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The significance of adult neurogenesis

Research Project

Project/Area Number 21240028
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionKyoto University

Principal Investigator

KAGEYA Maryoichiro  京都大学, ウイルス研究所, 教授 (80224369)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥47,320,000 (Direct Cost: ¥36,400,000、Indirect Cost: ¥10,920,000)
Fiscal Year 2011: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2010: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2009: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Keywords成体脳 / ニューロン新生 / 神経幹細胞 / 海馬 / 歯状回 / 嗅球 / 海馬・歯状回 / 性行動 / 母性行動 / フェロモン / 捕食者 / 主嗅球 / 副嗅球 / 遺伝子改変マウス / 顆粒細胞 / タモキシフェン誘導性Cre / 鋤鼻器
Research Abstract

To understand the significance of adult neurogenesis, we genetically ablated newly born neurons in the adult mouse brain. Mutant mice showed defects in predator odor avoidance. Furthermore, mutant males displayed deficits in male-male aggression and sexual behaviors toward females, while mutant females displayed deficits in fertility and nurturing. These results suggest that adult neurogenesis plays an essential role in predator avoidance and gender-specific responses that are olfactory-dependent and innately programmed.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (68 results)

All 2012 2011 2010 2009 Other

All Journal Article (32 results) (of which Peer Reviewed: 15 results) Presentation (21 results) Book (4 results) Remarks (8 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Mind bomb 1 is required for pancreatic b-cell formation2012

    • Author(s)
      Horn, S., Kobberup, S., Jorgensen. M. C., Kalisz, M., Klein, T., Kageyama, R., Gegg, M., Lickert, H., Lindner, J., Magnuson, M. A., Kong, Y.-Y, Serup, P., Ahnfelt-Ronne, J., Jensen, J. N.
    • Journal Title

      Proc. Natl. Acad. Sci

    • Related Report
      2011 Final Research Report
  • [Journal Article] Light-induced silencing of neural activity in Rosa26 knock-in mice conditionally expressing the microbial halorhodopsin eNpHR2. 0.2012

    • Author(s)
      Imayoshi, I., Tabuchi, S., Hirano, K., Sakamoto, M., Kitano, S., Miyachi, H., Yamanaka, A., and Kageyama, R.
    • Journal Title

      Res. in press

    • Related Report
      2011 Final Research Report
  • [Journal Article] In vivo evaluation of PhiC31 recombinase activity in transgenic mice2012

    • Author(s)
      Imayoshi, I., Hirano, K., Kitano, S., Mitachi, H., and Kageyama, R.
    • Journal Title

      Res. in press

    • Related Report
      2011 Final Research Report
  • [Journal Article] Light-induced silencing of neural activity in Rosa26 knock-in mice conditionally expressing the microbial halorhodopsin eNpHR2.02012

    • Author(s)
      I.Imayoshi, S.Tabuchi, K.Hirano, M.Sakamoto, S.Kitano, H.Miyachi, A.Yamanaka, R.Kageyama, R.
    • Journal Title

      Neuroscience Research

      Volume: (掲載確定)(印刷中) Issue: 1 Pages: 85-91

    • DOI

      10.1016/j.neures.2012.03.008

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A mechanism for gene-environment interaction in the etiology of congenital scoliosis2012

    • Author(s)
      Sparrow, D. B., Chapman, G., Smith, A. J., Mattar, M. Z., Major, J. A., O' Reilly, V. C., Saga, Y., Zackai, E. H., Dormans, J. P., Alman, B. A., McGregor, L., Kageyama, R., Kusumi, K., and Dunwoodie, S. L.
    • Journal Title

      Cell

      Volume: 149 Pages: 295-306

    • Related Report
      2011 Final Research Report
  • [Journal Article] The role of Hes genes in intestinaldevelopment, homeostasis and tumorformation2012

    • Author(s)
      Ueo T, Imayoshi T, Kobayashi T, OhtsukaT, Seno H, Nakae H, Chiba T, Kageyama R
    • Journal Title

      Development

      Volume: 139 Issue: 6 Pages: 1071-1082

    • DOI

      10.1242/dev.069070

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Notchl mediates visfatin-induced FGF-2 upregulation and endothelial angiogenesis.2011

    • Author(s)
      Bae, Y.-H., Park, H.-J., Kim, S. R., Kim, J. Y., Kang, Y. Kim, J. A., Wee, H.-J., Kageyama, R., Jung, J. S., Bae, M.-K., and Bae, S.-K.
    • Journal Title

      Cardiovasc. Res.

      Volume: 89 Issue: 2 Pages: 436-445

    • DOI

      10.1093/cvr/cvq276

    • Related Report
      2011 Final Research Report
  • [Journal Article] Fbxw7-dependent degradation of Notch is required for control of syemness and neuronal-glial differentiation in neural stem cells2011

    • Author(s)
      Matsumoto, A., Onoyama, I., Sunabori, T., Kageyama, R., Okano, H., and Nakayama, K. I.
    • Journal Title

      J. Biol. Chem

      Volume: 286 Issue: 15 Pages: 13754-13764

    • DOI

      10.1074/jbc.m110.194936

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression profiling of neural stem cells and identification of regulators of neural differentiation during cortical development2011

    • Author(s)
      Ohtsuka, T., Shimojo, H., Matsunaga, M., Watanabe, N., Kometani, K., Minato, N., and Kageyama, R.
    • Journal Title

      Stem Cells

      Volume: 29 Issue: 11 Pages: 1817-1828

    • DOI

      10.1002/stem.731

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Notch-Hes1 pathway is required for the development of IL-17-producing Yδ T cells2011

    • Author(s)
      K.Shibata
    • Journal Title

      Blood

      Volume: 118 Issue: 3 Pages: 586-593

    • DOI

      10.1182/blood-2011-02-334995

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Different types of oscillations in Notch and Fgf signaling regulate the spatiotemporal periodicity of somitogenesis2011

    • Author(s)
      Niwa, Y., Shimojo, H., Isomura, A., Gonzalez, A., Miyachi, H., and Kageyama, R.
    • Journal Title

      Genes & Dev

      Volume: 25 Issue: 11 Pages: 1115-1120

    • DOI

      10.1101/gad.2035311

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Continuous neurogenesis in the adult forebrain is required for innate olfactory responses2011

    • Author(s)
      M.Sakamoto, I.Imayoshi, T.Ohtsuka, M.Yamaguchi, K.Mori, R.Kageyama
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 108 Issue: 20 Pages: 8479-8484

    • DOI

      10.1073/pnas.1018782108

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development.2011

    • Author(s)
      Tateya, T., Imayoshi, I., Tateya, I., Ito, J., and Kageyama, R.
    • Journal Title

      Biol

      Volume: 352 Issue: 2 Pages: 329-340

    • DOI

      10.1016/j.ydbio.2011.01.038

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intronic delay is essential for oscillatory expression in the segmentation clock.2011

    • Author(s)
      Takashima, Y., Ohtsuka, T., Gonzalez, A., Miyachi, H., and Kageyama, R.
    • Journal Title

      Natl. Acad. Sci. USA

      Volume: 108 Issue: 8 Pages: 3300-3305

    • DOI

      10.1073/pnas.1014418108

    • NAID

      120002970830

    • Related Report
      2011 Final Research Report
  • [Journal Article] Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development.2011

    • Author(s)
      Tateya, T., Imayoshi, I., Tateya, I., Ito, J., Kageyama, K.
    • Journal Title

      Developmental Biology

      Volume: 352 Pages: 329-340

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Six 1 is indispensable for production of functional apical and basal progenitors during olfactory epithelial development.2010

    • Author(s)
      Ikeda, K., Kageyama, R., Suzuki, Y., and Kawakami, K.
    • Journal Title

      Int. J. Dev. Biol

      Volume: 54 Issue: 10 Pages: 1453-1464

    • DOI

      10.1387/ijdb.093041ki

    • Related Report
      2011 Final Research Report
  • [Journal Article] Hesl regulates embryonic stem cell differentiation by suppressing Notch signaling2010

    • Author(s)
      Kobayashi, T. and Kageyama, R.
    • Journal Title

      Genes to Cells

      Volume: 15 Issue: 7 Pages: 689-698

    • DOI

      10.1111/j.1365-2443.2010.01413.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] HES1 and HESS are dispensable for cartilage and endochondral bone formation2010

    • Author(s)
      Karlsson, C., Brantsing, C., Kageyama, R., and Lindahl, A.
    • Journal Title

      Cells Tissue Organs

      Volume: 192 Issue: 1 Pages: 17-27

    • DOI

      10.1159/000280416

    • Related Report
      2011 Final Research Report
  • [Journal Article] Maximizing functional photoreceptor differentiation from adult human retinal stem cells.2010

    • Author(s)
      Inoue, T., Coles, B., Dorval, K., Bremner, R., Bessho, Y., Kageyama, R., Hino, S., Matsuoka, M., Craft, C., McInnes, R., Temblay, F., Prusky, G., Tano, Y., and van der Kooy, D.
    • Journal Title

      Stem Cells

      Volume: 28 Issue: 5 Pages: 489-500

    • DOI

      10.1002/stem.27

    • Related Report
      2011 Final Research Report
  • [Journal Article] Zinc-finger genes Fezfl and Fezfl control neuronal differentiation by repressing Hes5 expression in forebrain2010

    • Author(s)
      Shimizu, T., Nakazawa, M., Kani, S., Bae, Y.-K., Shimizu, T., Kageyama, R., and Hibi, M.
    • Journal Title

      Development

      Volume: 137 Issue: 11 Pages: 1875-1885

    • DOI

      10.1242/dev.047167

    • Related Report
      2011 Final Research Report
  • [Journal Article] Essential roles of Notch signaling in maintenance of neural stem cells in the developing and adult brains.2010

    • Author(s)
      Imayoshi, I., Sakamoto, M., Yamaguchi, M., Mori, K., and Kageyama, R.
    • Journal Title

      J. Neurosci

      Volume: 30 Issue: 9 Pages: 3489-3498

    • DOI

      10.1523/jneurosci.4987-09.2010

    • Related Report
      2011 Final Research Report
  • [Journal Article] Hes1 regulates embryonic stem cell differentiation by suppressing Notch signaling.2010

    • Author(s)
      Kobayashi, T., Kageyama, R.
    • Journal Title

      Genes to Cells

      Volume: 15 Pages: 689-698

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Zinc-finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in forebrain2010

    • Author(s)
      Shimizu, T., Nakazawa, M., Kani, S., Bae, Y.-K., Shimizu, T., Kageyama, R., Hibi, M.
    • Journal Title

      Development

      Volume: 137 Pages: 1875-1885

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Essential roles of Notch signaling in maintenance of neural stem cells in the developing and adult brains2010

    • Author(s)
      Imayoshi, I., et al.
    • Journal Title

      Journal of Neuroscience 30

      Pages: 3489-3498

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatio-temporal pattern in somitogenesis : a non-Turing scenario with wave propagation.2009

    • Author(s)
      Nagahara, H., Ma, Y., Takenaka, Y., Kageyama, R., and Yoshikawa, K.
    • Journal Title

      Physical Rev. E

      Volume: 80 Issue: 2

    • DOI

      10.1103/physreve.80.021906

    • Related Report
      2011 Final Research Report
  • [Journal Article] The first Hesl dimer inhibitors from natural products.2009

    • Author(s)
      Arai, M., Masada, A., Ohtsuka, T., Kageyama, R., and Ishibashi, M.
    • Journal Title

      Chemistry Letters

      Volume: 19 Pages: 5778-5781

    • Related Report
      2011 Final Research Report
  • [Journal Article] Notch-Hesl pathway contributes to the cochlear prosensory formation potentially through the transcriptional down-regulation of p27(Kip1)2009

    • Author(s)
      Murata, J., Ohtsuka, T., Tokunaga, A., Nishiike, S., Inohara, H., Okano, H., and Kageyama, R.
    • Journal Title

      J. Neurosci. Res

      Volume: 87 Issue: 16 Pages: 3521-3534

    • DOI

      10.1002/jnr.22169

    • Related Report
      2011 Final Research Report
  • [Journal Article] The cyclic gene Hesl contributes to diverse differentiation responses of embryonic stem cells2009

    • Author(s)
      Kobayashi, T., Mizuno, H., Imayoshi, I., Furusawa, C., Shirahige, K., and Kageyama, R.
    • Journal Title

      Genes & Dev

      Volume: 223 Issue: 16 Pages: 1870-1875

    • DOI

      10.1101/gad.1823109

    • Related Report
      2011 Final Research Report
  • [Journal Article] Hopf Bifurcation in the Presomitic Mesoderm during the Mouse Segmentation2009

    • Author(s)
      Gonzalez, A., and Kageyama, R.
    • Journal Title

      J. Theor. Biol

      Volume: 259 Pages: 176-189

    • Related Report
      2011 Final Research Report
  • [Journal Article] The cyclic gene Hesl contributes to diverse differentiation responses of embryonic stem cells2009

    • Author(s)
      Kobayashi, T., et al.
    • Journal Title

      Genes & Development 23

      Pages: 1870-1875

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic regulation of Notch signaling in neural progenitor cells2009

    • Author(s)
      Kageyama, R., et al.
    • Journal Title

      Current Opinion in Cell Biology 21

      Pages: 733-740

    • NAID

      120001759395

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      Niwa, Y., Shimojo, H., Kageyama, R.
    • Journal Title

      Systems Biology(Springer)

      Pages: 199-207

    • Related Report
      2009 Annual Research Report
  • [Presentation] Functional significance of neurogenesis in the olfactory bulb2011

    • Author(s)
      Kageyama, R
    • Organizer
      Keystone Symposium--Adult Neurogenesis
    • Place of Presentation
      Taos, USA(招待講演)
    • Year and Date
      2011-01-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Spatiotemporal regulation of somitogenesis by the oscillator networks of the segmentation clock.2011

    • Author(s)
      Kageyama, R.
    • Organizer
      Annual Meeting of American Society for Cell Biology
    • Place of Presentation
      Denver, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Essential roles of Notch signaling in embryonic and adult neural stem cells2011

    • Author(s)
      Kageyama R.
    • Organizer
      23rd Biennial Meeting of the International Society for Neurochemistry
    • Place of Presentation
      Athens, Greece
    • Related Report
      2011 Annual Research Report
  • [Presentation] Spatiotemporal regulation of somitogenesis by the oscillator networks of the segmentation clock2011

    • Author(s)
      Kageyama R.
    • Organizer
      Annual Meeting of American Society for Cell Biology
    • Place of Presentation
      Denver, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] The role of Notch signaling in proliferation and differentiation of neural stem cells2010

    • Author(s)
      Kageyama, R.
    • Organizer
      Fondation Des Treilles
    • Place of Presentation
      France
    • Related Report
      2011 Final Research Report
  • [Presentation] TThe oscillator networks in the somite segmentation clock2010

    • Author(s)
      Kageyama, R.
    • Organizer
      The Notch Meeting V
    • Place of Presentation
      Athens, Greece
    • Related Report
      2011 Final Research Report
  • [Presentation] The role of Notch signaling in embryonic and adult neural stem cells2010

    • Author(s)
      Kageyama, R.
    • Organizer
      The Company of Biologists Workshops
    • Place of Presentation
      West Sussex, UK
    • Related Report
      2011 Final Research Report
  • [Presentation] Essential roles of Notch signaling in embryonic and adult neural stem cells2010

    • Author(s)
      Kageyama, R.
    • Organizer
      23^<rd> Biennial Meeting of the International Society for Neurochemistry
    • Place of Presentation
      Athens, Greece
    • Related Report
      2011 Final Research Report
  • [Presentation] Ultradian oscillations in somite segmentation and other biological events2010

    • Author(s)
      Kageyama, R.
    • Organizer
      The 6^<th> bHLH Symposium
    • Place of Presentation
      Shanghai, China
    • Related Report
      2011 Final Research Report
  • [Presentation] The significance and mechanism of ultradian oscillations in somite segmentation and other biological events2010

    • Author(s)
      Kageyama, R.
    • Organizer
      International Workshop on Timing and Dynamics in Biological SystemsJDresden
    • Place of Presentation
      Germany
    • Related Report
      2011 Final Research Report
  • [Presentation] The role of Notch signaling in embryonic and adult neural stem cells2010

    • Author(s)
      Kageyama, R.
    • Organizer
      Perspectives of Stem Cells
    • Place of Presentation
      Sao Paulo, Brazil
    • Related Report
      2011 Final Research Report
  • [Presentation] The role of Notch signaling in embryonic and adult neural stem cells2010

    • Author(s)
      Kageyama, R.
    • Organizer
      ENP Neural Stem Cell Meeting
    • Place of Presentation
      Abbaye des Vaux de Cernay, France
    • Related Report
      2011 Final Research Report
  • [Presentation] The role of Notch signaling in embryonic and adult neurogenesis2010

    • Author(s)
      Kageyama, R.
    • Organizer
      18^<th> Biennial Meeting of the International Society for Developmental Neuroscience
    • Place of Presentation
      Lisbon, Portugal
    • Related Report
      2011 Final Research Report
  • [Presentation] The role of Notch signling in proliferation and differentiation of adult neural stem cells2009

    • Author(s)
      Kageyama, R.
    • Organizer
      Joint Japan-Australia-New Zealand Symposium-Building a Functional BrainJAuckland
    • Place of Presentation
      New Zealand
    • Related Report
      2011 Final Research Report
  • [Presentation] Functional significance of neurogenesis in the olfactory bulb.2009

    • Author(s)
      Kageyama, R.
    • Organizer
      Keystone Symposium-Adult Neurogenesis
    • Place of Presentation
      Taos, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Essential roles of Notch signaling in embryonic and adult neural stem cells2009

    • Author(s)
      Kageyama, R.
    • Organizer
      Notch and Stem Cells
    • Place of Presentation
      London, UK
    • Related Report
      2011 Final Research Report
  • [Presentation] The role of Hes1 oscillations in regulation of stem progenitor cells2009

    • Author(s)
      Kageyama, R.
    • Organizer
      The Notch Meeting V
    • Place of Presentation
      Athens, Greece
    • Related Report
      2011 Final Research Report
  • [Presentation] Ultradian oscillators in somite segmentation and other biological events2009

    • Author(s)
      Kageyama, R.
    • Organizer
      Symposium on Developmental Biology
    • Place of Presentation
      London, UK
    • Related Report
      2011 Final Research Report
  • [Presentation] The role of Hes1 in proliferation and differentiation of neural stem cells2009

    • Author(s)
      Kageyama, R.
    • Organizer
      EMBO Workshop/5^<th> International Symposium on bHLH transcription factors
    • Place of Presentation
      London, UK
    • Related Report
      2011 Final Research Report
  • [Presentation] Ultradian oscillators in somite segmentation and other biological events2009

    • Author(s)
      Kageyama, R.
    • Organizer
      8^<th> International Conference on Information Processing in Cells and Tissues
    • Place of Presentation
      Ascona, Switzerland
    • Related Report
      2011 Final Research Report
  • [Presentation] The role of Hesl oscillations in regulation of stem/progenitor cells2009

    • Author(s)
      R.Kageyama
    • Organizer
      Notch meeting
    • Place of Presentation
      Athens, Greece
    • Related Report
      2009 Annual Research Report
  • [Book] ltradian oscillations in Notch signaling regulate dynamic biological events2010

    • Author(s)
      Kageyama, R., Niwa, Y., Shimojo, H., Kobayashi, T., and Ohtsuka, T.
    • Publisher
      Curr. Top. Dev. Biol
    • Related Report
      2011 Final Research Report
  • [Book] 2010 YearBook of Science & Technology2010

    • Author(s)
      Kageyama, R., Niwa, Y., and Shimojo, H.
    • Publisher
      McGraw-Hill
    • Related Report
      2011 Final Research Report
  • [Book] McGraw-Hill 2010 YearBook of Science & Technology2010

    • Author(s)
      Kageyama, R., Niwa, Y., Shimojo, H.
    • Total Pages
      467
    • Publisher
      McGraw-Hill
    • Related Report
      2010 Annual Research Report
  • [Book] In Systems Biology(Eds, S. Nakanishi, R. Kageyama, and D. Watanabe)2009

    • Author(s)
      Niwa, Y., Shimojo, H., and Kageyama, R.
    • Publisher
      Springer
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.virus.kyoto-u.acjp/Lab/Kageyama/index.html

    • Related Report
      2011 Final Research Report
  • [Remarks] マスコミ報(1)道振動遺伝子Hes1が胚性幹細胞の多様な分化応答に寄与:朝日新聞(平成21年8月15日夕刊8面)、京都新聞(8月15日夕刊8面)、日本経済新聞(8.月16日34面)、毎日新聞(8月15日夕刊7面)および読売新聞(8月15日夕刊2面)

    • Related Report
      2011 Final Research Report
  • [Remarks] (2)胚性幹細胞におけるHes1オシレーションの意義: NHK教育テレビサイエンスZERO平成22年4月3日

    • Related Report
      2011 Final Research Report
  • [Remarks] (3)成体脳ニューロン新生と匂い情報処理: NHK教育テレビサイエンスZERO平成22年6月26日

    • Related Report
      2011 Final Research Report
  • [Remarks] (4)分節時計遺伝子がリズムを刻むにはイントロンによる発現の遅れが必須:朝日新聞(平成23年2月8日)、京都新聞(2月8日朝刊)

    • Related Report
      2011 Final Research Report
  • [Remarks] (5)成体脳におけるニューロン新生は先天的な匂い応答に必要である。:京都新聞(平成23年5月3日21面)

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.virus.kyoto-u.ac.jp/Lab/Kageyama/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.virus.kyoto-u.ac.jp/Lab/Kageyama/index.html

    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 多能性幹細胞からの神経細胞の分化誘導方法2010

    • Inventor(s)
      影山龍一郎、小林妙子
    • Industrial Property Rights Holder
      国立大学法人京都大学
    • Filing Date
      2010-07-15
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 多能性幹細胞からの神経細胞の分化誘導方法2009

    • Inventor(s)
      影山龍一郎、小林妙子
    • Industrial Property Rights Holder
      国立大学法人京都大学
    • Industrial Property Number
      2009-168045
    • Filing Date
      2009-07-16
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 多能性幹細胞からの神経細胞の分化誘導方法2009

    • Inventor(s)
      影山龍一郎, 小林妙子
    • Industrial Property Rights Holder
      京都大学
    • Industrial Property Number
      2009-168045
    • Filing Date
      2009-07-16
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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