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Personalized medicine for age-related macular degeneration

Research Project

Project/Area Number 21249084
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionKyoto University

Principal Investigator

YOSHIMURA Nagahisa  京都大学, 医学研究科, 教授 (70211662)

Co-Investigator(Kenkyū-buntansha) OTANI Atsushi  京都大学, 医学研究科, 講師 (30314222)
YAMASHIRO Kenji  京都大学, 医学研究科, 助教 (80399617)
YAMADA Ryo  京都大学, 医学研究科, 教授 (50301106)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥44,980,000 (Direct Cost: ¥34,600,000、Indirect Cost: ¥10,380,000)
Fiscal Year 2011: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2010: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2009: ¥20,670,000 (Direct Cost: ¥15,900,000、Indirect Cost: ¥4,770,000)
Keywords眼細胞生物学 / 加齢黄斑変性 / 個別化医療 / 遺伝子多型 / テーラーメード医療
Research Abstract

We successfully made quick detection kit for ARMS2 A69S single nucleotide polymorphism. We used this kit for our out-patients and made sure that it is practically usable for clinic. Since A69S genotype was associated with the visual outcome after photodynamic therapy but to with the visual outcome after anti-VEGF therapy, A69S genotype would determine which patients should be treated with photodynamic therapy, and which patients should be treated with anti-VEGF drug. In addition to ARMS2, we found that VEGF gene and PEDF gene were associated with the response to treatment for are-related macular degeneration.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (68 results)

All 2012 2011 2010 2009

All Journal Article (64 results) (of which Peer Reviewed: 34 results) Presentation (4 results)

  • [Journal Article] Significance ofC2/CFB variants in age-related macular degeneration and polypoidal choroidalvasculopathy in a Japanese population2012

    • Author(s)
      Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Akagi-Kurashige Y, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, Matsuo K, TajimaK, Matsuda F, Yoshimura N.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 53 Pages: 794-8

    • Related Report
      2011 Final Research Report
  • [Journal Article] Macular Choroidal Thickness and Volume in Eyes With Angioid Streaks Measured by Swept Source Optical Coherence Tomography2012

    • Author(s)
      Ellabban AA, Tsujikawa A, Matsumoto A, Ogino K, Hangai M, Ooto S, Yamashiro K, Akiba M, Yoshimura N.
    • Journal Title

      Am JOphthalmol

    • NAID

      120004161067

    • Related Report
      2011 Final Research Report
  • [Journal Article] Relationship between retinal morphological findings and visual function in age-related macular degeneration2012

    • Author(s)
      Akagi-Kurashige Y, Tsujikawa A, Oishi A, Ooto S, Yamashiro K, Tamura H, Nakata I, Ueda-Arakawa N, Yoshimura N.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

    • NAID

      120004873995

    • Related Report
      2011 Final Research Report
  • [Journal Article] Vascular endothelial growth factor gene polymorphisms and choroidalneovascularization in highly myopic eyes2012

    • Author(s)
      Akagi-Kurashige Y, Kumagai K, Yamashiro K, Nakanishi H, Nakata I, MiyakeM, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Yamada R, Matsuda F, Yoshimura N
    • Journal Title

      Invest Ophthalmol Vis Sci

    • Related Report
      2011 Final Research Report
  • [Journal Article] Factors Associated With the Response of Age-Related Macular Degeneration to Intravitreal Ranibizumab Treatment2012

    • Author(s)
      Yamashiro K, Tomita K, Tsujikawa A, Nakata I, Akagi-Kurashige Y, Miyake M, Ooto S, Tamura H, Yoshimura N
    • Journal Title

      Am J Ophthalmol

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vascular endothelial growth factor gene polymorphisms and choroidal neovascularization in highly myopic eyes2012

    • Author(s)
      Akagi-Kurashige Y, Kumagai K, Yamashiro K, Nakanishi H, Nakata I, Miyake M, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Yamada R, Matsuda F, Yoshimura N
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: (in press) Issue: 4 Pages: 2349-53

    • DOI

      10.1167/iovs.11-9405

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macular Choroidal Thickness and Volume in Eyes With Angioid Streaks Measured by Swept Source Optical Coherence Tomography2012

    • Author(s)
      Ellabban AA, Tsujikawa A, Matsumoto A, Ogino K, Hangai M, Ooto S, Yamashiro K, Akiba M, Yoshimura N
    • Journal Title

      Am J Ophthalmol

      Volume: (in press) Issue: 6 Pages: 1133-1143.e1

    • DOI

      10.1016/j.ajo.2011.12.013

    • NAID

      120004161067

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between retinal morphological findings and visual function in age-related macular degeneration2012

    • Author(s)
      Akagi-Kurashige Y, Tsujikawa A, Oishi A, Ooto S, Yamashiro K, Tamura H, Nakata I, Ueda-Arakawa N, Yoshimura N
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: (in press) Issue: 8 Pages: 68-80

    • DOI

      10.1007/s00417-012-1928-5

    • NAID

      120004873995

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significance of C2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese population2012

    • Author(s)
      Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Akagi-Kurashige Y, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, Matsuo K, Tajima K, Matsuda F, Yoshimura N
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 53 Issue: 2 Pages: 794-798

    • DOI

      10.1167/iovs.11-8468

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of elastin gene polymorphism to age-related macular degeneration and polypoidal choroidalvasculopathy2011

    • Author(s)
      Yamashiro K, Mori K, Nakata I, Tsuchihashi T, Horie-Inoue K, Nakanishi H, Tsujikawa A, Saito M, Iida T, Yamada R, Matsuda F, Inoue S, Awata T, Yoneya S, Yoshimura N
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52 Pages: 8780-4

    • Related Report
      2011 Final Research Report
  • [Journal Article] Development of polypoidal lesions inage-related macular degeneration2011

    • Author(s)
      Tsujikawa A, Ojima Y, Yamashiro K, Ooto S, Tamura H, Nakata I, Yoshimura N
    • Journal Title

      Eye

      Volume: 25 Pages: 481-8

    • Related Report
      2011 Final Research Report
  • [Journal Article] Association of lesion size and visual prognosis to polypoidal choroidalvasculopathy2011

    • Author(s)
      Tsujikawa A, Ojima Y, Yamashiro K, Nakata I, Ooto S, Tamura H, Nakanishi H, Hayashi H, Otani A, Yoshimura N
    • Journal Title

      Am J Ophthalmol

      Volume: 151 Pages: 961-972

    • Related Report
      2011 Final Research Report
  • [Journal Article] Retinal micro structural abnormalities in central serous chorioretinopathy andpolypoidal choroidal vasculopathy2011

    • Author(s)
      Ooto S, Tsujikawa A, Mori S, Tamura H, Yamashiro K, Otani A, Yoshimura N
    • Journal Title

      Retina

      Volume: 31 Pages: 527-34

    • Related Report
      2011 Final Research Report
  • [Journal Article] Association between the SERPING1 gene andage-related macular degeneration andpolypoidal choroidal vasculopathy in Japanese2011

    • Author(s)
      Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, TsujikawaA, Otani A, Saito M, Iida T, Oishi A, MatsuoK, Tajima K, Matsuda F, Yoshimura N
    • Journal Title

      PLoS One

      Volume: 6 Pages: 19108-19108

    • Related Report
      2011 Final Research Report
  • [Journal Article] Genetic variants in pigment epithelium-derived factor influence response of polypoidal choroidalvasculopathy to photodynamic therapy2011

    • Author(s)
      Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, TsujikawaA, Otani A, Ooto S, Tamura H, Saito M, SaitoK, Iida T, Oishi A, Kurimoto Y, Matsuda F, Yoshimura N.
    • Journal Title

      Ophthalmology

      Volume: 118 Pages: 1408-15

    • Related Report
      2011 Final Research Report
  • [Journal Article] VEGFgene polymorphism and response tointravitreal bevacizumab and triple therapy in age-related macular degeneration2011

    • Author(s)
      Nakata I, Yamashiro K, NakanishiH, Tsujikawa A, Otani A, Yoshimura N.
    • Journal Title

      Jpn J Ophthalmol

      Volume: 55 Pages: 435-43

    • Related Report
      2011 Final Research Report
  • [Journal Article] Prognostic factors for visual outcomes 2-years afterintravitreal bevacizumab for myopicchoroidal neovascularization2011

    • Author(s)
      Nakanishi H, Tsujikawa A, Yodoi Y, Ojima Y, Otani A, Tamura H, Yamashiro K, Ooto S, Yoshimura N.
    • Journal Title

      Eye

      Volume: 25 Pages: 375-81

    • Related Report
      2011 Final Research Report
  • [Journal Article] Macular choroidal thickness and volume in normal subjects measured by swept-source optical coherence tomography2011

    • Author(s)
      Hirata M, Tsujikawa A, MatsumotoA, Hangai M, Ooto S, Yamashiro K, Akiba M, Yoshimura N.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52 Pages: 4971-8

    • Related Report
      2011 Final Research Report
  • [Journal Article] Association of 15q14 and 15q25 with high myopia in Japanese2011

    • Author(s)
      Hayashi H, Yamashiro K, NakanishiH, Nakata I, Kurashige Y, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Ozaki M, Yamada R, Matsuda F, Yoshimura N.
    • Journal Title

      Invest Ophthalmol VisSci

      Volume: 52 Pages: 4853-8

    • Related Report
      2011 Final Research Report
  • [Journal Article] Association of elastin gene polymorphism to age-related macular degeneration and polypoidal choroidal vasculopathy2011

    • Author(s)
      Yamashiro K, Mori K, Nakata I, Tsuchihashi T, Horie-Inoue K, Nakanishi H, Tsujikawa A, Saito M, Iida T, Yamada R, Matsuda F, Inoue S, Awata T, Yoneya S, Yoshimura N
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52 Pages: 8780-4

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of polypoidal choroidal vasculopathy with photodynamic therapy combined with intravitreal injections of ranibizumab2011

    • Author(s)
      Tomita K, Tsujikawa A, Yamashiro K, Ooto S, Tamura H, Otani A, Nakayama Y, Yoshimura N
    • Journal Title

      Am J Ophthalmol

      Volume: 153 Issue: 1 Pages: 68-80

    • DOI

      10.1016/j.ajo.2011.07.001

    • NAID

      120003726137

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] VEGF gene polymorphism and response to intravitreal bevacizumab and triple therapy in age-related macular degeneration2011

    • Author(s)
      Nakata I, Yamashiro K, Nakanishi H, Tsujikawa A, Otani A, Yoshimura N
    • Journal Title

      Jpn J Ophthalmol

      Volume: 55 Issue: 5 Pages: 435-43

    • DOI

      10.1007/s10384-011-0061-z

    • NAID

      10029688706

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macular choroidal thickness and volume in normal subjects measured by swept-source optical coherence tomography2011

    • Author(s)
      Hirata M, Tsujikawa A, Matsumoto A, Hangai M, Ooto S, Yamashiro K, Akiba M, Yoshimura N
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52 Issue: 8 Pages: 4971-4978

    • DOI

      10.1167/iovs.11-7729

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between the SERPING1 gene and age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese2011

    • Author(s)
      Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, Matsuo K, Tajima K, Matsuda F, Yoshimura N
    • Journal Title

      PLoS One

      Volume: 6 Issue: 4 Pages: e19108-e19108

    • DOI

      10.1371/journal.pone.0019108

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of lesion size and visual prognosis to polypoidal choroidal vasculopathy2011

    • Author(s)
      Tsujikawa A, Ojima Y, Yamashiro K, Nakata I, Ooto S, Tamura H, Nakanishi H, Hayashi H, Otani A, Yoshimura N
    • Journal Title

      Am J Ophthalmol

      Volume: 151 Issue: 6 Pages: 961-972

    • DOI

      10.1016/j.ajo.2011.01.002

    • NAID

      120003184066

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic variants in pigment epithelium-derived factor influence response of polypoidal choroidal vasculopathy to photodynamic therapy2011

    • Author(s)
      Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Ooto S, Tamura H, Saito M, Saito K, Iida T, Oishi A, Kurimoto Y, Matsuda F, Yoshimura N
    • Journal Title

      Ophthalmology

      Volume: 118 Issue: 7 Pages: 1408-15

    • DOI

      10.1016/j.ophtha.2010.12.011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of 15q14 and 15q25 with high myopia in Japanese2011

    • Author(s)
      Hayashi H, Yamashiro K, Nakanishi H, Nakata I, Kurashige Y, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Ozaki M, Yamada R, Matsuda F, Yoshimura N
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52 Issue: 7 Pages: 4853-4858

    • DOI

      10.1167/iovs.11-7311

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of Lesion Size and Visual Prognosis to Polypoidal Choroidal Vasculopathy.2011

    • Author(s)
      Tsujikawa A, Ojima Y, Yamashiro K, Nakata I, Ooto S, Tamura H, Nakanishi H, Hayashi H, Otani A, Yoshimura N.
    • Journal Title

      Am J Ophthalmol.

      Volume: (in press)

    • NAID

      120003184066

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of 15q14 and 15q25 with High Myopia in Japanese.2011

    • Author(s)
      Hayashi H, Yamashiro K, Nakanishi H, Nakata I, Kurashige Y, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Ozaki M, Yamada R, Matsuda F, Yoshimura N.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retinal microstructural abnormalities in central serous chorioretinopathy and polypoidal choroidal vasculopathy.2011

    • Author(s)
      Ooto S, Tsujikawa A, Mori S, Tamura H, Yamashiro K, Otani A, Yoshimura N.
    • Journal Title

      Retina.

      Volume: 31 Pages: 527-534

    • NAID

      120004225529

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sterile endophthalmitis afterintravitreal injection of bevacizumabobtained from a single batch2010

    • Author(s)
      Yamashiro K, Tsujikawa A, Miyamoto K, Oh H, Otani A, Tamuara H, Ooto S, Sasahara M, Iwama D, Yoshimura N.
    • Journal Title

      Retina

      Volume: 30 Pages: 485-90

    • NAID

      120002949750

    • Related Report
      2011 Final Research Report
  • [Journal Article] Treatment of polypoidal choroidal vasculopathy byintravitreal injection of bevacizumab2010

    • Author(s)
      Tsujikawa A, Ooto S, Yamashiro K, Tamura H, Otani A, Yoshimura N.
    • Journal Title

      Jpn J Ophthalmol

      Volume: 54 Pages: 310-9

    • Related Report
      2011 Final Research Report
  • [Journal Article] Punctate hyper fluorescent spots associated with central serouschorioretinopathy as seen on indocyaninegreen angiography2010

    • Author(s)
      Tsujikawa A, Ojima Y, Yamashiro K, Ooto S, Tamura H, Nakagawa S, Yoshimura N.
    • Journal Title

      Retina

      Volume: 30 Pages: 801-9

    • Related Report
      2011 Final Research Report
  • [Journal Article] Intravitreal bevacizumab for type 1 idiopathic macular telangiectasia2010

    • Author(s)
      Takayama K, Ooto S, Tamura H, Yamashiro K, Otani A, Tsujikawa A, Yoshimura N.
    • Journal Title

      Eye

      Volume: 24 Pages: 1492-7

    • Related Report
      2011 Final Research Report
  • [Journal Article] Thickness of photoreceptor layers inpolypoidal choroidal vasculopathy and central serous chorioretinopathy2010

    • Author(s)
      Ooto S, Tsujikawa A, Mori S, Tamura H, Yamashiro K, Yoshimura N.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: 248 Pages: 1077-86

    • Related Report
      2011 Final Research Report
  • [Journal Article] High-resolution imaging of resolved central serous chorioretinopathy using adaptive optics scanning laserophthalmoscopy2010

    • Author(s)
      Ooto S, Hangai M, Sakamoto A, Tsujikawa A, Yamashiro K, Ojima Y, Yamada Y, Mukai H, Oshima S, Inoue T, Yoshimura N
    • Journal Title

      Ophthalmology

      Volume: 117

    • Related Report
      2011 Final Research Report
  • [Journal Article] Restoration of outer segments of foveal photoreceptors after resolution of central serouschorioretinopathy2010

    • Author(s)
      Ojima Y, Tsujikawa A, Yamashiro K, Ooto S, Tamura H, Yoshimura N
    • Journal Title

      Jpn J Ophthalmol.

      Volume: 54 Pages: 55-60

    • Related Report
      2011 Final Research Report
  • [Journal Article] Joint effect of cigarette smoking and CFH and LOC387715/HTRA1 polymorphisms onpolypoidal choroidal vasculopathy2010

    • Author(s)
      Nakanishi H, Yamashiro K, Yamada R, Gotoh N, Hayashi H, Nakata I, Saito M, Iida T, Oishi A, Kurimoto Y, Matsuo K, Tajima K, Matsuda F, Yoshimura N
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 51 Pages: 6183-7

    • Related Report
      2011 Final Research Report
  • [Journal Article] Single-nucleotide polymorphisms in the promoter region of matrixmetalloproteinase-1,-2, and-3 in Japanese with high myopia2010

    • Author(s)
      Nakanishi H, Hayashi H, Yamada R, Yamashiro K, Nakata I, Shimada N, Ohno-Matsui K, Mochizuki M, Ozaki M, Yoshitake S, Kuriyama S, Saito M, Iida T, Matsuo K, Matsuda F, Yoshimura N
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 51 Pages: 4432-6

    • Related Report
      2011 Final Research Report
  • [Journal Article] ARMS2/HTRA1 and CFH polymorphisms are not associated withchoroidal neovascularization in highly myopic eyes of the elderly Japanese population2010

    • Author(s)
      Nakanishi H, Gotoh N, Yamada R, Yamashiro K, Otani A, Hayashi H, TsujikawaA, Shimada N, Ohno-Matsui K, Mochizuki M, Saito M, Saito K, Iida T, Matsuda F, Yoshimura N.
    • Journal Title

      Eye

      Volume: 24 Pages: 1078-84

    • Related Report
      2011 Final Research Report
  • [Journal Article] Relationship between retinal sensitivity and morphologic changes in eyes with confluent soft drusen2010

    • Author(s)
      Iwama D, Tsujikawa A, Ojima Y, Nakanishi H, Yamashiro K, Tamura H, OotoS, Yoshimura N
    • Journal Title

      Clin Experiment Ophthalmol

      Volume: 38 Pages: 483-8

    • Related Report
      2011 Final Research Report
  • [Journal Article] Macular hole formation following photodynamic therapy combined with intravitreal injection ofbevacizumab and triamcinolone acetonide2010

    • Author(s)
      Iwama D, Ooto S, Tsujikawa A, Yamashiro K, Yoshimura N.
    • Journal Title

      Jpn J Ophthalmol

      Volume: 54 Pages: 364-6

    • Related Report
      2011 Final Research Report
  • [Journal Article] CFH and ARMS2variations in age-related macular degeneration, polypoidal choroidalvasculopathy, and retinal angiomatous proliferation2010

    • Author(s)
      Hayashi H, Yamashiro K, Gotoh N, Nakanishi H, Nakata I, Tsujikawa A, OtaniA, Saito M, Iida T, Matsuo K, Tajima K, Yamada R, Yoshimura N.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 51 Pages: 5914-9

    • Related Report
      2011 Final Research Report
  • [Journal Article] Prognostic factors of vitreous hemorrhage secondary to exudative age-related macular degeneration2010

    • Author(s)
      Hasegawa T, Otani A, Sasahara M, Gotoh N, Ooto S, Tamura H, Yamashiro K, Tsujikawa A, Yoshimura N.
    • Journal Title

      Am J Ophthalmol

      Volume: 149 Pages: 322-329

    • NAID

      120001823762

    • Related Report
      2011 Final Research Report
  • [Journal Article] Haplotypeanalysis of the ARMS2/HTRA1 region in Japanese patients with typicalneovascular age-related macular degeneration or polypoidal choroidal vasculopathy2010

    • Author(s)
      Gotoh N, Yamashiro K, Nakanishi H, Saito M, Iida T, Yoshimura N
    • Journal Title

      Jpn J Ophthalmol

      Volume: 54 Pages: 609-14

    • Related Report
      2011 Final Research Report
  • [Journal Article] Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration2010

    • Author(s)
      Chen W, Stambolian D, Edwards AO, Branham KE, Othman M, Jakobsdottir J, Tosakulwong N, Pericak-Vance MA, Campochiaro PA, Klein ML, Tan PL, ConleyYP, Kanda A, Kopplin L, Li Y, AugustaitisKJ, Karoukis AJ, Scott WK, Agarwal A, Kovach JL, Schwartz SG, Postel
    • Journal Title

      Proc Natl Acad Sci USA.

      Volume: 107 Pages: 7401-6

    • Related Report
      2011 Final Research Report
  • [Journal Article] Genetic Variants in Pigment Epithelium-Derived Factor Influence Response of Polypoidal Choroidal Vasculopathy to Photodynamic Therapy.2010

    • Author(s)
      Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Ooto S, Tamura H, Saito M, Saito K, Iida T, Oishi A, Kurimoto Y, Matsuda F, Yoshimura N.
    • Journal Title

      Ophthalmology.

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Haplotype analysis of the ARMS2/HTRA1 region in Japanese patients with typical neovascular age-related macular degeneration or polypoidal choroidal vasculopathy.2010

    • Author(s)
      Gotoh N, Yamashiro K, Nakanishi H, Saito M, Iida T, Yoshimura N.
    • Journal Title

      Jpn J Ophthalmol.

      Volume: 54 Pages: 609-614

    • NAID

      10027666485

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macular hole formation following photodynamic therapy combined with intravitreal injection of bevacizumab and triamcinolone acetonide.2010

    • Author(s)
      Iwama D, Ooto S, Tsujikawa A, Yamashiro K, Yoshimura N.
    • Journal Title

      Jpn J Ophthalmol.

      Volume: 54 Pages: 364-366

    • NAID

      10027204735

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of polypoidal choroidal vasculopathy by intravitreal injection of bevacizumab.2010

    • Author(s)
      Tsujikawa A, Ooto S, Yamashiro K, Tamura H, Otani A, Yoshimura N.
    • Journal Title

      Jpn J Ophthalmol.

      Volume: 54 Pages: 310-319

    • NAID

      10027204523

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Joint effect of cigarette smoking and CFH and LOC387715/HTRA1 polymorphisms on polypoidal choroidal vasculopathy.2010

    • Author(s)
      Nakanishi H, Yamashiro K, Yamada R, Gotoh N, Hayashi H, Nakata I, Saito M, Iida T, Oishi A, Kurimoto Y, Matsuo K, Tajima K, Matsuda F, Yoshimura N.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 51 Pages: 6183-6187

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-resolution imaging of resolved central serous chorioretinopathy using adaptive optics scanning laser ophthalmoscopy.2010

    • Author(s)
      Ooto S, Hangai M, Sakamoto A, Tsujikawa A, Yamashiro K, Ojima Y, Yamada Y, Mukai H, Oshima S, Inoue T, Yoshimura N.
    • Journal Title

      Ophthalmology.

      Volume: 117 Pages: 1800-1809

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between retinal sensitivity and morphologic changes in eyes with confluent soft drusen.2010

    • Author(s)
      Iwama D, Tsujikawa A, Ojima Y, Nakanishi H, Yamashiro K, Tamura H, Ooto S, Yoshimura N.
    • Journal Title

      Clin Experiment Ophthalmol.

      Volume: 38 Pages: 483-488

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CFH and ARMS2 variations in age-related macular degeneration, polypoidal choroidal vasculopathy, and retinal angiomatous proliferation.2010

    • Author(s)
      Hayashi H, Yamashiro K, Gotoh N, Nakanishi H, Nakata I, Tsujikawa A, Otani A, Saito M, Iida T, Matsuo K, Tajima K, Yamada R, Yoshimura N.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 51 Pages: 5914-5919

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single-nucleotide polymorphisms in the promoter region of matrix metal loproteinase-1, -2, and -3 in Japanese with high myopia.2010

    • Author(s)
      Nakanishi H, Hayashi H, Yamada R, Yamashiro K, Nakata I, Shimada N, Ohno-Matsui K, Mochizuki M, Ozaki M, Yoshitake S, Kuriyama S, Saito M, Iida T, Matsuo K, Matsuda F, Yoshimura N.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 51 Pages: 4432-4436

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.2010

    • Author(s)
      Chen W, Stambolian D, Edwards AO, Branham KE, Othman M, Jakobsdottir J, Tosakulwong N, Pericak-Vance MA, Campochiaro PA, Klein ML, Tan PL, Conley YP, Kanda A, Kopplin L, Li Y, Augustaitis KJ, Karoukis AJ, Scott WK, Agarwal A, Kovach JL, Schwartz SG, Postel EA, Brooks M, Baratz KH, Brown WL, Complications of Age-Related Macular Degeneration Prevention Trial Research Group, Brucker AJ, Orlin A, Brown G, Ho A, Regillo C, Donoso L, Tian L, Kaderli B, Hadley D, Hagstrom SA, Peachey NS, Klein R, Klein BE, Gotoh N, Yamashiro K, Ferris Iii F, Fagerness JA, Reynolds R, Farrer LA, Kim IK, Miller JW, Corton M, Carracedo A, Sanchez-Salorio M, Pugh EW, Doheny KF, Brion M, Deangelis MM, Weeks DE, Zack DJ, Chew EY, Heckenlively JR,, Yoshimura N, Iyengar SK, Francis PJ, Katsanis N, Seddon JM, Haines JL, Gorin MB, Abecasis GR, Swaroop A.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 107 Pages: 7401-7406

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thickness of photoreceptor layers in polypoidal choroidal vasculopathy and central serous chorioretinopathy.2010

    • Author(s)
      Ooto S, Tsujikawa A, Mori S, Tamura H, Yamashiro K, Yoshimura N.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol.

      Volume: 248 Pages: 1077-1086

    • NAID

      120002514711

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Punctate hyperfluorescent spots associated with central serous chorioretinopathy as seen on indocyanine green angiography.2010

    • Author(s)
      Tsujikawa A, Ojima Y, Yamashiro K, Ooto S, Tamura H, Nakagawa S, Yoshimura N.
    • Journal Title

      Retina

      Volume: 30 Pages: 801-809

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration2010

    • Author(s)
      Chen W, Stambolian D, Edwards AO, et al.
    • Journal Title

      Proc Natl Acad Sci USA (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic factors of vitreous hemorrhage secondary to exudative age-rel ated macular degeneration.2010

    • Author(s)
      Hasegawa T, Otani A, Sasahara M, et al.
    • Journal Title

      Am J Ophthalmol 149

      Pages: 322-329

    • NAID

      120001823762

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ARMS2/HTRA1 and CFH polymorphisms are not associated with choroidal neovascularization in highly myopic eyes of the elderly Japanese population.2010

    • Author(s)
      Nakanishi H, Gotoh N, Yamada R, et al.
    • Journal Title

      Eye (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A genome-wide association analysis identified a movel susceptible locus for pathological myopia at 11q24.1.2009

    • Author(s)
      Nakanishi H, Yamada R, Gotoh N, et al.
    • Journal Title

      Plos Genet. 5

      Pages: 1-7

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ARMS2 (LOC387715) variants in Japanese patients with exudative agerelated macular degeneration and polypoidal choroidal vasculopathy.2009

    • Author(s)
      Gotoh N, Nakanishi H, Hayashi H, et al.
    • Journal Title

      Am J Ophthalmol. 147

      Pages: 1037-41

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Absence of association between COL1A1 polymorphisms and high myopia in the Japanese population.2009

    • Author(s)
      Nakanishi H, Yamada R, Gotoh N, et al.
    • Journal Title

      Invest Ophthalmol Vis Sci. 50

      Pages: 544-550

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ARMS2遺伝子A69S多型の迅速検出キットの開発および加齢黄斑変性診療における臨床応用2009

    • Author(s)
      山城健児、後藤謙元、中西秀雄, 等
    • Organizer
      第63回日本臨床眼科学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-10-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] ポリープ状脈絡膜血管症への光線力学療法の治療効果とARMS2 A69S多きちまはとの相関2009

    • Author(s)
      林寿子、山城健児、中西秀雄, 等
    • Organizer
      第63回日本臨床眼科学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-10-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 加齢黄斑変性に対するbevacizumab硝有子体内投与の治療効果とARMS2 A69S2009

    • Author(s)
      仲田勇夫、山城健児、中西秀雄, 等
    • Organizer
      第63回日本臨床眼科学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 疾患感受性一塩基多型からAMDとPCVを考える2009

    • Author(s)
      吉村長久
    • Organizer
      第63回日本臨床眼科学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-10-09
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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