| Project/Area Number |
21300235
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ISHII Naokata 東京大学, 大学院・総合文化研究科, 教授 (20151326)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAZATO Kouichi 日本体育大学, 体育学部, 教授 (00307993)
OCHI Eusuke 明治学院大学, 教養教育センター, 講師 (90468778)
NEYA Mitsuo 東京大学, 大学院・総合文化研究科, 助教 (30359640)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2009: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | レジスタンストレーニング / 筋肥大 / 効果転移 / 循環因子 / プロテオーム解析 / 培養筋芽細胞 / シグナル伝達系 / 運動・トレーニング / プオテオーム解析 / 培養筋細胞 / タンパク質合成 / ショットガン解析 / 血流制限 |
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| Research Abstract |
A low-intensity resistance training for upper arm muscles, if ineffective for muscle hypertrophy, can cause muscle hypertrophy when combined with a resistance training with vascular occlusion for thigh muscles("cross-transfer" of muscle hypertrophy ; Madarame et al., 2008). The present study investigated the role played by systemic factors in this cross-transfer effect. Training experiments with humans showed that conventional, high-intensity resistance training can also cause the similar cross-transfer effect. In addition, proteomic analysis of serum samples taken before and after the training with vascular occlusion showed significant changes in the concentration of several growth factors. When serum was taken from rats subjected to high-intensity resistance training and then added to cultured myoblasts, it caused significant changes in signal transduction substrates related to protein synthesis. These results suggest that some growth factors within serum play important parts in the cross-transfer effect of muscle hypertrophy.
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