Nuclear receptors as therapeutic targets for diabeticnephropathy.

• Project/Area Number: 21249053
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Okayama University
• Principal Investigator: MAKINO Hirofumi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (50165685)
• Co-Investigator(Kenkyū-buntansha): WADA Jun 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (30294408)
• Co-Investigator(Renkei-kenkyūsha): OGAWA Daisuke 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (70535195)
• Project Period (FY): 2009 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥45,500,000 (Direct Cost: ¥35,000,000、Indirect Cost: ¥10,500,000); Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000); Fiscal Year 2011: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000); Fiscal Year 2010: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000); Fiscal Year 2009: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
• Keywords: 核内受容体 / 糖尿病性腎症 / レチノイド / 細胞周期 / 糸球体上皮細胞 / PPAR / RXR / LXR

Research Abstract

In the development of diabetic nephropathy, the hypertrophy of renal cells is important for the initial disease process and chronic inflammation further promotes the progression of the disease. Modulator for nuclear receptors may improve these pathological processes. Peroxisome proliferator-activated receptor (PPAR)-δand Liver X receptor (LXR) agonists exerted therapeutic potential by improving inflammation. Retinoid X receptor (RXR) antagonist demonstrated therapeutic potential by correcting cell-cycle abnormalities and cellular hypertrophy. Modulators for nuclear receptors are beneficial for the treatment of diabetic nephropathy.

Research Products

• [Journal Article] Serum galectin-9 levels are elevated in the patients with type 2 diabetes and chronic kidney disease (2013)
  • Author(s): Kurose Y, Wada J, Kanzaki M, Teshigawara S, Nakatsuka A, Murakami K, Inoue K, Terami T, Katayama A, Watanabe M,Higushi C, Eguchi J, Miyatake N, Makino H
  • Journal Title: BMC Nephrol Volume: 14 Pages: 23-23
  • NAID: 120005324795
  • Peer Reviewed
• [Journal Article] Vaspin inhibits apoptosis of endothelial cells as a ligand for cell-surface GRP78/VDAC complex (2013)
  • Author(s): Nakatsuka A, Wada J, Iseda I, Teshigawara S, Higashio K, Murakami K, Kanzaki M, Inoue K, Terami T, Katayama A, Hida K, Eguchi J, Ogawa D, Matsuki Y, Hiramatsu R, Tagita H, Kakuta S, Iwakura Y, Makino H
  • Journal Title: Circ Res Volume: 112(5) Pages: 771-780
  • Peer Reviewed
• [Journal Article] Telmisartan attenuates diabetic nephropathy by suppressing ixidative stress in db/db mice (2013)
  • Author(s): Sato-Horiguchi C, Ogawa D, Wada J, Tachibana H, Kodera R, Eguchi J, Nakatsuka A, Terami N, Shikata K, Makino H
  • Journal Title: Nephron Exp Nephrol Volume: 121(3-4)
  • Peer Reviewed
• [Journal Article] The effects of telmisartan treatment on the abdominal fat depot in patients with metabolic syndrome and essential hypertension: Abdominal fat Depot Intervention Program of Okayama (ADIPO) (2013)
  • Author(s): Murakami K, Wada J, Ogawa D, Horiguchi CS, Miyoshi T, Sasaki M, Uchida HA, Nakamura Y, Makino H
  • Journal Title: Diab Vasc Dis Res Volume: 10(1) Pages: 93-96
  • Peer Reviewed
• [Journal Article] The effects of telmisartan treatment on the abdominal fat depot in patients with metabolic syndrome and essential hypertension: Abdominal fat Depot Intervention Program of Okayama (ADIPO). (2013)
  • Author(s): Murakami K
  • Journal Title: Diab Vasc Dis Res Volume: 10(1) Issue: 1 Pages: 93-96
  • DOI: 10.1177/1479164112444640
  • Peer Reviewed
• [Journal Article] Telmisartan attenuates diabetic nephropathy by suppressing ixidative stress in db/db mice. (2013)
  • Author(s): Sato-Horiguchi C
  • Journal Title: Nephron Exp Nephrol Volume: 121(3-4) Issue: 3-4 Pages: 97-108
  • DOI: 10.1159/000343102
  • Peer Reviewed
• [Journal Article] Vaspin inhibits apoptosis of endothelial cells as a ligand for cell-surface GRP78/VDAC complex. (2013)
  • Author(s): Nakatsuka A
  • Journal Title: Cir Res Volume: 112(5) Issue: 5 Pages: 771-780
  • DOI: 10.1161/circresaha.111.300049
  • Peer Reviewed
• [Journal Article] Serum galectin-9 levels are elevated in the patients with type 2 diabetes and chronic kidney disease. (2013)
  • Author(s): Kurose Y
  • Journal Title: BMC Nephrol Volume: 14 Issue: 1 Pages: 23-23
  • DOI: 10.1186/1471-2369-14-23
  • Peer Reviewed
• [Journal Article] The serum vaspin levels are reduced in Japanese chronic hemodialysis patients. (2012)
  • Author(s): Inoue J, Wada J, Teshigawara S, Hida K, Nakatsuka A, Takatori U, Kojo S, Akagi S, Nakao K, Miyatake N, McDonald JF, Makino H
  • Journal Title: BMC Nephrol Volume: 13(1) Pages: 163-163
  • NAID: 120005315579
  • Peer Reviewed
• [Journal Article] Activation of liver x receptor inhibits osteopontin and ameliorates diabetic nephropathy (2012)
  • Author(s): Tachibana H, Ogawa D, Matsushita Y,Bruemmer D, Wada J, Teshigawara S, Eguchi J, Sato-Horiguchi C, Uchida HA, Shikata K, Makino H
  • Journal Title: J Am Soc Nephrol Volume: 23(11) Pages: 1835-1846
  • Peer Reviewed
• [Journal Article] Vaspin is an adipokine ameliorating ER stress in obesity as a ligand for cell-surface GRP78/MTJ-1 complex. (2012)
  • Author(s): Nakatsuka A, Wada J, Iseda I, Teshigawara S, Higashio K, Murakami K, Kanzaki M, Inoue K, Terami T, Katayama A, Hida K, Eguchi J, Horiguchi CS, Ogawa D, Matsuki Y, Hiramatsu R, Yagita H, Kakuta S, Iwakura Y, Makino H
  • Journal Title: Diabetes Volume: 61(11) Pages: 2823-2832
  • NAID: 120005300245
  • Peer Reviewed
• [Journal Article] The therapeutic potential of synthetic human atrial natriuretic peptide in nephrotic syndrome: a randomized controlled trial. (2012)
  • Author(s): Kanzaki M, Wada J, Kikumoto Y, Akagi S, Nakao K, Sugiyama H, Makino H
  • Journal Title: Int J Nephrol Renovasc Dis Volume: 5 Pages: 91-96
  • Peer Reviewed
• [Journal Article] Hydrogen-rich water prevents progression of non-alcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice. (2012)
  • Author(s): Kawai D, Takaki A, Nakatsuka A, Wada J, Tamaki N, Yasunaka T, Koike K, Tsuzaki R, Matsumoto K, Miyake Y, Shiraha H, Morita M, Makino H, Yamamoto K
  • Journal Title: Hepatology Volume: 56(3) Pages: 912-921
  • Peer Reviewed
• [Journal Article] Serum vaspin concentrations are closely related to insulin resistance and rs77060950 at SERPINA12 genetically defines distinct group with higher serum levels in Japanese population. (2012)
  • Author(s): Teshigawara S, Wada J, Hida K, Nakatsuka A, Eguchi J, Murakami K, Kanzaki M, Inoe K, Terami T, Katayama A, Iseda I, Matsushita Y, Miyatake N, McDonald JF, Hotta K, Makino H
  • Journal Title: J Clin Endocrinol Metab Volume: 97(7)
  • NAID: 120005232486
  • Peer Reviewed
• [Journal Article] Galectin-9 and T cell immunoglobulin mucin-3 pathway is a therapeutic target for type 1 diabetes (2012)
  • Author(s): Kanzaki M, Wada J, Sugiyama K, Nakatsuka A, Teshigawara S, Murakami K, Inoue K, Terami T, Katayama A, Eguchi J, Akiba H, Yagita H, Makino H
  • Journal Title: Endocrinology Volume: 153(2) Pages: 612-620
  • Peer Reviewed
• [Journal Article] Impact of circulating vaspin levels on metabolic variables in elderly twins (2012)
  • Author(s): Hida K, Poulsen P, Teshigawara S, Nilsson E, Friedrichsen M, Ribel-Madsen R, Grunnet L, Lund SS, Wada J, Vaag A
  • Journal Title: Diabetologia Volume: 55(2) Pages: 530-532
  • Peer Reviewed
• [Journal Article] RXR antagonism induces G0/G1 cell cycle arrest and ameliorates obesity by up-regulating the p53-p21^Cip1pathway in adipocytes. (2012)
  • Author(s): Nakatsuka A, Wada J, Hida K, Hida A, Eguchi J, Teshigawara S, Murakami K, Kanzaki M, Inoue K, Terami T, Katayama A, Ogawa D, Kagechika H, Makino H
  • Journal Title: J Pathol Volume: 226(5) Pages: 784-795
  • NAID: 130004505771
  • Peer Reviewed
• [Journal Article] Impact of circulating vaspin levels on metabolic variables in elderly twins. (2012)
  • Author(s): Hida K
  • Journal Title: Diabetologia Volume: 55(2) Issue: 2 Pages: 530-532
  • DOI: 10.1007/s00125-011-2385-0
  • Peer Reviewed
• [Journal Article] Galectin-9 and T cell immunoglobulin mucin-3 pathway is a therapeutic target for type 1 diabetes. (2012)
  • Author(s): Kanzaki M
  • Journal Title: Endocrinology Volume: 153(2) Issue: 2 Pages: 612-620
  • DOI: 10.1210/en.2011-1579
  • Peer Reviewed
• [Journal Article] Serum vaspin concentrations are closely related to insulin resistance and rs77060950 at SERPINA12 genetically defines distinct group with higher serum levels in Japanese population. (2012)
  • Author(s): Teshigawara S
  • Journal Title: J Clin Endocrinol Metab Volume: 97(7) Issue: 7 Pages: E1202-E1207
  • DOI: 10.1210/jc.2011-3297
  • Peer Reviewed
• [Journal Article] Activation of liver x receptor inhibits osteopontin and ameliorates diabetic nephropathy. (2012)
  • Author(s): Tachibana H
  • Journal Title: J Am Soc Nephrol Volume: 23(11) Issue: 11 Pages: 1835-1846
  • DOI: 10.1681/asn.2012010022
  • Peer Reviewed
• [Journal Article] The serum vaspin levels are reduced in Japanese chronic hemodialysis patients. (2012)
  • Author(s): Inoue J
  • Journal Title: BMC Nephrol Volume: 13(1) Issue: 1 Pages: 163-163
  • DOI: 10.1186/1471-2369-13-163
  • Peer Reviewed
• [Journal Article] RXR antagonism induces G0/G1 cell cycle arrest and ameliorates obesity by up-regulating the p53-p21Cip1 pathway in adipocytes (2012)
  • Author(s): Nakatsuka A, et al
  • Journal Title: J Pathol Volume: 226(5) Issue: 5 Pages: 784-795
  • DOI: 10.1002/path.3001
  • Peer Reviewed
• [Journal Article] Galectin-9 and T cell immunoglobulin mucin-3 pathway is a therapeutic target for type 1 diabetes (2012)
  • Author(s): Kanzaki M, et al
  • Journal Title: Endocrinology Volume: 51(6) Pages: 619-623
  • Peer Reviewed
• [Journal Article] High glucose increases metallothionein expression in renal proximal tubular epithelial cells. (2011)
  • Author(s): Ogawa D, Asanuma M, Miyazaki I, Tachibana H, Wada J, Sogawa N, Sugaya T, Kitamura S, Maeshima Y, Shikata K, Makino H
  • Journal Title: Exp Diabetes Res Volume: 2011 Pages: 534872-534872
  • Peer Reviewed
• [Journal Article] Icodextrin increases technique survival rate in peritoneal dialysis patients with diabetic nephropathy by improving body fluid management: a randomized controlled trial. (2011)
  • Author(s): Takatori Y, Akagi S, Sugiyama H, Inoue J, Kojo S, Morinaga H, Nakao K, Wada J, Makino H
  • Journal Title: Clin J Am Soc Nephrol Volume: 6(6) Pages: 1337-1344
  • Peer Reviewed
• [Journal Article] Activation of Peroxisome Proliferator-Activated Receptor δInhibits Streptozotocin-Induced Diabetic Nephropathy Through Anti-Inflammatory Mechanisms in Mice (2011)
  • Author(s): Matsushita Y, Ogawa D, Wada J, Yamamoto N, Shikata K, Sato C, Tachibana H, Toyota N, Makino H.
  • Journal Title: Diabetes Volume: 60(3) Pages: 960-968
  • Peer Reviewed
• [Journal Article] P-selectin glycoprotein ligand-1 deficiency is protective against obesity-related insulin resistance (2011)
  • Author(s): Sato C, Shikata K, Hirota D, Sasaki M, Nishishita S, Miyamoto S, Kodera R, Ogawa D, Tone A, Kataoka HU, Wada J, Kajitani N, Makino H
  • Journal Title: Diabetes Volume: 60(1) Pages: 189-99
  • Peer Reviewed
• [Journal Article] Icodextrin increases technique survival rate in peritoneal dialysis patients with diabetic nephropathy by improving body fluid management : a randomized controlled trial (2011)
  • Author(s): Takatori Y, et al
  • Journal Title: Clin J Am Soc Nephrol Volume: 6 Pages: 1337-1344
  • Peer Reviewed
• [Journal Article] High glucose increases metallothionein expression in renal proximal tubular epithelial cells (2011)
  • Author(s): Ogawa D, et al
  • Journal Title: Exp Diabetes Res Volume: 2011 Pages: 534872-534872
  • Peer Reviewed
• [Journal Article] In vivo delivery of gremlin siRNA plasmid reveals therapeutic potential against diabetic nephropathy by recovering bone morphogenetic protein-7. (2010)
  • Author(s): Zhang Q, Shi Y, Wada J, Malakauskas SM, Liu M, Ren Y, Du C, Duan H, Li Y, Li Y, Zhang Y
  • Journal Title: PLoS ONE Volume: 5(7)
  • Peer Reviewed
• [Journal Article] Effects of icodextrin peritoneal dialysis solution on the peritoneal membrane in the STZ-induced diabetic rat model with partial nephrectomy (2010)
  • Author(s): Nakao A, Nakao K, Takatori Y, Kojo S, Inoue J, Akagi S, Sugiyama H, Wada J, Makino H
  • Journal Title: Nephrol Dial Transplant Volume: 25(5) Pages: 1479-1488
  • Peer Reviewed
• [Journal Article] Simvastatin inhibits osteoclast differentiation induced by bone morphogenetic protein-2 and RANKL through regulating MAPK, AKT and Src signaling. (2010)
  • Author(s): Yamashita, M., F.Otsuka, T.Mukai, R.Yamanaka, H.Otani, Y.Matsumoto, E.Nakamura, M.Takeo, K.E.Sada, H.
  • Journal Title: Regul Pept Volume: 162 Pages: 99-108
  • Peer Reviewed
• [Journal Article] Involvement of the bone morphogenetic protein system in endothelin- and aldosterone-induced cell proliferation of pulmonary arterial smooth muscle cells isolated from human patients with pulmonary arterial hypertension. (2010)
  • Author(s): Yamanaka, R., F.Otsuka, K.Nakamura, M.Yamashita, H.Otani, M.Takeda, Y.Matsumoto, K.F.Kuoano, H.Ito, H.
  • Journal Title: Hypertens Res Volume: 33 Pages: 435-445
  • Peer Reviewed
• [Journal Article] Effects of bone morphogenetic protein (BMP) on adrenocorticotropin production by pituitary corticotrope cells : involvement of up-regulation of BMP receptor signaling by somatostatin analogs. (2010)
  • Author(s): Tsukamoto, N., F.Otsuka, T.Miyoshi, R.Yamanaka, K.Inegaki, M.Yamashita, H.Otani, M.Takeda, J.Suzuki, T.Ogura, Y.
  • Journal Title: Endocrinology Volume: 151 Pages: 1129-1141
  • Peer Reviewed
• [Journal Article] Influencing factors for dietary behaviors of patients with diabetic nephropathy. (2010)
  • Author(s): Sumiyoshi, K., C.Kawata, K.Shikata, H.Makino.
  • Journal Title: Acta Med Okayama Volume: 64 Pages: 39-47
  • NAID: 120002311418
  • Peer Reviewed
• [Journal Article] Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT-Japan) : Rationale and study design. (2010)
  • Author(s): Shikata, K., M.Haneda, D.Koya, Y.Suzuki, Y.Tomino, K.Yamada, S.Maeda, N.Kawakami, T.Uzu, M.Nishimura, C.Sato
  • Journal Title: Diabetes Res Clin Pract Volume: 87 Pages: 228-232
  • Peer Reviewed
• [Journal Article] Roles of bone morphogenetic protein-6 in aldosterone regulation by adrenocortical cells. (2010)
  • Author(s): Otani, H., F.Otsuka, K.Inagaki, J.Suzuki, H.Makino.
  • Journal Title: Acta Med Okayama Volume: 64 Pages: 213-218
  • NAID: 120002383776
  • Peer Reviewed
• [Journal Article] Effects of icodextrin peritoneal dialysis solution on the peritoneal membrane in the STZ-induced diabetic rat model with partial nephrectomy. (2010)
  • Author(s): Nakao, A., K.Nakao, Y.Takatori, S.Kojo, J.Inoue, S.Akagi, H.Sugiyama, J.Wada, H.Makino.
  • Journal Title: Nephrol Dial Transplant Volume: 25 Pages: 1479-1488
  • Peer Reviewed
• [Journal Article] A novel antagonistic effect of the bone morphogenetic protein system on prolactin actions in regulating steroidogenesis by granulosa cells. (2010)
  • Author(s): Nakamura, E., F.Otsuka, K.Inagaki, T.Miyoshi, R.Yamanaka, N.Tsukamoto, J.Suzuki, T.Ogura, H.Makino.
  • Journal Title: Endocrinology Volume: 151 Pages: 5506-5518
  • Peer Reviewed
• [Journal Article] Functional relationship between fibroblast growth factor-8 and bone morphogenetic proteins in regulating steroidogenesis by rat granulosa cells. (2010)
  • Author(s): Miyoshi, T., F.Otsuka, M.Yamashita, K.Inagaki, E.Nakamura, N.Tsukamoto, M.Takeda, J.Suzuki, H.Makino.
  • Journal Title: Mol Cell Endocrinol Volume: 325 Pages: 84-92
  • Peer Reviewed
• [Journal Article] Estrogen and glucocorticoid regulate osteoblast differentiation through the interaction of bone morphogenetic protein-2 and tumor necrosis factor-alpha in C2C12 cells. (2010)
  • Author(s): Matsumoto, Y., F.Otsuka, M.Takano, T.Mukai, R.Yamanaka, M.Takeda, T.Miyoshi, K.Inagaki, K.E.Sada, H.Makino.
  • Journal Title: Mol Cell Endocrinol Volume: 325 Pages: 118-127
  • Peer Reviewed
• [Journal Article] Sensitization to alloxan-induced diabetes and pancreatic cell apoptosis in acatalasemic mice. (2010)
  • Author(s): Kikumoto, Y., H.Sugiyama, T.Inoue, H.Morinaga, K.Takiue, M.Kitagawa, N.Fukuoka, M.Saeki, Y.Maeshima, D.H.Wang.
  • Journal Title: Biochim Biophys Acta Volume: 1802 Pages: 240-246
  • Peer Reviewed
• [Journal Article] Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritis. (2010)
  • Author(s): Kawabata, T., K.Nishida, K.Takasugi, H.Ogawa, K.Sada, Y.Kadota, J.Inagaki, S.Hirohata, Y.Ninomiya, H.Makino.
  • Journal Title: Arthritis Res Ther Volume: 12
  • Peer Reviewed
• [Journal Article] Microinflammation is a common risk factor for progression of nephropathy and atherosclerosis in Japanese patients with type 2 diabetes. (2010)
  • Author(s): Kajitani, N., K.Shikata, A.Nakamura, T.Nakatou, M.Hiramatsu, H.Makino.
  • Journal Title: Diabetes Res Clin Pract Volume: 88 Pages: 171-176
  • Peer Reviewed
• [Journal Article] Differential expression of glycogenes in tonsillar B lymphocytes in association with proteinuria and renal dysfunction in IgA nephropathy. (2010)
  • Author(s): Inoue, T., H.Sugiyama, Y.Hiki, K.Takiue, H.Morinaga, M.Kitagawa Y.Maeshima, K.Fukushima, K.Nishizaki, H.
  • Journal Title: Clin Immunol Volume: 136 Pages: 447-455
  • Peer Reviewed
• [Journal Article] Sensitization to alloxan-induced diabetes and pancreatic cell apoptosis in acatalasemic mice (2010)
  • Author(s): Kikumoto Y, Sugiyama H, Inoue T, Morinaga H, Takiue K, Fukuoka N, Saeki M, Maeshima Y, Wang DH, Ogino K, Masuoka N, Makino H
  • Journal Title: Biochim Biophys Acta 1802(2) Pages: 240-246
  • Peer Reviewed
• [Journal Article] Diabetic Nephrepathy Remission and Regression Team Trial in Japan(DNETT-Japan) : Rationale and study design. (2010)
  • Author(s): Shikata K, Haneda M, Koya D, Suzukj Y, Tomino Y, Yamada K, Maeda S, Kawakami N, Uzu T, Nishimura M, Sato C, Ogawa D, Makino H ; DNETT-Japan Study Group
  • Journal Title: Diabetes Res Clin Pract 87(2) Pages: 228-232
  • Peer Reviewed
• [Journal Article] Endothelial barrier protection by FTY720 under hyperglycemic condition: involvement of focal adhesion kinase, small GTPases, and adherens junction proteins. (2009)
  • Author(s): Sarai K, Shikata K, Shikata Y, Omori K, Watanabe N, Sasaki M, Nishishita S, Wada J, Goda N, Kataoka N, Makino H
  • Journal Title: Am J Physiol Cell Physiol Volume: 297(4)
  • Peer Reviewed
• [Journal Article] Olmesartan and Temocapril Prevented the Development of Hyperglycemia and the Deterioration of Pancreatic Islet Morphology in Otsuka-Long-Evans-Tokushima Fatty Rats (2009)
  • Author(s): Kaihara M, Nakamura Y, Sugimoto T, Uchida H, Norii H, Hanayama Y, Makino H
  • Journal Title: Acta Med Okayama 63(1) Pages: 35-42
  • NAID: 120002313118
  • Peer Reviewed
• [Journal Article] Urinary excretions of lipocalin-type prostaglandin D synthase predict renal injury in type-2 diabetes : a cross-sectional and prospective multicentre study (2009)
  • Author(s): Makino H, Uehara Y, Seiki K, Urada Y on behalf of L-PGDS Clinical Research Group of Kidney
  • Journal Title: Nephrol Dial Transplant 24 Pages: 475-482
  • Peer Reviewed
• [Journal Article] Long-term effect of modification of dietary protein intake on the progression of diabetic nephropathy : a randomized controlled trial (2009)
  • Author(s): Koya D, Haneda M, Inomata S, Suzuki J, Suzuki D, Makino H, Shikata K, Murakami Y, Tomino Y, Yamada K, Araki S, Kashiwagi Y, Kikkawa R on behalf of the Low-Protein Diet Study Group
  • Journal Title: Diabetologia 52 Pages: 2037-2045
  • Peer Reviewed
• [Journal Article] Beta-Blocker Prescription and Outcomes in Hemodialysis Patients from The Japan Dialysis Outcomes and Practice Patterns Study. (2009)
  • Author(s): Nakao K, Makino H, Morita S, Takahashi Y, Akizawa T, Saito A, Asano Y, Kurokawa K, Fukuhara S, Akiba T, for the JDOPPS investigators group
  • Journal Title: Nephron Clin Pract 113(3)
  • Peer Reviewed
• [Journal Article] Vasohibin-1, a negative feedback regulator of angiogenesis, ameliorates renal alterations in a mousemodel of diabetic nephropathy (2009)
  • Author(s): Nasu T, Maeshima Y, Kinomura M, Hirokoshi-Kawahara K, Tanabe K, Sugiyama H, Sonoda H, Sato Y, Makino H
  • Journal Title: Diabetes 58(10) Pages: 2365-2375
  • Peer Reviewed
• [Journal Article] Clinical usefulness of a prognostic score in histological analysis of renal biopsy in patients with lupus nephritis (2009)
  • Author(s): Kojo S, Sada KE, Kobayashi M, Maruyama M, Maeshima Y, Sugiyama H, Makino H
  • Journal Title: J Rheumatol 36(10) Pages: 2218-2223
  • Peer Reviewed
• [Journal Article] Effects of icodextrin peritoneal dialysis solution on the peritoneal membrane in the STZ-induced diabetic rat model with partial nephrectomy (2009)
  • Author(s): Nakao A, Nakao K, Takatori Y, Kojo S, Inoue J, Akagi S, Sugiyama H, Wada J, Makino H
  • Journal Title: Nephrol Dial Transplant (In press)
  • Peer Reviewed
• [Journal Article] Urinary excretions of lipocalin-type prostaglandin D synthase predict renal injury in type-2 diabetes : a cross-sectional and prospective multicentre study. (2009)
  • Author(s): Uehara Y, Makino H, Seiki K, Urade Y, LPGDS Clinical Research Group of Kidney
  • Journal Title: Nephrol Dial Transplant 24(2) Pages: 475-482
  • Peer Reviewed
• [Journal Article] Endothelial barrier protection by FTY720 under hyperglycemic condition : involvement of focal adhesionkinase, small GTPases, and adherens function proteins. (2009)
  • Author(s): Sarai K, Shikata K, Shikata Y, Omori K, Watanabe N, Sasaki M, Nishishita S, Wada J, Goda N, Kataoka N, Makino H
  • Journal Title: Am J Physiol Cell Physiol 297(4)
  • Peer Reviewed
• [Presentation] Renin angiotensin system inhibition in diabetic nephropathy. (2012)
  • Author(s): Makino H:
  • Organizer: ASN Kidney Week 2012
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2012-11-02
• [Presentation] Basic mechanism underlying diabetic nephropathy and CKD. (2011)
  • Author(s): Makino H:
  • Organizer: World Congress of Nephrology
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2011-04-11
• [Presentation] Basic Mechanisms Underlying Diabetic Nephropathy and CKD (2011)
  • Author(s): Hirofumi Makino
  • Organizer: World Congress of Nephrology
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2011-04-11
• [Presentation] 全身を制御する腎臓-33年の腎臓研究を顧みて- (2010)
  • Author(s): 槇野博史
  • Place of Presentation: 神戸市
  • Year and Date: 2010-06-17
• [Presentation] 全身を制御する腎臓-33年の腎臓研究を顧みて- (2010)
  • Author(s): 槇野博史
  • Organizer: 第53回日本腎臓学会学術総会
  • Place of Presentation: 神戸ポートピアホテル(神戸市)(会長講演)
  • Year and Date: 2010-06-17
• [Presentation] Thiazolidinediones and diabetic nephropathy (2009)
  • Author(s): Makino H
  • Organizer: World Congress of Nephrology
  • Place of Presentation: Milan, Italy
  • Year and Date: 2009-05-22
• [Presentation] Thiazolidiones and diabetic kidney disease (2009)
  • Author(s): Makino H
  • Organizer: World Congress of Nephrology
  • Place of Presentation: Milan, Italy
  • Year and Date: 2009-05-22
• [Presentation] Renin angiotensin system inhibition in diabetic nephropathy.
  • Author(s): Makino H
  • Organizer: ASN Kidney Week 2012
  • Place of Presentation: San Diego, CA, USA
  • Invited
• [Book] 糖尿病×CKD診療ガイド (2012)
  • Author(s): 槇野博史
  • Total Pages: 197
  • Publisher: 南山堂
• [Book] CKDのサイエンス-基礎と臨床- (2010)
  • Author(s): 槇野博史編
  • Total Pages: 230
  • Publisher: 南山堂