Effects of exercise and food restriction during childhood on the set point for body weight in genetically obese OLETF rats
| Project/Area Number |
21300256
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
SUZUKI Masato 東京慈恵会医科大学, 医学部, 教授 (10110925)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAUCHI Hideki 東京慈恵会医科大学, 医学部, 講師 (60220224)
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| Co-Investigator(Renkei-kenkyūsha) |
MACHIDA Shuichi 東海大学, 体育学部, 准教授 (40421226)
KIMURA Masaki 慶應義塾大学, 薬学部, 講師 (40383666)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 体重セットポイント / 幼若齢期 / 運動 / 給餌制限 / 体重 / 除脂肪量 / UCP-3mRNA / 幼若齢 / 自発運動 / 内臓脂肪量 / エネルギー代謝 / 血清脂質 / 血清レプチン / 体重のセットポイント / 成長～成熟期 / 自発走運動 / 動物用CT測定装置 / 内臟脂肪重量 / 除脂肪重量 / 血清レプチン濃度 / 壮年期 / 食事制限 / 内臓脂肪 / レプチン発現量 |
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| Research Abstract |
The present study was conducted to examine whether a decrease in energy expenditure caused by reduced physical activity during childhood or an increase in energy intake caused by overeating during childhood was responsible for resetting the set point for body weight(BW). At the completion of the experiment, lean body mass(LBM); energy metabolism-related enzymes such as CS, SDH, and PFK ; and UCP-3mRNA expression were significantly higher in the exercise group than in the diet-restriction and sedentary groups. The present study suggests that prevention of BW gain by performing regular exercise during childhood contributes to increased skeletal muscle mass and enhanced energy expenditure. Further, early-onset exercise may contribute to resetting the set point for BW in individuals genetically predisposed to obesity.
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Report
(4 results)
Research Products
(6 results)
