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StudiesonMetastasisofDigestiveCancersUsingMouseModels

Research Project

Project/Area Number 21229005
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Pathological medical chemistry
Research InstitutionKyoto University

Principal Investigator

TAKETO Makoto  京都大学, 大学院・医学研究科, 教授 (70281714)

Co-Investigator(Kenkyū-buntansha) AOKI Masahiro  京都大学, 大学院・医学研究科, 准教授 (60362464)
KITAMURA Takanori  京都大学, 大学院・医学研究科, 助教 (10378622)
SONOSHITA Masahiro  京都大学, 大学院・医学研究科, 准教授 (80511857)
AOKI Koji  京都大学, 大学院・医学研究科, 助教 (40402862)
FUJISHITA Teruaki  京都大学, 大学院・医学研究科, 助教 (50511870)
Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥207,090,000 (Direct Cost: ¥159,300,000、Indirect Cost: ¥47,790,000)
Fiscal Year 2012: ¥52,000,000 (Direct Cost: ¥40,000,000、Indirect Cost: ¥12,000,000)
Fiscal Year 2011: ¥52,000,000 (Direct Cost: ¥40,000,000、Indirect Cost: ¥12,000,000)
Fiscal Year 2010: ¥52,000,000 (Direct Cost: ¥40,000,000、Indirect Cost: ¥12,000,000)
Fiscal Year 2009: ¥51,090,000 (Direct Cost: ¥39,300,000、Indirect Cost: ¥11,790,000)
Keywords分子腫瘍学 / 転移 / 消化器がん / マウスモデル / 未分化骨髄球 / Notch / 消化器癌
Research Abstract

Metastasis is responsible for most cancer deaths. Here, we show that immature myeloid cells (iMCs) promote liver metastasis of colon cancer cells. We also found that Notch signaling stimulates colon cancer metastasis, and endogenous metastasis suppressor Aes inhibits the signaling. In addition, we demonstrate that JNK stimulates tumor formation in the intestine by activating mTORC1 signaling. These results should open new horizons in metastasis research and treatment of colon cancer.

Assessment Rating
Verification Result (Rating)

A

Report

(6 results)
  • 2013 Research Progress Assessment (Verification Result) ( PDF )
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (127 results)

All 2012 2011 2010 2009 Other

All Journal Article (79 results) (of which Peer Reviewed: 64 results) Presentation (41 results) (of which Invited: 4 results) Remarks (6 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Roles of stromal microenvironment in colon cancer progression2012

    • Author(s)
      Taketo MM.
    • Journal Title

      J Biolchem

    • Related Report
      2012 Final Research Report
  • [Journal Article] Roles of stromal microenvironment in colon cancer progression.2012

    • Author(s)
      Taketo MM.
    • Journal Title

      J Biolchem.

      Volume: 151 Pages: 477-481

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temporal control of neural crest lineage generation by Wnt/β-catenin signaling.2012

    • Author(s)
      Hari, L., I. Miescher, Shakhova, O., Suter, U., Chin, L., Taketo, M., Richardson, W. D., Kessaris, N. , Sommer, L.
    • Journal Title

      Development

      Volume: 139 Pages: 2107-2117

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new Cre driver mouse line, Tcf21/Pod1-Cre, targets metanephric mesenchyme.2012

    • Author(s)
      Maezawa, Y., M. Binnie, Li, C., Thorner, P., Hui, C.-C., Alman, B., Taketo, M. M., Quaggin, S. E.
    • Journal Title

      PLoSone

      Volume: 7

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] WNT signaling increases proliferation and impairs differentiation of stem cells in the devloping crebellum.2012

    • Author(s)
      Pei, Y., S. N. Brun, Markant, S. L., Lento, W., Gibson, P., Taketo, M. M. Giovannini, M., Gilbertson, R. J., Wechsler-Reya, R. J.
    • Journal Title

      Development

      Volume: 139 Pages: 1724-1733

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wnt signaling has opposing roles in the developing and the adult brain that are modulated by hipk1.2012

    • Author(s)
      Marinaro C, Pannese M, Weinandy F, Sessa A, Bergamaschi A, Taketo MM, Broccoli V, Comi G, Götz M, Martino G, Muzio L.
    • Journal Title

      Cereb Cortex.

      Volume: 22 Pages: 2415-27

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] β-Catenin stabilization in skeletal muscles, but not in motor neurons, leads to aberrant motor innervation of the muscle during neuromuscular development in mice.2012

    • Author(s)
      Liu Y, Sugiura Y, Wu F, Mi W, Taketo MM, Cannon S, Carroll T, Lin W.
    • Journal Title

      Dev Biol.

      Volume: 366 Pages: 255-67

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea.2012

    • Author(s)
      Chai R, Kuo B, Wang T, Liaw EJ, Xia A, Jan TA, Liu Z, Taketo MM, Oghalai JS, Nusse R, Zuo J, Cheng AG.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 109 Pages: 8167-72

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] β-Catenin gain of function in muscles impairs neuromuscular junction formation.2012

    • Author(s)
      Wu H, Lu Y, Barik A, Joseph A, Taketo MM, Xiong WC, Mei L.
    • Journal Title

      Development

      Volume: 139 Pages: 2392-404

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of CXCR3 and CXCR4 in colorectal cancer metastasis.2012

    • Author(s)
      Murakami T, Kawada K, Iwamoto M, Akagami M, Hida K, Nakanishi Y, Kanda K, Kawada M, Seno H, Taketo MM, Sakai Y.
    • Journal Title

      Int J Cancer.

      Volume: 132 Pages: 276-287

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Canonical Wnt signaling regulates smooth muscle precursor development in the mouse ureter.2012

    • Author(s)
      Trowe MO, Airik R, Weiss AC, Farin HF, Foik AB, Bettenhausen E, Schuster-Gossler K, Taketo MM, Kispert A.
    • Journal Title

      Development

      Volume: 139 Pages: 3099-108

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression.2012

    • Author(s)
      Reis M, Czupalla CJ, Ziegler N, Devraj K, Zinke J, Seidel S, Heck R, Thom S, Macas J, Bockamp E, Fruttiger M, Taketo MM, Dimmeler S, Plate KH, Liebner S.
    • Journal Title

      J Exp Med.

      Volume: 209 Pages: 1611-27

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Col1a1-cre mediated activation of β-catenin leads to aberrant dento-alveolar complex formation.2012

    • Author(s)
      Kim TH, Bae CH, Jang EH, Yoon CY, Bae Y, Ko SO, Taketo MM, Cho ES.
    • Journal Title

      Anat. Cell Biol.

      Volume: 45 Pages: 193-202

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Mullerian inhibiting substance type 2 receptor suppresses tumorigenesis in testes with sustained β-catenin signaling.2012

    • Author(s)
      Tanwar PS, Commandeur AE, Zhang L, Taketo MM, Teixeira JM.
    • Journal Title

      Carcinogenesis

      Volume: 33 Pages: 2351-2361

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Excessive Wnt/β-catenin signaling disturbs tooth-root formation.2012

    • Author(s)
      Bae CH, Lee JY, Kim TH, Baek JA, Lee JC, Yang X, Taketo MM, Jiang R, Cho ES.
    • Journal Title

      J. Periodontal Res.

      Volume: Oct 11

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dclk1 distinguishes between tumor and normal stem cells in the intestine.2012

    • Author(s)
      Nakanishi Y, ...Taketo MM, Yonehara S, Chiba T.
    • Journal Title

      Nature Genet.

      Volume: 45 Pages: 98-103

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties.2012

    • Author(s)
      Schwitalla S, ... Taketo MM, ... Greten FR.
    • Journal Title

      Cell

      Volume: 152 Pages: 25-38

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ectopic Wnt/beta-catenin signaling induces neurogenesis in the spinal cord and hindbrain floor date2012

    • Author(s)
      Joksimovic M, Patel M, Taketo M, Johnson R, Awatramani R
    • Journal Title

      PLoS One

      Volume: 7 Issue: 1 Pages: e30266-e30266

    • DOI

      10.1371/journal.pone.0030266

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Runx3 is required for full activation of regulatory T cells to prevent colitis-associated tumor formation2011

    • Author(s)
      Sugai M, Aoki K, Osato M, Nambu Y, Ito K, Taketo MM, Shimizu A.
    • Journal Title

      J Immunol

      Volume: 186 Pages: 6515-6520

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] JNK signaling promotes intestinal tumorigenesis through mTOR complex1 activation in ApcΔ 716 mice2011

    • Author(s)
      Fujishita T, Aoki M, and Taketo MM.
    • Journal Title

      Gatroenterology

      Volume: 140(in press)

    • Related Report
      2012 Final Research Report
  • [Journal Article] Reflections on the spread of metastasis to cancer prevention2011

    • Author(s)
      Taketo MM
    • Journal Title

      Cancer Prev. Res

      Volume: 4 Pages: 324-328

    • Related Report
      2012 Final Research Report
  • [Journal Article] Significance and mechanism of lymph node metastasis in cancer progression2011

    • Author(s)
      Kawada K and Taketo MM.
    • Journal Title

      Cancer Res

      Volume: 71 Pages: 1214-1218

    • Related Report
      2012 Final Research Report
  • [Journal Article] Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling2011

    • Author(s)
      Sonoshita M, Aoki M, Fuwa H, Aoki K, Hosogi H, Sakai Y, Hashida H, Takabayashi A, Sasaki M, Robine S, Itoh K, Yoshioka K, Kakizaki F, Kitamura K, Oshima M, and Taketo MM.
    • Journal Title

      Cancer Cell

      Volume: 19 Pages: 125-137

    • Related Report
      2012 Final Research Report
  • [Journal Article] Suppression of colonic polyposis by homeoprotein CDX2 through its nontranscriptional function that stabilizes p27Kip12011

    • Author(s)
      Aoki K, Kakizaki F, Sakashita H, Manabe T, Aoki M, and Taketo MM.
    • Journal Title

      Cancer Res

      Volume: 71 Pages: 593-602

    • Related Report
      2012 Final Research Report
  • [Journal Article] Prospero-related homeobox 1 gene (Prox1)is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis2011

    • Author(s)
      Karalay O,.Doberauer K, Vadodaria KC, Knobloch M, Berti L, Miquelajauregui A, Schwark M, Jagasia R, Taketo MM, Tarabykin V, Lie DC, Jessberger S.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 108 Issue: 14 Pages: 5807-5812

    • DOI

      10.1073/pnas.1013456108

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] β-Catenin signaling regulates the timing of cell differentiation in mouse retinal progenitor cells2011

    • Author(s)
      Ouchi Y, Baba Y, Koso H, Taketo MM, Iwamoto T, Aburatani H, Watanabe S
    • Journal Title

      Mol Cell Neurosci

      Volume: 46 Issue: 4 Pages: 770-780

    • DOI

      10.1016/j.mcn.2011.02.010

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] JNK signaling promotes intestinal tumorigenesis through mTOR compleXlactivation in ApcΔ716 mice2011

    • Author(s)
      Fujishita T, Aoki M, Taketo MM
    • Journal Title

      Gastroenterology

      Volume: 140 Issue: 5 Pages: 1566-1563

    • DOI

      10.1053/j.gastro.2011.02.007

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mammalian Target of Rapamycin Is a Therapeutic Target for Murine Ovarian Endometrioid Adenocarci nomas with Dysregulated Wnt/β-Catenin and PTEN2011

    • Author(s)
      Tanwar PS, Zhang L, Kaneko-Tarui T, Curley MD, Taketo MM, Rani P, Roberts DJ, Teixeira JM
    • Journal Title

      PLoS One

      Volume: 6 Issue: 6 Pages: e20715-e20715

    • DOI

      10.1371/journal.pone.0020715

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coordinated activation of wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration2011

    • Author(s)
      Rabbani P, Takeo M, Chou W, Myung P,Bosenberg M, Chin L, Taketo MM, Ito M
    • Journal Title

      Cell

      Volume: 145 Issue: 6 Pages: 941-955

    • DOI

      10.1016/j.cell.2011.05.004

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ras mutation cooperates with β-catenin activation to drive bladder tumourigenesis2011

    • Author(s)
      Ahmad I, Patel R, Liu Y, Singh LB, Taketo MM, Wu XR, Leung HY,Sansom OJ
    • Journal Title

      Cell Death Dis

      Volume: 2 Issue: 3 Pages: e124-e124

    • DOI

      10.1038/cddis.2011.7

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wnt/{beta}-Catenin Pathway in Podocytes Integrates Cell Adhesion, Differentiation, and Survival2011

    • Author(s)
      Kato H, Gruenwald A, Suh JH, Miner JH, Barisoni-Thomas L, Taketo MM, Faul C, Millar SE, Holzman LB, Susztak K
    • Journal Title

      J Biol Chem

      Volume: 286 Pages: 26003-26015

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] From the Cover : Increased Wingless (Wnt)signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans2011

    • Author(s)
      Gaston-Massuet C, Andoniadou CL, Signore M, Jayakody SA, Charolidi N, Kyeyune R, Vernay B, Jacques TS, Taketo MM, Le Tissier P, Dattani MT, Mart inez-Barbera JP
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 108 Issue: 28 Pages: 11482-11487

    • DOI

      10.1073/pnas.1101553108

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adenomatous polyposis coli heterozygous knockout mice display hypoactivity and age-dependent working memory deficits2011

    • Author(s)
      Koshimizu H, Fukui Y, Takao K, Ohira K, Tanda K, Nakanishi K, Toyama K, Oshima M,Take to MM, Miyakawa T
    • Journal Title

      Front Behav Neurosci

      Volume: 5 Pages: 85-85

    • DOI

      10.3389/fnbeh.2011.00085

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development2011

    • Author(s)
      Jin YR, Han XH, Taketo MM, Yoon JK
    • Journal Title

      Development

      Volume: 139 Issue: 10 Pages: 1821-1830

    • DOI

      10.1242/dev.075796

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis2011

    • Author(s)
      Beyer C, Schramm A, Akhmetshina A, Dees C, Kireva T, Gelse K, Sonnylal S, de Crombrugghe B, Taketo MM, Distler O, Schett G, Distler JH
    • Journal Title

      Ann Rheum Dis

      Volume: 71 Issue: 5 Pages: 761-767

    • DOI

      10.1136/annrheumdis-2011-200568

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Taketo MM, de Rooij DG, Adams IR, Chaboissier MC2011

    • Author(s)
      Chassot AA, Gregoire EP, Lavery R,
    • Journal Title

      RSPO1/β-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary PLoS One

      Volume: 6 Issue: 10 Pages: e25641-e25641

    • DOI

      10.1371/journal.pone.0025641

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanisms of liver metastasis2011

    • Author(s)
      Kawada K, HaSegawa S, Murakami T, Itatani Y, Hosogi H, Sonoshita M, Kitamura T, Fujishita T, Iwamoto M, Matsumoto T, Matsusue R, Hida K, Akiyaraa G, Okoshi K, Yamada M, Kawamura J, Taketo MM, Sakai Y
    • Journal Title

      Int J Clin Oncol

      Volume: 16 Issue: 5 Pages: 464-472

    • DOI

      10.1007/s10147-011-0307-2

    • NAID

      10030246531

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche2011

    • Author(s)
      Yamazaki S, Ema H, Karlsson G, Yamaguchi T, Miyoshi H, Shioda S, Taketo MM, Karlsson S, Iwama A, Nakauchi H
    • Journal Title

      Cell

      Volume: 147 Issue: 5 Pages: 1146-1158

    • DOI

      10.1016/j.cell.2011.09.053

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] β-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas2011

    • Author(s)
      Damsky WE, Curley DP, Santhanakrishnan M, Rosenbaum LE, Platt JT, Gould Rothberg BE, Taketo MM, Dankort D, Rimm DL, McMahon M, Bosenberg M
    • Journal Title

      Cancer Cell

      Volume: 20 Issue: 6 Pages: 741-754

    • DOI

      10.1016/j.ccr.2011.10.030

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling.2011

    • Author(s)
      Sonoshita M, Aoki M, Fuwa H, Aoki K, Hosogi H, Sakai Y, Hashida H, Takabayashi A, Sasaki M, Robine S, Itoh K, Yoshioka K, Kakizaki F, Kitamura K, Oshima M, Taketo MM.
    • Journal Title

      Cancer Cell

      Volume: 19 Pages: 125-137

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of colonic polyposis by homeoprotein CDX2 through its non transcriptional function that stabilizes p27^<Kip1>.2011

    • Author(s)
      Aoki K, Kakizaki F, Sakashita H, Manabe T, Aoki M, Taketo MM.
    • Journal Title

      Cancer Res.

      Volume: 71 Pages: 593-602

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significance and mechanism of lymph node metastasis in cancer progression.2011

    • Author(s)
      Kawada K, Taketo MM.
    • Journal Title

      Cancer Res.

      Volume: 71 Pages: 1214-1218

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reflections on the spread of metastasis to cancer prevention.2011

    • Author(s)
      Taketo MM.
    • Journal Title

      Cancer Prev.Res.

      Volume: 4 Pages: 324-328

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] JNK signaling promotes intestinal tumorigenesis through mTOR complex1 activation in Apc^<716> mice.2011

    • Author(s)
      Fujishita T, Aoki M, Taketo MM.
    • Journal Title

      Gastroenterology

      Volume: 140(In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ras mutation cooperates with β-catenin activation to drive bladder tumourigenesis.2011

    • Author(s)
      Ahmad I, Patel R, Liu Y, Singh LB, Taketo MM, Wu XR, Leung HY, Sansom OJ.
    • Journal Title

      Cell Death Dis.

      Volume: 2

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epithelial Wnt/β-catenin signaling regulates palatal shelf fusion through regulation of Tgfβ3 expression.2011

    • Author(s)
      He F, Xiong W, Wang Y, Li L, Liu C, Yamagami T, Taketo MM, Zhou C, Chen Y.
    • Journal Title

      Dev.Biol.

      Volume: 350 Pages: 511-519

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ectodermal Wnt/β-catenin signaling shapes the mouse face.2011

    • Author(s)
      Reid BS, Yang H, Melvin VS, Taketo MM, Williams T.
    • Journal Title

      Dev.Biol.

      Volume: 349 Pages: 261-269

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation.2011

    • Author(s)
      Ahmad I, Morton JP, Singh LB, Radulescu SM, Ridgway RA, Patel S, Woodgett J, Winton DJ, Taketo MM, Wu XR, Leung HY, Sansom OJ.
    • Journal Title

      Oncogene

      Volume: 30 Pages: 178-189

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CDX Transcription Factors Positively Regulate Expression of Solute Carrier Family 5, Member 8 in the Colonic Epithelium.2010

    • Author(s)
      Kakizaki F, Aoki K, Miyoshi H, Carrasco N, Aoki M and Taketo MM.
    • Journal Title

      Gastroenterology

      Volume: 138 Pages: 627-635

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Journal Article] LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domain2010

    • Author(s)
      Deguchi A, Miyoshi H, Kojima Y, Okawa K, Aoki M, and Taketo MM.
    • Journal Title

      J. Biol. Chem.

      Volume: 285 Pages: 18283-18290

    • Related Report
      2012 Final Research Report
  • [Journal Article] Inactivation of CCR1 suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model2010

    • Author(s)
      Kitamura T, Fujishita T, Loetscher P, Revesz L, Hashida H, Kizaka-Kondoh S, Aoki M, and Taketo MM.
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 107 Pages: 13063-13068

    • Related Report
      2012 Final Research Report
  • [Journal Article] LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domain.2010

    • Author(s)
      Deguchi A, Miyoshi H, Kojima Y, Okawa K, Aoki M, Taketo MM
    • Journal Title

      J.Biol.Chem.

      Volume: 285 Pages: 18283-18290

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inactivation of CCR1 suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model.2010

    • Author(s)
      Kitamura T, Fujishita T, Loetscher P, Revesz L, Hashida H, Kizaka-Kondoh S, Aoki M, Taketo MM.
    • Journal Title

      Proc.Natl.Acad.Sci.USA

      Volume: 107 Pages: 13063-13068

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Subtypes of medulloblastoma have distinct developmental origins.2010

    • Author(s)
      Gibson P, Tong Y, Robinson G, Thompson MC, Currle DS, Eden C, Kranenburg TA, Hogg T, Poppleton H, Martin J, Finkelstein D, Pounds S, Weiss A, Patay Z, Scoggins M, Ogg R, Pei Y, Yang ZJ, Brun S, Lee Y, Zindy F, Lindsey JC, Taketo MM, Boop FA, Sanford RA, Gajjar A, Clifford SC, Roussel MF, McKinnon PJ, Gutmann DH, Ellison DW, Wechsler-Reya R, Gilbertson RJ.
    • Journal Title

      Nature

      Volume: 468 Pages: 1095-1099

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Focal Mullerian duct retention in male mice with constitutively activated beta-catenin expression in the Mullerian duct Mesenchyme.2010

    • Author(s)
      Tanwar PS, Zhang L, Tanaka Y, Taketo MM, Donahoe PK, Teixeira JM.
    • Journal Title

      Proc Natl Acad Sci USA.

      Volume: 107 Pages: 16142-16147

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wnt/β-catenin signaling regulates postnatal development and regeneration of the salivary gland.2010

    • Author(s)
      Hai B, Yang Z, Millar SE, Choi YS, Taketo MM, Nagy A, Liu F.
    • Journal Title

      Stem Cells Dev.

      Volume: 19 Pages: 1793-1801

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant expression of a beta-catenin gain-of-function mutant induces hyperplastic transformation in the mouse cornea.2010

    • Author(s)
      Zhang Y, Call MK, Yeh LK, Liu H, Kochel T, Wang IJ, Chu PH, Taketo MM, Jester JV, Kao WW, Liu CY.
    • Journal Title

      J.Cell Sci.

      Volume: 123 Pages: 1285-1294

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CDX transcription factors positively regulate expression of solute carrier family 5, member 8 in the colonic epithelium.2010

    • Author(s)
      Kakizaki.F., et al.
    • Journal Title

      Gastroenterology 138

      Pages: 627-635

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced Level of Smoothened Suppresses Intestinal Tumorigenesis by Down-Regulation of Wnt Signaling2009

    • Author(s)
      Arimura S, Matsunaga A, Kitamura T, Aoki K, Aoki M, Taketo MM.
    • Journal Title

      Gastroenterology

      Volume: 137 Pages: 629-638

    • Related Report
      2012 Final Research Report
  • [Journal Article] Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb1+/- mice2009

    • Author(s)
      Miyoshi H, Deguchi A, Nakau M, Kojima Y, Mori A, Oshima M, Aoki M, Taketo MM.
    • Journal Title

      Cancer Sci.

      Volume: 100 Pages: 2046-53

    • Related Report
      2012 Final Research Report
  • [Journal Article] The role of mTORC1 pathway in intestinal tumorigenesis2009

    • Author(s)
      Fujishita T, Aoki M, Taketo MM.
    • Journal Title

      Cell Cycle

      Volume: 8 Pages: 3684-3687

    • Related Report
      2012 Final Research Report
  • [Journal Article] Role of bone marrow-derived cells in colon cancer: lessons from mouse model studies.2009

    • Author(s)
      Taketo MM.
    • Journal Title

      J Gastroenterol.

      Volume: 44 Pages: 93-102

    • Related Report
      2012 Final Research Report
  • [Journal Article] Mouse models of colon cancer2009

    • Author(s)
      Taketo MM, Edelmann W.
    • Journal Title

      Gastroenterology

      Volume: 136 Pages: 780-98

    • Related Report
      2012 Final Research Report
  • [Journal Article] Reduced level of Smoothened suppresses intestinal tumorigenesis by down-regulation of Wnt signaling.2009

    • Author(s)
      Arimura, S., et al.
    • Journal Title

      Gastroenterology 137

      Pages: 629-638

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb1+/-mice.2009

    • Author(s)
      Miyoshi, H., et al.
    • Journal Title

      Cancer Sci. 100

      Pages: 2046-2053

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of mTORC1 pathway in intestinal tumorigenesis.2009

    • Author(s)
      Fujishita, T., et al.
    • Journal Title

      Cell Cycle 8

      Pages: 3684-3687

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of prostaglandin E2 pathway promotes gastric hamartoma development with suppression of bone morphogenetic protein signaling.2009

    • Author(s)
      Oshima, H., et al.
    • Journal Title

      Cancer Res. 69

      Pages: 2729-2733

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic interactions of the androgen and Wnt/beta-catenin pathways for the masculinization of external genitalia.2009

    • Author(s)
      Miyagawa, S., et al.
    • Journal Title

      Mol.Endocrinol. 23

      Pages: 871-880

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Constitutive activation of beta-catenin in uterine stroma and smooth muscle leads to the development of mesenchymal tumors in mice.2009

    • Author(s)
      Tanwar, P.S., et al.
    • Journal Title

      Biol.Reprod. 81

      Pages: 545-552

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HDAC1 and HDAC2 regulate oliodendrocyte differentiation by disrupting the beta-catenin-TCF interaction.2009

    • Author(s)
      Ye, F., et al.
    • Journal Title

      Nat.Neurosci. 12

      Pages: 829-838

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation.2009

    • Author(s)
      Martinez, G., et al.
    • Journal Title

      Invest.Ophthalmol.Vis.Sci. 50

      Pages: 4794-4786

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction and downregulation of Sox17 and its possible roles during the course of gastrointestinal tumorigenesis.2009

    • Author(s)
      Du, Y.C., et al.
    • Journal Title

      Gastroenterology 137

      Pages: 1346-1357

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Wnt/beta-catenin pathway interacts differentially with PTHrP signaling to control chondrocyte hypertrophy ad final maturation.2009

    • Author(s)
      Guo, X., et al.
    • Journal Title

      PLoS One 4

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overactive beta-catenin signaling causes testicular Sertoli cell tumor development in the mouse.2009

    • Author(s)
      Chang, H., et al.
    • Journal Title

      Biol.Reprod. 81

      Pages: 842-849

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pax6 is essential for lens fiber cell differentiation.2009

    • Author(s)
      shaham, O., et al.
    • Journal Title

      Development 136

      Pages: 2567-2578

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatial and temporal regulation of Wnt/beta-catenin signaling si essential for development of the retinal gigment epithelium.2009

    • Author(s)
      Fujimura, N., et al.
    • Journal Title

      Dev.Biol. 334

      Pages: 31-45

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stabilized beta-catenin in lung epithelial cells changes cell fate and leads to tracheal and bronchial polyposis.2009

    • Author(s)
      Li, C., et al.
    • Journal Title

      Dev.Biol. 334

      Pages: 97-108

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dosage-dependent hedgehog signals integrated with Wnt/beta-cateni signaling regulate external genitalia formation as an appendicular program.2009

    • Author(s)
      Miyagawa, S., et al.
    • Journal Title

      Development 136

      Pages: 3969-3978

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antagonistic crosstalk of Wnt/beta-catenin/Bmp signaling within the Apical Ectodermal Ridge(AER) regulates interdigit formation.2009

    • Author(s)
      Villacorte, M., et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 391

      Pages: 1653-1757

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 大腸がんのマウスモデル2012

    • Author(s)
      武藤 誠
    • Organizer
      Japan Gast Study Group Meeting
    • Place of Presentation
      札幌市
    • Year and Date
      2012-07-07
    • Related Report
      2012 Final Research Report
  • [Presentation] INK signaling promotes intestinal tumorigenesis through mTORC1 pathway activation in ApeΔ716 mice2012

    • Author(s)
      藤下晃章, 青木正博, 武藤誠
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2012-03-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Novel molecular mechanisms that stimulate colon cancer invasion and metastasis2012

    • Author(s)
      武藤 誠
    • Organizer
      Infection, Immunity and Cancer
    • Place of Presentation
      京都大学
    • Year and Date
      2012-01-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Novel molecular mechanisms that stimulate colon cancer invasion and metastasis2012

    • Author(s)
      武藤誠
    • Organizer
      Infection, Immunity and Cancer
    • Place of Presentation
      京都大学(招待講演)
    • Year and Date
      2012-01-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Colon cancer microenvironment that helps invasion and metastasis: studies using mouse models2012

    • Author(s)
      武藤 誠
    • Organizer
      国際がん転移学会
    • Place of Presentation
      オーストラ リア、ブリスベン
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of bone marrow-derived CCR1+ Cells in colon cancer invasion and metastasis2012

    • Author(s)
      武藤 誠
    • Organizer
      がん免疫学会
    • Place of Presentation
      札幌市
    • Related Report
      2012 Final Research Report
  • [Presentation] Metastasis suppressor gene Aes/Aes is an endogenous Notch signal inhibitor2012

    • Author(s)
      武藤 誠
    • Organizer
      日本癌学会
    • Place of Presentation
      札幌市
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of bone marrow-derived CCR1+ Cells in colon cancer invasion and metastasis(口頭)2012

    • Author(s)
      武藤 誠
    • Organizer
      がん免疫学会
    • Place of Presentation
      札幌市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Colon cancer microenvironment that helps invasion and metastasis: studies using mouse models(招待講演)2012

    • Author(s)
      武藤 誠
    • Organizer
      国際がん転移学会
    • Place of Presentation
      オーストラリア、ブリスベン
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Metastasis suppressor gene AES/Aes is an endogenous Notch signal inhibitor(口頭)2012

    • Author(s)
      武藤 誠
    • Organizer
      日本癌学会
    • Place of Presentation
      札幌市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Critical roles of Notch signaling pathway in colon cancer metastasis(ポスター)2012

    • Author(s)
      園下 将大
    • Organizer
      国際がん転移学会
    • Place of Presentation
      オーストラリア、ブリスベン
    • Related Report
      2012 Annual Research Report
  • [Presentation] Suppression of Colon Cancer Metastasis by Aes through Inhibition of Notch Signaling(口頭)2012

    • Author(s)
      園下 将大
    • Organizer
      日本癌学会
    • Place of Presentation
      札幌市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Colon cancer metastasis suppressor Aes inhibits Notch signaling2011

    • Author(s)
      武藤 誠
    • Organizer
      The Notch Meeting V
    • Place of Presentation
      Athens, Greece
    • Year and Date
      2011-10-06
    • Related Report
      2012 Final Research Report
  • [Presentation] Colon cancer metastasis suppressor Aes inhibits Notch signaling2011

    • Author(s)
      武藤誠
    • Organizer
      The Notch Meeting V
    • Place of Presentation
      Athens, Greece(招待講演)
    • Year and Date
      2011-10-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] Stimulation of colon cancer metastasis by Notch signaling2011

    • Author(s)
      園下将大
    • Organizer
      第70回日本癌学会学術総会シンポジウムUse of animal models for advances in cancer prevention and treatment
    • Place of Presentation
      名古屋コングレスセンター(英語、招待講演)
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] JNK promotes intestinal tumor formation in mutant mice through activation of mTOR couplex 12011

    • Author(s)
      青木正博, 藤下晃章、武藤誠
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋コングレスセンター
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] The roles of mTORC1 in the intestinal adenocarcinoma2011

    • Author(s)
      藤下晃章、青木正博, 武藤誠
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋コングレスセンター
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] JNKシグナル伝達経路はmTORC1の活性化を介してApe変異マウスの腸管腫瘍形成を促進する2011

    • Author(s)
      青木正博, 藤下晃章、 武藤誠
    • Organizer
      第15回日本がん分子標的治療学会学術集会
    • Place of Presentation
      ホテル日航東京
    • Year and Date
      2011-06-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] JNK signaling promotes intestinal tumorigenesis through mTORC1 pathway activation in ApcΔ^<716> mice2010

    • Author(s)
      藤下晃章
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会
    • Place of Presentation
      神戸、日本
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] JNK signaling promotes intestinal tumorigenesis through mTOR complex 1 activation in ApcΔ716 mice2010

    • Author(s)
      藤下 晃章
    • Organizer
      第69回 日本癌学会・学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] JNK signaling promotes intestinal tumorigenesis through mTOR complex 1 activation in ApcΔ^<716> mice2010

    • Author(s)
      藤下晃章
    • Organizer
      第69回日本癌学会・学術総会
    • Place of Presentation
      大阪、日本
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 大会長企画シンポジウム 3PS12 Biology of cancer "New mechanisms of colon cancer metastasis"2010

    • Author(s)
      武藤 誠
    • Organizer
      第33回日本分子生物学会年 会・第83回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] ワークショップ 3W11 Notchシグナ ル:疾患解明を目指して "Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling"2010

    • Author(s)
      園下 将大
    • Organizer
      第33回日本分子生物学会年 会・第83回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] JCA-AACR Joint Symposium "Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling"2010

    • Author(s)
      武藤 誠
    • Organizer
      第69回 日本癌学会・学術総会
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] JNK signaling promotes intestinal tumorigenesis through mTORC1 pathway activation in ApcΔ716 mice"2010

    • Author(s)
      藤下 晃章
    • Organizer
      第33回日本分子生物学会年会・ 第83回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling2010

    • Author(s)
      園下 将大
    • Organizer
      Notch研究会
    • Place of Presentation
      千葉
    • Related Report
      2012 Final Research Report
  • [Presentation] Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling2010

    • Author(s)
      武藤誠
    • Organizer
      AACR Meeting on Colorectal Cancer : Biology to Therapy
    • Place of Presentation
      Philadelphia, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling2010

    • Author(s)
      武藤誠
    • Organizer
      Nature-CNIO Symposium : Frontiers in tumor progression
    • Place of Presentation
      Madrid, Spain
    • Related Report
      2010 Annual Research Report
  • [Presentation] New mechanisms of colon cancer metastasis2010

    • Author(s)
      武藤誠
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会
    • Place of Presentation
      神戸、日本
    • Related Report
      2010 Annual Research Report
  • [Presentation] Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling2010

    • Author(s)
      園下将大
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会
    • Place of Presentation
      神戸、日本
    • Related Report
      2010 Annual Research Report
  • [Presentation] Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling2010

    • Author(s)
      武藤誠
    • Organizer
      第69回日本癌学会・学術総会
    • Place of Presentation
      大阪、日本(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling2010

    • Author(s)
      園下将大
    • Organizer
      Notch研究会
    • Place of Presentation
      千葉、日本
    • Related Report
      2010 Annual Research Report
  • [Presentation] A novel mechanism of colon cancer invasion and metastasis : role of bone marrow-derived cells.2009

    • Author(s)
      Taketo, M.M.
    • Organizer
      FASEB TGF-beta Meeting
    • Place of Presentation
      Phoenis, AZ, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling.2009

    • Author(s)
      Taketo, M.M.
    • Organizer
      Notch Meeting 2009
    • Place of Presentation
      Athens, Greece
    • Related Report
      2009 Annual Research Report
  • [Presentation] "Cellular Target Therapy "for colon cancer metastasis : a new strategy based on tumor microenvironment.2009

    • Author(s)
      Taketo, M.M.
    • Organizer
      The 14^<th> Japan-Korea Cancer Research Workshop
    • Place of Presentation
      Kanazawa, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] 癌細胞骨髄由来細胞の相互作用2009

    • Author(s)
      武藤誠
    • Organizer
      第98回 日本病理学会総会
    • Place of Presentation
      京都、日本
    • Related Report
      2009 Annual Research Report
  • [Presentation] 大腸がん浸潤における骨髄細胞の役割2009

    • Author(s)
      武藤誠
    • Organizer
      第6回 日本病理学会カンファレンス
    • Place of Presentation
      筑波、日本
    • Related Report
      2009 Annual Research Report
  • [Presentation] The role of CCR1-expressing myeloid cells in invasion and metastasis of colon cancer cells2009

    • Author(s)
      北村剛規
    • Organizer
      第82回 日本生化学会大会
    • Place of Presentation
      神戸、日本
    • Related Report
      2009 Annual Research Report
  • [Presentation] 消化管腫瘍形成におけるSmoothened及びmTORC1の役割2009

    • Author(s)
      青木正博
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜、日本
    • Related Report
      2009 Annual Research Report
  • [Presentation] 大腸がんのマウスモデル(口頭)

    • Author(s)
      武藤 誠
    • Organizer
      Japan Gast Study Group Meeting
    • Place of Presentation
      札幌市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 大腸がんの悪性化メカニズム(口頭)

    • Author(s)
      園下 将大
    • Organizer
      第4回生命科学阿波おどりシンポジウム
    • Place of Presentation
      徳島市
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • Related Report
      2012 Final Research Report
  • [Remarks] 京都大学大学院医学研究科遺伝薬理学教室ホームページ

    • URL

      http://www4.mfour.med.kyoto-u.ac.jp/frameTOP(J).htm

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www4.mfour.med.kyoto-u.ac.jp/frameTOP(J).htm

    • Related Report
      2011 Annual Research Report
  • [Remarks] 京都大学広報

    • URL

      http://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2010/100629_1.htm

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2010/110119_1.htm

    • Related Report
      2010 Annual Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www4.mfour.med.kyoto-u.ac.jp/frameTOP(J).htm

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] CXCR3阻害剤を含有する医薬組成物2010

    • Inventor(s)
      武藤誠, 河田健二
    • Industrial Property Rights Holder
      国立大学法人京都大学
    • Acquisition Date
      2010-02-12
    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2019-07-29  

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