Gunnar von Heijne, Declan Dolye, Jack E. Dixon
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜(神奈川)
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Molecular mechanisms and potential biological roles of voltage-sensing phosphoinositide phosphatases.2011

    • Author(s)
      Yasushi Okamura
    • Organizer
      第10回JBSバイオフロンティア国際シンポジウム
    • Place of Presentation
      福岡(福岡県)
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Characterization of substrate specificity of voltage-sensing phosphoinositide phosphatase, VSP, with relationship to PTEN2011

    • Author(s)
      Tatsuki Kurokawa
    • Organizer
      第10回JBSバイオフロンティア国際シンポジウム
    • Place of Presentation
      福岡(福岡県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Crystal structure of the cytoplasmic PTEN-like region of Ci-VSP provides insight into substrate specificity and redox regulation of the phosphoinositide phosphatase activity.2011

    • Author(s)
      Makoto Matsuda
    • Organizer
      第10回JBSバイオフロンティア国際シンポジウム
    • Place of Presentation
      福岡(福岡県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Coupling of the phosphoinositide phosphatase activity of Ci-VSP to its voltage sensor.2011

    • Author(s)
      Sohei Sakata
    • Organizer
      第10回JBSバイオフロンティア国際シンポジウム
    • Place of Presentation
      福岡(福岡県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 電位依存性ホスファターゼVSPの動作原理2010

    • Author(s)
      岡村康司
    • Organizer
      特定領域研究公開シンポジウム細胞感覚:セルセンサーのモーダルシフト
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2010-12-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] カタユウレイボヤ精子走化性における誘引物質受容機構2010

    • Author(s)
      吉田薫、稲葉一男、吉田学
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      兵庫(神戸)
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 膜電位依存性ホスファターゼCi-VSPの電位依存的な酵素活性の計測とモデリング2010

    • Author(s)
      坂田宗平、岡村康司
    • Organizer
      第103回近畿生理学談話会
    • Place of Presentation
      大阪
    • Year and Date
      2010-10-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 電位依存性プロトンチャネル細胞内領域の結晶構造と機能的意義2010

    • Author(s)
      藤原祐一郎、岡村康司
    • Organizer
      生理学研究所研究会
    • Place of Presentation
      愛知(岡崎)(招待講演)
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 電位依存性プロトンチャネルにおけるS4トポロジー解析2010

    • Author(s)
      黒川竜紀、岡村康司
    • Organizer
      生理学研究所研究会
    • Place of Presentation
      愛知(岡崎)(招待講演)
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 電位依存性プロトンチャネルVSOPのトポロジー解析2010

    • Author(s)
      黒川竜紀、岡村康司
    • Organizer
      Neuro2010(第33回日本神経科学大会、第53回日本神経化学会大会、第20回日本神経回路学会大会合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 膜電位感受性ホスファターゼVSPの細胞質領域のX線結晶構造解析2010

    • Author(s)
      松田真、坂田宗平、竹下浩平、鈴木守、山下栄樹、岡村康司、中川敦史
    • Organizer
      日本蛋白質科学会年会
    • Place of Presentation
      札幌
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 電位感受性ホスファターゼの動作原理と役割2010

    • Author(s)
      岡村康司、黒川竜紀、坂田宗平、平郁子、大河内善史、山口真二、小笠原道生、本間光一
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡(招待講演)
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 電位依存性プロトンチャネル細胞内コイルドコイル領域のX線結晶構造解析と機能解析2010

    • Author(s)
      藤原祐一郎、黒川竜紀、竹下浩平、中川敦史、岡村康司
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 電位依存性プロトンチャネルにおけるS4のトポロジー解析2010

    • Author(s)
      黒川竜紀、岡村康司
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡(招待講演)
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] ホスホイノシチドの急速な脱リン酸化による一過性TRPC6チャネルの不活性化2010

    • Author(s)
      今井裕子、森誠之、岡村康司、井上隆司
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡(招待講演)
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 電位センサーの動きが飽和した高い膜電位における電位依存性ホスファターゼの酵素活性の解析2010

    • Author(s)
      坂田宗平、岡村康司
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] VSOP/Hv1 proton channels sustain superoxide production, calcium entry, and cell migration by limiting the depolanrization and acidification of activated neutrophils.2010

    • Author(s)
      Chemaly AE, Okochi Y, Sasaki M, Arnandeau S, Okamura Y, Demaurex N.
    • Organizer
      Biophysical society meeting
    • Place of Presentation
      San Fransicso、 U.S.A.
    • Year and Date
      2010-02-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Membrane topology of S4 of the mouse voltage-gated proton channel2010

    • Author(s)
      Sakata S, Kurokawa T, Norholm MH, Takagi M, Okochi Y, von Heijne G, Okamura Y.
    • Organizer
      Biophysical society meeting
    • Place of Presentation
      San Fransicso、 U.S.A.
    • Year and Date
      2010-02-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] ホヤゲノムから見出された電位センサー蛋白の動作原理と応用2009

    • Author(s)
      岡村康司
    • Organizer
      第34回日本比較内分泌学会大会・日本比較生理生化学会第31回大会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Voltage-gated proton channel is expressed on phagosome2009

    • Author(s)
      Okochi Y, Sasaki M, Okamura Y
    • Organizer
      第32回日本神経科学会大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mechanisms and roles of voltage-sensing proteins without pore structure2009

    • Author(s)
      Okamura Y
    • Organizer
      第36回国際生理学会
    • Place of Presentation
      京都国際会館(京都府)
    • Year and Date
      2009-08-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] The role of C-terminal cytoplasmic regions in dimerization of voltage-gated proton channel2009

    • Author(s)
      Kurokawa K, Okochi Y, Okamura Y
    • Organizer
      36th International congress of physiological sciences
    • Place of Presentation
      京都国際会館(京都府)
    • Year and Date
      2009-07-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Voltage-dependent phosphatase activities of Ci-VSP at high membrane potential.2009

    • Author(s)
      Sakata S, Hossain M.S., Okamura Y.
    • Organizer
      第36回国際生理学会
    • Place of Presentation
      京都国際会館(京都府)
    • Year and Date
      2009-07-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Alteration of cellular phosphoinositides by voltage-sensing phosphatases2009

    • Author(s)
      Okamura Y, Hossain M.l.
    • Organizer
      第36回国際生理学会
    • Place of Presentation
      京都国際会館(京都府)
    • Year and Date
      2009-07-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Hv1 proton channels sustain superoxide production and calcium signaling in neutrophils2009

    • Author(s)
      Chemaly A.El, Okochi Y, Sasaki M, Arnaudeau, Okamura Y, Demaurex N.
    • Organizer
      第36回国際生理学会
    • Place of Presentation
      京都国際会館(京都府)
    • Year and Date
      2009-07-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] KCNE1 modulates KCNQ1 through specific amino acid residues in the pore region2009

    • Author(s)
      Nakajo K, Nishino A, Okamura Y, Kubo Y
    • Organizer
      第36回国際生理学会
    • Place of Presentation
      京都国際会館(京都府)
    • Year and Date
      2009-07-29
    • Related Report
      2009 Annual Research Report
  • [Book] Voltage-gated proton channels.Comprehensive Biophysics ed. Montal M.2013

    • Author(s)
      Okamura Y
    • Publisher
      Elsevier
    • Related Report
      2013 Final Research Report
  • [Book] 生物学辞典第五版2013

    • Author(s)
      岡村康司, 分担執筆及び分担編集
    • Publisher
      岩波書店
    • Related Report
      2013 Final Research Report
  • [Book] 生物学時点 第五版2013

    • Author(s)
      巌佐 庸、倉谷 滋、斎藤 成也、塚谷 裕一
    • Total Pages
      2192
    • Publisher
      岩波書店
    • Related Report
      2012 Annual Research Report
  • [Book] 実験医学増刊Vol.28 No.20分子から個体へと深化する脂質生物学2010

    • Author(s)
      岡村康司、佐々木雄彦, 横溝岳彦, 竹縄忠臣/編
    • Total Pages
      237
    • Publisher
      羊土社
    • Related Report
      2010 Annual Research Report
  • [Book] Voltage-gated ion channels and novel sensing proteins. Handbook of Neurochemistry and Molecular Neurobiology: Neural Signaling Mechanisms: ed. Mikoshiba K.2009

    • Author(s)
      Okamura Y
    • Publisher
      Springer
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://resou.osaka-u.ac.jp/ja/research/2014/20140303_1

    • Related Report
      2013 Final Research Report
  • [Remarks] 大阪大学大学院・医学系研究科・統合生理学教室

    • URL

      http://www.med.osaka-u.ac.jp/pub/phys2/okamura/index.html

    • Related Report
      2012 Annual Research Report
  • [Remarks] 大阪大学医学系研究科統合生理学教室HP

    • URL

      http://www.med.osaka-u.ac.jp/pub/phys2/okamura/research/present.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/phys2/okamura/index.html

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 電位依存性プロトンチャネルポリペプチドおよびその利用2011

    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2011-12-22
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 新規イオンチャネル様ポリペプチドおよびその利用2011

    • Inventor(s)
      佐藤矩行・岡村康司・岩崎広英・村田喜理
    • Industrial Property Rights Holder
      佐藤矩行・岡村康司・岩崎広英・村田喜理
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2011-08-19
    • Related Report
      2013 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2019-07-29  

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