Mode of action study of antibacterial compounds for rational molecular design
Project/Area Number |
21310136
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Living organism molecular science
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Research Institution | Tohoku University |
Principal Investigator |
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Project Period (FY) |
2009-04-01 – 2013-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
|
Keywords | 抗菌性物質 / 耐性菌 / バンコマイシン / バンコマイシン耐性菌 / 抗生物質 / ドッキング実験 / 光親和性標識 / 薬剤耐性 / 構造活性相関 / メカニズム解析 |
Research Abstract |
Vancomycin is a clinically used antibacterial against nosocomial infections. However, vancomycin-resistant enterococci (VRE) is now widespread over the world. Moreover, the resistant nature of VRE has been transferred to Staphylococcus aureus, the major nosocomial pathogen. In this study, chemical modifications of vancomycin was conducted to restore its activity to the resistant bacteria. Three major achievements are the following. 1) Cell wall intermediates of vancomycin-resistant bacteria were chemically prepared. It made it possible to examine peptidoglycan biosynthesis in vitro greater in detail. 2) A novel vancomycin modification method using cross-coupling reaction was developed. 3) The active conformation of vancomycin dimers was experimentally suggested.
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Report
(5 results)
Research Products
(21 results)
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[Journal Article] Mode of Action of Van-M-02, a Novel Glycopeptide Inhibitor of Peptidoglycan Synthesis, in Vancomycin-resistant Bacteria2010
Author(s)
Miura, K.; Yamashiro, H.; Uotani, K.; Kojima, S.; Yutsudo, T.; Lu, J.; Yoshida, O.; Yamano, Y.; Maki, H.; Arimoto, H
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Journal Title
Antimicrobial Agents and Chemotherapy
Volume: 54
Issue: 2
Pages: 960-962
DOI
Related Report
Peer Reviewed
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[Journal Article] Discovery of a novel series of semi-synthetic vancomycin derivatives effective against vancomycin-resistant bacteria2010
Author(s)
Nakama,Y.; Yoshida,O.; Yoda, M.; Araki,K.; Sawada, Y.; Nakamura, J.; Xu, S.; Miura, K.; Maki, H.; Arimoto, H
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Journal Title
Journal of Medicinal Chemistry
Volume: 53
Issue: 6
Pages: 2528-2533
DOI
Related Report
Peer Reviewed
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