Roles of protein phosphorylation in regulatory mechanism of presynaptic functions.
| Project/Area Number |
21300141
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MIYAOKA Hitoshi 北里大学, 医学部, 教授 (40209862)
ITAKURA Makoto 北里大学, 医学部, 講師 (30398581)
AZUMA Sadahiro 北里大学, 医学部, 助教 (80348507)
YAMAMORI Saori 北里大学, 医学部, 助教 (30464803)
KATAOKA Masakazu 信州大学, 工学部, 准教授 (90332676)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2009: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Keywords | 神経伝達物質 / SNAREタンパク質 / 開口放出 / シナプス前世制御 / タンパク質リン酸化 / ストレス / てんかん / ドーパミン / リン酸化 / SNAP-25 / PKC / シナプトゾーム / ノックインマウス / プロテインキナーゼC / 情動異常 |
|---|
| Research Abstract |
SNAP-25 is a presynaptic protein essential for neurotransmitter release from presynaptic nerve terminals. SNAP-25 is phosphorylated at Ser^<187> in protein kinase-dependent manner. We found that the phosphorylation SNAP-25 was regulated by protein phosphatase 2A, and played essential roles in the PKC-dependent regulation of dopamine release from presynaptic nerve terminals, and in the suppression of epilepsy during early postnatal period.
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Report
(4 results)
Research Products
(57 results)
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[Journal Article] A Single Amino Acid Mutation in SNAP-25 Induces Anxiety-Related Behavior in Mouse2011
Author(s)
Kataoka M, Yamamori S, Suzuki E, Watanabe S, Sato T, Miyaoka H, Azuma S, Ikegami S, Kuwahara R, Suzuki-Migishima R, Nakahara Y, Nihonmatsu I, Inokuchi K, Katoh-Fukui Y, Yokoyama M, Takahashi M
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Journal Title
NAID
Related Report
Peer Reviewed
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[Journal Article] TARPs gamma-2 and gamma-7 are essential for AMPA receptor expression in the cerebellum2010
Author(s)
Yamazaki M, Fukaya M, Hashimoto K, Yamasaki M, Tsujita M, Itakura M, Abe M, Natsume R, Takahashi M, Kano M, Sakimura K, Watanabe M
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Journal Title
Eur J Neurosci
Volume: 31
Pages: 2204-2220
Related Report
Peer Reviewed
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