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Systemic factors responsible for cross-transfer effect of muscle hypertrophy after resistance exercise training

Research Project

Project/Area Number 21300235
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Sports science
Research InstitutionThe University of Tokyo

Principal Investigator

ISHII Naokata  東京大学, 大学院・総合文化研究科, 教授 (20151326)

Co-Investigator(Kenkyū-buntansha) NAKAZATO Kouichi  日本体育大学, 体育学部, 教授 (00307993)
OCHI Eusuke  明治学院大学, 教養教育センター, 講師 (90468778)
NEYA Mitsuo  東京大学, 大学院・総合文化研究科, 助教 (30359640)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2009: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Keywordsレジスタンストレーニング / 筋肥大 / 効果転移 / 循環因子 / プロテオーム解析 / 培養筋芽細胞 / シグナル伝達系 / 運動・トレーニング / プオテオーム解析 / 培養筋細胞 / タンパク質合成 / ショットガン解析 / 血流制限
Research Abstract

A low-intensity resistance training for upper arm muscles, if ineffective for muscle hypertrophy, can cause muscle hypertrophy when combined with a resistance training with vascular occlusion for thigh muscles("cross-transfer" of muscle hypertrophy ; Madarame et al., 2008). The present study investigated the role played by systemic factors in this cross-transfer effect. Training experiments with humans showed that conventional, high-intensity resistance training can also cause the similar cross-transfer effect. In addition, proteomic analysis of serum samples taken before and after the training with vascular occlusion showed significant changes in the concentration of several growth factors. When serum was taken from rats subjected to high-intensity resistance training and then added to cultured myoblasts, it caused significant changes in signal transduction substrates related to protein synthesis. These results suggest that some growth factors within serum play important parts in the cross-transfer effect of muscle hypertrophy.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (37 results)

All 2012 2011 2010 2009 Other

All Journal Article (32 results) (of which Peer Reviewed: 32 results) Presentation (3 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Roles played by protein metabolism and myogenic progenitor cells in exercise-induced muscle hypertrophy and their relation to resistance training regimens2012

    • Author(s)
      Ishii, N., Ogasawara, R., Kobayashi, K. and Nakazato, K
    • Journal Title

      J. Phys. Fitness Sports Med.

      Volume: 1 Pages: 83-94

    • NAID

      10031158929

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles played by protein metabolism and myogenic progenitor cells in exercise-induced muscle hypertrophy and their relation to resistance training regimens2012

    • Author(s)
      Ishii, N., Ogasawara, R., Kobayashi, K., Nakazato, K.
    • Journal Title

      Journal of Physical Fitness and Sports Medicine

      Volume: 1(In press)

    • NAID

      10031158929

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of UVB-induced HIF-1αup-regulation by hyperoxia does not prevent wrinkle formation associated with increased MMPs activity in mouse skin2011

    • Author(s)
      Kawada, S. and Ishii, N
    • Journal Title

      Biomed. Res.

      Volume: 32 Pages: 363-372

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blood flow-restricted training does not improve jump performance in untrained young men2011

    • Author(s)
      Madarame H, Ochi E, Tomioka Y, Nakazato K, Ishii N
    • Journal Title

      Acta Physiol. Hung.

      Volume: 98 Pages: 465-471

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increase in serum growth hormone induced by electrical stimulation of muscle combined with blood flow restriction2011

    • Author(s)
      Inagaki, Y., Madarame, H., Neya, M. and Ishii, N
    • Journal Title

      Eur. J. Appl. Physiol.

      Volume: 111 Pages: 2715-2722

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Muscular hypertrophy and changes in cytokine production after eccentric training in the rat skeletal muscle2011

    • Author(s)
      Ochi. E., Nakazato, K. and Ishii, N
    • Journal Title

      J. Str. Condition. Res.

      Volume: 25 Pages: 2283-2292

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of icing on muscle regeneration after crush injury to skeletal muscles in rats2011

    • Author(s)
      Takagi, R., Fujita, N., Arakawa, T., Kawada, S., Ishii, N. and Miki, A
    • Journal Title

      Med, J. Appl. Physiol.

      Volume: 110 Pages: 382-388

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acceleration and force reveal different mechanisms of electromechanical delay2011

    • Author(s)
      Sasaki, K., Sasaki, T. and Ishii, N
    • Journal Title

      Sci. Sport Exerc.

      Volume: 43 Pages: 1200-1206

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Muscular hypertrophy and changes in cytokine production after eccentric training rat skeletal muscle2011

    • Author(s)
      Ochi, E., Nakazato, K., Ishii, N.
    • Journal Title

      Journal of Strength and Conditioning Research

      Volume: 25 Issue: 8 Pages: 2283-2292

    • DOI

      10.1519/jsc.0b013e3181f1592e

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acceleration and force reveal different mechanisms of electromechanical delay2011

    • Author(s)
      Sasaki, K., Sasaki, T., Ishii, N.
    • Journal Title

      Medicine and Science in Sports and Exercise

      Volume: 43 Issue: 7 Pages: 1200-1206

    • DOI

      10.1249/mss.0b013e318209312c

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ageing related differences in maximum force, unloaded velocity and power of human leg multi-joint movement2010

    • Author(s)
      Yamauchi, J., Mishima, C., Nakayama, S. and Ishii, N
    • Journal Title

      Gerontology

      Volume: 56 Pages: 167-174

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bilateral Asymmetry in Joint Torque during Squat Exercise Performed by Long Jumpers2010

    • Author(s)
      Kobayashi, Y., Kubo, J., Matsubayashi, T., Matsuo, A., Kobayashi, K. and Ishii, N
    • Journal Title

      J. Str. Condition. Res.

      Volume: 24 Pages: 2826-2830

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Elevation of myostatin and FOXOs in prolonged muscular impairment induced by eccentric contractions in rat medial gastrocnemius muscle2010

    • Author(s)
      Ochi, E., Hirose, T., Hiranuma, K., Min, S., Ishii, N. and Nakazato, K
    • Journal Title

      J. Appl. Physiol.

      Volume: 108 Pages: 306-313

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endocrine responses to upper-and lower-limb resistance exercises with blood flow restriction2010

    • Author(s)
      Madarame H., Sasaki, K. and Ishii N.
    • Journal Title

      Acta Physiologica Hungarica

      Volume: 97 Pages: 192-200

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of low-intensity resistance exercise with blood flow restriction on coagulation system in healthy subjects2010

    • Author(s)
      Madarame, H., Ishii, N., 他8名
    • Journal Title

      Clin. Physiol. Funct. Imag.

      Volume: 30 Pages: 210-213

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Time course change of IGF-1/Akt/mTOR/p70S6K pathway activation in rat gastrocnemius muscle during repeated bouts of eccentric exercise2010

    • Author(s)
      Ochi, E., Ishii, N. and K. Nakazato
    • Journal Title

      J. Sports Sci. Med.

      Volume: 9 Pages: 170-175

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased oxygen tension attenuates acute ultraviolet-B-induced skin angiogenesis and wrinkle formation2010

    • Author(s)
      Kawada, S., Ohtani, M. and Ishii, N
    • Journal Title

      Am J. Physiol.

      Volume: 299

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Unloaded shortening velocity of voluntarily and electrically activated human dorsiflexor muscles in vivo2010

    • Author(s)
      Sasaki, K. and Ishii, N
    • Journal Title

      PLoS ONE

      Volume: 5(9)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of low-intensity cycle training with restricted leg blood flow on thigh muscle volume and VO2max in young men2010

    • Author(s)
      Abe, T., Fujita, S., Ishii, N
    • Journal Title

      J. Sport Sci. Med.

      Volume: 9 Pages: 452-458

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Elevation of myostatin and FOXOs in prolonged muscular impairment induced by eccentric contractions in rat medial gastrocnemius muscle.2010

    • Author(s)
      Ochi, E., Hirose, T., Hiranuma, K., Min, S., Ishii, N., Nakazato, K.
    • Journal Title

      Journal of Applied Physiology

      Volume: 108 Pages: 306-313

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endocrine responses to upper-and lower-limb resistance exercises with blood flow restriction.2010

    • Author(s)
      Madarame H., Sasaki, K., Ishii N.
    • Journal Title

      Acta Physiologica Hungarica

      Volume: 97 Pages: 192-200

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Time course change of IGF-1/Akt/mTOR/p70S6K pathway activation in rat gastrocnemius muscle during repeated bouts of eccentric exercise.2010

    • Author(s)
      Ochi, E., Ishii, N., Nakazato.K.
    • Journal Title

      Journal of Sports Science and Medicine

      Volume: 9 Pages: 170-175

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevation of myostatin and FOXOs in prolonged muscular impairment induced by eccentric contractions in rat medial gastrocnemius muscle.2010

    • Author(s)
      Ochi, E., Hirose, T., Hiranuma, K., Min, S., Ishii, N., Nakazato, K.
    • Journal Title

      J.Appl.Physiol. 108

      Pages: 306-313

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Time course change of IGF-1/Akt/mTOR/p7OS6K pathway activation in rat gastrocnemius muscle during repeated bouts of eccentric exercise.2010

    • Author(s)
      Ochi, E., Ishii, N., Nakazato, K.
    • Journal Title

      J.Sports Sci.Med. (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hormonal and metabolic responses to slow movement resistance exercise with different durations of concentric and eccentric actions2009

    • Author(s)
      Goto, K., Ishii, N., Kizuka, T., Kraemer, R. R., Honda, Y. and Takamatsu, K
    • Journal Title

      Eur. J. Appl. Physiol.

      Volume: 106 Pages: 731-739

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Force-velocity, force-power relationships of bilateral and unilateral leg multi-joint movements in young and elderly women2009

    • Author(s)
      Yamauchi, J., Mishima, C., Nakayama, S. and Ishii, N
    • Journal Title

      J. Biomech.

      Volume: 41 Pages: 2151-2157

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Laser flash photolysis of diazo-2, a caged calcium chelator : The relationship between the extent and rate of smooth muscle relaxation2009

    • Author(s)
      Pelc, R., Ishii, N. and Ashley, C. C
    • Journal Title

      J. Laser Applications

      Volume: 21 Pages: 32-38

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peripheral venous occlusion causing cardiac hypertrophy and changes in biological parameters in rats2009

    • Author(s)
      Kawada, S. and Ishii, N
    • Journal Title

      Eur. J. Appl. Physiol.

      Volume: 105 Pages: 909-917

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Significant roles of microtubules in mature striated muscle deduced from the correlation between tubulin and its molecular chaperone alpha B-crystallin in rat muscles2009

    • Author(s)
      Jee, H., Sakurai, T., Kawada, S., Ishii, N. and Atomi, Y
    • Journal Title

      J. Physiol. Sci.

      Volume: 59 Pages: 149-155

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Low-intensity resistance training with slow movement and tonic force generation(LST) increases basal limb blood flow2009

    • Author(s)
      Tanimoto. M., Ishii, N., 他6名
    • Journal Title

      Clinical Physiol. Funct Imag

      Volume: 29 Pages: 128-135

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in muscle activation and force generation patterns during cycling movements due to low-intensity squat training with slow movement and tonic force generation(LST)2009

    • Author(s)
      Tanimoto. M., Miyachi, M. and Ishii, N
    • Journal Title

      J. Str. Conditon. Res.

      Volume: 23 Pages: 2367-2376

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peripheral venous occlusion causing cardiac hypertrophy and changes in biological parameters in rats.2009

    • Author(s)
      Kawada, S., Ishii, N.
    • Journal Title

      Eur.J.Appl.Physiol. 105

      Pages: 909-917

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] リハビリテーションのための低負荷強度筋力トレーニング2011

    • Author(s)
      石井直方
    • Organizer
      日本柔道整復接骨医学会大会
    • Place of Presentation
      千葉幕張メッセ
    • Year and Date
      2011-10-23
    • Related Report
      2011 Final Research Report
  • [Presentation] リハビリテーションのための低負荷強度筋力トレーニング2011

    • Author(s)
      石井直方
    • Organizer
      日本柔道整復接骨医学会大会
    • Place of Presentation
      千葉幕張メッセ(招待講演)
    • Year and Date
      2011-10-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 筋力増強の・カニズムとその応用2010

    • Author(s)
      石井直方
    • Organizer
      第114回中部日本整形外科災害学会
    • Place of Presentation
      名古屋国際会識場
    • Year and Date
      2010-04-09
    • Related Report
      2010 Annual Research Report
  • [Book] ボディメンテナンスメソッド2010

    • Author(s)
      石井直方
    • Total Pages
      159
    • Publisher
      成美堂出版(東京)
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.c.u-tokyo.ac.jp/info/research/faculty/list/mds/mds-ls/f002506.html

    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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