Preparation of molecularly imprinted gel beads that selectively adsorb endotoxin
| Project/Area Number |
21310062
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental technology/Environmental materials
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| Research Institution | Tokyo University of Technology |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
AIBA Seiichi 産業技術総合研究所, 生物プロセス研究部門, 主任研究員 (50344156)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | 高分子合成 / 分子認識 / 表面・界面物性 / 有害化学物質 / エンドトキシン / 分子インプリント法 / アミノ酸 / トリペプチド / 表面プラズモン共鳴法 / アクリルアミド誘導体 |
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| Research Abstract |
To remove endotoxin from water, we plan to develop polymer hydrogels that selectively adsorb endotoxin. We successfully prepared polymer hydrogels with endotoxin-binding sites by applying a molecular imprinting technique and using amino acid derivatives or tripeptide derivatives as functional monomers. The hydrogels obtained selectively adsorbed endotoxin even in a coexistence of the other substances, and after adsorption of endotoxin to the hydrogels was completed the hydrogels could be regenerated by washing with acidic and basic solutions.
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Report
(4 results)
Research Products
(12 results)
