Develo pments of the target cooling and dosimetry systems for the use of the accelerator boron neutron capture therapy

• Project/Area Number: 21310039
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Hiroshima University
• Principal Investigator: MASAHARU Hoshi 広島大学, 原爆放射線医科学研究所, 教授 (50099090)
• Co-Investigator(Kenkyū-buntansha): ZHUMADILOV Kassym 広島大学, 原爆放射線医科学研究所, 特任准教授 (40530770) ; ENDO Satoru 広島大学, 大学院・工学研究院, 准教授 (90243609) ; ISHIKAWA Masayori 北海道大学, 大学院・医学研究科, 教授 (80314772)
• Co-Investigator(Renkei-kenkyūsha): TAKADA Masashi 放射線医学総合研究所, 主任研究員 (50291109) ; SATO Hitoshi 茨城県立医療大学, 保健医療学部, 准教授 (90285057)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000); Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2009: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
• Keywords: 放射線 / BNCT / 加速器 / 中性子 / リチウムターゲット / 線量測定 / 冷却システム / Liターゲット / 中性子線量 / ホウ素 / 線量評価

Research Abstract

New target system for the accelerator boron neutron capture therapy by using water cooling system was developed. The target was tested 6 times using the 3MeV proton beam of the accelerator in National Institute for Radiological Sciences with the same power per unit area and was verified to have enough ability to keep the temperature below about 100 degrees. From these results we can manufacture an actual target system. For the dosimetry system we used new plastic including boron and made verified the possibility of the new chamber system to measure necessary neutrons for boron neutron capture therapy system.

Research Products

• [Journal Article] Development of monitoring method of spatial neutron distribution inneutrons. gamma rays mixed field usingimaging plate for NCT-De pression of the field (2011)
  • Author(s): Tanaka, K., Endo, S., Hoshi, M., Takada, J.
  • Journal Title: Applied Radiation andIsotopes Volume: 69 Pages: 1885-1887
  • Peer Reviewed
• [Journal Article] Estimation of Beta-Ray Skin Dose From Exposure to Fission Fall out from The Hiro shima Atomic Bomb (2011)
  • Author(s): Endo, S., Tanaka, K., Shizuma, K., Hoshi, M. and Imanaka, I
  • Journal Title: Radiation Prote ction Dosimetry Pages: 1-7
  • Peer Reviewed
• [Journal Article] Development of monitoring method of spatial neutron distribution in neutrons-gamma rays mixed field using imaging plate for NCT-Depression of the field (2011)
  • Author(s): Tanaka, K.
  • Journal Title: Applied Radiation and Isotopes Volume: 69 Pages: 1885-1887
  • Peer Reviewed
• [Journal Article] Estimation of beta-ray skin dose from exposure tofission fallout from the Hiroshimaa to mic bomb (2011)
  • Author(s): Endo S, Tanaka K, Shizuma K, Hoshi M, Imanaka T
  • Journal Title: Radiation Protection Dosimetry Volume: 143 Issue: 1 Pages: 1-7
  • DOI: 10.1093/rpd/ncr407
  • Peer Reviewed
• [Journal Article] Measurement of microdosimetrics pectra produced from a 290 MeV/ nSpread Out Bragg Peak carbon beam (2010)
  • Author(s): Endo, S., Takada, M., Tanaka, H., Onizuka, Y., Tanaka, K., Miyahara, N., Baba, H., Oishi, A., Ishikawa, M., Hoshi, M., Kimura, S., Minematsu, M., Morimune, Y., Kojima, Y., Shizuma, K.
  • Journal Title: Radiation and EnvironmentBiophysics Volume: 49 Pages: 469-475
  • Peer Reviewed
• [Journal Article] Genome-Wide Expression Changes in Saccharo myces cerevisiae in Response to High-LET Ionizing Radiation (2010)
  • Author(s): Mizukami-Murata, S., Iwahashi, H., Kimura, S., Nojima, K., Sakurai, Y., Saitou, T., Fujii, N., Murata, Y., Suga, S., Kitagawa, K., Tanaka, K., Endo, S., Hoshi, M.
  • Journal Title: Applied Bioche mistry and Biote chnology Volume: 162 Pages: 855-870
  • Peer Reviewed
• [Journal Article] Dosime tricverification of the anisotropic an alytical algo rithm in lunge quivalent heteroge neities with and without bone e quivalen the terogeneities (2010)
  • Author(s): Ono, k., Endo, S., Tanaka, K., Hoshi, M., Hirokawa, Y.
  • Journal Title: MedicalPhysics Volume: 37 Pages: 4456-4463
  • Peer Reviewed
• [Journal Article] Measurements of neutron distributionin neutrons-gamma rays mixed fieldusing imaging plate for neutroncapture the rapy (2010)
  • Author(s): Tanaka, K., Endo, S., Hoshi, M.
  • Journal Title: Applied Radiation and Isotopes Volume: 68 Pages: 207-210
  • Peer Reviewed
• [Journal Article] Mixed field dosimetry of accelerator-based neutron source for BNCT (2010)
  • Author(s): 中尾稔, 鬼塚昌彦, 馬場大海, 深堀麻衣, 田中憲一, 星正治, 佐々木雅之
  • Journal Title: Japanese Journal of Medical Physics Volume: 30 Pages: 200-201
  • Peer Reviewed
• [Journal Article] The Consideration of Biological Effectiveness of Low EnergyProtons Using Biophysical Modeling of the Effects Induced by Exposure of V79Cells (2010)
  • Author(s): Khvostunov, I., Nikjoo, H., Uehara, S., Hoshi, M.
  • Journal Title: Radiobiology and Radioe cology Volume: 55 Pages: 1067-1075
  • Peer Reviewed
• [Journal Article] The Consideration of Biological Effectiveness of Low Energy Protons Using Biophysical Modeling of The Effects Induced By Exposure of V79Cells (2010)
  • Author(s): Khvostunov, I., Nikjoo, H., Uehara, S., Hoshi, M.
  • Journal Title: Russian Journal of Radiation Biology & Radioecology Volume: 50 Pages: 81-89
  • Peer Reviewed
• [Journal Article] Measurement of microdosimetric spectra produced from a 290 MeV/n Spread Out Bragg Peak carbon beam (2010)
  • Author(s): Endo, S.
  • Journal Title: Radiation and Environment Biophysics Volume: 49 Pages: 469-475
  • Peer Reviewed
• [Journal Article] Genome-Wide Expression Changes in Saccharomyces cerevisiae in Response to High-LET Ionizing Radiation (2010)
  • Author(s): Mizukami-Murata, S.
  • Journal Title: Applied Biochemistry and Biotechnology Volume: 162(3) Pages: 855-870
  • Peer Reviewed
• [Journal Article] Dosimetric verification of the anisotropic analytical algorithm in lung equivalent heterogeneities with and without bone equivalent heterogeneities (2010)
  • Author(s): Ono, K.
  • Journal Title: Medical Physics Volume: 37(8) Pages: 4456-4463
  • Peer Reviewed
• [Journal Article] Development of monitoring method of spatial neutron distribution in neutrons-gamma rays mixed field using imaging plate (2010)
  • Author(s): Tanaka, K.
  • Journal Title: Challenges in Neutron Capture Therapy (Proc.of the 14th International Congress on Neutron Capture Therapy) Pages: 195-198
  • Peer Reviewed
• [Journal Article] Measurements of neutron distribution in neutrons-gamma rays mixed field using imaging plate for neutron capture therapy (2010)
  • Author(s): Tanaka, K.
  • Journal Title: Applied Radiation and Isotopes Volume: 68 Pages: 207-210
  • Peer Reviewed
• [Journal Article] A study on monitoring method of spatial neutron distribution using imaging plate for NCT (2010)
  • Author(s): 田中憲一
  • Journal Title: Proceedings of 2011 Annual Meeting of AESJ Pages: 687-687
  • Peer Reviewed
• [Journal Article] イメージングプレートを用いた中性子束分布測定法の検討 (2010)
  • Author(s): 田中憲一
  • Journal Title: 第7回日本中性子捕捉療法学会学術大会抄録集 Pages: 37-37
  • Peer Reviewed
• [Journal Article] Mixed field dosimetry of accelerator-based neutron source for BNCT (2010)
  • Author(s): 中尾稔
  • Journal Title: Japanese Journal of Medical Physics Volume: 30(Sup.5) Pages: 200-201
  • Peer Reviewed
• [Journal Article] The Consideration of Biological Effectiveness of Low Energy Protons Using Biophysical Modeling of the Effects Induced by Exposure of V79 Cells (2010)
  • Author(s): Khvostunov, I.K.
  • Journal Title: Biophysics Volume: 55(6) Pages: 1067-1075
  • Peer Reviewed
• [Journal Article] The Consideration of Biological Effectiveness of Low Energy Protons Using Biophysical Modeling of The Effects Induced By Exposure of V79 Cells (2010)
  • Author(s): Khvostunov, K.
  • Journal Title: Russian Journal of Radiation Biology & Radioecology 50(1) Pages: 81-89
  • Peer Reviewed
• [Journal Article] The microdosimentric consideration of RBE of low-energy protons on V79 cells (2010)
  • Author(s): Khvostunov, K.
  • Journal Title: III International Symposium under the auspices of UNESCO dedicated to the centenary of Academician N.M.Sisakian's birth, Moscow, Dubna, January 24-28, 2007, Book of abstracts Pages: 152-153
  • Peer Reviewed
• [Journal Article] The microdosimetric consideration of RBE of low-energy protons on V79 cells (2010)
  • Author(s): Khvostunov, K.
  • Journal Title: III International Symposium under the auspices of UNESCO dedicated to the centenary of Academician N.M.Sisakian's birth, Moscow, Dubna, January 24-28, 2007, Book of abstracts Pages: 336-338
  • Peer Reviewed
• [Journal Article] Microdosimetry on a Mini-Reactor UTR-KINKI for Educational Uses and Biological Researches (2009)
  • Author(s): Endo, S., Tanaka, K., Fujikawa, K., Horiguchi, T., Itoh, T., Onizuka, Y., Hoshi, M., Murataka, A., Kojima, Y. andShizuma, K.
  • Journal Title: Journal of Radiation Research Volume: 50 Pages: 83-87
  • NAID: 110007042072
  • Peer Reviewed
• [Journal Article] Microdosimetry on a Mini-Reactor UTR-KINKI for Educational Uses and Biological Researches (2009)
  • Author(s): Endo, S.
  • Journal Title: Journal of Radiation Research 50 Pages: 83-87
  • NAID: 110007042072
  • Peer Reviewed
• [Presentation] 加速器Liターゲット中性子源のための4重電離箱システムの開発 (2011)
  • Author(s): 中尾稔, 鬼塚昌彦, 馬場大海, 深堀麻衣, 田中憲一, 星正治, 佐々木雅之
  • Organizer: 平成22年度京都大学原子炉実験所専門研究会
  • Place of Presentation: 大阪府熊取町
• [Presentation] イメージングプレートによるNCT用中性子束分布測定法の検討 (2011)
  • Author(s): 田中憲一, 遠藤暁, 星正治, 高田純
  • Organizer: 日本原子力学会2011年春の年会
  • Place of Presentation: 福井市
• [Presentation] イメージングプレートを用いた線量分布測定法の検討 (2010)
  • Author(s): 田中憲一, 遠藤暁, 星正治, 高田純
  • Organizer: 第7回日本中性子捕捉療法学会学術大会
  • Place of Presentation: 東京都
• [Presentation] 加速器硼素中性子捕捉療法の混合場における線量評価 (2010)
  • Author(s): 中尾稔, 鬼塚昌彦, 馬場大海, 深堀麻衣, 田中憲一, 星正治, 佐々木雅之
  • Organizer: 第100回日本医学物理学会学術大会
  • Place of Presentation: 東京都
• [Presentation] Development of monitoring method of spatial neutron distribution in neutrons-gamma rays mixed field using imaging plate (2010)
  • Author(s): Tanaka, K., Endo, S., Hoshi, M. andTakada, J.
  • Organizer: 14thInternational Congress on Neutron Capture Therapy
  • Place of Presentation: Buenos Aires, Argentina
• [Presentation] Mixed field do simetry of accelerator-based neutron source for BNCT (2010)
  • Author(s): Nakao, M., Onitsuka, M., Baba, T., Fukahori, M., Tanaka, K., Hoshi, M., Sasaki, N.
  • Organizer: The 6th International Workshop on Personnel Monitoring
  • Place of Presentation: Ibaraki
• [Presentation] Development of monitoring method of spatial neutron distribution in neutrons-gamma rays mixed field using imaging plate (2010)
  • Author(s): Tanaka, K.
  • Organizer: 14th International Congress on Neutron Capture Therapy
  • Place of Presentation: Buenos Aires, Argentina
• [Presentation] Mixed field dosimetry of accelerator-based neutron source for BNCT (2010)
  • Author(s): Nakao, M.
  • Organizer: The 6th International Workshop on Personnel Monitoring
  • Place of Presentation: Ibaraki