Modification for immunological function via Toll-like receptors in macrophages due to physical exercise

• Project/Area Number: 21300237
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Sports science
• Research Institution: Kyorin University
• Principal Investigator: OHNO Hideki 杏林大学, 医学部, 教授 (00133819)
• Co-Investigator(Renkei-kenkyūsha): KIZAKI Takako 杏林大学, 医学部, 教授 (00322446) ; SAKURAI Takuya 杏林大学, 医学部, 助教 (20353477) ; OGASAWARA Jyunetsu 杏林大学, 医学部, 助教 (20415110)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000); Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2009: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
• Keywords: 運動 / マクロファージ / Toll様レセプター / 炎症反応 / 感染防御能 / グレリン / 肥満 / Toll様受容体 / 免疫機能 / 高脂肪食 / 炎症性反応 / 遊離脂肪酸 / 一酸化窒素合成酵素

Research Abstract

Exercise training prevented the infiltration of inflammatory macrophages to adipose tissue and exerted anti-inflammatory effects for obesity-related chronic inflammation. A high fat diet increased Toll-like receptor 2 expression in peritoneal macrophages and enhanced systemic inflammation. On the other hand, exercise training enhanced expression of ghrelin, which exerts potent anti-inflammatory effects in peritoneal macrophages, suggesting that exercise training suppresses a high fat diet-induced inflammation through ghrelin.

Research Products

• [Journal Article] Effect of exercise on HIF-1 and VEGF signaling (2012)
  • Author(s): Ohno, H., Shirato, K., Sakurai, T., Ogasawara, J., Sumitani, Y., Sato, S., Imaizumi, K., Ishida, H. & Kizaki, T
  • Journal Title: J. Phys. Fit. Sports Med Volume: 1 Pages: 5-16
  • NAID: 10031158921
  • Peer Reviewed
• [Journal Article] Copy number variations due to large genomic deletion in x. linked chronic granulomatous disease (2012)
  • Author(s): Arai, T., Oh-Ishi, T., Yamamoto, H., Nunoi, H., Kamizono, J., Uehara, M., Kubota, T., Sakurai, T., Kizaki, T. & Ohno, H.
  • Journal Title: PLoS One Volume: 7
  • Peer Reviewed
• [Journal Article] Preventive and improvement effects of exercise training and supplement intake in white adipose tissues on obesity and lifestyle-related diseases (2012)
  • Author(s): Sakurai, T., Ogasawara, J., Kizaki, Takahashi, K., Ishida, H., Miyazaki, H., Saitoh, D., Haga, S., Izawa, T. & Ohno, H.
  • Journal Title: Environ. Health Prev. Med Volume: 17(in press) Issue: 5 Pages: 348-356
  • DOI: 10.1007/s12199-012-0271-0
  • NAID: 10031120507
  • Peer Reviewed
• [Journal Article] The effects of exercise on macrophage function (2012)
  • Author(s): Kizaki, T., Sato, S., Sakurai, T., Ogasawara, J., Imaizumi, K., Izawa, T., Nagasawa, J., Saitoh, D., Haga, S. & Ohno, H.
  • Journal Title: J. Phys. Fit. Sports Med Volume: 1(in press)
  • NAID: 10031158932
  • Peer Reviewed
• [Journal Article] Exercise training and the promotion of neurogenesis and neurite outgrowth in the hippocampus (2012)
  • Author(s): Sakurai, T., Ogasawara, J., Kizaki, T., Ishibashi, Y., Fujiwara, T., Akagawa, K., Izawa, T., Radak, Z. & Ohno, H.
  • Journal Title: J. Phys. Fit. Sports Med Volume: 1(in press)
  • NAID: 10031158961
  • Peer Reviewed
• [Journal Article] Effects of ss_2-agonists and exercise on ss_2-adrenergic receptor signaling in skeletal muscles (2012)
  • Author(s): Sato, S., Shirato, K., Kizaki, T., Ohno, H., Tachiyashiki, K. & Imaizumi, K
  • Journal Title: J. Phys. Fit. Sports Med Volume: 1(in press)
  • Peer Reviewed
• [Journal Article] Effects of exercise on the hexosamine biosynthetic pathway and glycosylation (2012)
  • Author(s): Shirato, K., Kizaki, T., Ohno, H., & Imaizumi, K.
  • Journal Title: J. Phys. Fit. Sports Med Volume: 1(in press)
  • NAID: 10031158936
  • Peer Reviewed
• [Journal Article] Effect of physical exercise on lipolysis in white adipocytes (2012)
  • Author(s): Ogasawara, J., Sakurai, T., Kizaki, T., Takahashi, K., Sumitani, Y., Ishida, H., Izawa, T., Toshinai, K. & Ohno, H.
  • Journal Title: J. Phys. Fit. Sports Med Volume: 1(in press)
  • NAID: 10031158965
  • Peer Reviewed
• [Journal Article] Oxygen consumption and usage during physical exercise : The balance between oxidative stress and ROS-dependent adaptive signaling. Antioxid (2012)
  • Author(s): Radak, Z., Ohno, H. & Atalay, M
  • Journal Title: Redox Signal Volume: 17(in press)
  • Peer Reviewed
• [Journal Article] Erythropoietin, 2, 3 DPG, oxygen transport capacity, and altitude training in adolescent Alpine skiers (2012)
  • Author(s): Son, H. J., Kim, H. J., Kim, J. H., Ohno, H. & Kim, C. K.
  • Journal Title: Aviat. Space Environ. Med Volume: 83 Pages: 50-53
  • Peer Reviewed
• [Journal Article] Induction of mitochondrial uncoupling enhances VEGF_<120> but reduces MCP-1 release in mature 3T3-L1 adipocytes : Possible regulatory mechanism through endogenous ER stress and AMPK-related pathways (2012)
  • Author(s): Miyokawa-Gorin, K., Takahashi, K., Handa, K., Kitahara, A., Sumitani, Y., Katsuta, H., Tanaka, T., Nishida, S., Yoshimoto, K., Ohno, H. & Ishida, H
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 419 Issue: 2 Pages: 200205-200205
  • DOI: 10.1016/j.bbrc.2012.01.145
  • Peer Reviewed
• [Journal Article] Influence of mitochondrial DNA 5178 C/A polymorphism on serum cholesterol changes : a short-term follow-up in middle-aged Japanese men (2012)
  • Author(s): Honmyo, R., Kokaze, A., Karita, K., Yoshida, M., Ishikawa, M., & Ohno, H.
  • Journal Title: Environ. Health Prev. Med Volume: 17(in press) Issue: 5 Pages: 401-407
  • DOI: 10.1007/s12199-012-0268-8
  • NAID: 10031120514
  • Peer Reviewed
• [Journal Article] Effect of exercise on HIF-1 and VEGF signaling (2012)
  • Author(s): Ohno, H., et al
  • Journal Title: J.Phys.Fit.Sports Med. Volume: 1 Pages: 5-16
  • NAID: 10031158921
  • Peer Reviewed
• [Journal Article] Copy number variations due to large genomic deletion in X-linked chronic granulomatous disease (2012)
  • Author(s): Arai, T., et al
  • Journal Title: PLoS One Volume: 7 Issue: 2 Pages: e27782-e27782
  • DOI: 10.1371/journal.pone.0027782
  • Peer Reviewed
• [Journal Article] The effects of exercise on macrophage function (2012)
  • Author(s): Kizaki, T., et al
  • Journal Title: J.Phys.Fit.Sports Med. Volume: 1(in press)
  • NAID: 10031158932
  • Peer Reviewed
• [Journal Article] Exercise training and the promotion of neurogenesis and neurite outgrowth in the hippocampus (2012)
  • Author(s): Sakurai, T., et al
  • Journal Title: J.Phys.Fit.Sports Med. Volume: 1(in press)
  • NAID: 10031158961
  • Peer Reviewed
• [Journal Article] Effects of ss_2-agonists and exercise on ss_2-adrenergic receptor signaling in skeletal muscles (2012)
  • Author(s): Sato, S., et al
  • Journal Title: J.Phys.Fit.Sports Med. Volume: 1(in press)
  • Peer Reviewed
• [Journal Article] Effects of exercise on the hexosamine biosynthetic pathway and glycosylation (2012)
  • Author(s): Shirato, K., et al
  • Journal Title: J.Phys.Fit.Sports Med. Volume: 1(in press)
  • Peer Reviewed
• [Journal Article] Oxygen consumption and usage during physical exercise : The balance between oxidative stress and ROS-dependent adaptive signaling (2012)
  • Author(s): Radak, Z., et al
  • Journal Title: Antioxid.Redox Signal. Volume: 17(in press)
  • Peer Reviewed
• [Journal Article] Erythropoietin, 2,3 DPG, oxygen transport capacity, and altitude training in adolescent Alpine skiers (2012)
  • Author(s): Son, H.J., et al
  • Journal Title: Aviat.Space Environ.Med. Volume: 83 Pages: 50-53
  • Peer Reviewed
• [Journal Article] Involvement of leucine zipper transcription factor-like protein 1(Lztfl1) in the attenuation of cognitive impairment by exercise training (2011)
  • Author(s): Sakurai, T., Ogasawara, J., Kizaki, T., Ishibashi, Y., Fujiwara, T., Akagawa, K., Izawa, T., Oh-ishi, S., Haga, S. & Ohno, H.
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 416 Issue: 1-2 Pages: 125-129
  • DOI: 10.1016/j.bbrc.2011.11.008
  • Peer Reviewed
• [Journal Article] Voluntary exercise attenuates obesity-associated inflammation through ghrelin expressed in macrophages (2011)
  • Author(s): Kizaki, T., Maegawa, T., Sakurai, T., Ogasawara, J., Ookawara, T., Oh-ishi, S., Izawa, T., Haga, S. & Ohno, H.
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 413 Issue: 3 Pages: 454-459
  • DOI: 10.1016/j.bbrc.2011.08.117
  • Peer Reviewed
• [Journal Article] Augmented bacterial elimination by Kupffer cells after IL-18 pretreatment via IFN-γproduced from NK cells in Burn-injured mice (2011)
  • Author(s): Miyazaki, H., Kinoshita, M., Ono, S., Nakashima, M., Hara, E., Ohno, H., Seki, S. & Saitoh, D.
  • Journal Title: Burns Volume: 37 Issue: 7 Pages: 1208-1215
  • DOI: 10.1016/j.burns.2011.04.010
  • Peer Reviewed
• [Journal Article] 富士登山時の自律神経応答と身体の電気伝導率 (2011)
  • Author(s): 長澤純一、内藤祐二郎、杉山康司、笹尾真美、曽我部健、新美敬太、野口いづみ、芳賀脩光、石橋義永、木崎節子、大野秀樹
  • Journal Title: 登山医学 Volume: 31 Pages: 145-152
  • Peer Reviewed
• [Journal Article] 高度が味覚感度へ及ぼす影響-富士山における味覚定性定量検査- (2011)
  • Author(s): 笹尾真美、野口いづみ、新美敬太、曽我部健、井出正道、高野宏二、杉山康司、長澤純一、大野秀樹
  • Journal Title: 登山医学 Volume: 31 Pages: 127-131
  • Peer Reviewed
• [Journal Article] Effect of exercise training on the density of endothelial cells in the white adipose tissue of rats (2011)
  • Author(s): Hatano, D., Ogasawara, J., Endoh, S., Sakurai, T., Nomura, S., Kizaki, T., Ohno, H., Komabayashi, T. & Izawa, T.
  • Journal Title: Scand. J. Med. Sci Volume: 21 Issue: 6 Pages: 115-121
  • DOI: 10.1111/j.1600-0838.2010.01176.x
  • Peer Reviewed
• [Journal Article] Comparison of the effect of oligonol, a new lychee fruit-derived low molecular form of polyphenol, and epigallocatechin-3-gallate on lipolysis in rat primary adipocytes (2011)
  • Author(s): Ogasawara, J., Kitadate, K., Nishioka, H., Fujii, H., Sakurai, T., Kizaki, T., Izawa, T., Ishida, H. & Ohno, H.
  • Journal Title: Phytother Res Volume: 25 Issue: 3 Pages: 467-471
  • DOI: 10.1002/ptr.3296
  • Peer Reviewed
• [Journal Article] 食細胞の機能と低酸素環境 (2011)
  • Author(s): 大野秀樹、白土健、櫻井拓也、小笠原準悦、石橋義永、芳賀脩光、木崎節子
  • Journal Title: 臨床免疫.アレルギー科 Volume: 55 Pages: 239-246
  • NAID: 40018745187
• [Journal Article] Comparison of the effect of oligonol, a new lychee fruit-derived low molecular form of polyphenol, and epigallocatechin-3-gallate on lipolysis inrat primary adipocytes. (2011)
  • Author(s): Ogasawara, J., et al.
  • Journal Title: Phytother.Res. Volume: 250 Pages: 467-471
  • Peer Reviewed
• [Journal Article] Oligonol, an oligomerized lychee fruit-derived polyphenol, activates the Ras/Raf-1/MEK1/2 cascade independent of the IL-6 signaling pathway in rat primary adipocytes (2010)
  • Author(s): Ogasawara, J., Kitadate, K., Nishioka, H., Fujii, H., Sakurai, T., Kizaki, T., Izawa, T., Ishida, H., Tanno, M. & Ohno, H.
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 402 Issue: 3 Pages: 554-559
  • DOI: 10.1016/j.bbrc.2010.10.082
  • Peer Reviewed
• [Journal Article] Hormone-sensitive lipase is critical mediators of acute exercise-induced regulation of lipolysis in rat adipocytes (2010)
  • Author(s): Ogasawara, J., Nomura, S., Rahman, N., Sakurai, T., Kizaki, T., Izawa, T., Ishida, H., Haga, S. & Ohno, H.
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 400 Issue: 1 Pages: 134-139
  • DOI: 10.1016/j.bbrc.2010.08.026
  • Peer Reviewed
• [Journal Article] Effects of exercise training on adipogenesis of stromal-vascular fraction cells in rat epididymal white adipose tissue (2010)
  • Author(s): Sakurai, T., Endo, S., Hatano, D., Ogasawara, J., Kizaki, T., Oh-ishi, S., Izawa, T., Ishida, H. & Ohno, H.
  • Journal Title: Acta Physiol(Oxf) Volume: 200 Pages: 325-338
  • DOI: 10.1111/j.1748-1708.2010.02159.x
  • Peer Reviewed
• [Journal Article] Effect of exercise training on Adipocyte. size-dependent expression of leptin and adiponectin (2010)
  • Author(s): Miyazaki, S., Izawa, T., Ogasawara, J., Sakurai, T., Nomura, S., Kizaki, T., Ohno, H. & Komabayashi, T.
  • Journal Title: Life Sci Volume: 86 Issue: 17-18 Pages: 691-698
  • DOI: 10.1016/j.lfs.2010.03.004
  • Peer Reviewed
• [Journal Article] Exercise intensity and antioxidant ability (2010)
  • Author(s): Nagasawa, J., Kikkawa, K., Takai, T., Sakaguchi, A., Noguchi, I., Kizaki, T. & Ohno, H.
  • Journal Title: Rejuvenation Res Volume: 13 Issue: 2-3 Pages: 172-174
  • DOI: 10.1089/rej.2009.0933
  • Peer Reviewed
• [Journal Article] Exercise plays a preventive role against Alzheimer's disease (2010)
  • Author(s): Radak, Z., Hart, N, Sarga, L., Koltai, E., Atalay, M., Ohno, H. & Boldogh, I.
  • Journal Title: J. Alzheimers Dis Volume: 20 Issue: 3 Pages: 777-783
  • DOI: 10.3233/jad-2010-091531
  • Peer Reviewed
• [Journal Article] 低圧.低酸素環境が引き起こす酸化ストレスとオリゴノールの抗酸化効果 (2010)
  • Author(s): 長澤純一、杉山康塚、内丸仁、笹尾真美、高野宏二、野口いづみ、鈴木康弘、北舘健太郎、芳賀脩光、前川剛輝、櫻井拓也、小笠原準悦、木崎節子、大野秀樹
  • Journal Title: 登山医学 Volume: 30 Pages: 118-124
  • Peer Reviewed
• [Journal Article] 中国青海省の玉珠峰(6178 m)短期登頂の医学的検証-日中韓三国交流学生登山における検討- (2010)
  • Author(s): 野口いづみ、小坂健一郎、笹尾真美、前川剛輝、高野宏二、大野秀樹
  • Journal Title: 登山医学 Volume: 30 Pages: 125-130
  • Peer Reviewed
• [Journal Article] 登山の魅力と効能:登山は少子化を救えるか (2010)
  • Author(s): 大野秀樹
  • Journal Title: 地域総合研究 Volume: 11 Pages: 249-266
• [Journal Article] Hormone-sensitive lipase is critical mediators of acute exercise-induced regulation of lipolysis in rat adipocytes. (2010)
  • Author(s): Ogasawara, J., et al.
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 400 Pages: 134-139
  • Peer Reviewed
• [Journal Article] Oligonol, an oligomerized lychee fruit-derived polyphenol, activates the Ras/Raf-1/MEK1/2 cascade independent of the IL-6 signaling pathway in rat primary adipocytes. (2010)
  • Author(s): Ogasawara, J., et al.
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 402 Pages: 554-559
  • Peer Reviewed
• [Journal Article] Effects of exercise training on adipogenesis of stromal-vascular fraction cells in rat epididymal white adipose tissue. (2010)
  • Author(s): Sakurai, T., et al.
  • Journal Title: Acta Physiol.(Oxf) Volume: 200 Pages: 325-338
  • Peer Reviewed
• [Journal Article] 低圧・低酸素環境が引き起こす酸化ストレスとオリゴノールの抗酸化効果 (2010)
  • Author(s): 長澤純一, 他
  • Journal Title: 登山医学 Volume: 30 Pages: 118-124
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): 大野秀樹, 他
  • Journal Title: からだと温度の事典(朝倉書店) Pages: 516-517
• [Journal Article] (2010)
  • Author(s): 大野秀樹
  • Journal Title: 『日本臨床』:2010年増刊 肥満症[第2版]-基礎・臨床研究の進歩-(日本臨床社) Pages: 272-276
• [Journal Article] Oligomerized grape seed polyphenols attenuate inflammatory changes due to antioxidative properties in co-culture of adipocytes and macrophages (2009)
  • Author(s): Sakurai, T., Kitadate, K., Nishioka, K., Fujii, H., Kizaki, T., Kondoh, Y., Izawa, T., Ishida, H., Radak, Z. & Ohno, H.
  • Journal Title: J Nutr. Biochem Volume: 21 Pages: 47-54
  • Peer Reviewed
• [Journal Article] Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue (2009)
  • Author(s): Sakurai, T., Izawa, T., Kizaki, T., Ogasawara, J., Shirato, K., Imaizumi, K., Takahashi, K., Ishida, H. & Ohno, H.
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 379 Issue: 2 Pages: 605-609
  • DOI: 10.1016/j.bbrc.2008.12.127
  • Peer Reviewed
• [Journal Article] Oligonol, a new lychee fruit-derived low-molecular form of polyphenol, enhances lipolysis in primary rat adipocytes through activation of the ERK1/2 pathway (2009)
  • Author(s): Ogasawara, J., Kitadate, K., Nishioka, H., Fujii, H., Sakurai, T., Kizaki, T., Izawa, T., Ishida, H. & Ohno, H.
  • Journal Title: Phytother. Res Volume: 23 Issue: 11 Pages: 1626-1633
  • DOI: 10.1002/ptr.2846
  • Peer Reviewed
• [Journal Article] Hypoxia-inducible factor-1αsuppresses the expression of macrophage scavenger receptor 1 (2009)
  • Author(s): Shirato, K., Kizaki, T., Sakurai, T., Ogasawara, J., Ishibashi, Y., Iijima, T., Okada, C., Noguch, I., Imaizumi, K., Taniguchi, N. & Ohno, H.
  • Journal Title: Pflugers Arch Volume: 459 Issue: 1 Pages: 93-103
  • DOI: 10.1007/s00424-009-0702-y
  • Peer Reviewed
• [Journal Article] Swimming training prevents induction of suppressor macrophages in mice during acute exposure to cold (2009)
  • Author(s): Ohno, H., Haga, S., Takemasa, T., Sakurai, T., Ogasawara, J., Shirato, K., Ishibashi, Y., Imaizumi, K. & Kizaki, T.
  • Journal Title: Adv. Exerc. Sports Physiol Volume: 15 Pages: 1-7
  • NAID: 110007330710
  • Peer Reviewed
• [Journal Article] 新規低分子ポリフェノールOligonolの抗酸化作用 (2009)
  • Author(s): 櫻井拓也、北舘健太郎、西岡浩、藤井創、久島達也、安部茂、木崎節子、小笠原準悦、白土健、石橋義永、井澤鉄也、今泉和彦、鈴木健二、中野法彦、大野秀樹
  • Journal Title: FOOD FUNCTION Volume: 5 Pages: 2-7
• [Journal Article] 低酸素誘導因子(HIF)-1αはマクロファージスカベンジャー受容体1の発現を抑制する (2009)
  • Author(s): 大野秀樹、白土健、前川剛輝、櫻井拓也、小笠原準悦、石橋義永、木崎節子、野口いづみ、長澤純一、荻原理江、貫田宗男、鈴木健二、大石修司、今泉和彦、芳賀脩光
  • Journal Title: 登山医学 Volume: 29 Pages: 203-212
  • Peer Reviewed
• [Journal Article] Oligomerized grape seed polyphenols attenuate inflammatory changes due to antioxidative properties in coculture of adipocytes and macrophages (2009)
  • Author(s): Sakurai, T., et al.
  • Journal Title: J Nutr.Biochem. 21 Pages: 47-54
  • Peer Reviewed
• [Journal Article] Hypoxia-inducible factor-1 α suppresses the expression of macrophage scavenger receptor 1 (2009)
  • Author(s): Shirato, K., et al.
  • Journal Title: Pflugers Arch. 459 Pages: 93-103
  • Peer Reviewed
• [Journal Article] Oligonol, a new lychee fruit-derived low-molecular form of polyphenol, enhances lipolysis in primary rat adipocytes through activation of the ERK1/2 pathway (2009)
  • Author(s): Ogasawara, J., et al.
  • Journal Title: Phytother. Res. 23 Pages: 1626-1633
  • Peer Reviewed
• [Journal Article] Swimming training prevents induction of suppressor macrophages in mice during acute exposure to cold (2009)
  • Author(s): Ohno, H., et al.
  • Journal Title: Adv.Exerc.Sports Physiol. 15 Pages: 1-7
  • NAID: 110007330710
  • Peer Reviewed
• [Journal Article] Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue (2009)
  • Author(s): Sakurai, T., et al.
  • Journal Title: Biochem. Biophys. Res.Commun. 379 Pages: 605-609
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 大野秀樹, 他
  • Journal Title: 登山の医学ハンドブック(杏林書院)
• [Journal Article] (2009)
  • Author(s): 大野秀樹
  • Journal Title: 『臨床スポーツ医学』2009年臨時増刊号 スポーツ栄養・食事ガイド[競技力向上とコンディショニングのためのスポーツ栄養学](文光堂) Pages: 166-173
• [Journal Article] Effect of exercise training on the density of endothelial cells in the white adipose tissue of rats.
  • Author(s): Hatano, D., et al.
  • Journal Title: Scand.J.Med.Sci.Sports Volume: (in press)
  • Peer Reviewed
• [Journal Article] Exercise plays a preventive role against Alzheimer's disease
  • Author(s): Radak Z, et al.
  • Journal Title: J Alzheimers Dis. (in press)
  • Peer Reviewed
• [Journal Article] Effect of exercise training on adipocyte-size-dependent expression of leptin and adiponectin
  • Author(s): Miyazaki, S., et al.
  • Journal Title: Life Sci. (in press)
  • Peer Reviewed
• [Journal Article] Exercise intensity and antioxidant ability
  • Author(s): Nagasawa, J., et al.
  • Journal Title: Rejuvenation Res. (in press)
  • Peer Reviewed
• [Presentation] 水泳運動は骨格筋前駆細胞から褐色脂肪細胞への分化シグナルを促進する (2012)
  • Author(s): 小笠原準悦, ほか
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 2012-03-25
• [Presentation] Oligonolは神経細胞において小胞体ストレス減弱作用をもつ (2012)
  • Author(s): 櫻井拓也, ほか
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都
• [Presentation] Oligonolは神経細胞において小胞体ストレスを減弱させる (2011)
  • Author(s): 櫻井拓也, ほか
  • Organizer: 第9回日本予防医学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-20
• [Presentation] 運動は骨格筋から褐色脂肪細胞への分化を活性化するか (2011)
  • Author(s): 小笠原準悦, ほか
  • Organizer: 第40回杏林医学会総会
  • Place of Presentation: 三鷹
  • Year and Date: 2011-11-19
• [Presentation] Preventive effects of Oligonol on cognitive impairment in senescence-accelerated mice and identification of its molecular target in hippocampus (2011)
  • Author(s): Sakurai, T., et al
  • Organizer: 19th International Congress on Nutrition and Integrative Medicine
  • Place of Presentation: Sapporo
  • Year and Date: 2011-10-16
• [Presentation] 骨格筋から褐色脂肪細胞への分化機構に及ぼす寒冷曝露と水泳運動の効果 (2011)
  • Author(s): 小笠原準悦, ほか
  • Organizer: 第66回日本体力医学会大会
  • Place of Presentation: 下関
  • Year and Date: 2011-09-17
• [Presentation] 筋委縮時におけるリボゾームRNA合成低下を引き起こす因子の検討 (2011)
  • Author(s): 町田正直, ほか
  • Organizer: 第66回日本体力医学会大会
  • Place of Presentation: 下関
  • Year and Date: 2011-09-17
• [Presentation] 脂肪細胞の脂肪分解反応に及ぼす新規カテキン型ポリフェノール複合体Oligonolの効果 (2011)
  • Author(s): 小笠原準悦, ほか
  • Organizer: 第21回体力・栄養・免疫学会大会
  • Place of Presentation: 東京
  • Year and Date: 2011-08-28
• [Presentation] 運動は老化促進モデルマウスの認知機能障害を予防する (2011)
  • Author(s): 櫻井拓也, ほか
  • Organizer: 第19回日本運動生理学会大会
  • Place of Presentation: 徳島
  • Year and Date: 2011-08-26
• [Presentation] 人生をアクティブに送るコツ…登山と恋愛の効能 (2011)
  • Author(s): 大野秀樹
  • Organizer: 第1回東京伝統生薬研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-07-03
• [Presentation] 富士登山時の自律神経応答と身体の電気伝導率 (2011)
  • Author(s): 長澤純一, ほか
  • Organizer: 第31回日本登山医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-11
• [Presentation] 高度が味覚へ及ぼす影響-富士山における味覚定性定量検査- (2011)
  • Author(s): 笹尾真美, ほか
  • Organizer: 第31回日本登山医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-11
• [Presentation] 糖尿病発症予防研究における睡眠時間と睡眠の質の検討 (2011)
  • Author(s): 根本浩一郎, ほか
  • Organizer: 第84回日本産業衛生学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-18
• [Presentation] 脂肪細胞肥大化にともなう低酸素非依存的VEGF分泌制御機構の解析 (2011)
  • Author(s): 高橋和人, ほか
  • Organizer: 第65回日本栄養・食糧学会大会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-15
• [Presentation] The lipolytic activity in adipocytes differs between normal and high fat diet mice via changes in the trafficking of β_2-adrenergic receptor (2011)
  • Author(s): Ogasawara, J., et al.
  • Organizer: 第88回日本生理学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-30
• [Presentation] マウスビタミンC代謝に対する急性運動の影響 (2011)
  • Author(s): 人見嘉哲, 他
  • Organizer: 第81回日本衛生学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2011-03-28
• [Presentation] 肥満抑制効果を有するOligonolによる脂肪分解反応の調節機構の解明 (2011)
  • Author(s): 小笠原準悦, 他
  • Organizer: 第81回日本衛生学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2011-03-28
• [Presentation] 運動およびOligonolの摂取は老化促進モデルマウスの認知機能障害を予防する (2011)
  • Author(s): 櫻井拓也, 他
  • Organizer: 第81回日本衛生学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2011-03-27
• [Presentation] 老化促進モデルマウスの認知機能障害に対するOligonolの予防効果 (2010)
  • Author(s): 櫻井拓也, 他
  • Organizer: 第8回日本予防医学会学術総会
  • Place of Presentation: 金沢
  • Year and Date: 2010-12-12
• [Presentation] 新規低分子かポリフェノール(Oligonol)による脂肪分解反応の調節メカニズム (2010)
  • Author(s): 小笠原準悦, 他
  • Organizer: 第39回杏林医学会総会
  • Place of Presentation: 三鷹
  • Year and Date: 2010-11-20
• [Presentation] 老化促進モデルマウスの認知機能障害に対する運動トレーニング効果 (2010)
  • Author(s): 櫻井拓也, 他
  • Organizer: 第65回日本体力医学会大会
  • Place of Presentation: 市川
  • Year and Date: 2010-09-16
• [Presentation] 持久運動トレーニングによる脂肪細胞のATGL発現変化と調節メカニズム.第18回日本運動生理学会大会 (2010)
  • Author(s): 小笠原準悦, 他
  • Organizer: 第18回日本運動生理学会大会
  • Place of Presentation: 鹿児島
  • Year and Date: 2010-08-01
• [Presentation] Both Oligonol and exercise have preventive effects on cognitive impairment in senescence-accelerated mice. (2010)
  • Author(s): Sakurai, T., et al.
  • Organizer: 18th International Congress on Nutrition and Integrative Medicine
  • Place of Presentation: Sapporo
  • Year and Date: 2010-07-25
• [Presentation] Oligonol, a new lychee fruit-derived low molecular form of polyphenol, enhances lipolysis in primary rat adipocytes via adtivation of the ERK 1/2 pathway. (2010)
  • Author(s): Ogasawara, J., et al.
  • Organizer: 11th International Congress on Obesity.
  • Place of Presentation: Stochholm
  • Year and Date: 2010-07-13
• [Presentation] 運動トレーニングによる脂肪細胞の脂肪分解反応とAdipose Triglyceride Lipaseの役割 (2010)
  • Author(s): 小笠原準悦, 他
  • Organizer: 第80回日本衛生学会学術総会
  • Place of Presentation: 仙台
  • Year and Date: 2010-05-11
• [Presentation] 運動および新規低分子化ポリフェノールOligonolによる脂肪組織酸化ストレス軽減効果 (2010)
  • Author(s): 櫻井拓也, 他
  • Organizer: 第80回日本衛生学会総会:連携研究会酸化ストレス研究会シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2010-05-09
• [Presentation] 富士山山頂における睡眠時の低酸素症に対する口腔内装置の効果-中高年者における検討- (2010)
  • Author(s): 野口いづみ, 他
  • Organizer: 平成21年度富士山測候所利活用に関する成果報告会
  • Place of Presentation: 東京大学小柴ホール(東京都)
  • Year and Date: 2010-01-24
• [Presentation] 低酸素環境に対する抗酸化剤の効果 (2010)
  • Author(s): 長澤純一, 他
  • Organizer: 平成21年度富士山測候所利活用に関する成果報告会
  • Place of Presentation: 東京大学小柴ホール(東京都)
  • Year and Date: 2010-01-24
• [Presentation] 運動トレーニングによる肥満・生活習慣病および認知症予防効果とそのメカニズム (2010)
  • Author(s): 櫻井拓也, 他
  • Organizer: 文部科学省学術フロンティア研究プロジェクト「ライフステージに応じた健康増進と多様性保持」第4回研究会
  • Place of Presentation: 早稲田大学所沢キャンパス(埼玉県)
  • Year and Date: 2010-01-06
• [Presentation] 脂肪代謝に及ぼす新規低分子化ポリフェノール(Oligonol)の効果と作用機序 (2010)
  • Author(s): 小笠原準悦, 他
  • Organizer: 文部科学省学術フロンティア研究プロジェクト「ラィフステージに応じた健康増進と多様性保持」第4回研究会
  • Place of Presentation: 早稲田大学所沢キャンパス(埼玉県)
  • Year and Date: 2010-01-06
• [Presentation] Hypoxia-inducible factor-1α suppresses the expression of macrophage scavenger receptor 1 (2009)
  • Author(s): Kizaki, T., et al.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2009-12-03
• [Presentation] 運動トレーニングは脂肪組織由来幹細胞の脂肪細胞分化を抑制する効果をもつ (2009)
  • Author(s): 櫻井拓也, 他
  • Organizer: 第38回杏林医学会総会
  • Place of Presentation: 杏林大学三鷹キャンパス(東京都)
  • Year and Date: 2009-11-21
• [Presentation] 運動をプローブとしたアルツハイマー型認知症予防に対する新規ターゲット分子の検索 (2009)
  • Author(s): 櫻井拓也, 他
  • Organizer: 第38回杏林医学会総会
  • Place of Presentation: 杏林大学三鷹キャンパス(東京都)
  • Year and Date: 2009-11-21
• [Presentation] 運動トレーニングによる脂肪細胞の脂肪分解反応の充進にはadipose triglyceride lipase(ATGL)の発現変化が関与する (2009)
  • Author(s): 小笠原準悦, 他
  • Organizer: 第64回日本体力医学会大会
  • Place of Presentation: 朱鷺メッセ(新潟県)
  • Year and Date: 2009-09-20
• [Presentation] 過負荷刺激による筋肥大過程における網羅的遺伝子発現の解析からの新規経路の探索 (2009)
  • Author(s): 町田正直, 他
  • Organizer: 第64回日本体力医学会大会
  • Place of Presentation: 朱鷺メッセ(新潟県)
  • Year and Date: 2009-09-20
• [Presentation] in vivoインスリン感受性に及ぼすアディポネクチンの効果 (2009)
  • Author(s): 長澤純一, 他
  • Organizer: 第64回日本体力医学会大会
  • Place of Presentation: 朱鷺メッセ(新潟県)
  • Year and Date: 2009-09-18
• [Presentation] 脂肪細胞サイズに依存したアデイポカイン遺伝子発現に及ぼす運動トレーニングの影響 (2009)
  • Author(s): 井澤鉄也, 他
  • Organizer: 第64回日本体力医学会大会
  • Place of Presentation: 朱鷺メッセ(新潟県)
  • Year and Date: 2009-09-18
• [Presentation] 脂肪組織由来幹細胞の脂肪細胞分化に及ぼす運動トレーニングの影響 (2009)
  • Author(s): 櫻井拓也, 他
  • Organizer: 第64回日本体力医学会大会
  • Place of Presentation: 朱鷺メッセ(新潟県)
  • Year and Date: 2009-09-18
• [Presentation] Hypoxia-inducible factor-1α regulates expression of mRNA for macrophage scavenger receptor 1 (2009)
  • Author(s): Shirato, K., et al.
  • Organizer: 36th International Congress of Physiological Sciences
  • Place of Presentation: Kyoto International Conference Center(Kyoto)
  • Year and Date: 2009-07-31
• [Presentation] 急性運動は脂肪細胞の脂肪分解反応をどのように調節するのか (2009)
  • Author(s): 前川剛輝, 他
  • Organizer: 第17回日本運動生理学会大会
  • Place of Presentation: 東京慈恵会医科大学西新橋校(東京都)
  • Year and Date: 2009-07-26
• [Presentation] 脂肪組織由来幹細胞の脂肪細胞への分化は運動トレーニングによって抑制される (2009)
  • Author(s): 櫻井拓也, 他
  • Organizer: 第17回日本運動生理学会大会
  • Place of Presentation: 東京慈恵会医科大学西新橋校(東京都)
  • Year and Date: 2009-07-25
• [Presentation] The signal transduction pathway of Oligonol-induced phosphorylation on ERK1/2 in primary rat adipocytes (2009)
  • Author(s): Ogasawara, J., et al.
  • Organizer: 17th International Symposium of AHCC Research Association
  • Place of Presentation: Royton Sappro(Hokkaido)
  • Year and Date: 2009-07-25
• [Presentation] 低酸素誘導因子(HIF)-1αはマクロファージスカベンジャー受容体1の発現を抑制する (2009)
  • Author(s): 大野秀樹, 他
  • Organizer: 第29回日本登山医学会学術集会
  • Place of Presentation: 東京コンファレンスセンター品川(東京都)
  • Year and Date: 2009-05-31
• [Presentation] 低圧低酸素環境下における睡眠時の低酸素症に対する口腔内装置の効果-中高年者における検討- (2009)
  • Author(s): 野口いづみ, 他
  • Organizer: 第29回日本登山医学会学術集会
  • Place of Presentation: 東京コンファレンスセンター品川(東京都)
  • Year and Date: 2009-05-30
• [Presentation] 職域における2型糖尿病発症予防研究第5報～介入3年後の検討～ (2009)
  • Author(s): 根本浩一郎, 他
  • Organizer: 第82回日本産業衛生学会
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2009-05-21
• [Presentation] New lychee fruit-derived polyphenol Oligonol converted into a low-molecular form improves exercise-induced fatigue (2009)
  • Author(s): Sakurai, T., et al.
  • Organizer: 3eme Symposium Nutrition, Biologie de I'Oxygene et Medecine-Paris 2009
  • Place of Presentation: Campus des Cordeliers(France)
  • Year and Date: 2009-04-09
• [Book] 機能性食品素材と運動療法-生活習慣病予防と運動機能維持向上を目指して- (2012)
  • Author(s): 大野秀樹, ほか
  • Publisher: シーエムシー出版(印刷中)
• [Book] 明治安田厚生事業団第27回健康医科学研究助成論文集平成22年度 (2012)
  • Author(s): 櫻井拓也, ほか
  • Total Pages: 156
  • Publisher: 東京六法出版
• [Book] 脂肪組織のエクササイズバイオロジー1冊まるごと脂肪組織と運動の話 (2011)
  • Author(s): 櫻井拓也, ほか
  • Total Pages: 180
  • Publisher: ナップ
• [Book] Proceedings 19th International Congress on Nutrition and Integrative Medicine (2011)
  • Author(s): 櫻井拓也, ほか
  • Total Pages: 174
  • Publisher: アミノアップ化学
• [Book] 公益財団法人中冨健康科学振興財団第22回研究助成業績集平成23年版 (2011)
  • Author(s): 小笠原準悦, ほか
  • Total Pages: 158
  • Publisher: 医薬ジャーナル社
• [Book] からだと温度の事典 (2010)
  • Author(s): 大野秀樹, 他
  • Total Pages: 640
  • Publisher: 朝倉書店
• [Book] 運動生理学のニューエビデンス (2010)
  • Author(s): 櫻井拓也, 他
  • Total Pages: 464
  • Publisher: 真興交易(株)医書出版部
• [Book] 運動と免疫 からだをまもる運動のふしぎ (2009)
  • Author(s): 大野秀樹, 他編
  • Total Pages: 420
  • Publisher: ナップ
• [Book] 登山は元気を与えてくれる総合芸術-登山は少子化を救うかもしれない (2009)
  • Author(s): 大野秀樹
  • Total Pages: 162
  • Publisher: ナップ
• [Patent(Industrial Property Rights)] 遺伝子導入促進剤及びそれを含む遺伝導入用組成物 (2010)
  • Inventor(s): 人見嘉哲、大野秀樹
  • Industrial Property Rights Holder: 人見嘉哲、大野秀樹
  • Acquisition Date: 2010-04-23